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Contents

Elsevier

What is and What we can get from Reaxys

How to use Reaxys

Your question

The world’s leading provider of Science and Technology information, Medical since 1880. HQ in Amsterdam .

Serving >30 million scientists, students and health and information professions. 76% of Top 1000 R&D

companies using Elsevier solutions.

Elsevier has been part of the local Chinese scientific research landscape for more than 20 years. More than 60%

of all full-text usage in China comes from Elsevier Journals.

Physics

Mathematics & Computer Science

Social Sciences

Earth Sciences

Environmental Science

Life Sciences

Materials Science & Engineering

Chemistry & Chemical Engineering

ELS 26%

Polymer • Neuroscience • The Lancet • Catalysis Today

Bioorganic & Medicinal Chemistry Letters

#1 Global Provider Publish 26% of world’s

journal articles

Sales in 180+ countries

$3.3 billion in revenue (2011)

2,200 journals yearly

Global team 74 offices in 24 countries

7,000 Journal Editors

70,000 Editorial Board Members

600,000 authors

Scientific Research Articles Published Multi-disciplinary content

Introduction of Elsevier

DISCOVERY

PRE-CLINICAL

CLINICAL POST-

MARKET

OUR PORTFOLIO ADDRESSES KEY CHALLENGES ACROSS THE PHARMA R&D VALUE CHAIN

SERVING THE LIFE SCIENCES SPACE

Search full-text, peer-

reviewed journal

articles

Database for access to

abstract & citation

Characterize

targets & analyze

disease pathways

Characterize & discover

molecules

Identify & confirm lead

compounds

Translate preclinical

data in humans

(Translational)

Monitor drug

adverse events &

real-world evidence

data in literature

Integrate the world of

data & solutions

Drug Candidate Selection

Go-No Go Decision Preclinical

Data Validation

Managing risk

4

Text Mining & Data Integration

Broader full-text indexing of

biomedical content

Workflow-Specific Solutions:

Broad-Based Solutions:

Contents

Elsevier


How to use Reaxys

Your question

Acknowledgement

Reaxys

What is reaxys?

What we can get from Reaxys?

7

WHAT’S IN A TYPICAL CHEMISTRY DOCUMENT (PUBLICATION OR PATENT)?

Scientific topic, author Chemical reactions

Chemical spectra

Experimental procedures

Substances and their

physicochemical properties

Cannot be searched by

text terms in full text



Can be searched in full

text, but you don’t want

to read the whole paper

in you are interested

only by this section!





Can be searched in full

text, but difficult to find

the right search term

Chemical structure

DR. OLIVIER BARBERAN | 2014| ELSEVIER

8

A Bibliographic Database

>46 million records

(from ~16,000 journal titles plus records from key patent organisations)

A Substance Database

> 78 million substances (total)

~ 57 million substances (unique)

A Chemical Reaction Database

> 36 million reactions

A Property Database

> 500 million experimental properties

in > 500 fields in > 130 subject areas

Reaxys 2014

Reaxys (Many TYPES of databases all in one)

INTEGRATED

DATABASES

INTEROPERABILITY WITH

Reaxys (We are becoming more and more powerful~)

0

10

20

30

40

50

60

Total Unique Substances

(millions)

30

32

34

36

38

40

Total Reactions

(millions)

0

10

20

30

40

50

Total Bibliographic Records

(millions)

0

5000

10000

15000

20000

Total Journal

Titles

0

2

4

6

8

10

12

Major Functions

REAXYS 2012 REAXYS 2014

Reaxys (We are becoming more and more powerful~)

~57.0 Million unique Substances

~36.6 Million Reactions

~500 Million experimental properties

~16,000 Journal Titles

(Life Science, Chemistry&Engineering,

Pharmacology, Enviromental Science, Books, Conference

proceedings, Editorials etc. )

~46 Million Bibliographic Records

> 500 Search fields(through querylet)

Contents

Elsevier


How to use Reaxys

Your question

How to Use Reaxys (http://www.reaxys.com)


Current 19

Reactions Selected


All yield >90%!

Filter by



Without de-protection list!


Position&Stereo isomers Widest

(http://www.reaxys.com) How to Use Reaxys Reactions– Tautomers

(http://www.reaxys.com) How to Use Reaxys

1: only 8 reactions compare

to the 13 before.

2: No anymore!


G: Any groups


Atom mapping


The same as before!


That’ not what we need!!

(http://www.reaxys.com) How to Use Reaxys Reactions– Make bond as reaction center

(http://www.reaxys.com) How to Use Reaxys Reactions-Rentention/Inversion


Inversion

(http://www.reaxys.com) How to Use Reaxys Advance Search


We will get: 1, Substructures on all atoms, 2: No ring closure

3: Yield>70%, 4: NMR exits

(http://www.reaxys.com) How to Use Reaxys Substances


Single Structure

Salt

(http://www.reaxys.com) How to Use Reaxys Substances—Position Variation Bond

What we need

1. Pyridin with only one X substitute. 2. The position of X was not certain

(http://www.reaxys.com)

Substances—Position Variation Bond

What we need

1. Pyridin with only one X substitute. 2. The position of X was not certain

How to Use Reaxys


Substances

How to Use Reaxys


How to make a synthetic plan

1: Tafinlar (GSK)

2: Approved by FDA in 2013

3: mutation-positive


2 synthetic routes designed by Reaxys


Literature

Update in Reaxys

OUR GOAL: MAKE CONTENT MORE DISCOVERABLE, MORE EASILY!

1

0

1

Ask Reaxys Reaxys Tree

Ask Reaxys provides new

user experience for text

searching: content better

discoverable, answers more

immediately available

ReaxysTree lets users

“browse” the database by

taxonomies: helps with

search precision and answer

comprehension

Formula Builder improves

the searchability of

substances through

molecular formulas: easy

way to find substances right

across the Periodic Table

Formula Builder


Ask Reaxys –A question relating to literature

How to Use Reaxys

(http://www.reaxys.com) How to Use Reaxys Ask Reaxys –Search for substances by name

(http://www.reaxys.com) How to Use Reaxys Ask Reaxys –Text querys relating to reactions

(http://www.reaxys.com) How to Use Reaxys Reaxystree–Find any term search box

(http://www.reaxys.com) How to Use Reaxys Reaxystree–Chemical reaction classes

Display all reactions and all

substances

(http://www.reaxys.com) How to Use Reaxys Reaxystree–Named Reaction

Sep

tem

ber 2

, 20

14

S

lide 1

12


Formular Builder

(http://www.reaxys.com) Your questions

GuoBao Victor Ren, Ph.D

Life Science Solution Customer Consutant, China

Tel: +86 21 61333055

Mobile: +86 13816752637

Email: [email protected]

[email protected]

Other introduction of Reaxys functions

will be continued~~! Thanks for your

questions and suggestion!

mailto:[email protected]

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