© copyright asd gmbh 2006 asd asd advanced simulation & design gmbh virtual product development...

© Copyright ASD GmbH 2006

ASDASD Advanced Simulation & Design GmbHVirtual product development in medical technology and engineering

www.ASD-online.com

Multi-level modelling in the design of

cardiovascular treatments

Catrin Bludszuweit-Philipp

ICT BIO Conference 2006


OutlineOutline

11 ASD competenciesASD competencies

22 challenges for endovascular device designchallenges for endovascular device design

33 multilevel endovascular device analysismultilevel endovascular device analysis

44 virtual stenting platform in @neurISTvirtual stenting platform in @neurIST


ASD - expert simulation servicesASD - expert simulation services

Complexsystem analysis


Simulations for medical devicesSimulations for medical devices

mimic reality closely

benefit treatment

reduce costs and time-to-market

understand needs and demands from industry and medical community:

Two main tasks for simulation experts:

give insights and motivations for use of modern technologies


Challenges for endovascular devise designChallenges for endovascular devise design

excellent mechanical properties (flexibility, strength, durability)

haemodynamically alligned

non-damaging to vascular wall

thrombosis - controllable

local drug-provider

adaptable to patient anatomy & conditions

Aims:

Optimisation and customisation of endovascular devices:


Multilevel endovascular device analysisMultilevel endovascular device analysis

Haemodynamics

Vascular wallmechanics

Device designDevice mechanics

Biological responseThrombosis

Chemical processesDrug delivery

Genetics

Cardiovascularsystems

Patient-specificanatomies

Multilevelstent / coil analysis


anatomy

mesh

expand stent into mesh

1D - modelwall

mechanics

flow

simulatinginteraction with wall

aneurysm

biological responses(thrombosis + aneurysm rupture)

virtual optimisation of treatment, device design & operation planning

Just a dream?



Developing of IT infrastructure for managing and processing of heterogeneous data associated with the diagnosis and treatment of cerebral aneurysms and subarachnoid haemorrage.

Integrative suite within @neurIST:

@neuEndo virtual stenting and coiling of patient-specific virtual stenting and coiling of patient-specific anatomies anatomies

Consolidation of competencies in @neurIST:

Make the dream

become true!



Thank you very much for

your attention


Patient-specific anatomies

inflow

outflow

aneurysm

patient-specific geometry

generation of numerical grid


Cardiovascular System

1D compartmental model1D compartmental model

Transient pressure profil in the arterial system predictedTransient pressure profil in the arterial system predictedby the 1D compartmental model by the 1D compartmental model


Haemodynamics

Prediction of flow field in cerebral aneurysms by CFD analysis Prediction of flow field in cerebral aneurysms by CFD analysis

blood vesselblood vessel

flow direction

aneurysm

stream lines

wall shear stress

flow direction

aneurysm


Vascular wall mechanics

Development of constitute equations for the tissueDevelopment of constitute equations for the tissue

Load-dependent tissue remodellingLoad-dependent tissue remodelling

Simulation of local weakening and mechanical failureSimulation of local weakening and mechanical failure


Device Design & Analysis of Device Mechanics

FE-Analysis of Stent expansion FE-Analysis of Stent expansion

Analysis of mechanical failure (e.g. buckling, life time prediciton)Analysis of mechanical failure (e.g. buckling, life time prediciton)

Interaction of endovascular devices with the flow fieldInteraction of endovascular devices with the flow field

Analysis of thrombosis riskAnalysis of thrombosis risk

Estimation of drug deliveryEstimation of drug delivery

Simulation of drug elutionSimulation of drug elutionTransfer of flow-induced forcesTransfer of flow-induced forces

wall shear stresswall shear stress

velocityvelocity

mass transfer ratemass transfer rate

concentrationconcentration


Thrombosis

Deposited activated platelets

Increased deposition in regions of long exposure times

Centrifugal blood pumphigh shear forces

thrombotic materials

flow stagnation

white and red thrombi

Thrombosis Modelling:

starting thrombus growth

platelet deposition andthrombus growth

© copyright asd gmbh 2006 asd asd advanced simulation & design gmbh virtual product development...

Documents

copyright asd gmbh

asd competencies

neurist slide

endovascular device

attention slide

d compartmental model

device design operation

d model wall mechanics