www.pureessencelabs.com

BrainEssence™

Promotes Problem-Solving Ability and Clearer Memory*

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www.pureessencelabs.com

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to

diagnose, treat, cure or prevent any disease.

Pure Essence Laboratories, Inc. P.O. Box 95397, Las Vegas, NV 89193

(888) 254-8000 - Fax: (702) 990-7405

Cognisetin™ (98% fisetin)Cognisetin™ is a proprietary extract containing 98% fisetin. Fisetin is a direct antioxidant, and also supports the production of L-Glutathione. It retards the formation of the lipid peroxides that may cause brain cell inflammation. Because it can cross the blood-brain barrier, its benefits can be delivered directly to brain cells.*

Mucuna Pruriens (15% l-dopa)Mucuna is an herb that contains l-dopa, from which we make dopamine. This neurotransmitter elevates mood, promotes a healthy mental attitude, and excites the sensory and pleasure centers in the brain.*

Bacopa (35% bacosides)Bacopa is Ayurvedic medicine’s primary botanical for promoting problem-solving skills and enhancing learning and memory. In an Australian study, it improved cognitive performance and helped subjects more quickly commit newly learned facts to memory. Another study showed it lowered anxiety levels and reduced mental fatigue. Two other studies showed that it improved learning and memory even in children between the ages of five and eight.*

Rhodiola (5% rosavins)Rhodiola grows mostly in the Siberian region of Russia. It is new to the United States because the Cold War prevented data sharing between scientists in the USSR and the United States. However, in the last decade, its benefits have been revealed. Studies have shown that it increases cellular energy while reducing markers of fatigue. It has also been shown to reduce the effects of stress.*

An amazing study in Russia observed 60 foreign students learning the Russian language. One group received 100 mg of Rhodiola extract per day, and the other group did not. The Rhodiola group showed a 61% better rate of learning the language, suffered 30% less mental fatigue, and scored higher marks on final examinations.*

Ashwagandha (4% withanolides)Ashwagandha is Ayurveda’s premier remedy for stress. It has been used for centuries to promote a sense of calm and help the body cope with stress. Anything that helps calm the stress reaction benefits brain function by reducing the levels of stress hormones that damage brain cells. Ashwagandha has long been used to promote a sense of calm and to improve mental function.*

BrainEssence™As we age, brain cells die. Because of this, we reach our learning peak at about 30 years of age. Soon after, age-related brain decline begins.

This reality has led to the production of countless “memory” supplements. However, most work in only a single direction or provide only modest nutrient levels. For maximum memory and problem-solving support, you must take the holistic approach of addressing all the issues listed herein. This requires meaningful levels of every nutrient BrainEssence™ provides.*

BrainEssence™ begins with 100 mg of Phosphatidylserine in each daily serving. It contains 800 mg of Acetyl-L-Carnitine and 15 mg of BioVinca® (Vinpocetine), which is further bolstered by its 10 mg of Cognisetin. It provides 200 mg each of standardized Bacopa, Mucuna and Ashwagandha, and the full 100 mg of the Rhodiola extract that the students learning Russian received. It also adds 100 mg of Alpha lipoic acid, which helps Acetyl-L-Carnitine to provide more energy to the brain.*

Each of these ingredients, in these amounts, may produce notable benefits within four to six months. But, because of the synergy they create together, BrainEssence™ will make a difference in only seven to 10 days.*

In short, BrainEssence™ is light years beyond any other brain supplement. It is so profound, in fact, that we guarantee it to outperform any other brain supplement you’ve ever used and to your complete satisfaction.*

References1. Schreiber S, Kampf-Sherf O, Gorfine M, Kelly D, Oppenheim Y, Lerer B., “An open trial of plant-source derived phosphatidylserine for treatment of age-related cognitive decline,” Isr J Psychiatry Relat Sci. 37(4) (2000), 302-7.2. Kato-Kataoka A, Sakai M, Ebina R, Nonaka C, Asano T, Miyamori T., “Soybean-derived phosphatidylserine improves memory function of the elderly Japanese subjects with memory complaints,” J Clin Biochem Nutr. 47(3) (2010),246-55. 3. Spasov AA, Wikman GK, Mandrikov VB, Mironova IA, Neumoin VV., “A double-blind, placebo-controlled pilot study of the stimulating and adaptogenic effect of Rhodiola rosea SHR-5 extract on the fatigue of students caused by stress during an examination period with a repeated low-dose regimen,” Phytomedicine, 7(2) (2000), 85-9.4. Stough C, Downey LA, Lloyd J, Silber B, Redman S, Hutchison C, Wesnes K, Nathan PJ., “Examining the nootropic effects of a special extract of Bacopa monnieri on human cognitive functioning: 90 day double-blind placebo-controlled randomized trial,” Phytother Res, 22(12)(2008), 1629-34.5. Stough C, Lloyd J, Clarke J, Downey LA, Hutchison CW, Rodgers T, Nathan PJ., “The chronic effects of an extract of Bacopa monnieri (Brahmi) on cognitive function in healthy human subjects,” Psychopharmacology, 156(4) (2001), 481-4.6. Géza Szilágyi, Zoltán Nagy, László Balkay, István Boros, Miklós Emri, Szabolcs Lehel, Teréz Márián, Tamás Molnár, Szabolcs Szakáll, Lajos Trón, Dániel Bereczki, László Csiba, István Fekete, Levente Kerényi, László Galuska, József Varga, Péter Bönöczk, Ádám Vas, Balázs Gulyás, “Effects of vinpocetine on the redistribution of cerebral blood flow and glucose metabolism in chronic ischemic stroke patients: a PET study”, Journal of the neurological sciences, volume 229 (2005), 275-284.7. Valikovics A., “Investigation of the effect of vinpocetine on cerebral blood flow and cognitive functions,” [Article in Hungarian], Ideggyogy Sz, 30;60(7-8) (2007), 301-10.8. Shibuya, T., Sato, K., “Effects of vinpocetine on experimental brain ischemia, histological study of brain monomines,” Igaku No Ayumi , 139, 3, (1986), 217-219.9. Sharma R., Chaturvedi C., Tewari PV., “Efficacy of Bacopa monnieri in revitalizing intellectual functions in children,” J. Res Edu Indian Med, Jan-June 1-12 (197)10. Negi KS, Singh YD, Kushwaha KP, et al, “Clinical evaluation of memory enhancing properties of Memory Plus in children with attention deficit hyperactivity disorder,” Ind J Psychiatry, 42: Supplement, (2002).

Renewing What Your Brain Needs Most*

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Phosphatidylserine (PS) Phosphatidylserine (PS) is an essential fatty acid that countless studies have shown has a positive impact on memory and problem-solving skills. It does this in four ways:

1) Increases the fluidity of brain cell membranes, which increases the number of neurotransmitter receptors. This improves communication between brain cells.*

2) Increases the number of ChAT (cholineacetyl-transferase)-positive cells in the brain, which increases the production of acetylcholine.*

3) Stimulates the production of the neurotransmitter, dopamine.*

4) Promotes glucose metabolism in brain cells, thus increasing brain energy.*

Dozens of studies confirm the value of PS in brain function.*

“It’s On the Tip of My Tongue…”You don’t need to be told when age-related brain dysfunction rears its head. Short-term memory begins to fade. Words don’t come as quickly as they once did. Details are more difficult to recall. Car keys, cell phones, and eyeglasses get harder to find.

These challenges occur because nerve cells (neurons) in the brain lose some of their ability to transmit data. This, in turn, is triggered by:

1) Fewer neurotransmitters2) Fewer neurotransmitter receptors3) Dry, brittle brain cell membranes4) Reduced energy in brain cells a.) poor utilization of oxygen b.) poor glucose metabolism c.) poor mitochondrial function5) Brain cell damage by accumulation of stress

hormones 6) Oxidative damage to brain cells 7) Restricted blood flow to brain

NeurotransmittersNeurotransmitters are chemicals that carry data from one neuron to another. When this data travels smoothly from cell to cell, problem-solving and memory function at high levels. Neurotransmitters associated with problem-solving, memory, and positive attitude include acetylcholine, dopamine, noradrenaline, and serotonin.

Neurotransmitter ReceptorsReceptors are specialized “sockets” into which only very specific “plugs” can fit. Each neurotransmitter requires its own receptors. The more healthy receptors you have, the more effective your neurotransmitters will be.

Neuron MembranesNeuron membranes are the outer portions of the cells found in the nervous system. They are the parts of cells on which neurotransmitter receptors are located. They should be pliable, flexible, and permeable. When they become dry and brittle, the number of receptors declines. Poor membrane quality may be caused by free radical oxidation, calcification, lack of fatty acids or dehydration.

Neuronal EnergyLike all cells, neurons require energy. The less energy they have, the more memory and problem-solving will suffer.

StressStress takes its toll on everything we do. The more you react to stressful situations, the more stress hormones you secrete, and the more they build up in various tissues. When they accumulate in the brain, they kill brain cells. While the loss of brain cells and certain levels of stress are unavoidable in life, limiting cell loss can only help.

Free Radical OxidationFree radicals are electrons that spin off from molecules. Some free radicals are a normal part of human metabolism, while others come from alcohol, tobacco, drugs, environmental pollutants, industrial and technological chemicals, etc. These free radicals are like little dive bombers that constantly assault cells. When they hit the cells, they cause oxidation, the same process that causes metal to rust.

While you can’t completely prevent free radical oxidation, you can minimize it with foods and supplements that contain antioxidants. To protect brain cells, you need antioxidants that can cross the blood-brain barrier. This barrier protects the brain from poisons, but also prevents most nutrients from reaching it.

These Things Can Be Fixed Neurotransmitters, neurotransmitter receptors, and the quality of neuron membranes and living brain cells themselves decline with age. Energy available to brain cells also declines, as does the ability to neutralize ever-increasing accumulations of stress hormones and the effects of free radical oxidation. Fortunately, nature provides nutrients that can help slow or stem these tides and thereby support problem-solving abilities and promote clearer memory. BrainEssence™ combines the best and broadest-acting of these nutrients.*

BioVinca® (Vinpocetine)Vinpocetine is derived from the periwinkle plant. It has been used for many years in Europe as a dietary supplement to support memory, problem-solving skills, and vision. It, too, works in several ways:

1) Increases blood flow to the brain.*

2) Increases the rate at which brain cells produce ATP for energy by supporting the utilization of glucose and oxygen.*

3) Increases brain levels of acetylcholine, dopamine, serotonin, and noradrenaline.*

More than 100 clinical trials involving over 20,000 subjects have been conducted with Vinpocetine. It is indispensable as a brain nutrient and is also a major nutrient for vision health.*

Acetyl-L-Carnitine (ALCAR)Acetyl-L-Carnitine (ALCAR) also works in several ways to enhance memory and learning skills:

1) Increases the production and release of acetylcholine.*

2) Supports neurons in the hippocampus and prefrontal cortex, which encourage memory and learning processes.*

3) Promotes flexibility and permeability in neuron membranes.*

4) Vitalizes the electron transport aspects of energy production.*

5) Serves as a direct antioxidant and promotes the production of L-Glutathione and CoQ10, thus protecting brain cells from oxidative damage.*

Alpha Lipoic Acid (ALA)Alpha lipoic acid (ALA) is Acetyl-L-Carnitine’s natural partner in encouraging the mitochondria of cells to produce energy. It is also a valuable antioxidant, makes vitamins C and E more protective by recharging them, and increases intracellular levels of the body’s master antioxidant, L-Glutathione.*

Supplement FactsServing Size: 2 Tablets

SUGGESTED USE: Two tablets in the morning, or one tablet in the morning and one in the evening.

Other Ingredients: l-leucine, silicon dioxide, croscarmellose sodium, stearic acid, cellulose. Storage: Keep tightly closed at room temperature. Caution: Please keep all supplements out of children’s reach.

Ingredient Amount Per Serving %DVAcetyl-L-Carnitine 800 mg *Ashwagandha (4% withanolides) 200 mg *Bacopa monnieri (35% bacosides) 200 mg *Mucuna pruriens (15% l-dopa) 200 mg *Alpha lipoic acid 100 mg *Phosphatidylserine (Sharp PS®, soy-free) 100 mg *Rhodiola (5% rosavins) 100 mg *BioVinca® (Vinpocetine) 15 mg *Cognisetin® (98% fisetin) 10 mg *

AVAILABLE SIZES: 30 Tablets, 60 Tablets

*Daily Value not established. Estimated Whole Food Value 8,300 mg

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Sharp PS® is a registered trademark of Enzymotec Ltd. BioVinca® is a trademark of Cyvex® Nutrition, Inc. Cognisetin® is a trademark of Cyvex® Nutrition, Inc.