Undiagnosed Diabetes, Pre-diabetes and Cardiovascular Risk in Alberta Métis Settlements: Results of the Mobile Diabetes Screening Initiative (MDSi). ELLEN L. TOTH1*, KELLI RALPH-CAMPBELL1, TRACY CONNOR1, ALISON MEIKLE1, MARY PICK1, MARGARET DANIELS2, PAULINE THOMPSON3, SHERI POHAR4 1Department of Medicine, University of Alberta, Edmonton, AB, 2Kikino Métis Settlement, AB, 3Buffalo Lake Métis Settlement, AB, 4Canadian Agency for Drugs and Technologies in Health, Edmonton, AB There is convincing research documenting the burden of diabetes within First Nations populations, but much less is known about diabetes amongst the Métis. The Mobile Diabetes Screening Initiative (MDSi) is addressing this gap in knowledge by screening for undiagnosed diabetes and cardiovascular risk within Métis community settings throughout northern Alberta. Two mobile vans equipped with portable screening technology travel to Alberta’s eight Métis Settlements. Anthropometrics and clinical parameters (BP, FPG, A1c, cholesterol, triglycerides, microalbumin) are collected on clients whose diabetes status is unknown (“unknowns”). Between November 2003 and December 2006, MDSI screened812 “unknown” Métis clients (679 adults, 133 children). 5% of the adults screened had undiagnosed diabetes (FPG: ≥7.0 mmol/L), 51% had pre-diabetes (FPG: 5.6-6.9 mmol/L), 83% wereoverweight/obese (BMI ≥25), and 85% had a parent with diabetes. No children screened had diabetes, but 21% had pre-diabetes. Additionally, 27% of adults and 15% of children screened had metabolic syndrome using NCEP/ATP III criteria; for both groups, waist circumference was the most prevalent correlate. Our data are the most detailed available to-date regarding type 2 diabetes amongst Métis people in Alberta. Our documented rates for both adults and children are consistent with higher rates reported for First Nations groups elsewhere in Canada, suggestingcommon disease determinants.