Research outputsListing of Research outputs

Stage of prolonged survival in ALS –: Author's replyAl-Chalabi, A., Fang, T., Khleifat, A. A., Meurgey, J-H., Jones, A., Leigh, P. N. & Bensimon, G. Jul 2018 In : The Lancet Neurology. 17, 7, p. 579-580 2 p.Research output: Contribution to journal › Article

Stage at which riluzole treatment prolongs survival in patients with amyotrophic lateral sclerosis: a retrospective analysis of data from a dose-ranging studyFang, T., Al Khleifat, A., Meurgey, J-H., Jones, A., Leigh, P. N., Bensimon, G. & Al-Chalabi, A. 7 Mar 2018 In : Lancet Neurology.Research output: Contribution to journal › Article

Comparison of the King's and MiToS staging systems for ALSFang, T., Al Khleifat, A., Stahl, D. R., Lazo La Torre, C., Murphy, C., Young, C., Shaw, P. J., Leigh, P. N., Al-Chalabi, A. & Uk-Mnd LicalS 5 Jan 2017 In : Amyotrophic lateral sclerosis & frontotemporal degeneration. p. 1-6 6 p.Research output: Contribution to journal › Article

Rare genetic variation in UNC13A may modify survival in amyotrophic lateral sclerosisGaastra, B., Shatunov, A., Pulit, S., Jones, A. R., Sproviero, W., Gillett, A., Chen, Z., Kirby, J., Fogh, I., Powell, J. F., Leigh, P. N., Morrison, K. E., Shaw, P. J., Shaw, C. E., van den Berg, L. H., Veldink, J. H., Lewis, C. M. & Al-Chalabi, A. 2 Sep 2016 In : Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration . 17, 7-8, p. 593-599 7 p.Research output: Contribution to journal › Article

NEK1 variants confer susceptibility to amyotrophic lateral sclerosisKenna, K. P. , van Doormaal, P. T. C. , Dekker, A. M. , Ticozzi, N. , Kenna, B. J. , Diekstra, F. P. , van Rheenen, W. , van Eijk, K. R. , Jones, A. R. , Keagle, P. , Shatunov, A. , Sproviero, W. , Smith, B. N. , van Es, M. A. , Topp, S. D. , Kenna, A. , Miller, J. W. , Fallini, C. , Tiloca, C. , McLaughlin, R. L. & 31 others Vance, C., Troakes, C., Colombrita, C., Mora, G., Calvo, A., Verde, F., Al-Sarraj, S., King, A., Calini, D., de Belleroche, J., Baas, F., van der Kooi, A. J., de Visser, M., Ten Asbroek, A. L. M. A., Sapp, P. C., McKenna-Yasek, D., Polak, M., Asress, S., Muñoz-Blanco, J. L., Strom, T. M., Meitinger, T., Morrison, K. E., Lauria, G., Williams, K. L., Leigh, P. N., Nicholson, G. A., Turner, M. R., Glass, J. D., Al-Chalabi, A., Shaw, C. E. & SLAGEN Consortium 1 Sep 2016 In : Nature Genetics. 48, 9, p. 1037-42 6 p.Research output: Contribution to journal › Letter

Decision Making About Gastrostomy and Noninvasive Ventilation in Amyotrophic Lateral SclerosisMartin, N. H., Lawrence, V., Murray, J., Janssen, A., Higginson, I., Lyall, R., Burman, R., Leigh, P. N., Al-Chalabi, A. & Goldstein, L. H. Aug 2016 In : Qualitative Health Research. 26, 10, p. 1366-1381Research output: Contribution to journal › Article

Genome-wide association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosisvan Rheenen, W. , Shatunov, A. , Dekker, A. M. , McLaughlin, R. L. , Diekstra, F. P. , Pulit, S. L. , van der Spek, R. A. A. , Võsa, U. , de Jong, S. , Robinson, M. R. , Yang, J. , Fogh, I. , van Doormaal, P. T. , Tazelaar, G. H. P. , Koppers, M. , Blokhuis, A. M. , Sproviero, W. , Jones, A. R. , Kenna, K. P. , van Eijk, K. R. & 31 others Harschnitz, O., Schellevis, R. D., Brands, W. J., Medic, J., Menelaou, A., Vajda, A., Ticozzi, N., Lin, K., Rogelj, B., Vrabec, K., Ravnik-Glavač, M., Koritnik, B., Zidar, J., Leonardis, L., Grošelj, L. D., Millecamps, S., Salachas, F., Meininger, V., de Carvalho, M., Pinto, S., Fratta, P., Topp, S., Curtis, C., Shaw, C. E., Smith, B. N., Leigh, P. N., Powell, J., Lewis, C. M., Breen, G., Al-Chalabi, A. & PARALS Registry 25 Jul 2016 In : Nature Genetics.Research output: Contribution to journal › Article

Accepting or declining non-invasive ventilation or gastrostomy in amyotrophic lateral sclerosis: patients’ perspectivesGreenaway, L. P., Martin, N. H., Lawrence, V. C., Janssen, A., Al-Chalabi, A., Leigh, P. N. & Goldstein, L. H. Apr 2015 In : Journal of Neurology. 262, 4, p. 1002-1013 12 p.Research output: Contribution to journal › Article

Psychological as well as illness factors influence acceptance of non-invasive ventilation (NIV) and gastrostomy in amyotrophic lateral sclerosis (ALS): A prospective population studyMartin, N. H., Landau, S., Janssen, A., Lyall, R., Higginson, I., Burman, R., McCrone, P., Sakel, M., Ellis, C. M., Shaw, C. E., Al-Chalabi, A., Leigh, P. N. & Goldstein, L. H. Sep 2014 In : Amyotrophic lateral sclerosis & frontotemporal degeneration. 15, 5-6, p. 376-387 12 p.Research output: Contribution to journal › Article

Health utility decreases with increasing clinical stage in amyotrophic lateral sclerosisJones, A. R., Jivraj, N., Balendra, R., Murphy, C., Kelly, J., Thornhill, M., Young, C., Shaw, P. J., Leigh, P. N., Turner, M. R., Steen, I. N., McCrone, P. & Al-Chalabi, A. Jun 2014 In : Amyotrophic lateral sclerosis & frontotemporal degeneration. 15, 3-4, p. 285-291 7 p.Research output: Contribution to journal › Article

Behavioural and emotional symptoms of apathy are associated with distinct patterns of brain atrophy in neurodegenerative disordersStanton, B. R., Leigh, P. N., Howard, R. J., Barker, G. J. & Brown, R. G. Oct 2013 In : Journal of Neurology. 260, 10, p. 2481-2490 9 p., N/AResearch output: Contribution to journal › Article

Residual association at C9orf72 suggests an alternative amyotrophic lateral sclerosis-causing hexanucleotide repeatJones, A. R., Woollacott, I., Shatunov, A., Cooper-Knock, J., Buchman, V., Sproviero, W., Smith, B., Scott, K. M., Balendra, R., Abel, O., McGuffin, P., Ellis, C. M., Shaw, P. J., Morrison, K. E., Farmer, A., Lewis, C. M., Leigh, P. N., Shaw, C. E., Powell, J. F. & Al-Chalabi, A. Sep 2013 In : Neurobiology of Aging. 34, 9, p. 2234.e1-2234.e7 7 p., N/AResearch output: Contribution to journal › Article

Symptom prevalence, severity and palliative care needs assessment using the Palliative Outcome Scale: a cross-sectional study of patients with Parkinson's disease and related neurological conditionsSaleem, T., Higginson, I. J., Chaudhuri, K. R., Martin, A-M., Burman, R. & Leigh, P. N. Sep 2013 In : Palliative Medicine. 27, 8, p. 722-731 10 p.Research output: Contribution to journal › Article

Genetic and epigenetic studies of amyotrophic lateral sclerosisAl-Chalabi, A., Kwak, S., Mehler, M., Rouleau, G., Siddique, T., Strong, M. & Leigh, P. N. May 2013 In : Amyotrophic lateral sclerosis & frontotemporal degeneration. 14, S1, p. 44-52 9 p.Research output: Contribution to journal › Article

Lithium in patients with amyotrophic lateral sclerosis (LiCALS): a phase 3 multicentre, randomised, double-blind, placebo-controlled trialUKMND-LiCALS Study Group Apr 2013 In : Lancet Neurology. 12, 4, p. 339-345 7 p.Research output: Contribution to journal › Article

Age of onset of amyotrophic lateral sclerosis is modulated by a locus on 1p34.1The ALSGEN Consortium Jan 2013 In : Neurobiology of Aging. 34, 1, p. 357.e7-19 13 p.Research output: Contribution to journal › Article

Erratum: Residual association of chromosome 9P21 SNPS with ALS after exclusion of C9ORF72 mutated cases (Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration (2012) 13 (18))Jones, A., Shatunov, A., Ellis, C. M., Leigh, P. N., Shaw, C. E. & Al-Chalabi, A. Jan 2013 In : Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration . 14, 1, p. 80 1 p.Research output: Contribution to journal › Comment/debate

Automated, high accuracy classification of parkinsonian disorders: a pattern recognition approachMarquand, A., Filippone, M., Ashburner, J., Girolami, M., Mourao-Miranda, J., Barker, G. J., Williams, S. C. R., Leigh, P. N. & Blain, C. R. V. 2013 In : PloS one. 8, 7, e69237Research output: Contribution to journal › Article

Symptoms and quality of life in late stage Parkinson syndromes: a longitudinal community study of predictive factorsHigginson, I. J., Gao, W., Saleem, T. Z., Chaudhuri, K. R., Burman, R., McCrone, P. & Leigh, P. 7 Nov 2012 In : PL o S One . 7, 11, 11 p., e46327Research output: Contribution to journal › Article

Mapping of gene expression reveals CYP27A1 as a susceptibility gene for sporadic ALSDiekstra, F. P. , Saris, C. G. J. , van Rheenen, W. , Franke, L. , Jansen, R. C. , van Es, M. A. , van Vught, P. W. J. , Blauw, H. M. , Groen, E. J. N. , Horvath, S. , Estrada, K. , Rivadeneira, F. , Hofman, A. , Uitterlinden, A. G. , Robberecht, W. , Andersen, P. M. , Melki, J. , Meininger, V. , Hardiman, O. , Landers, J. E. & 8 others Brown, R. H., Shatunov, A., Shaw, C. E., Leigh, P. N., Al-Chalabi, A., Ophoff, R. A., van den Berg, L. H. & Veldink, J. H. 11 Apr 2012 In : PL o S One . 7, 4, p. e35333 9 p., 35333Research output: Contribution to journal › Article

A proposed staging system for amyotrophic lateral sclerosisRoche, J. C., Rojas-Garcia, R., Scott, K. M., Scotton, W., Ellis, C. E., Burman, R., Wijesekera, L., Turner, M. R., Leigh, P. N., Shaw, C. E. & Al-Chalabi, A. Mar 2012 In : Brain. 135, 3, p. 847 - 852 6 p.Research output: Contribution to journal › Article

The anatomy of cognitive impairment in amyotrophic lateral sclerosis: More than frontal lobe dysfunctionTsermentseli, S., Leigh, P. N. & Goldstein, L. H. Feb 2012 In : Cortex. 48, 2, p. 166 - 182 17 p.Research output: Contribution to journal › Literature review

No evidence for a large difference in ALS frequency in populations of African and European origin: A population based study in inner city LondonRojas-Garcia, R., Scott, K. M., Roche, J. C., Scotton, W., Martin, N., Janssen, A., Goldstein, L. H., Leigh, P. N., Ellis, C. M., Shaw, C. E. & Al-Chalabi, A. Jan 2012 In : Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders. 13, 1, p. 66 - 68 3 p.Research output: Contribution to journal › Article

Altered patterns of cortical activation in ALS patients during attention and cognitive response inhibition tasksGoldstein, L. H., Newsom-Davis, I. C., Bryant, V., Brammer, M., Leigh, P. N. & Simmons, A. Dec 2011 In : Journal of Neurology. 258, 12, p. 2186-2198 13 p.Research output: Contribution to journal › Article

The risk to relatives of patients with sporadic amyotrophic lateral sclerosisHanby, M. F., Scott, K. M., Scotton, W., Wijesekera, L., Mole, T., Ellis, C. E., Leigh, P. N., Shaw, C. E. & Al-Chalabi, A. Dec 2011 In : Brain. 134, 12, p. 3451 - 3454 4 p.Research output: Contribution to journal › Article

Protocol for a double-blind randomised placebo-controlled trial of lithium carbonate in patients with amyotrophic Lateral Sclerosis (LiCALS) [Eudract number: 2008-006891-31]Al-Chalabi, A., Shaw, P. J., Young, C. A., Morrison, K. E., Murphy, C., Thornhill, M., Kelly, J., Steen, I. N., Leigh, P. N. & UKMND-LiCALS 21 Sep 2011 In : Bmc Neurology. 11, 14 p., 111Research output: Contribution to journal › Article

The economic costs of progressive supranuclear palsy and multiple system atrophy in France, Germany and the United KingdomMcCrone, P., Payan, C. A. M., Knapp, M., Ludolph, A., Agid, Y., Leigh, P. N., Bensimon, G. & NNIPPS Study Group 8 Sep 2011 In : PloS one. 6, 9, 9 p., e24369Research output: Contribution to journal › Article

Differential corticospinal tract degeneration in homozygous 'D90A' SOD-1 ALS and sporadic ALSBlain, C. R. V., Brunton, S., Williams, V. C., Leemans, A., Turner, M. R., Andersen, P. M., Catani, M., Stanton, B. R., Ganesalingham, J., Jones, D. K., Williams, S. C. R., Leigh, P. N. & Simmons, A. Aug 2011 In : Journal of Neurology, Neurosurgery and Psychiatry. 82, 8, p. 843-849 7 p., N/AResearch output: Contribution to journal › Article

Low index-to-ring finger length ratio in sporadic ALS supports prenatally defined motor neuronal vulnerabilityVivekananda, U., Manjalay, Z-R., Ganesalingam, J., Simms, J., Shaw, C. E., Leigh, P. N., Turner, M. R. & Al-Chalabi, A. Jun 2011 In : Journal of Neurology, Neurosurgery and Psychiatry. 82, 6, p. 635 - 637 3 p.Research output: Contribution to journal › Article

An estimate of amyotrophic lateral sclerosis heritability using twin dataAl-Chalabi, A., Fang, F., Hanby, M. F., Leigh, P. N., Shaw, C. E., Ye, W. & Rijsdijk, F. Dec 2010 In : Journal of Neurology, Neurosurgery and Psychiatry. 81, 12, p. 1324 - 1326 3 p., N/AResearch output: Contribution to journal › Article

Chromosome 9p21 in sporadic amyotrophic lateral sclerosis in the UK and seven other countries: a genome-wide association studyShatunov, A. , Mok, K. , Newhouse, S. , Weale, M. E. , Smith, B. , Vance, C. , Johnson, L. , Veldink, J. H. , van Es, M. A. , van den Berg, L. H. , Robberecht, W. , Van Damme, P. , Hardiman, O. , Farmer, A. E. , Lewis, C. M. , Butler, A. W. , Abel, O. , Andersen, P. M. , Fogh, I. , Silani, V. & 17 others Chiò, A., Traynor, B. J., Melki, J., Meininger, V., Landers, J. E., McGuffin, P., Glass, J. D., Pall, H., Leigh, P. N., Hardy, J., Brown, R. H., Powell, J. F., Orrell, R. W., Morrison, K. E., Shaw, P. J., Shaw, C. E. & Al-Chalabi, A. Oct 2010 In : Lancet Neurology. 9, 10, p. 986-94 9 p.Research output: Contribution to journal › Article

The association between ALS and population density: A population based studyScott, K. M., Abhinav, K., Wijesekera, L., Ganesalingam, J., Goldstein, L. H., Janssen, A., Dougherty, A., Willey, E., Stanton, B. R., Turner, M. R., Ampong, M-A., Sakel, M., Orrell, R., Howard, R., Shaw, C. E., Leigh, P. N. & Al-Chalabi, A. Oct 2010 In : Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders. 11, 5, p. 435 - 438 4 p.Research output: Contribution to journal › Article

The sex ratio in amyotrophic lateral sclerosis: A population based studyManjaly, Z. R., Scott, K. M., Abhinav, K., Wijesekera, L., Ganesalingam, J., Goldstein, L. H., Janssen, A., Dougherty, A., Willey, E., Stanton, B. R., Turner, M. R., Ampong, M-A., Sakel, M., Orrell, R. W., Howard, R., Shaw, C. E., Leigh, P. N. & Al-Chalabi, A. Oct 2010 In : Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders. 11, 5, p. 439 - 442 4 p.Research output: Contribution to journal › Article

Quantitative magnetic resonance spectroscopic imaging in Parkinson's disease, progressive supranuclear palsy and multiple system atrophyGuevara, C. A., Blain, C. R., Stahl, D., Lythgoe, D., Leigh, P. N. & Barker, G. Sep 2010 In : European Journal of Neurology. 17, 9, p. 1193 - 1202 10 p.Research output: Contribution to journal › Article

Marital relationships in amyotrophic lateral sclerosisAtkins, L., Brown, R. G., Leigh, P. N. & Goldstein, L. H. Aug 2010 In : Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders. 11, 4, p. 344 - 350 7 p.Research output: Contribution to journal › Article

Nutritional factors associated with survival following enteral tube feeding in patients with motor neurone diseaseRio, A., Shaw, C., Willey, E., Ampong, M. -A., Wijesekera, L., Rittman, T., Leigh, P. N., Sidhu, P. S. & Al-Chalabi, A. Aug 2010 In : JOURNAL OF HUMAN NUTRITION AND DIETETICS. 23, 4, p. 408 - 415 8 p.Research output: Contribution to journal › Article

Prevalence of depression in amyotrophic lateral sclerosis and other motor disordersTaylor, L., Wicks, P., Leigh, P. N. & Goldstein, L. H. Aug 2010 In : European Journal of Neurology. 17, 8, p. 1047 - 1053 7 p.Research output: Contribution to journal › Article

AMYOTROPHIC LATERAL SCLEROSIS MUTANT VESICLE-ASSOCIATED MEMBRANE PROTEIN-ASSOCIATED PROTEIN-B TRANSGENIC MICE DEVELOP TAR-DNA-BINDING PROTEIN-43 PATHOLOGYTudor, E. L., Galtrey, C. M., Perkinton, M. S., Lau, K. -F., De Vos, K. J., Mitchell, J. C., Ackerley, S., Hortobagyi, T., Vamos, E., Leigh, P. N., Klasen, C., McLoughlin, D. M., Shaw, C. E. & Miller, C. C. J. May 2010 In : Neuroscience. 167, 3, p. 774 - 785 12 p.Research output: Contribution to journal › Article

MOTOR NEURON DISEASE Focusing the mind on ALS: updated practice parametersLeigh, P. N. & Wijesekera, L. C. Apr 2010 In : Nature Reviews Neurology. 6, 4, p. 191 - 192 2 p.Research output: Contribution to journal › Article

Mutations in FUS, an RNA processing protein, cause familial amyotrophic lateral sclerosis type 6Vance, C. , Rogelj, B. , Hortobágyi, T. , De Vos, K. J. , Nishimura, A. L. , Sreedharan, J. , Hu, X. , Smith, B. , Ruddy, D. , Wright, P. , Ganesalingam, J. , Williams, K. L. , Tripathi, V. , Al-Saraj, S. , Al-Chalabi, A. , Leigh, P. N. , Blair, I. P. , Nicholson, G. , de Belleroche, J. , Gallo, J-M. & 2 others Miller, C. C. & Shaw, C. E. 27 Feb 2009 In : Science. 323, 5918, p. 1208-11 4 p.Research output: Contribution to journal › Article

Riluzole treatment, survival and diagnostic criteria in Parkinson plus disorders: The NNIPPS StudyNNIPPS Study Group, Bensimon, G. , Ludolph, A. , Agid, Y. , Vidailhet, M. , Payan, C. , Leigh, P. N. , Ludolph, A. C. , Dib, M. , Lacomblez, L. , Burn, D. , Landwehrmeyer, B. , Asselain, B. , Allain, H. , Chadwick, D. , Perret, J. E. , Warlow, C. , Ben-Shlomo, Y. , Bonnet, A. M. , Fermanian, J. & 31 others Verny, M., Moore, P., Tranchant, C., Borg, M., McCrone, P., Durif, F., Evans, A., Viallet, F., Verin, M., Deasy, N., Jarosz, J., Al-Sarraj, S., Brown, R., Al-Chalabi, A., Wood, N., Dougherty, A., Murphy, C., Schulz, J. B., Chaudhuri, K. R., Heaney, D., Blain, C., Azam, S., Williams, V., Isaacs, J., Smallman, C., Stanton, B., Dittner, A., Donnellan, C., Secker, D., Langman, A. & Lomax, C. 1 Jan 2009 In : Brain. 132, 1, p. 156-171 16 p.Research output: Contribution to journal › Article

TDP-43 mutations in familial and sporadic amyotrophic lateral sclerosisSreedharan, J., Blair, I. P., Tripathi, V. B., Hu, X., Vance, C., Rogelj, B., Ackerley, S., Durnall, J. C., Williams, K. L., Buratti, E., Baralle, F., de Belleroche, J., Mitchell, J. D., Leigh, P. N., Al-Chalabi, A., Miller, C. C., Nicholson, G. & Shaw, C. E. 21 Mar 2008 In : Science. 319, 5870, p. 1668-1672 5 p.Research output: Contribution to journal › Article

Cortical 5-HT1A receptor binding in patients with homozygous D90A SOD1 vs sporadic ALSTurner, M. R., Rabiner, E. A., Al-Chalabi, A., Shaw, C. E., Brooks, D. J., Leigh, P. N. & Andersen, P. M. Apr 2007 In : Neurology. 68, 15, p. 1233 - 1235 3 p.Research output: Contribution to journal › Article

Longitudinal predictors of psychological distress and self-esteem in people with ALSGoldstein, L. H., Atkins, L., Landau, S., Brown, R. G. & Leigh, P. N. Nov 2006 In : Neurology. 67, 9, p. 1652 - 1658 7 p.Research output: Contribution to journal › Article

Predictors of psychological distress in carers of people with amyotrophic lateral sclerosis: a longitudinal studyGoldstein, L. H., Atkins, L., Landau, S., Brown, R. & Leigh, P. N. Jun 2006 In : Psychological Medicine. 36, 6, p. 865 - 875 11 p.Research output: Contribution to journal › Article

Motor neuron disease presenting following prolonged diaphragm paralysisSteier, J., Jolley, C., Leigh, P. N., Polkey, M. I. & Moxham, J. 2006 In : Respiratory Medicine Extra. 2, 3, p. 98-100 3 p.Research output: Contribution to journal › Article

ALS2/Alsin regulates Rac-PAK signaling and neurite outgrowth.Tudor, E. L., Perkinton, M. S., Schmidt, A., Ackerley, S., Brownlees, J., Jacobsen, N. J. O., Byers, H. L., Ward, M., Hall, A., Leigh, P. N., Shaw, C. E., McLoughlin, D. M. & Miller, C. C. J. 14 Oct 2005 In : Journal of Biological Chemistry. 280, 41, p. 34735 - 34740 6 p.Research output: Contribution to journal › Article

Abnormal cortical excitability in sporadic but not homozygous D90A SOD1 ALS.Turner, M. R., Osei-Lah, A. D., Hammers, A., Al-Chalabi, A., Shaw, C. E., Andersen, P. M., Brooks, D. J., Leigh, P. N. & Mills, K. R. Sep 2005 In : Journal of Neurology, Neurosurgery and Psychiatry. 76, 9, p. 1279 - 1285 7 p.Research output: Contribution to journal › Article

Comparison of two percutaneous radiological gastrostomy tubes in the nutritional management of ALS patients.Rio, A., Ampong, M. A., Turner, M. R., Shaw, A. S., Al-Chalabi, A., Shaw, C. E., Leigh, P. N. & Sidhu, P. S. Sep 2005 In : Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders. 6, 3, p. 177 - 181 5 p.Research output: Contribution to journal › Article

Distinct cerebral lesions in sporadic and 'D90A' SOD1 ALS: studies with [11C] flumazenil PETTurner, M. R., Hammers, A., Al-Chalabi, A., Shaw, C. E., Andersen, P. M., Brooks, D. J. & Leigh, P. N. Jun 2005 In : Brain. 128, 6, p. 1323 - 1329 7 p.Research output: Contribution to journal › Article

Mills' and other isolated upper motor neurone syndromes: in vivo study with 11C-(R)-PK11195 PETTurner, M. R., Gerhard, A., Al-Chalabi, A., Shaw, C. E., Hughes, R. A. C., Banati, R. B., Brooks, D. J. & Leigh, P. N. Jun 2005 In : Journal of Neurology, Neurosurgery and Psychiatry. 76, 6, p. 871 - 874 4 p.Research output: Contribution to journal › Article

Cognitive change in ALS - A prospective studyAbrahams, S., Leigh, P. N. & Goldstein, L. H. 12 Apr 2005 In : Neurology. 64, 7, p. 1222 - 1226 5 p.Research output: Contribution to journal › Article

[11C] - WAY100635 PET demonstrates marked 5-HT1A receptor changes in sporadic ALSTurner, M. R., Rabiner, E. A., Hammers, A., Al-Chalabi, A., Grasby, P. M., Shaw, C. E., Brooks, D. J. & Leigh, P. N. Apr 2005 In : Brain. 128, 4, p. 896 - 905 10 p.Research output: Contribution to journal › Article

Living with motor neurone disease: lives, experiences of services and suggestions for changeHughes, R. A., Sinha, A., Higginson, I., Down, K. & Leigh, P. N. Jan 2005 In : Health and Social Care in the Community. 13, 1, p. 64 - 74 11 p.Research output: Contribution to journal › Article

Changes in memory for emotional material in amyotrophic lateral sclerosis (ALS)Papps, B., Abrahams, S., Wicks, P., Leigh, P. N. & Goldstein, L. H. 2005 In : Neuropsychologia. 43, 8, p. 1107 - 1114 8 p.Research output: Contribution to journal › Article

No association of the SOD1 locus and disease susceptibility or phenotype in sporadic ALSBroom, W. J., Parton, M. J., Vance, C., Russ, C., Andersen, P. M., Hansen, V., Leigh, P. N., Powell, J. F., Al-Chalabi, A. & Shaw, C. E. 28 Dec 2004 In : Neurology. 63, 12, p. 2419 - 2422 4 p.Research output: Contribution to journal › Article

Morphological differences of intraneuronal ubiquitin-positive inclusions in the dentate gyrus and parahippocampal gyrus of motor neuron disease with dementiaYaguchi, M., Fujita, Y., Amari, M., Takatama, M., Al-Sarraj, S., Leigh, P. N. & Okamoto, K. Dec 2004 In : Neuropathology. 24, 4, p. 296 - 301 6 p.Research output: Contribution to journal › Article

Entristar skin-level gastrostomy tube: Primary placement with radiologic guidance in patients with radiologic guidance in patients with amyotrophic lateral sclerosisShaw, A. S., Ampong, M. A., Rio, A., McClure, J., Leigh, P. N. & Sidhu, P. S. Nov 2004 In : Radiology. 233, 2, p. 392 - 399 8 p.Research output: Contribution to journal › Article

A novel somatodendritic marker defined by a peptide derived from the ALS2 proteinBros, V., Shemilt, S. J. A., Cooper, J. D., Skaper, S. D., Leigh, P. N. & Gallo, J. M. 5 Oct 2004 In : Neuroreport. 15, 14, p. 2155 - 2159 5 p.Research output: Contribution to journal › Article

Word retrieval in amyotrophic lateral sclerosis: a functional magnetic resonance imaging studyAbrahams, S., Goldstein, L. H., Simmons, A., Brammer, M. J., Williams, S. C. R., Giampietro, V. & Leigh, P. N. Jul 2004 In : Brain. 127, 7, p. 1507 - 1517 11 p.Research output: Contribution to journal › Article

A novel central motor conduction abnormality in D90A-homozygous patients with amyotrophic lateral sclerosisOsei-Lah, A. D., Turner, M. R., Andersen, P. M., Leigh, P. N. & Mills, K. R. Jun 2004 In : Muscle and Nerve. 29, 6, p. 790 - 794 5 p.Research output: Contribution to journal › Article

Amyotrophic lateral sclerosis: a consensus viewpoint on designing and implementing a clinical trialLeigh, P. N., Swash, M., Iwasaki, Y., Ludolph, A., Meininger, V., Miller, R. G., Mitsumoto, H., Shaw, P., Tashiro, K. & Van Den Berg, L. Jun 2004 In : Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders. 5, 2, p. 84 - 98 15 p.Research output: Contribution to journal › Literature review

Cortical selective vulnerability in Motor Neurone Disease: A morphometric studyMaekawa, S., Al-Sarraj, S., Kibble, M., Landau, S., Parnavelas, J., Cotter, D., Everall, I. & Leigh, P. N. Jun 2004 In : Brain. 127, 6, p. 1237 - 1251 15 p.Research output: Contribution to journal › Article

Efficacy and safety of xaliproden in amyotrophic lateral sclerosis: results of two phase III trialsMeininger, V., Bensimon, G., Bradley, W. G., Brooks, B. R., Douillet, P., Eisen, A. A., Lacomblez, L., Leigh, P. N. & Robberecht, W. Jun 2004 In : Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders. 5, 2, p. 107 - 117 11 p.Research output: Contribution to journal › Article

Nutritional management in MND/ALS patients: an evidence based reviewHeffernan, C., Jenkinson, C., Holmes, T., Feder, G., Kupfer, R., Leigh, P. N., McGowan, S., Rio, A. & Sidhu, P. Jun 2004 In : Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders. 5, 2, p. 72 - 83 12 p.Research output: Contribution to journal › Literature review

p38alpha stress-activated protein kinase phosphorylates neurofilaments and is associated with neurofilament pathology in amyotrophic lateral sclerosisAckerley, S., Grierson, A. J., Banner, S., Perkinton, M. S., Brownlees, J., Byers, H. L., Ward, M., Thornhill, P., Hussain, K., Waby, J. S., Anderton, B. H., Cooper, J. D., Dingwall, C., Leigh, P. N., Shaw, C. E. & Miller, C. C. J. Jun 2004 In : Molecular and Cellular Neurosciences. 26, 2, p. 354 - 364 11 p.Research output: Contribution to journal › Article

Gigaxonin is associated with the Golgi and dimerises via its BTB domainCullen, V. C., Brownlees, J., Banner, S., Anderton, B. H., Leigh, P. N., Shaw, C. E. & Miller, C. C. J. 9 Apr 2004 In : Neuroreport. 15, 5, p. 873 - 876 4 p.Research output: Contribution to journal › Article

Evidence of widespread cerebral microglial activation in amyotrophic lateral sclerosis: An [11 C]-PK11195 positron emission tomography StudyTurner, M. R., Cagnin, A., Turkheimer, F. E., Miller, C. C. J., Shaw, C. E., Brooks, D. J., Leigh, P. N. & Banati, R. B. Apr 2004 In : Neurobiology of Disease. 15, 3, p. 601 - 609 9 p.Research output: Contribution to journal › Article

Degradation properties of polyglutamine-expanded human androgen receptor in transfected cellsCullen, D. A., Leigh, P. N. & Gallo, J. M. 11 Mar 2004 In : Neuroscience Letters. 357, 3, p. 175 - 178 4 p.Research output: Contribution to journal › Article

Building user involvement in motor neurone disease: key lessonsHughes, R. A., Down, K., Sinha, A., Higginson, I. J. & Leigh, P. Feb 2004 In : JOURNAL OF INTERPROFESSIONAL CARE. 18, 1, p. 80 - 81 2 p.Research output: Contribution to journal › Article

The effect of polyglutamine expansion in the human androgen receptor on its ability to suppress beta-catenin-Tcf/Lef dependent transcriptionCullen, D. A., Killick, R., Leigh, P. N. & Gallo, J. M. 2 Jan 2004 In : Neuroscience Letters. 354, 1, p. 54 - 58 5 p.Research output: Contribution to journal › Article

MMT vs MVIC - Low-tech scores high?Leigh, P. N. & Mitsumoto, H. 9 Dec 2003 In : Neurology. 61, 11, p. 1472 - 1473 2 p.Research output: Contribution to journal › Editorial

The management of motor neurone diseaseLeigh, P. N., Abrahams, S., Al-Chalabi, A., Ampong, M. A., Goldstein, L. H., Johnson, J., Lyall, R., Moxham, J., Mustfa, N., Rio, A., Shaw, C., Willey, E. & King's MND Care Research Team Dec 2003 In : Journal of Neurology, Neurosurgery and Psychiatry. 74, 4, p. 32 - 47 16 p.Research output: Contribution to journal › Article

Cough augmentation in amyotrophic lateral sclerosisMustfa, N., Aiello, M., Lyall, R. A., Nikoletou, D., Olivieri, D., Leigh, P. N., Davidson, A. C., Polkey, M. I. & Moxham, J. 11 Nov 2003 In : Neurology. 61, 9, p. 1285 - 1287 3 p.Research output: Contribution to journal › Article

Protective effects of estrogens on polyglutamine-expanded human androgen receptor aggregationDarrington, R. S., Leigh, P. N. & Gallo, J. M. 16 Oct 2003 In : Neuroscience Letters. 350, 1, p. 37 - 40 4 p.Research output: Contribution to journal › Article

Functional magnetic resonance imaging of verbal fluency and confrontation naming using compressed image acquisition to permit overt responses.Abrahams, S., Goldstein, L. H., Simmons, A., Brammer, M. J., Williams, S. C. R., Giampietro, V., Andrew, C. M. & Leigh, P. N. 1 Sep 2003 In : Human Brain Mapping. 20, 1, p. 29 - 40 12 p.Research output: Contribution to journal › Article

Two families with familial amyotrophic lateral sclerosis are linked to a novel locus on chromosome 16qRuddy, D. M., Parton, M. J., Al-Chalabi, A., Lewis, C. M., Vance, C., Smith, B. N., Leigh, P. N., Powell, J. F., Siddique, T., Meyjes, E. P., Baas, F., De Jong, V. & Shaw, C. E. 1 Aug 2003 In : American Journal of Human Genetics. 73, 2, p. 390 - 396 7 p.Research output: Contribution to journal › Article

VEGF is a modifier of amyotrophic lateral sclerosis in mice and humans and protects motoneurons against ischemic deathLambrechts, D. , Storkebaum, E. , Morimoto, M. , Del-Favero, J. , Desmet, F. , Marklund, S. L. , Wyns, S. , Thijs, V. , Andersson, J. , van Marion, I. , Al-Chalabi, A. , Bornes, S. , Musson, R. , Hansen, V. , Beckman, L. , Adolfsson, R. , Singh Pall, H. , Prats, H. , Vermeire, S. , Rutgeerts, P. & 14 others Katayama, S., Awata, T., Leigh, N., Lang-Lazdunski, L., Dewerchin, M., Shaw, C., Moons, L., Vlietinck, R., Morrison, K. E., Robberecht, W., Van Broeckhoven, C., Collen, D., Andersen, P. M. & Carmeliet, P. 1 Aug 2003 In : Nature Genetics. 34, 4, p. 383 - 394 12 p.Research output: Contribution to journal › Article

Patients' health-related quality-of-life and health state values for motor neurone disease/amyotrophic lateral sclerosisGreen, C., Kiebert, G., Murphy, C., Mitchell, J. D., O'Brien, M., Burrell, A. & Leigh, P. N. Aug 2003 In : Quality of Life Research. 12, 5, p. 565 - 574 10 p.Research output: Contribution to journal › Article

Variants in the ALS2 gene are not associated with sporadic amyotrophic lateral sclerosisAl-Chalabi, A., Hansen, V. K., Simpson, C. L., Xi, J., Hosler, B. A., Powell, J. F., McKenna-Yasek, D., Shaw, C. E., Leigh, P. N. & Brown, R. H. Aug 2003 In : NEUROGENETICS. 4, 4, p. 221 - 222 2 p.Research output: Contribution to journal › Letter

Ciliary neurotrophic factor genotype does not influence clinical phenotype in amyotrophic lateral sclerosisAl-Chalabi, A., Scheffler, M. D., Smith, B. N., Parton, M. J., Cudkowicz, M. E., Andersen, P. M., Hayden, D. L., Hansen, V. K., Turner, M. R., Shaw, C. E., Leigh, P. N. & Brown, R. H. 1 Jul 2003 In : Annals of Neurology. 54, 1, p. 130 - 134 5 p.Research output: Contribution to journal › Article

Prolonged survival in motor neuron disease: a descriptive study of the King's database 1990-2002Turner, M. R., Parton, M. J., Shaw, C. E., Leigh, P. N. & Al-Chalabi, A. 1 Jul 2003 In : Journal of Neurology, Neurosurgery and Psychiatry. 74, 7, p. 995 - 997 3 p.Research output: Contribution to journal › Article

Identification of a novel, membrane-associated neuronal kinase, cyclin-dependent kinase 5/p35-regulated kinaseKesavapany, S., Lau, K. F., Ackerley, S., Banner, S. J., Shemilt, S. J., Cooper, J. D., Leigh, P. N., Shaw, C. E., McLoughlin, D. M. & Miller, C. C. 15 Jun 2003 In : Journal of Neuroscience. 23, 12, p. 4975 - 4983 9 p.Research output: Contribution to journal › Article

Riluzole and motor neurone disease.Turner, M. R., Al-Chalabi, A., Shaw, C. E. & Leigh, P. N. Jun 2003 In : PRACTICAL NEUROLOGY. 3, 3, p. 160 - 169 10 p.Research output: Contribution to journal › Article

Neurofilament heavy chain side arm phosphorylation regulates axonal transport of neurofilamentsAckerley, S., Thornhill, P., Grierson, A. J., Brownlees, J., Anderton, B. H., Leigh, P. N., Shaw, C. E. & Miller, C. C. J. 12 May 2003 In : Journal of Cell Biology. 161, 3, p. 489 - 495 7 p.Research output: Contribution to journal › Article

Health-related locus of control: does it change in motor neurone disease (MND)?Goldstein, L. H., Atkins, L. & Leigh, P. N. Apr 2003 In : Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders. 4, 1, p. 27 - 30 4 p.Research output: Contribution to journal › Article

A virtual user involvement forum for people living with motor neurone diseaseHughes, R. A., Down, K., Sinha, A., Higginson, I. J. & Leigh, P. N. 2003 In : Journal of Telemedicine and Telecare. 9, 6, p. 352 - 353 2 p.Research output: Contribution to journal › Letter

Amino acids for amyotrophic lateral sclerosis / motor neuron diseaseParton, M., Mitsumoto, H. & Leigh, P. N. 2003 In : Cochrane Database of Systematic Reviews. 4, p. CD003457Research output: Contribution to journal › Article

D90A-SOD1 mediated amyotrophic lateral sclerosis: a single founder for all cases with evidence for a Cis-acting disease modifier in the recessive haplotypeParton, M. J., Broom, W., Andersen, P. M., Al-Chalabi, A., Leigh, P. N., Powell, J. F., Shaw, C. E. & D90A SOD1 ALS Consortium Dec 2002 In : Human Mutation. 20, 6, p. 473- 473Research output: Contribution to journal › Article

Ligand-dependent aggregation of polyglutamine-expanded androgen receptor in neuronal cellsDarrington, R. S., Butler, R., Leigh, P. N., McPhaul, M. J. & Gallo, J. M. 15 Nov 2002 In : Neuroreport. 13, 16, p. 2117 - 2120 4 p.Research output: Contribution to journal › Article

Charcot-Marie-Tooth disease neurofilament mutations disrupt neurofilament assembly and axonal transport.Brownless, J., Ackerley, S., Grierson, A. J., Jacobsen, N. J., Shea, K., Anderton, B. H., Leigh, P. N., Shaw, C. E. & Miller, C. C. 1 Nov 2002 In : Human Molecular Genetics. 11, 23, p. 2837 - 2844 8 p.Research output: Contribution to journal › Article

Correlates of quality of life in motor neurone disease.Goldstein, L. H., Atkins, L. & Leigh, P. N. Sep 2002 In : Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders. 3, 3, p. 123 - 129 7 p.Research output: Contribution to journal › Article

Building user participation to reshape services for people affected by motor neurone diseaseDown, K., Sinha, A., Hughes, R., Higginson, I., Leigh, N. & Shaw, C. Aug 2002 In : JOURNAL OF INTERPROFESSIONAL CARE. 16, 3, p. 289 - 290 2 p.Research output: Contribution to journal › Article

Imaging: MRS/MRI/PET/SPECT: SummaryLeigh, P. N., Simmons, A., Williams, S., Williams, V., Turner, M. & Brooks, D. 2002 In : Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders. 3, SUPPL. 1, p. S75 - S80Research output: Contribution to journal › Conference paper

Long-term safety of riluzole in amyotrophic lateral sclerosisLacomblez, L., Bensimon, G., Leigh, P. N., Debove, C., Bejuit, R., Truffinet, P., Meininger, V., ALS Study Group I & ALS Study Group II 2002 In : Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders. 3, 1, p. 23 - 29 7 p.Research output: Contribution to journal › Article

Prognostic modelling of therapeutic interventions in amyotrophic lateral sclerosisTurner, M. R., Bakker, M., Sham, P., Shaw, C. E., Leigh, P. N. & Al-Chalabi, A. 2002 In : Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders. 3, 1, p. 15 - 21 7 p.Research output: Contribution to journal › Article

The challenges for policies and practices relating to MND health and social care. 13th International Symposium on ALS/ MND, MelbourneHughes, R. A., Sinha, A., Higginson, I. J., Down, K. & Leigh, P. N. 2002 In : Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders.Research output: Contribution to journal › Article

Volumetric analysis reveals corticospinal tract degeneration and extramotor involvement in ALSEllis, C. M., Suckling, J., Amaro, E., Bullmore, E. T., Simmons, A., Williams, S. C. R. & Leigh, P. N. 13 Nov 2001 In : Neurology. 57, 9, p. 1571 - 1578 8 p.Research output: Contribution to journal › Article

Journal of the Neurological Sciences: PrefaceLeigh, P. N. & Robberecht, W. 15 Oct 2001 In : Journal of the Neurological Sciences. 191, 1-2, p. 2 1 p.Research output: Contribution to journal › Article

Patients' health-related quality of life and utilities associated with different stages of amyotrophic lateral sclerosisKiebert, G. M., Green, C., Murphy, C., Mitchell, J. D., O'Brien, M., Burrell, A. & Leigh, P. N. 15 Oct 2001 In : Journal of the Neurological Sciences. 191, 1-2, p. 87 - 93 7 p.Research output: Contribution to journal › Conference paper

The effect of non-invasive positive pressure ventilation (NIPPV) on cognitive function in amyotrophic lateral sclerosis (ALS): a prospective study.Lyall, R. A., Newsom-Davis, I., Leigh, P. N., Moxham, J. & Goldstein, L. H. Oct 2001 In : Journal of Neurology, Neurosurgery and Psychiatry. 71, 4, p. 482 - 487 6 p.Research output: Contribution to journal › Article

A prospective study of quality of life in ALS patients treated with noninvasive ventilationLyall, R. A., Donaldson, N., Fleming, T., Wood, C., Newsom-Davis, I., Polkey, M. I., Leigh, P. N. & Moxham, J. 10 Jul 2001 In : Neurology. 57, 1, p. 153 - 156 4 p.Research output: Contribution to journal › Article

Progress in the pathogenesis of amyotrophic lateral sclerosisShaw, C. E., al-Chalabi, A. & Leigh, N. Jan 2001 In : CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS. 1, 1, p. 69 - 76 8 p.Research output: Contribution to journal › Article

A brief guide to ALS on-line informationGowrie, I. J., Leigh, P. N. & Radunovic, A. 2001 In : Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders. 2, 2, p. 59 - 62 4 p.Research output: Contribution to journal › Editorial

Androgen-induced up-regulation of tubulin isoforms in neuroblastoma cells.Butler, R., Leigh, P. N. & Gallo, J. M. 2001 In : Journal of Neurochemistry. 78, 4, p. 854 - 861 8 p.Research output: Contribution to journal › Article

Clinical trials in ALS: An overviewTurner, M. R., Parton, M. J. & Leigh, P. N. 2001 In : Seminars in Neurology. 21, 2, p. 167 - 175 9 p.Research output: Contribution to journal › Article

Intron 7 retention and exon 3 skipping EAAT2 mRNA variants are not associated with amyotrophic lateral sclerosisFlowers, J. M., Powell, J. F., Leigh, P. N., Andersen, P. & Shaw, C. E. 2001 In : Annals of Neurology. 49, 5, p. 643 - 649 7 p.Research output: Contribution to journal › Article

Mutations in the lysyl oxidase gene are not associated with amyotrophic lateral sclerosisChioza, B. A., Ujfalusy, A., Csiszar, K., Leigh, P. N., Powell, J. F. & Radunovic, A. 2001 In : Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders. 2, 2, p. 93 - 97 5 p.Research output: Contribution to journal › Article

Respiratory muscle strength and ventilatory failure in amyotrophic lateral sclerosisLyall, R. A., Donaldson, N., Polkey, M. I., Leigh, P. N. & Moxham, J. 2001 In : Brain. 124, 10, p. 2000 - 2013 14 p.Research output: Contribution to journal › Article

Special Issue - Advances in Amyotrophic Lateral Sclerosis - PrefaceLeigh, P. N. & Robberecht, W. 2001 In : Journal of the Neurological Sciences. 191, 1-2, p. 1 - 1 1 p.Research output: Contribution to journal › Editorial

p35/cdk5 binds and phosphorylates beta-catenin and regulates beta-catenin/presenilin-1 interactionKesavapany, S., Lau, K. F., McLoughlin, D. M., Brownlees, J., Ackerley, S., Leigh, P. N., Shaw, C. E. & Miller, C. C. J. 2001 In : European Journal of Neuroscience. 13, 2, p. 241 - 247 7 p.Research output: Contribution to journal › Article

Attributions, strain and depression in carers of partners with MND: a preliminary investigationGoldstein, L. H., Adamson, M., Barby, T., Down, K. & Leigh, P. N. 1 Nov 2000 In : Journal of the Neurological Sciences. 180, 1-2, p. 101 - 106 6 p.Research output: Contribution to journal › Conference paper

Phenotypic differences between African and white patients with motor neuron disease: a case-control studyTomik, B., Nicotra, A., Ellis, C. M., Murphy, C., Rabe-Hesketh, S., Parton, M., Shaw, C. E. & Leigh, P. N. Aug 2000 In : Journal of Neurology, Neurosurgery and Psychiatry. 69, 2, p. 251 - 253 3 p.Research output: Contribution to journal › Article

Glutamate slows axonal transport of neurofilaments in transfected neuronsAckerley, S., Grierson, A. J., Brownlees, J., Thornhill, P., Anderton, B. H., Leigh, P. N., Shaw, C. E. & Miller, C. C. J. 10 Jul 2000 In : Journal of Cell Biology. 150, 1, p. 165 - 175 11 p.Research output: Contribution to journal › Article

Verbal fluency and executive dysfunction in amyotrophic lateral sclerosis (ALS)Abrahams, S., Leigh, P. N., Harvey, A., Vythelingum, G. N., Grise, D. & Goldstein, L. H. 1 Jun 2000 In : Neuropsychologia. 38, 6, p. 734 - 747 14 p.Research output: Contribution to journal › Article

Extramotor involvement in ALS: PET studies with the GABA(A) ligand [C-11]flumazenilLloyd, C. M., Richardson, M. P., Brooks, D. J., Al-Chalabi, A. & Leigh, P. N. 2000 In : Brain. 123, p. 2289 - 2296 8 p.Research output: Contribution to journal › Article

Giant cell arteritis of the cervical radicular vessels presenting with diaphragmatic weaknessLeigh, P. N. & Shaw, C. E. 2000 In : Journal of Neurology, Neurosurgery and Psychiatry. 68, 4, p. 536 - 537 2 p.Research output: Contribution to journal › Letter

Phosphorylation of neurofilament heavy chain side-arms by stress activated protein kinase-1b/Jun N-terminal kinase-3Brownlees, J., Yates, A., Bajaj, N. P., Davis, D., Anderton, B. H., Leigh, P. N., Shaw, C. E. & Miller, C. C. J. 2000 In : Journal of Cell Science. 113, 3, p. 401 - 407 7 p.Research output: Contribution to journal › Article

Positron emission tomography (PET) - its potential to provide surrogate markers in ALSTurner, M. R. & Leigh, P. N. 2000 In : Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders. 1, 4, p. S17 - S22Research output: Contribution to journal › Conference paper

Quantitative proton magnetic resonance spectroscopy of the subcortical white matter in motor neuron diseaseEllis, C. M., Simmons, A., Glover, A., Dawson, J. M., Williams, S. C. R. & Leigh, P. N. 2000 In : Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders. 1, 2, p. 123 - 129 7 p.Research output: Contribution to journal › Article

Recent advances in amyotrophic lateral sclerosis. [Review] [82 refs]Al-Chalabi, A. & Leigh, P. N. 2000 In : Current Opinion in Neurology. 13, 4, p. 397 1 p.Research output: Contribution to journal › Article

ALSODatabase: Database of SOD1 (and other) gene mutations in ALS on the InternetEuropean FALS Grp ALSOD Consort & Leigh, P. N. Dec 1999 In : Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders. 1, 1, p. 45 - 49 5 p.Research output: Contribution to journal › Article

Distinct hyperintense MRI signal changes in the corticospinal tracts of a patient with motor neuron diseaseEllis, C. M., Simmons, A., Dawson, J. M., Williams, S. C. R. & Leigh, P. N. Dec 1999 In : Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders. 1, 1, p. 41 - 44 4 p.Research output: Contribution to journal › Article

Polymorphisms in the glutamate transporter gene EAAT2 in European ALS patientsJackson, M., Steers, G., Leigh, P. N. & Morrison, K. E. 1999 In : Journal of Neurology. 246, 12, p. 1140 - 1144 5 p.Research output: Contribution to journal › Article

Exploring the temporal nature of hemodynamic responses of cortical motor areas using functional MRISamuel, M., Williams, S., Leigh, P. N., Simmons, A., Chakraborti, S., Andrew, C. M., Friston, K. J., Goldstein, L. H. & Brooks, D. J. Dec 1998 In : Neurology. 51, 6, p. 1567-75 9 p.Research output: Contribution to journal › Article

A proton magnetic resonance spectroscopic study in ALS: correlation with clinical findingsEllis, C. M., Simmons, A., Andrews, C., Dawson, J. M., Williams, S. & Leigh, P. N. Oct 1998 In : Neurology. 51, 4, p. 1104-9 6 p.Research output: Contribution to journal › Article

No association between Parkinson's disease and low-activity alleles of catechol O-methyltransferaseHoda, F., Nicholl, D., Bennett, P., Arranz, M., Aitchison, K. J., Al-Chalabi, A., Kunugi, H., Vallada, H., Leigh, P. N., Chaudhuri, K. R. & Collier, D. A. 21 Nov 1996 In : Biochemical and Biophysical Research Communications. 228, 3, p. 780-784 5 p.Research output: Contribution to journal › Article

Proton Magnetic Resonance Spectroscopy of the Striatum in Parkinson's Disease Patients with Motor Response FluctuationsRay Chaudhuri, K., Lemmens, G. M., Williams, S. C. R., Ellis, C., Lloyd, C. M., Dawson, J., Simmons, A. & Leigh, P. N. 1 Apr 1996 In : Parkinsonism & Related Disorders. 2, 2, p. 63-67 5 p.Research output: Contribution to journal › Article

The above report is produced using the following setupOrdered by: null