0 overview of the endocrine system - dr hertoghe medical...
TRANSCRIPT
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GH MSH ACTH LH, FSH TSHThyroid HormonesCalcitonin
DHEACortisolAldosterone
TestosteroneDihydrotestosterone (DHT)
Parathormone
EstrogensProgesterone
InsulinGlucagon
Pineal Gland
4 Parathyroid Glands
2 Adrenal Glands (Cortex)
Anterior Pituitary
Males: 2 Testicles
Pancreas
Thymus
Thyroid
Hypothalamus
LiverIGF-1
Thymosins
VasopressinOxytocin TRH
2 KidneysErythropoietin
Melatonin Epithalon
EstrogensProgesterone
Females: 2 Ovaries
MED-MEDRF-27811 – © -Medica IRF
com
Top Hormones helpful To Reverse aging
Thick hair, skin, muscles; Leanness
Muscled bodymasculine body
2. Testosterone
1. IGF-1-Growth hormone
2. Estradiol
Feminine bodyBeautiful breasts
ProgesteroneNo excess breasts
3. Insulin(longacting)
Firm arms, skinFirm buttocks
4. Thyroidhormones
Lean face, lean body
5. Vasopressin/6. Aldosterone
Normal (undeep) eyes,
Smooth skin
7. Cortisol No age spots
8. Melanotan IIDark skinFirm thighs
Hypothalamus
VasopressinOxytocin
Secreted into the bloodstream
at the level of the pituitary gland
Tiny skin folds
Sunken eyes
Tiny skin folds
Sharp naso-labial fold
Sharp forehead wrinkles
Skin folds more visible when pulling on the skin
Vasopressin-poor Vasopressin-rich
Smoothskin
Dehydrated skin
Oxytocin-poorOxytocin-rich
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Growth HormoneMSH ACTH LH, FSH TSH
AnteriorPituitary
BEFORE AFTER 2 months GH& 4 months TESTO
GH treatment: The change!
GH treatment: The change!
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Typical changes of body composition is shown with DXA
during GH replacement therapyin
a patient of 42 years with 18 yearsuntreated GH deficiency
initial condition
GH replacement since 2 years
GH treatment: The change!
Obesity
MSH (Melanocyte Stimulating Hormone)
AnteriorPituitary
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Pineal Gland
MelatoninEpithalon
Melatonin deficiencyTired
During the day
tensed
sleepy
Melatonin sufficient
Prematureaging
ThyroidHormone
Calcitonin
Thyroid
Thyroid therrapy
Morning
or at rest (longtime sitting
Thyroid deficiency
Physical signs are more important in the morning
In the evening: looks best, much deflated
Puffy face, swollen lower eyelids
Swollen hands and feet
Thyroid sufficient
Kara Goucher, middle distance and long distance runner
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SUBJECTS: morbidlyobese patients => "zerocalorie" diets oftenweeks => release oforganochlorines,accumulated in the fattissue of the dieters overyears & are nowliberated within months=> Self-intoxication! =>sudden thyroid fn(Pelletier. 2002;Tremblay. 2004; Hue.2006).
http://suppversity.blogspot.be/2012/08/hypothyroid-cold-tired-depressed-try.html
Accumulation of organo-chlorines => thyroidfunction (may be set free by low calorie diet)
SUBJECTS: Morbidly obese patients
RESULTS Pelletier et al. . 2002. found stat. sign.
negative assoc. between serum active thyroid
hormone T3 & the amount of ...
• hexachlorobenzene (HCB), which was used as a
• pesticide until 1965
• in the production of rubber, aluminum, & dyes
• in wood preservation
• currently formed as a byproduct during the manufacture of otherchemicals, mainly solvents and pesticides
*PCB 156, one of the members of the polychlorinated biphenyl (PCB)family of chemicals that has now been banned from industrial insulators andlubricants, because of substantial evidence of its
• carcinogenic & neurotoxic effectshttp://suppversity.blogspot.be/2012/08/hypothyroid-cold-tired-depressed-try.html
HCB & PCB=> thyroid function(may be set free by low calorie diet)
Thymus
Thymosins
Thymosin-alpha-1 deficientInfected, inflammed
Thymosin-alpha-1 sufficient
DHEACortisolAldosterone
2 Adrenal Glands (Cortex)
....Adrenal medulla
Adrenal cortex
Adrenal medulla
Adrenal cortex *Cortisol => provides energy, takes inflammation away
*DHEA => builds up, protects against cortisol catabolism
*Aldosterone => keeps blood pressure up /water in the
body
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Cortisol Deficiency Adequate Cortisol Cortisol & DHEA
DeficiencyAdequate
Cortisol & DHEA
In a 6-month study of elderly people, researchers at Washington University School of Medicine in St. Louis found that the hormone dehydroepiandrosterone(DHEA) significantly reduced abdominal fat and improved insulin action.
Before and after MRI images of a cross-section of a patient’s abdomen in the clinical trial of DHEA show the reductionin visceral and subcutaneous fat.
DHEA => visceral & subcutaneous fat in elderly persons Aldosterone deficiency
Desire to lay down
Low aldosterone => low blood pressure
2 Kidneys2 Kidneys: Erythropoietin
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EPO is ideal for endurance efforts
Runner of ultramarathons
EPO supplemented athlete?
Liver
IGF-1
IGF-1 Deficiency IGF-1 Excess
Pancreas
InsulinGlucagon Insulin excess =>
<= Insulin deficit
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Insulin Deficient
Insulin Excess
Insulin Sufficient
EstrogensProgesterone Testosterone
Females: 2 Ovaries
Slight estrogen & progesterone deficiency
Afterpregnancy
41*Epidemiology. 2002 Nov;13(6):675-84. Ovarian hormones in premenopausal women: variation by demographic, reproductive and menstrual cycle characteristics. Windham GC, Elkin E, Fenster L, Waller K, Anderson M, Mitchell PR, Lasley B, Swan SH. Department of Health Services, Division of Environmental and Occupational Disease Control, Oakland, CA 94612, USA. [email protected]
SUBJECTS: healthy, premenop. women, 411 women age 18-39 yrs => biomarkers of ovarian fn (daily urinary metabolites of estrogen & progesterone) => about 1,500 cycles
RESULTS: Estrogen metabolite levels• elevations of 10-13% in both baseline (days 1-5) & average follicular-phase
estrogen metabolite levels in cycles + short follicular phase • 7-13% higher in the follicular & luteal phases in Hispanics > whites, slightly
higher > nonwhite, non-Hispanic women (primarily Asians).
• lower in women + prior pregnancy• lower in women + later age at menarche
Women with Prior pregnancy=> lower serum E2 metabolites
women + high levels of estrogenlow estrogen levelsMen tended to rate women with higher levels of estrogen as more attractive, healthier & more feminine-looking
Research at the University of St. Andrews
Hair volume
Rose cheeks
Volume of face
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EstrogenDeficiency
EstrogenExcess
Testosterone-poor rich
Testosterone-sufficient
*Oral contraceptives decrease saliva testosterone but do not affect the rise in testosterone associated with athletic competition
*David A. Edwards, , J. Laurel O'Neal Department of Psychology, Emory University, Atlanta, GA 30322, USA
AbstractWomen athletes from intercollegiate soccevolleyball, and softball teams, and women skaters from a team competing in an amateur roller derby league => saliva samples before warm-up and immediately after the completion of one or more sanctioned competitions. RESULTS:• Women using oral contraceptives (OCs,
= 29) had a significantly lower mean levof saliva testosterone (T) than non-users(n = 51). =>OC use is likely to contributeto individual differences in measures of psychological processes and/or behaviorwhich are causally related to individual differences in circulating testosterone.
• Whether for soccer, volleyball, softball, or roller derby, competition was associated with a robust increase in saliva T.
• Although OC users had significantly lowel l l h b f d
Oral contraceptives -> saliva testosterone but do not affect the testosterone associated with athletic competition
Oral Contraceptives
users
Nonusers
Serumtesto-
sterone(pg/ml)
Test
Testosterone deficiency after ovarierrectomy in women
TestosteroneDihydrotestosterone (DHT)
EstrogensProgesterone
2 Testicles
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Testosteroneprovides
a masculine body
Testosterone improvedTestosterone deficient