01_m032_28139
TRANSCRIPT
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RAJIV GANDHI UNIVERSITY OF HEALTH SCIENCES,
BANGALORE, KARNATAKA.
ANNEXURE - II
PROFORMA FOR REGISTRATION OF SUBJECTS FOR DISSERTATION
1. Name of the Candidate and
Address (in block letters)
Dr. SHEREEF YAHIYA. !
"#S$%RAD&A$E IN E.N.$!
DE"AR$EN$ #F E.N.$!
S. NI'AIN%A""A EDICA C#E%E
H. S. * H#S"I$A RESEARCH
CEN$RE! NA+ANA%AR! ,A%A*#$ -
/0123! *ARNA$A*A.
2. Name of the Instit4tion S. NI'AIN%A""A EDICA C#E%E
H. S. * H#S"I$A RESEARCH
CEN$RE! NA+ANA%AR! ,A%A*#$ -
/0123! *ARNA$A*A.
3. Co4rse of St4d5 and S4b6ect .S. (E.N.$) 78 YEARS9
4. Date of Admission to Co4rse 81:2:3211.
. $itle of the $o;ic RANDOMI!ED COMPARATIVE STUDY
TO EVALUATE EFFICACY OF
HYPERTONIC SALINE AGAINST
ISOTONIC SALINE IN THE
TREATMENT OF CHRONIC SINUSITIS
IN H. S. K HOSPITAL " RESEARCH
CENTRE , BAGALKOT.
#. B$%&' R&()*& +' & I&/&/ 0+$
#.1 N&&/ '+$ & ()/
1
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Chronic sin4sitis has a hi
e;idemioloork or school >ith the associated decrease in ;rod4cti=it5. If all the
costs >ere meas4red! chronic sin4sitis costs in h4orld>ide are hied interest in de=elo;in< and
doc4mentin< efficacio4s ancillar5 thera;ies that co4ld s4;;lement or abrohich >ill
affect their o=erall sense of >ellBbein
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Nasal irriith isotonic or h5;ertonic saline can im;ro=e
m4cociliar5 clearance time in =ario4s nasal ;atholoe=er contro=ers5
e?ists re of this! since no st4d5 of s4ch kind is done in ,aill be 4ndertaken for the first time in o4r instit4tion!
S. Ni6alineeks and noticed a com;liance of
//.3. Discontin4ation of the treatment >as d4e to b4rnin< sensation in the
nose and throat in /./3 of h5;ertonic saline
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saline treatment ed siice dail5 for 8 to >eeks. "atients rated nasal disease
s;ecific s5m;toms and com;leted a selfBadministered 4alit5 of >ell beinB4;. 0 of ;atients re;orted
s5m;tomatic im;ro=ement and 3 re;orted ad=erse side effects or no
beneficial effects from nasal irrias 3 amonho came for follo>B4;.
St4d5 cond4cted b5 Homer '' et al. of &* in December 3222
e=al4ated the effect of the tonicit5 of saline nasal do4chin< sol4tions on
m4cociliar5 clearance in order to ascertain >hether h5;ertonicit5 conferred
an5 ad=antaere 4sed and
m4cociliar5 clearance >ere meas4red b5 the saccharin clearance time (SC$).
$he res4ltant SC$ after administration of saline >as si
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St4d5 cond4cted b5 Da=iskas E et al. of S5dne5! A4stralia in 3223 Fall
sho>ed that lonith h5;ertonic saline(HS) or mannitol ma5
benefit ;atients >ith m4cociliar5 d5sf4nction.
abnitK DA! ormald "' of Adelaide! So4th A4stralia in a5 322
cond4cted st4d5 on /2 health5 =ol4nteers and the5 >ere randomiKed to recei=e
2. saline s;ra5 to one nostril and 8.2 saline s;ra5 to the other. $he5
collected ciliated cells and Ciliar5 ,eat Fre4enc5 >as calc4lated 4sinith 2. saline! 12.1 HK
>ith 8.2 saline. (" M .2).0
4ltimethod st4d5 b5 Raba
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rhinosin4sitis b5 Ha4;tman %! R5an of $e?as! &SA in No=ember 3220
com;ared the effect of t>o saline nasal s;ra5s on nasal ;atenc5 and
m4cociliar5 clearance. Nasal ;atenc5 and m4cociliar5 clearance meas4rements
>ere taken before and after the treatment. ,oth sol4tions im;ro=ed saccharine
clearance times (" M 2.2221). ,4ffered ;h5siolo
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to de=elo; a ;rotocol for standardiKed 4se of saline sol4tion irriB4; till 81st'an4ar5 3218 >ill be incl4ded in the
st4d5. Detailed clinical histor5 >ill be obtained follo>ed b5 clinical
e?amination. Data >ill be anal5Ked from findin
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Anal5sis of data >ill take 3 months! $5;in< and ;rintin< >ill also take 3
months. So! total d4ration of st4d5 >ill take 10 months.
Informed consent >ill be obtained from the ;atients
A= I9;)(%+ 9$%&$%6
1. All cases of chronic sin4sitis in the aill be incl4ded.
B= E>9;)(%+ 9$%&$%6
1. "atients >ith kno>n anatomical defect that obstr4cts the sin4ses.
3. "atients >ith ;ol5; and m4cocele that obstr4cts the sin4ses.
S6*
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Cases of chronic sin4sitis >ill be treated >ith isotonic saline nasal
dro;s for one
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$reatment >ith h5;ertonic saline =ers4s normal saline nasal >ash of ;ediatric
chronic sin4sitis. ' Aller
of nasal irriith m4cociliar5 d5sf4nction. ' Aerosol ed
3223 FallO 1(8) 881B1.
0. abnitK DA! ormald "'. A blinded! randomiKed! controlled st4d5 on the
effect of b4ffered 2. and 8 sodi4m chloride intranasal s;ra5s on ciliar5
beat fre4enc5. ar5nn@s
otorhinolar5n
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"R#FESS#R AND HEAD!
DE"AR$EN$ #F E.N.$!
S. NI'AIN%A""A EDICA C#E%E!
,A%A*#$.
11.2 Si
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B. V. V. S6?6(
S. NIJALINGAPPA MEDICAL COLLEGE " H. S. K HOSPITAL " RESEARCH CENTRE,
NAVANAGAR, BAGALKOT :12, KARNATAKA.
D&