1 23.1 metabolism and cell structure 23.2 atp and energy 23.3 important coenzymes in metabolic...
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23.1 Metabolism and Cell Structure 23.2 ATP and Energy23.3 Important Coenzymes in Metabolic Pathways
Chapter 23 Metabolic Pathways for Carbohydrates
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Metabolism involves: Catabolic reactions
that break down large, complex molecules to provide energy and smaller molecules.
Anabolic reactions that use ATP energy to build larger molecules.
Metabolism
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Stages of Metabolism
Catabolic reactions are organized as stages: In Stage 1, digestion breaks down large
molecules into smaller ones that enter the bloodstream.
In Stage 2, molecules in the cells are broken down to two- and three-carbon compounds.
In Stage 3, compounds are oxidized in the citric acid cycle to provide energy.
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Stages of Metabolism
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Cell Structure Metabolic reaction occur in specific sites
within cells.
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Cell Components and Function
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ATP and Energy In cells, energy is stored in adenosine triphosphate
(ATP).
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Hydrolysis of ATP
The hydrolysis of ATP to ADP releases 7.3 kcal (31 kJ/mole). ATP ADP + Pi + 7.3 kcal (31 kJ/mole)
The hydrolysis of ADP to AMP releases 7.3 kcal (31 kJ/mole). ADP AMP + Pi + 7.3 kcal (31 kJ/mole)
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Hydrolysis of ATP to ADP and ADP to AMP
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ATP and Muscle Contraction Muscle fibers contains filaments of actin and
myosin. When a nerve impulse increases Ca2+, the
filaments slide closer together to contract muscle.
The hydrolysis of ATP in muscle provides the energy for contraction.
As Ca2+ and ATP decrease, the filaments return to the relaxed position.
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ATP and Muscle Contraction
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Coenzyme NAD+
In cells, the oxidation of compounds provides 2H as 2H+ and 2e- that reduce coenzymes.
NAD+ (nicotinamide adenine dinucleotide) participates in reactions that produce a carbon-oxygen double bond (C=O).Oxidation O
||CH3—CH2—OH CH3—C—H + 2H+ + 2e-
ReductionNAD+ + 2H+ + 2e- NADH + H+
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Structure of Coenzyme NAD+
NAD+ (nicotinamide adenine dinucleotide) contains ADP, ribose, and nicotinamide.
NAD+ reduces to NADH when the nicotinamide group accepts H+ and 2e-.
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Coenzyme FAD
FAD participates in reactions that produce a carbon-carbon double bond (C=C).
Oxidation —CH2—CH2— —CH=CH— + 2H+ + 2e-
ReductionFAD + 2H+ + 2e- FADH2
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Structure of Coenzyme FAD FAD (flavin
adenine dinucleotide) contains ADP and riboflavin (vitamin B2).
FAD reduces to FADH2 when flavin accepts 2H+ and 2e-.
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Coenzyme A CoA activates acyl groups such as the two-carbon
acetyl group for transfer. O O || ||
CH3—C— + HS—CoA CH3—C—S—CoA