1 aldehydes and ketones. carbonyl compounds the compounds occur widely in nature as intermediates in...
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Examples of carbonyl compounds AmoxicillinTRANSCRIPT
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Aldehydes and Ketones
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Carbonyl compounds The compounds occur widely in nature as
intermediates in metabolism and biosynthesis They are also common as chemicals, as solvents,
monomers, adhesives, agrichemicals and pharmaceuticals
planar about the double bond and have bond angles of approximately 120°.
Strongly polarized because of the high electronegativity of oxygen relative to carbon.
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Examples of carbonyl compounds
Amoxicillin
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Carbonyl compounds reactions
1- Nucleophilic addition reactions
2- Nucleophilic acyl substitution reactions
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Carbonyl compounds reactions
3- Alpha-Substitution Reactions
4- Carbonyl Condensation Reactions
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Naming Aldehydes and Ketones
Aldehydes are named by replacing the terminal -e of the corresponding alkane name with –al
The parent chain must contain the CHO group The CHO carbon is numbered as C1
If the CHO group is attached to a ring, use the suffix -carbaldehyde
2-(1-chloroethyl)-4-methylpentanal
H
OCl
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Common names for aldehydes
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Naming Ketones Replace the terminal -e of the alkane name with –one Parent chain is the longest one that contains the
ketone group Numbering begins at the end nearer the carbonyl
carbon
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Ketones with Common Names
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Ketones and Aldehydes as Substituents The R–C=O as a substituent is an acyl group is used
with the suffix -yl from the root of the carboxylic acid CH3CO: acetyl; CHO: formyl; C6H5CO: benzoyl
The prefix oxo- is used if other functional groups are present and the doubly bonded oxygen is labeled as a substituent on a parent chain
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Preparation of Aldehydes and Ketones Preparing Aldehydes Oxidize primary alcohols using pyridinium
chlorochromate (PCC) Reduce an ester with diisobutylaluminum
hydride (DIBAH)
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Preparing Ketones Oxidize a 2° alcohol Many reagents possible: choose for the specific
situation (scale, cost, and acid/base sensitivity)
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Aryl Ketones by Acylation Friedel–Crafts acylation of an aromatic ring with an
acid chloride in the presence of AlCl3 catalyst
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Methyl Ketones by Hydrating Alkynes
Hydration of terminal alkynes in the presence of Hg2+
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Ketone and Aldehyde from Ozonolysis Ozonolysis of alkenes yields ketones if one of the
unsaturated carbon atoms is disubstituted