1. entry by droplet infection 2. day 5 – inflammation & immune response 3. alveoli fill with...
TRANSCRIPT
![Page 1: 1. Entry by Droplet Infection 2. Day 5 – Inflammation & Immune Response 3. Alveoli fill with Fluid 4. Oedema collapses Alveoli 5. Day12 – Hypoxia](https://reader036.vdocument.in/reader036/viewer/2022062322/5697bf9e1a28abf838c9478f/html5/thumbnails/1.jpg)
![Page 2: 1. Entry by Droplet Infection 2. Day 5 – Inflammation & Immune Response 3. Alveoli fill with Fluid 4. Oedema collapses Alveoli 5. Day12 – Hypoxia](https://reader036.vdocument.in/reader036/viewer/2022062322/5697bf9e1a28abf838c9478f/html5/thumbnails/2.jpg)
![Page 3: 1. Entry by Droplet Infection 2. Day 5 – Inflammation & Immune Response 3. Alveoli fill with Fluid 4. Oedema collapses Alveoli 5. Day12 – Hypoxia](https://reader036.vdocument.in/reader036/viewer/2022062322/5697bf9e1a28abf838c9478f/html5/thumbnails/3.jpg)
![Page 4: 1. Entry by Droplet Infection 2. Day 5 – Inflammation & Immune Response 3. Alveoli fill with Fluid 4. Oedema collapses Alveoli 5. Day12 – Hypoxia](https://reader036.vdocument.in/reader036/viewer/2022062322/5697bf9e1a28abf838c9478f/html5/thumbnails/4.jpg)
1. Entry by Droplet Infection2. Day 5 – Inflammation & Immune Response3. Alveoli fill with Fluid4. Oedema collapses Alveoli5. Day12 – Hypoxia & Resp
Failure
![Page 5: 1. Entry by Droplet Infection 2. Day 5 – Inflammation & Immune Response 3. Alveoli fill with Fluid 4. Oedema collapses Alveoli 5. Day12 – Hypoxia](https://reader036.vdocument.in/reader036/viewer/2022062322/5697bf9e1a28abf838c9478f/html5/thumbnails/5.jpg)
![Page 6: 1. Entry by Droplet Infection 2. Day 5 – Inflammation & Immune Response 3. Alveoli fill with Fluid 4. Oedema collapses Alveoli 5. Day12 – Hypoxia](https://reader036.vdocument.in/reader036/viewer/2022062322/5697bf9e1a28abf838c9478f/html5/thumbnails/6.jpg)
![Page 7: 1. Entry by Droplet Infection 2. Day 5 – Inflammation & Immune Response 3. Alveoli fill with Fluid 4. Oedema collapses Alveoli 5. Day12 – Hypoxia](https://reader036.vdocument.in/reader036/viewer/2022062322/5697bf9e1a28abf838c9478f/html5/thumbnails/7.jpg)
Dr Yung of HongKong University hasIsolated the corona virus from
CIVET CAT
Prof Vikramasinghe Director, Astrobiology,Cardiff University says
Virus came from OUTER SPACE
Lancet
![Page 8: 1. Entry by Droplet Infection 2. Day 5 – Inflammation & Immune Response 3. Alveoli fill with Fluid 4. Oedema collapses Alveoli 5. Day12 – Hypoxia](https://reader036.vdocument.in/reader036/viewer/2022062322/5697bf9e1a28abf838c9478f/html5/thumbnails/8.jpg)
Developing a Drug for SARS
![Page 9: 1. Entry by Droplet Infection 2. Day 5 – Inflammation & Immune Response 3. Alveoli fill with Fluid 4. Oedema collapses Alveoli 5. Day12 – Hypoxia](https://reader036.vdocument.in/reader036/viewer/2022062322/5697bf9e1a28abf838c9478f/html5/thumbnails/9.jpg)
Contributions from
The VIII World Congress
on
EndometriosisFebruary, 2002
![Page 10: 1. Entry by Droplet Infection 2. Day 5 – Inflammation & Immune Response 3. Alveoli fill with Fluid 4. Oedema collapses Alveoli 5. Day12 – Hypoxia](https://reader036.vdocument.in/reader036/viewer/2022062322/5697bf9e1a28abf838c9478f/html5/thumbnails/10.jpg)
AETIOPATHOLOGY
• Identification of Candidate Gene - Treolar• Endometriosis develops from reflux of specific
cell types, altered by peritoneal environment & not from eutopic endometrium
- Redwine &Taylor• Tumour Necrosis factor-a in peritoneal fluid - Lebovic• Decreased macrophage recruitment & Impaired
Phagocytosis - Kharfi et al
![Page 11: 1. Entry by Droplet Infection 2. Day 5 – Inflammation & Immune Response 3. Alveoli fill with Fluid 4. Oedema collapses Alveoli 5. Day12 – Hypoxia](https://reader036.vdocument.in/reader036/viewer/2022062322/5697bf9e1a28abf838c9478f/html5/thumbnails/11.jpg)
DIAGNOSIS
Search for a specific Diagnostic Marker
• Serum CA-19-9 and CA-125 may be useful
- Harada
• Endometrial Biopsy & Aromatase assay
- Deenadayalu
![Page 12: 1. Entry by Droplet Infection 2. Day 5 – Inflammation & Immune Response 3. Alveoli fill with Fluid 4. Oedema collapses Alveoli 5. Day12 – Hypoxia](https://reader036.vdocument.in/reader036/viewer/2022062322/5697bf9e1a28abf838c9478f/html5/thumbnails/12.jpg)
TREATMENT
• No benefit with Post op Interferon-a2b or GnRHa
- Randomized Trial by Acien
• Surgery during Luteal phase doubled the incidence of Recurrence compared to Proliferative phase
- Schweppe
![Page 13: 1. Entry by Droplet Infection 2. Day 5 – Inflammation & Immune Response 3. Alveoli fill with Fluid 4. Oedema collapses Alveoli 5. Day12 – Hypoxia](https://reader036.vdocument.in/reader036/viewer/2022062322/5697bf9e1a28abf838c9478f/html5/thumbnails/13.jpg)
ENDOMETRIOSIS & INFERTILITY
• Controlled Ovarian Stimulation & IUI and IVF result in acceptable Pregnancy rates
- Dmowski • IVF is the most effective Treatment
- Rickles• Laparoscopic excision of Endometrioma has no
effect on IVF results
- Marconi
![Page 14: 1. Entry by Droplet Infection 2. Day 5 – Inflammation & Immune Response 3. Alveoli fill with Fluid 4. Oedema collapses Alveoli 5. Day12 – Hypoxia](https://reader036.vdocument.in/reader036/viewer/2022062322/5697bf9e1a28abf838c9478f/html5/thumbnails/14.jpg)
GANGA & JAMUNABorn in May 2000 to aNepali Gurkha couple
CRANIOPAGUSIncidence: 1 in 2 millionSeparated successfully at
S’pore Gen Hospital
82 Hrs of Surgery + 17 Hrs To patch up Openings in Skull
usingSTEALTH computerised system to guide Vascular
Anastamosis
![Page 15: 1. Entry by Droplet Infection 2. Day 5 – Inflammation & Immune Response 3. Alveoli fill with Fluid 4. Oedema collapses Alveoli 5. Day12 – Hypoxia](https://reader036.vdocument.in/reader036/viewer/2022062322/5697bf9e1a28abf838c9478f/html5/thumbnails/15.jpg)
NeurosurgeonsKieth Goh
And Chumpon Chan
![Page 16: 1. Entry by Droplet Infection 2. Day 5 – Inflammation & Immune Response 3. Alveoli fill with Fluid 4. Oedema collapses Alveoli 5. Day12 – Hypoxia](https://reader036.vdocument.in/reader036/viewer/2022062322/5697bf9e1a28abf838c9478f/html5/thumbnails/16.jpg)
Source: Readers Digest April 2003
![Page 17: 1. Entry by Droplet Infection 2. Day 5 – Inflammation & Immune Response 3. Alveoli fill with Fluid 4. Oedema collapses Alveoli 5. Day12 – Hypoxia](https://reader036.vdocument.in/reader036/viewer/2022062322/5697bf9e1a28abf838c9478f/html5/thumbnails/17.jpg)
The Cochrane Review August 2000
• Comparison of Continuous EFM & Intermittent Auscultation in Labour
• 9 Trials: >18,000 Mothers• Conclusion: No short term or long term benefit
of continuous EFM in Labour• Increased incidence of Caesarean Section & Assisted vaginal Deliveries• Recommendation: Reduce or Abandon
Continuous EFM in low risk cases
![Page 18: 1. Entry by Droplet Infection 2. Day 5 – Inflammation & Immune Response 3. Alveoli fill with Fluid 4. Oedema collapses Alveoli 5. Day12 – Hypoxia](https://reader036.vdocument.in/reader036/viewer/2022062322/5697bf9e1a28abf838c9478f/html5/thumbnails/18.jpg)
![Page 19: 1. Entry by Droplet Infection 2. Day 5 – Inflammation & Immune Response 3. Alveoli fill with Fluid 4. Oedema collapses Alveoli 5. Day12 – Hypoxia](https://reader036.vdocument.in/reader036/viewer/2022062322/5697bf9e1a28abf838c9478f/html5/thumbnails/19.jpg)
“Yes we’re all cousins,
That’s what I believe,
Because we’re children
Of Adam and Eve…
But we’re kissing cousins”
Elvis Presley
song, 1964
![Page 20: 1. Entry by Droplet Infection 2. Day 5 – Inflammation & Immune Response 3. Alveoli fill with Fluid 4. Oedema collapses Alveoli 5. Day12 – Hypoxia](https://reader036.vdocument.in/reader036/viewer/2022062322/5697bf9e1a28abf838c9478f/html5/thumbnails/20.jpg)
EUTHANASIA
• PASSIVE : Withdrawal of Life Support
• ACTIVE : Through Direct Action
• PHYSICIAN-ASSISTED : By providing Information or Means
• INVOLUNTARY : With disregard to person’s wishes
![Page 21: 1. Entry by Droplet Infection 2. Day 5 – Inflammation & Immune Response 3. Alveoli fill with Fluid 4. Oedema collapses Alveoli 5. Day12 – Hypoxia](https://reader036.vdocument.in/reader036/viewer/2022062322/5697bf9e1a28abf838c9478f/html5/thumbnails/21.jpg)
![Page 22: 1. Entry by Droplet Infection 2. Day 5 – Inflammation & Immune Response 3. Alveoli fill with Fluid 4. Oedema collapses Alveoli 5. Day12 – Hypoxia](https://reader036.vdocument.in/reader036/viewer/2022062322/5697bf9e1a28abf838c9478f/html5/thumbnails/22.jpg)
![Page 23: 1. Entry by Droplet Infection 2. Day 5 – Inflammation & Immune Response 3. Alveoli fill with Fluid 4. Oedema collapses Alveoli 5. Day12 – Hypoxia](https://reader036.vdocument.in/reader036/viewer/2022062322/5697bf9e1a28abf838c9478f/html5/thumbnails/23.jpg)
“Doctor Death”Philip Nitschke
Demonstrating his “Death Machine”
which generates COIn Sydney
on 31 May 03
![Page 24: 1. Entry by Droplet Infection 2. Day 5 – Inflammation & Immune Response 3. Alveoli fill with Fluid 4. Oedema collapses Alveoli 5. Day12 – Hypoxia](https://reader036.vdocument.in/reader036/viewer/2022062322/5697bf9e1a28abf838c9478f/html5/thumbnails/24.jpg)
EUTHANASIA
• Some states in US & Australia allow passive euthanasia
• Netherlands first in the world to legally sanction – April 2003
• Belgium & France to follow• Applies to continuous, unbearable & incurable
pain• On request voluntarily, independently &
persistently• Second opinion must be taken
![Page 25: 1. Entry by Droplet Infection 2. Day 5 – Inflammation & Immune Response 3. Alveoli fill with Fluid 4. Oedema collapses Alveoli 5. Day12 – Hypoxia](https://reader036.vdocument.in/reader036/viewer/2022062322/5697bf9e1a28abf838c9478f/html5/thumbnails/25.jpg)
Second Opinions
•Second opinion is Patient’s Right
•Opinion only after review of History, All records & Physical Examination
From the book,
“Second Opinions” by E Groupman of Harvard Medical School