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1 Predicting the Chronic Effects of PAHs using the Target Lipid Model of Narcotic Toxicity Joy McGrath Dominic Di Toro HydroQual, Inc. SETAC North America 27 th Annual Meeting Montreal, Canada November 5-9, 2006

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Page 1: 1 Predicting the Chronic Effects of PAHs using the Target Lipid Model of Narcotic Toxicity Joy McGrath Dominic Di Toro HydroQual, Inc. SETAC North America

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Predicting the Chronic Effects of PAHs using the

Target Lipid Model of Narcotic Toxicity

Joy McGrathDominic Di Toro

HydroQual, Inc.

SETAC North America 27th Annual MeetingMontreal, Canada

November 5-9, 2006

Page 2: 1 Predicting the Chronic Effects of PAHs using the Target Lipid Model of Narcotic Toxicity Joy McGrath Dominic Di Toro HydroQual, Inc. SETAC North America

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Acknowledgement

Funding for this project was provided by

the Coastal Response Research Center

www.crrc.unh.edu

Page 3: 1 Predicting the Chronic Effects of PAHs using the Target Lipid Model of Narcotic Toxicity Joy McGrath Dominic Di Toro HydroQual, Inc. SETAC North America

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Acute Toxicity QSARs for Narcotics

Page 4: 1 Predicting the Chronic Effects of PAHs using the Target Lipid Model of Narcotic Toxicity Joy McGrath Dominic Di Toro HydroQual, Inc. SETAC North America

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Computation of Effect Concentrations

Water

* *W OW LLog(C ) 0.936log(K ) log(C ) cc

*LC = Species specific critical target lipid body burden, mol/ goctanol = mol/ glipid

cc = Chemical class adjustment, -0.352 for PAHs

*WC = Acute water-effect concentration, mmol/ L

*

* WW

C ,acuteC , chronic

ACR

Sediment

* *S OC WC ,oc K x C

g/ kgOC L/ kgOC g/ l

Page 5: 1 Predicting the Chronic Effects of PAHs using the Target Lipid Model of Narcotic Toxicity Joy McGrath Dominic Di Toro HydroQual, Inc. SETAC North America

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Acute Effects (lethality) – Single Exposures

Water Column Sediment

Page 6: 1 Predicting the Chronic Effects of PAHs using the Target Lipid Model of Narcotic Toxicity Joy McGrath Dominic Di Toro HydroQual, Inc. SETAC North America

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Chronic Effects (Growth, Reproduction, Mortality) – Single Exposures

Page 7: 1 Predicting the Chronic Effects of PAHs using the Target Lipid Model of Narcotic Toxicity Joy McGrath Dominic Di Toro HydroQual, Inc. SETAC North America

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Water Column – Chronic Sublethal Effects

Page 8: 1 Predicting the Chronic Effects of PAHs using the Target Lipid Model of Narcotic Toxicity Joy McGrath Dominic Di Toro HydroQual, Inc. SETAC North America

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90% Confidence Limits in Predicted Effect Concentration

Page 9: 1 Predicting the Chronic Effects of PAHs using the Target Lipid Model of Narcotic Toxicity Joy McGrath Dominic Di Toro HydroQual, Inc. SETAC North America

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Water Column – Other Chronic Sublethal Effects - PAH Mixtures

Rhodes et al, 2005

Page 10: 1 Predicting the Chronic Effects of PAHs using the Target Lipid Model of Narcotic Toxicity Joy McGrath Dominic Di Toro HydroQual, Inc. SETAC North America

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HC5 Values for Water and Sediment

Page 11: 1 Predicting the Chronic Effects of PAHs using the Target Lipid Model of Narcotic Toxicity Joy McGrath Dominic Di Toro HydroQual, Inc. SETAC North America

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Comparison of HC5s and NOECs for PAHs

WATER SEDIMENT