1 predicting the chronic effects of pahs using the target lipid model of narcotic toxicity joy...
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Predicting the Chronic Effects of PAHs using the
Target Lipid Model of Narcotic Toxicity
Joy McGrathDominic Di Toro
HydroQual, Inc.
SETAC North America 27th Annual MeetingMontreal, Canada
November 5-9, 2006
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Acknowledgement
Funding for this project was provided by
the Coastal Response Research Center
www.crrc.unh.edu
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Acute Toxicity QSARs for Narcotics
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Computation of Effect Concentrations
Water
* *W OW LLog(C ) 0.936log(K ) log(C ) cc
*LC = Species specific critical target lipid body burden, mol/ goctanol = mol/ glipid
cc = Chemical class adjustment, -0.352 for PAHs
*WC = Acute water-effect concentration, mmol/ L
*
* WW
C ,acuteC , chronic
ACR
Sediment
* *S OC WC ,oc K x C
g/ kgOC L/ kgOC g/ l
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Acute Effects (lethality) – Single Exposures
Water Column Sediment
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Chronic Effects (Growth, Reproduction, Mortality) – Single Exposures
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Water Column – Chronic Sublethal Effects
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90% Confidence Limits in Predicted Effect Concentration
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Water Column – Other Chronic Sublethal Effects - PAH Mixtures
Rhodes et al, 2005
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HC5 Values for Water and Sediment
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Comparison of HC5s and NOECs for PAHs
WATER SEDIMENT