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Page 1: 1/ Thomson Scientific/ 13 July 2015 Investigator Portal

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Investigator Portal

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Investigator Portal - Key points

• Why did Prous Science create Investigator Portal?

• Content• How much?

• Where from?

• Functionality - Alerts, saved queries, datasets

• Development update• New therapeutic areas

• Product & Business development

• Selling Investigator Portal• Features, Benefits & Unique Selling Points

• Authentication models

• Search examples

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Investigator Portal - Key points

• Why did Prous Science create Investigator Portal?

• Content• How much?

• Where from?

• Functionality - Alerts, saved queries, datasets

• Development update• New therapeutic areas

• Product & Business development

• Selling Investigator Portal• Features, Benefits & Unique Selling Points

• Authentication models

• Search examples

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Investigator Portal - Target Users

Translational Research Team

• Clinical researchers

• Epidemiologists

• Geneticists

• Biologists

• Pharmacologists

• Chemists

• Pharmacists

• Biostatisticians

• Bioengineers

• Data managers

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Investigator Portal - Key points

• Why did Prous Science create Investigator Portal?

• Content• How much?

• Where from?

• Functionality - Alerts, saved queries, datasets

• Development update• New therapeutic areas

• Product & Business development

• Selling Investigator Portal• Features, Benefits & Unique Selling Points

• Authentication models

• Search examples

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Investigator Portal Content – Quantity

Knowledge Area Number of recordsDrugs & Biologics 275.000Therapeutic Targets 6000Targetscapes 30Animations 440Genomics 7.500Biomarkers 92Experimental Pharmacology 685.000Pharmacokinetics 350.000Clinical Studies 83.000Disease monographs 96Literature 810.000Patents 105.000

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Over 350 scientific venues per year covered by medical reporters and writers including official sessions, symposia, poster and oral sessions,coverage

Press ReleasesAnnual/Quarterly Reports

Investor Conferences

11 Patent Offices around the world provide constant updates on product patent status

FDA / EMEA/PMDA (Japan)

Over 1,500 journals screened regularly, covering disease and treatment information

Over 500 direct collaborators around the world, dedicated to excellence in the delivery of scientific knowledge.

• Academia• Research centers• Scientific societies• Clinical practice

• Thought leaders• Regulatory agencies • Healthcare industry experts

• Patent Offices

• Journals

• Scientific Congresses

• Company Information

• Regulatory Agencies

• Contributor Network

Sources of Information

Investigator Portal Content – Sources

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Investigator Portal - Key points

• Why did Prous Science create Investigator Portal?

• Content• How much?

• Where from?

• Funcionality - Alerts, saved queries, datasets

• Development update• New therapeutic areas

• Product & Business development

• Selling Investigator Portal• Features, Benefits & Unique Selling Points

• Authentication models

• Search examples

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Investigator Portal – Development update

• New therapeutic areas• Neurological disorders

• Psychiatry

• Urological disorders

• Infectious diseases

• AIDS

• Digestive diseases

• Diabetes

• Oncology

• Respiratory diseases

• Cardiology

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Investigator Portal – Development update

Product development

• Therapeutic areas

• Self registration

• Bugs

• Branding

Business development

• Positioning

Later today:

• Marketing

• Pricing

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Investigator Portal - Key points

• Why did Prous Science create Investigator Portal?

• Content• How much?

• Where from?

• Funcionality - Alerts, saved queries, datasets

• Development update• New therapeutic areas

• Product & Business development

• Selling Investigator Portal• Features, Benefits & Unique Selling Points

• Authentication models

• Search examples

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Investigator Portal – The Translational Research Knowledge Base

• Benefits to the Customer/User• Faster access to structured and relevant information – Saves time

• Standardised presentation of information – Saves effort

• Reduces need for multiple databases – Saves money

• Unique Selling Points• ‘First in class’ unique information resource for translational researchers

• Integrates multiple knowledge areas

• Organized by medical specialties

• Analyzed, structured and indexed data, (not bibliographic database)

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Investigator Portal – Authentication models

• Site-wide access

• IP range authenticated

• Username and Password

• Trials

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Click here to see the list of therapeutic targets that have been implicated in this pathology

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See full record for EGFR

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Full record for EGFR

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Full record for EGFR

Links to external databased with records on EGFR

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Links available from the full record include direct link to the Swiss-Prot entry for this target

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Links available from the full record include direct link to the Protein Data Bank entry for this target

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Prous Science medical writers provide a short overview of each target’s importance in pathological process

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See the molecular landscapes showing the involvement of key targets in different disease processes

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Scroll down for further data on this therapeutic target

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Multimedia animations illustrate in greater detailpathological processes and therapeutic pathways

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See which other research groups are developing molecules using the same target

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Start networking or keeping an eye on the competition!

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Search results are indexed and structured around 12 interlinked Knowledge Areas

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Click here for a list of molecules acting on EGFR as a target

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We have now jumped to the Drugs & Biologics Knowledge Area for the results related to EGFR as a target

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Refine search by regulatory agency

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Select only those molecules approved by the Food & Drug Administration (FDA)...

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...and view the subset of results

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View the full record for this drug

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Full record for lapatinib

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Search results are indexed and structured around 12 interlinked Knowledge Area

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Click here to see the list of clinical studies related to this molecule

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The list of clinical studies related to this molecule

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Click here to look at the adverse event profile of this drug

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Details of adverse events reported for this drug in clinical studies

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Click here to see the biomarkers associated with this molecule

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We are now in the recently launched Biomarkers Knowledge Area

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Click to access the full record for a given biomarker

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Full record for HER2 as a biomarker

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Investigator PortalThe Translational Research Knowledge base

Philip Purnell, M.Sc.

Senior Product Manager, Prous Science