1 title: protective and pathological functions of cd8 + t cells in

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Page 1: 1 Title: Protective and pathological functions of CD8 + T cells in

Leishmania braziliensis

L. braziliensis

1. Serviço de Imunologia, Hospital Universitário Prof. Edgard Santos, Universidade

Federal da Bahia, Salvador, BA, Brazil

Instituto Nacional de Ciência e Tecnologia de Doenças Tropicais - INCT-DT

(CNPq/MCT), Salvador, BA, Brazil

Departamento de Farmacologia, Escola de Medicina de Ribeirão Preto,

Universidade de São Paulo, São Paulo, Brazil

4. Department of Pathobiology, School of Veterinary Medicine, University of

Pensylvania, Philadelphia, PA, USA.

IAI Accepts, published online ahead of print on 22 December 2014Infect. Immun. doi:10.1128/IAI.02404-14Copyright © 2014, American Society for Microbiology. All Rights Reserved.

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Page 2: 1 Title: Protective and pathological functions of CD8 + T cells in

L. braziliensis

L. braziliensis

γ

γ

γ L. braziliensis

Leishmania braziliensis

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Page 3: 1 Title: Protective and pathological functions of CD8 + T cells in

Leishmania.

Leishmania

γ Leishmania

Leishmania braziliensis

L. braziliensis

Leishmania

L. braziliensis

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Page 4: 1 Title: Protective and pathological functions of CD8 + T cells in

L. braziliensis

L.

braziliensis

L. braziliensis

in vitro γ

γ

L. braziliensis

L. braziliensis

L.

braziliensis

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Page 5: 1 Title: Protective and pathological functions of CD8 + T cells in

γ

L. braziliensis

ex vivo

α

α

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α

α α

γ

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α α α

α

L. braziliensis

α

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Page 8: 1 Title: Protective and pathological functions of CD8 + T cells in

α α

Leishmania

L.braziliensis

L. braziliensis

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U

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Page 10: 1 Title: Protective and pathological functions of CD8 + T cells in

L. braziliensis

L. braziliensis

versus

L. braziliensis

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L.braziliensis

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L. braziliensis

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Page 14: 1 Title: Protective and pathological functions of CD8 + T cells in

L.braziliensis

L. braziliensis

L. braziliensis

γ

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Page 15: 1 Title: Protective and pathological functions of CD8 + T cells in

L.

braziliensis

L.

braziliensis L. major

Leishmania

γ

L.(V.) panamensis,

L. amazonensis

in vitro

L. braziliensis

Leishmania

L. braziliensis L. panamensis

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Page 16: 1 Title: Protective and pathological functions of CD8 + T cells in

L. braziliensis

L. braziliensis

L. braziliensis

et al.

L.

braziliensis

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Page 17: 1 Title: Protective and pathological functions of CD8 + T cells in

L. braziliensis

L. braziliensis

T. cruzi

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γ

T. cruzi

L. braziliensis

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γ γ

γ

γ

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γ

γ

U

L.

braziliesis versus

U

L. braziliensis

versus

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L.braziliensis

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