10 informatics related drivers of change that could disrupt pharmacy practice in the next 5 years...
TRANSCRIPT
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10 Informatics Related Drivers of Change That Could Disrupt Pharmacy Practice in the Next 5
Years
Philip E. [email protected]
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1. Red Balloon Challenge
• The challenge is to be the first to submit the locations of 10 moored, 8-foot, red, weather balloons at 10 fixed locations in the continental United States. The balloons will be in readily accessible locations and visible from nearby roads
Time to Solve = 8 hours 52 minutes
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1. Location and Build Up• Considered intractable• 29 Oct – Dr Dugan announces the DARPA Network Challenge at UCLA;• DARPA issues press release to targeted media and bloggers• DARPA NETWORK CHALLENGE – PROJECT REPORT – FEBRUARY 16, 2010329 Oct –
Huffington Post posts the DNC announcement (many of the initial citations for early blogs are linked back to the Huffington Post article
• )31 Oct – MSSV posts very thoughtful and widely cited blog on the nature of the DNC and expected strategies for winning (http://mssv.net/2009/10/31/how to‐ ‐win the darpa network challenge/‐ ‐ ‐ ‐
• 1 Nov – Slashdot posts DNC announcement (http://news.slashdot.org/story/09/11/02/0056236/Find DARPAs Balloons Win ‐ ‐ ‐ ‐40K?art_pos=5)2 Nov – Wiki tracking DNC teams is launched (http://redballoon.wikispaces.com/Groups)
• 4 Nov – Video of Dr. Regina E. Dugan’s speech is available on YouTube(http://www.youtube.com/watch?v=N85ryOFVeQg)
• 13 Nov – DNC team SpotBigRed posts first video seeking team members(http://www.youtube.com/watch?v=0vz8ZI‐8aXA&feature=response_watch) Steady trickle of traffic to the DNC website, an average of 1000 new visitors daily
• 24 Nov – Registration for the DNC opens. DARPA_News tweets that registration is open
• 1Dec– 1Dec– 2 Dec –3Dec– 3Dec–3Dec– 3Dec–4Dec– 4Dec–5Dec– 5Dec–New York Times story runs (http://www.nytimes.com/2009/12/01/science/01darpa.html?_r=1) MSNBC.com story runs (http://cosmiclog.msnbc.msn.com/archive/2009/12/01/2139419.aspx) NPR’s Here and Now broadcasts story on DNC. Includes interview with GA Tech Research Institute I Spay A Red Balloon team (http://www.hereandnow.org/2009/12/rundown 122 2/#3) Rachel Maddow show ‐ ‐broadcasts story on DNC (http://www.youtube.com/watch?v=4wyMB0gx_3Y#watch main area) Team Farc announced ‐ ‐(http://www.fark.com/cgi/comments.pl?IDLink=4816872) (Farc will become the #1 media referring site for web traffic) MIT Media Lab team launches website and recursive recruiting emails Nerdfighter team releases video blog (vlog) (http://nerdfighters.ning.com/profiles/blog/list?q=%2440%2C000+of+Red+Balloons) DNC is the lead story on the CNN Tech page (http://www.cnn.com/2009/TECH/12/04/darpa.balloon.challenge/index.html) Scientific American story runs (http://www.scientificamerican.com/article.cfm?id=darpa network challenge) Balloons launched CNN Headline News story runs, ‐ ‐includes interview with the MIT Media Lab Team https://networkchallenge.darpa.mil/ProjectReport.pdf
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1. Factors Impacting Team Performance
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1. Findings
• Traditional mass media is predictable• Viral diffusion when it occurs is rapid• Twitter alone revealed ½ the balloons in one
day• Successful team accrued a network of
collaborators very quickly• Social networks can change things
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Much Has Happened Since Then
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2. Visualization
Under the best circumstances remote conferencing is possible over 8000 miles as if you were there – this will be the Skype video of tomorrow and will inflict social change
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Geography is not an issue
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2. Visualization – Impact on Pharmacy Practice
• Your thoughts?
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3. Systems Pharmacology
• Tykerb – Breast cancer
• Gleevac – Leukemia, GI cancers
• Nexavar – Kidney and liver cancer
• Staurosporine – natural product – alkaloid – uses many e.g., antifungal antihypertensive
Collins and Workman 2006 Nature Chemical Biology 2 689-700
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4. Drug Repositioning
• Similarities between drug binding sites and TB proteins are found for 61/268 drugs
• 41 of these drugs could potentially inhibit more than one TB protein
No. of potential TB targets
No.
of
drug
s raloxifenealitretinoin
conjugated estrogens &methotrexate
ritonavir
testosteronelevothyroxine
chenodiol
Kinnings et al 2010 PLoS Comp. Biol. 6(11): e1000976
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5. Personalized Medicine
http://pharmacogenomics.ucsd.edu/
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6. Robotics/Sensors
• I get into my wife’s car by touching the door handle. In a few seconds the music on my iPhone starts playing and will be interrupted when a call comes in and I can answer it and speak without my hands leaving the wheel…
• Forgetting about uncontrollable acceleration – how could these technologies translate to pharmacy practice?
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6. Robotics/Sensors
• Examples?
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7. Open ScienceJosh Sommer and Chordoma Disease
http://fora.tv/2010/04/23/Sage_Commons_Josh_Sommer_Chordoma_Foundation#fullprogram
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8. Health Care Reform
http://www.nacds.org/user-assets/pdfs/newsrelease/2009/Pharmacy_Principles_for_Health_Care_Reform.pdf
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9 Translational Medicine
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10. University – Commercial Partnerships