10/11/2005 1 overview nsf engineering research center for structured organic composites

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OverviewOverview

NSF Engineering Research Center

for Structured Organic Composites

Center for Structured Organic Composites (C-SOC) Rutgers – NJIT – Purdue – UPRM

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University-Industry-Government University-Industry-Government PartnershipPartnership


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A Structured Organic Composite A Structured Organic Composite


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C-SOC Vision of Desired StateC-SOC Vision of Desired State

Given active organic substances & administration/delivery requirements,

• Development of structured organic composite product

• Design of associated process• Manufacturing execution will occur via

Model-predictive integrated framework based on fundamental understanding

supported by a minimum of key experiments


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C-SOC MissionC-SOC Mission

1: Develop a scientific foundation for the optimal design of structured organic composites.

2: Develop science and engineering methods for designing, scaling, optimizing and controlling relevant manufacturing processes.

3: Establish effective educational and technology transfer vehicles.

4: Establish effective mechanisms for the inclusion and participation of minorities and women at all levels.


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Development Programs:Test Beds

THRUST 1: Fundamental Knowledge on Materials, Synthesis & Functionalization

Project P1, P2, P3

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TB1TB1

Environment /Marketplace

REQUIREMENTS

OUTCOMES

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TB4TB4

TB3TB3

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TB5TB5

PRODUCTS

ManufacturingControl, SynthesisStructuring & Monitoring

PRODUCT IDEAS

Ideas forNew Materials& Applications

THRUST 2: Fundamental Knowledge on Composites, Synthesis & Characterization

P4, P5, P6

Materials Properties &

Synthesis

Required Structure

Required Functionality

THRUST 3: Technology Integration Manufacturing Science P7, P8, P9

Structuring Methods

Thrust Areas:Projects

CSOC Integrated Research PlanCSOC Integrated Research Plan


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Initial Project Line-up

P1

• Thrust 1: Material Synthesis and FunctionalizationFunctionalized Nanoparticles for Tissue Targeting

Functionalized Particles by Nanocoating

Mechanical Strength of Small Organic Crystals• Thrust 2: Composites Synthesis and Characterization

DEM for Realistic Particle Processing Computations

Deagglomeration of Nano- and Micro-agglomerates

Multiscale Computational Tools for Dissolution and Disintegration• Thrust 3: Manufacturing Science

Synthesis and Design of Integrated Composite Manuf. Processes

Real-time Monitoring of Pharmaceutical Manufacturing Processes

MPC Control Strategies for Blending Operations

P2

P3

P4

P5

P6

P7

P8

P9

• Projects focus on basic and enabling research addressing technical gaps and focusing on overcoming technical barriers


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P4: Discrete Element Models for Realistic P4: Discrete Element Models for Realistic Particle Processing ComputationsParticle Processing Computations

• Motivation– Need for correlating system

behavior to process conditions and powder properties

– Need to scale from the particle level to the unit operation level

– Mechanistic understanding for coarse grain models necessary for active control

• Approach– Large scale 3D simulations of

realistic scenarios– Accurate inter-particle

interactionsCarl Wassgren Purdue (Project Leader)

Steve Beaudoin Purdue (Inter-particle force models) Maureen Howley NJIT (DEM-continuum modeling)

Silvina Tomassone Rutgers (DEM-continuum modeling)


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P6: Multiscale Computational Tools for P6: Multiscale Computational Tools for Dissolution and DisintegrationDissolution and Disintegration

• Motivation: – Dissolution and disintegration

profiles are key characteristics of any delivery system.

– Relation between ingredient properties/processing with dissolution profiles is unpredictable.

– Need for methodologies to

accurately predict active release.

• Approach: – Combine, expand and develop

existing multiscale models and simulations techniques (MD, discrete-continuum, FEM).

Mike Harris Purdue (Project Leader)Piero Armenante NJIT (dissolution)

Alberto Cuitiño Rutgers (multiscale modeling) Fernando Muzzio Rutgers (mixing, dissolution)


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ERC Matrix Organization of ResearchERC Matrix Organization of Research

Thrust I: Materials Synthesis and Functionalization

Thrust II: Composites Synthesis and Characterization

Thrust III: Manufacturing Science

Granular Micro-

composites

Macro-composites

Engineered particulate ingredients

TB 1: Microjet synthesis of

micro-& nano-particles

TB 4: Wetsynthesis of hierarchical

microcomposites

TB 5: Continuous manufacturing

of dry macrocomposites

TB 3:Multicomp particles using in-line liquid-

liquid dispersion

TB 2: Micro-particle synthesis

via impinging jet precipitation

TB 6: Mini-manufacturing :

Controlled Formation of Composites

Thrusts, Development programs and Test beds


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TB 1: Continuous Particle Synthesis & TB 1: Continuous Particle Synthesis & Coating via Ink-Jet TechnologyCoating via Ink-Jet Technology

Goal: Demonstrate use of micro-jet methods to formuniformly sized particles from solutions/suspensions

Team Leader: Basaran (ChE, Purdue)Members: Glasser (ChE, Rutgers), Khusid (ME, NJIT)

Mitra (Chem, NJIT), Rinaldi (ChE,UPR)


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TB 6: Mini-Manufacturing System: TB 6: Mini-Manufacturing System: Controlled Formation of CompositesControlled Formation of Composites

Goal: Design & demonstrate compact, dose-on-demand pharmaceutical mini-factory

Team Leader: Reklaitis (ChE, Purdue)Members: Basaran (ChE, Purdue)Khusid (ME, NJIT)Li (Chem, Rutgers)Pinal (IPPH, Purdue) Takhistov (FSci,Rutgers)


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UG GRADK-12

Rutgers Science Explorer

REU

POST GRAD

Cont Educ. Mod.(Industry)

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Summer Intern. Program

REU

Summer School

EPICS Lab Facilities

M.S.

Ph. D.

HS Modules

HS Teacher Training/CEUs

Certificates

LSAMP / AGEP

LSAMP / AGEP

Minors

Education, Outreach, and Diversity Education, Outreach, and Diversity RoadmapRoadmap


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Multi-Institutional Leadership TeamMulti-Institutional Leadership Team

• Director: Fernando Muzzio, ChE Rutgers

• Deputy Director: Rex Reklaitis, ChE Purdue (Purdue site leader)

• Material Synthesis & Functionalization Thrust Leader: Raj Dave, ME NJIT (NJIT site leader)

• Composite Synthesis & Characterization Thrust Leader: Alberto Cuitino (Rutgers site leader), ME Rutgers

• Manufacturing Science Thrust Leader: Venkat Venkatasubramanian, ChE Purdue.

• UPR site Leader: Carlos Velazquez, ChE UPRM

• Education Director: Henrik Pedersen ChE Rutgers

• Outreach and Diversity Director: Holly Crawford, Engineering, Rutgers

• Development Program I Coordinator: Piero Armenante, ChE, NJIT

• Development Program II Coordinator: Ken Morris, Pharm, Purdue

• Development Program III Coordinator: Bo Michniak, Pharm, Rutgers


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Purdue TeamPurdue Team

• Ag & Bio Engr– Narsimhan– Okos*

• Chemical Engr– Agrawal– Basaran*– Beaudoin*– Harris*– Pekny– Ramkrishna*– Reklaitis*– Thomson– Venkatasubramanian*– Won

• Food Science– Nivens

• Industrial Pharmacy– Byrn– Carvajal*– Morris*– Pinal*– Taylor*

• Mechanical Engr– Kim (joint with ChE)– Sojka– Wassgren*

• Discovery Park– Basu– Blau– Joglekar

*Core faculty


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ERC-SOCERC-SOCIndustry and Nonprofit PartnersIndustry and Nonprofit Partners

IrvineIrvine

ExelusExelus


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Industry PartnersIndustry Partners

• Roles– Participate in decisions on research & education

directions– Participate in translating findings into practice– Help develop future work force: students & postdocs– Collaborate in specific bilateral technical projects

• Membership levels– Lead Center members

• Abbott, GSK, Lilly, PepsiCo, Pfizer, P&G– Regular Center memberships (three levels)

• Level 1: Regular members (9 so far)• Level 2: Center-wide technology affiliates (3 so far)• Level 3: Single thrust technology affiliates (2 so far)

• Bilateral Projects with industry on specific issues


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Annual Budget EstimateAnnual Budget Estimate

• NSF $3 MM• University cost-share $0.6 MM• Industry memberships $1 MM• Industry bilateral projects $2

MMe.g., Lilly commitment – $100K membership– $300K/y projects

• Potential for NSF supplements


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Center StatusCenter Status

C-SOC has passed multiple stage gates• Letter of Intent : Sept 1, 2004• Preproposal: Nov 8, 2004

– Invitation to submit full proposal March 1, 2005• Proposal: June 16, 2005

– Industrial partners: 28 committed– Selection for Site Visit: Sept 20, 2005

• Site Visit: Dec 6-7, 2005– Universities commit to 14 new faculty lines– Univ Puerto Rico commits to $1 million facility cost-share

• Reverse Site Visit: Jan 11, 2006• ERC Panel Positive Recommendation: Jan 18, 2006• Division Director sign-off: April 13, 2006• Completion of NSF approval process: mid-May, 2006

10/11/2005 1 overview nsf engineering research center for structured organic composites

Documents

composites synthesis

csoc mission

csoc vision of desired

synthesis characterization

material synthesis

functionality thrust

p3 development program

government partnership