10.antibiotics in brd prophylaxis and therapy
TRANSCRIPT
![Page 1: 10.antibiotics in brd prophylaxis and therapy](https://reader033.vdocument.in/reader033/viewer/2022042701/55a759191a28ab62458b4618/html5/thumbnails/1.jpg)
mêçéÜóä~ñáëI=jÉí~éÜóä~ñáë C=qÜÉê~éó
jÉêá~ä=cçêìã=çå=_oa
PMíÜ ëÉéíÉãÄÉê Ó Nëí çÅíçÄÉê OMNM`¨ÇêáÅ=abwfbo
cê~åÅÉ=oìãáå~åí=qÉÅÜåáÅ~ä pÉêîáÅÉë
![Page 2: 10.antibiotics in brd prophylaxis and therapy](https://reader033.vdocument.in/reader033/viewer/2022042701/55a759191a28ab62458b4618/html5/thumbnails/2.jpg)
ProphylaxisProphylaxis
Healthy animals treated.No BRD outbreak in the herd...
![Page 3: 10.antibiotics in brd prophylaxis and therapy](https://reader033.vdocument.in/reader033/viewer/2022042701/55a759191a28ab62458b4618/html5/thumbnails/3.jpg)
ProphylaxisProphylaxis
Herd management!Vaccinations!Antibiotics?
![Page 4: 10.antibiotics in brd prophylaxis and therapy](https://reader033.vdocument.in/reader033/viewer/2022042701/55a759191a28ab62458b4618/html5/thumbnails/4.jpg)
WhyWhy BRD & BRD & antibiopreventionantibioprevention in in the real life?the real life?
Fattening
Breeding herd
Vealcalves
![Page 5: 10.antibiotics in brd prophylaxis and therapy](https://reader033.vdocument.in/reader033/viewer/2022042701/55a759191a28ab62458b4618/html5/thumbnails/5.jpg)
FatteningFattening
France, Assie 2009 1167 young beef animals
1083 brought in 84 born at fattening site
71 herds 18,1% morbidity
1,2% for those born at fattening site 19,4% for those bought outside
![Page 6: 10.antibiotics in brd prophylaxis and therapy](https://reader033.vdocument.in/reader033/viewer/2022042701/55a759191a28ab62458b4618/html5/thumbnails/6.jpg)
FatteningFattening
Losses analysis Mortality (67%) Treatment costs
(16%) Management costs
(14%)
Losses analysis
0
0,1
0,2
0,3
0,4
0,5
0,6
0,7
0,8
0,9
1
Mortality Treatmentcosts
Managementcosts
![Page 7: 10.antibiotics in brd prophylaxis and therapy](https://reader033.vdocument.in/reader033/viewer/2022042701/55a759191a28ab62458b4618/html5/thumbnails/7.jpg)
Breeder Breeder herdherd
France, Assie 2009 7496 non-weaned calves 156 herds
17% morbidity
Income impact From -2% to -20%
![Page 8: 10.antibiotics in brd prophylaxis and therapy](https://reader033.vdocument.in/reader033/viewer/2022042701/55a759191a28ab62458b4618/html5/thumbnails/8.jpg)
Breeder Breeder herdherd
Treatment costs are always minor, regarding zootechnicallosses
Prevention management & income impact...Losses analysis and income impact of BRD, depending on the
incidence
0%
10%
20%
30%
40%
50%
60%
70%
80%
90%
100%
Low incidence(22% of herds)
Mild incidence(17% of herds)
High incidence(28% of herds)
Severe cases(12% of herds)
Zootechnical losses
Treatment andmanpower
Income impact
![Page 9: 10.antibiotics in brd prophylaxis and therapy](https://reader033.vdocument.in/reader033/viewer/2022042701/55a759191a28ab62458b4618/html5/thumbnails/9.jpg)
VealVeal calvescalves
3 years survey 42000 veal calves 78 herds
Prim’Holstein vealsBucket AMF All
Respiratory DiseasesNb of collective treatments
Veals individually treated %
Relapse
Other breed vealsBucket AMF All
Respiratory Diseases
Nb of collective treatments
Veals individually treated %
Relapse
![Page 10: 10.antibiotics in brd prophylaxis and therapy](https://reader033.vdocument.in/reader033/viewer/2022042701/55a759191a28ab62458b4618/html5/thumbnails/10.jpg)
WhateverWhatever the the breedingbreeding system system isis, , preventionprevention isis fundamentalfundamental
Herd management Vaccinations Antibiotics?
Only in very specific situations Veterinary prescription
ZACTRAN is the « tool » to avoidantibioprevention
![Page 11: 10.antibiotics in brd prophylaxis and therapy](https://reader033.vdocument.in/reader033/viewer/2022042701/55a759191a28ab62458b4618/html5/thumbnails/11.jpg)
mêçéÜóä~ñáëI=jÉí~éÜóä~ñáë C=qÜÉê~éójÉí~éÜóä~ñáë
![Page 12: 10.antibiotics in brd prophylaxis and therapy](https://reader033.vdocument.in/reader033/viewer/2022042701/55a759191a28ab62458b4618/html5/thumbnails/12.jpg)
MetaphylaxisMetaphylaxis
« Healthy » animals treatedbecause of BRD outbreak on other
animals close to them
![Page 13: 10.antibiotics in brd prophylaxis and therapy](https://reader033.vdocument.in/reader033/viewer/2022042701/55a759191a28ab62458b4618/html5/thumbnails/13.jpg)
UsualUsual metaphylaxismetaphylaxis strategystrategy
Curative treatment on sick animals+
Metaphylactic treatment on at-risk animals
![Page 14: 10.antibiotics in brd prophylaxis and therapy](https://reader033.vdocument.in/reader033/viewer/2022042701/55a759191a28ab62458b4618/html5/thumbnails/14.jpg)
TargetedTargeted metaphylaxismetaphylaxis
Curative treatment on sick animals+
Metaphylactic treatment on a part of at-risk animals
Thanks to extraordinary PK/PD parameters of ZACTRAN
![Page 15: 10.antibiotics in brd prophylaxis and therapy](https://reader033.vdocument.in/reader033/viewer/2022042701/55a759191a28ab62458b4618/html5/thumbnails/15.jpg)
Focus on...Focus on...
Extraordinary PK/PD parameters
![Page 16: 10.antibiotics in brd prophylaxis and therapy](https://reader033.vdocument.in/reader033/viewer/2022042701/55a759191a28ab62458b4618/html5/thumbnails/16.jpg)
Gamithromycin concentration in broncho-alveolar cells
0
2
4
6
8
10
12
14
16
18
20
0
1 da
y
2 da
ys
3 da
ys
4 da
ys
5 da
ys
6 da
ys
7 da
ys
8 da
ys
9 da
ys
10 d
ays
11 d
ays
12 d
ays
13 d
ays
14 d
ays
15 d
ays
Time after injection
µg/ml
MIC90 Mannheimia haemolytica MIC90 Pasteurella multocida & Histophilus somni
FastFast, , hugehuge concentration*, long concentration*, long lasting in the lasting in the heartheart of the of the lunglung
Fast acting< 30 minutes after one subcutaneous shot
Huge concentration18 to 36 times the MIC90
Long lasting
![Page 17: 10.antibiotics in brd prophylaxis and therapy](https://reader033.vdocument.in/reader033/viewer/2022042701/55a759191a28ab62458b4618/html5/thumbnails/17.jpg)
TargetedTargeted metaphylaxismetaphylaxis
Deux-Chaises (Allier) March-July 09 Aim
o Assess the efficacy of ZACTRAN in metaphylactic and curative treatments, in natural conditions
![Page 18: 10.antibiotics in brd prophylaxis and therapy](https://reader033.vdocument.in/reader033/viewer/2022042701/55a759191a28ab62458b4618/html5/thumbnails/18.jpg)
Field Field studystudy descriptiondescription
167 cattle from 8 different sources Males and females 4.5 months to 11 months of age 188 to 420 kg Limousin and Charolais
![Page 19: 10.antibiotics in brd prophylaxis and therapy](https://reader033.vdocument.in/reader033/viewer/2022042701/55a759191a28ab62458b4618/html5/thumbnails/19.jpg)
A confortable A confortable housinghousing
16 pens, 8 on each side of the aisle Bedded on straw (deep litter system) Straw added every 2-3 days, 3 kg per animal Constant level trough
Water from network (quality controlled water)
This isprophylaxis!
![Page 20: 10.antibiotics in brd prophylaxis and therapy](https://reader033.vdocument.in/reader033/viewer/2022042701/55a759191a28ab62458b4618/html5/thumbnails/20.jpg)
A A sanesane housinghousing
‘All-in All out’ Disinfected
Insecticide, virucidal and bactericidal
This isprophylaxis!
![Page 21: 10.antibiotics in brd prophylaxis and therapy](https://reader033.vdocument.in/reader033/viewer/2022042701/55a759191a28ab62458b4618/html5/thumbnails/21.jpg)
A A sanesane feedingfeeding
Food Baled hay on arrival Gradual shift towards a mixed ration
based on maize silage + concentrate (triticale, soybeans, grain corn, beet pulp, bran, minerals)
Fed once a day
This isprophylaxis!
![Page 22: 10.antibiotics in brd prophylaxis and therapy](https://reader033.vdocument.in/reader033/viewer/2022042701/55a759191a28ab62458b4618/html5/thumbnails/22.jpg)
A A completecomplete preventionprevention
The farmer manages the cattle as normal!
Weighing the day after arrival Vaccinations
RSV, BVD, PI3 , IBR
Deworming Ivomec D
This isprophylaxis!
![Page 23: 10.antibiotics in brd prophylaxis and therapy](https://reader033.vdocument.in/reader033/viewer/2022042701/55a759191a28ab62458b4618/html5/thumbnails/23.jpg)
4 days after arrival4 days after arrival……
13 clinical cases Allocation to 3 groups
Group 1: 13 clinical cases Group 2: 62 animals metaphylaxis Group 3: 92 animals monitored and
treated on a case by case basis
![Page 24: 10.antibiotics in brd prophylaxis and therapy](https://reader033.vdocument.in/reader033/viewer/2022042701/55a759191a28ab62458b4618/html5/thumbnails/24.jpg)
DecisionDecision criteriacriteria for for targetedtargeted metaphylaxismetaphylaxis
Sick animals (5-10%)Body weight < 270 kg« Farmer’s experience »
![Page 25: 10.antibiotics in brd prophylaxis and therapy](https://reader033.vdocument.in/reader033/viewer/2022042701/55a759191a28ab62458b4618/html5/thumbnails/25.jpg)
Groups 2 and 3 : a Groups 2 and 3 : a pertinent pertinent choicechoice
Weight is a major BRD risk factor
![Page 26: 10.antibiotics in brd prophylaxis and therapy](https://reader033.vdocument.in/reader033/viewer/2022042701/55a759191a28ab62458b4618/html5/thumbnails/26.jpg)
D 0 D 0 13 patients 13 patients 3 groups of animals3 groups of animals
Group 1Group 1 Group 2Group 2 Group 3Group 3
![Page 27: 10.antibiotics in brd prophylaxis and therapy](https://reader033.vdocument.in/reader033/viewer/2022042701/55a759191a28ab62458b4618/html5/thumbnails/27.jpg)
Housing of the 3 groupsHousing of the 3 groups
7 meters
![Page 28: 10.antibiotics in brd prophylaxis and therapy](https://reader033.vdocument.in/reader033/viewer/2022042701/55a759191a28ab62458b4618/html5/thumbnails/28.jpg)
7 meters
DD11
10 patients in Group 310 patients in Group 3
![Page 29: 10.antibiotics in brd prophylaxis and therapy](https://reader033.vdocument.in/reader033/viewer/2022042701/55a759191a28ab62458b4618/html5/thumbnails/29.jpg)
7 meters
DD225 patients more in Group 35 patients more in Group 3
![Page 30: 10.antibiotics in brd prophylaxis and therapy](https://reader033.vdocument.in/reader033/viewer/2022042701/55a759191a28ab62458b4618/html5/thumbnails/30.jpg)
7 meters
DD334 patients more in Group 34 patients more in Group 3
![Page 31: 10.antibiotics in brd prophylaxis and therapy](https://reader033.vdocument.in/reader033/viewer/2022042701/55a759191a28ab62458b4618/html5/thumbnails/31.jpg)
7 meters
DD662 patients more in Group 32 patients more in Group 3
![Page 32: 10.antibiotics in brd prophylaxis and therapy](https://reader033.vdocument.in/reader033/viewer/2022042701/55a759191a28ab62458b4618/html5/thumbnails/32.jpg)
7 meters
DD774 patients more in Group 34 patients more in Group 3
![Page 33: 10.antibiotics in brd prophylaxis and therapy](https://reader033.vdocument.in/reader033/viewer/2022042701/55a759191a28ab62458b4618/html5/thumbnails/33.jpg)
7 meters
DD881 patient more in Group 31 patient more in Group 3
![Page 34: 10.antibiotics in brd prophylaxis and therapy](https://reader033.vdocument.in/reader033/viewer/2022042701/55a759191a28ab62458b4618/html5/thumbnails/34.jpg)
7 meters
AtAt DD88
26 patients in Group 326 patients in Group 3
![Page 35: 10.antibiotics in brd prophylaxis and therapy](https://reader033.vdocument.in/reader033/viewer/2022042701/55a759191a28ab62458b4618/html5/thumbnails/35.jpg)
Complete prevention atComplete prevention at DD+14+14 ...and ...and for the for the restrest of the of the breedingbreeding timetime
7 meters
![Page 36: 10.antibiotics in brd prophylaxis and therapy](https://reader033.vdocument.in/reader033/viewer/2022042701/55a759191a28ab62458b4618/html5/thumbnails/36.jpg)
EconomicalEconomical analysisanalysis of the of the targetedtargeted metaphylaxismetaphylaxis
![Page 37: 10.antibiotics in brd prophylaxis and therapy](https://reader033.vdocument.in/reader033/viewer/2022042701/55a759191a28ab62458b4618/html5/thumbnails/37.jpg)
IndividualIndividual treatmenttreatment costscosts
Prevention is better than cure... And cheaperalso!
17,63 €3,64 €10,62 + 3,37 = 13,99 €Curative
13,19 €2,57 €10,62 €Metaphylaxis
Global cost per presentanimal
Manpower cost per presentanimal
Treatment cost per present animal
250 kg
![Page 38: 10.antibiotics in brd prophylaxis and therapy](https://reader033.vdocument.in/reader033/viewer/2022042701/55a759191a28ab62458b4618/html5/thumbnails/38.jpg)
TargetedTargeted metaphylaxismetaphylaxisisis profitableprofitable
Treatment cost per present animal
0
2
4
6
8
10
12
14
16
18
0% 5% 10% 15% 20% 25% 30% 35% 40% 45% 50% 55% 60% 65% 70% 75% 80% 85% 90% 95% 100%
Percentage of sick animals in Group 3
€ /
pre
sen
t an
imal
Global metaphylaxis
Targeted metaphylaxis + curative x%
Targeted metaphylaxis
The curative case-by-case managementis permitted thanks to
ZACTRAN PK/PD parameters
![Page 39: 10.antibiotics in brd prophylaxis and therapy](https://reader033.vdocument.in/reader033/viewer/2022042701/55a759191a28ab62458b4618/html5/thumbnails/39.jpg)
ZACTRAN allowsallows a more profitable monitoring of a more profitable monitoring of
BRD BRD outbreaksoutbreaks in in youngyoung cattlecattle fatteningfattening herdsherds
The « classical » strategy Curative treatment on sick animals+ Metaphylactic treatment on all the others
A new strategy thanks to ZACTRAN PK/PD parameters Curative treatment on sick animals+ Metaphylactic treatment on some* of the others+ Other animals monitored and treated on a case by case
basis
* Decision criteria<270 kg body weight for instance
![Page 40: 10.antibiotics in brd prophylaxis and therapy](https://reader033.vdocument.in/reader033/viewer/2022042701/55a759191a28ab62458b4618/html5/thumbnails/40.jpg)
mêçéÜóä~ñáëI=jÉí~éÜóä~ñáë C=qÜÉê~éóqÜÉê~éó
Great thanks to Maurizio Bonfanti
![Page 41: 10.antibiotics in brd prophylaxis and therapy](https://reader033.vdocument.in/reader033/viewer/2022042701/55a759191a28ab62458b4618/html5/thumbnails/41.jpg)
TherapyTherapy
EfficiencySafety
Practicality
![Page 42: 10.antibiotics in brd prophylaxis and therapy](https://reader033.vdocument.in/reader033/viewer/2022042701/55a759191a28ab62458b4618/html5/thumbnails/42.jpg)
ItalianItalian fieldfield ssttuuddyy
Aimo ZACTRAN vs Tulathromycin in BRD treatment
![Page 43: 10.antibiotics in brd prophylaxis and therapy](https://reader033.vdocument.in/reader033/viewer/2022042701/55a759191a28ab62458b4618/html5/thumbnails/43.jpg)
24 Limousin 24 Limousin heifersheifers withwithseveresevere BRDBRD
Date of arrival: 3 December 08 Prophylaxis on the first day after arrival
IBR, PI3 ,BVD, RSV Ivomec Plus
Trial start BRD outbreak
End of the trial 14 days after treatment
Avanti, avanti...Porca miseria... Limousines...
![Page 44: 10.antibiotics in brd prophylaxis and therapy](https://reader033.vdocument.in/reader033/viewer/2022042701/55a759191a28ab62458b4618/html5/thumbnails/44.jpg)
24 Limousin 24 Limousin heifersheifers withwithseveresevere BRDBRD
ZACTRAN group 13 animals
258 ± 32 kg
Tulathromycin group 11 animals
259 ± 33 kg
![Page 45: 10.antibiotics in brd prophylaxis and therapy](https://reader033.vdocument.in/reader033/viewer/2022042701/55a759191a28ab62458b4618/html5/thumbnails/45.jpg)
ZACTRAN group 4/13 relapses
Tulathromycin group 9/11 relapses
D1
ZACTRAN group 13 animals
258 ± 32 kg
Tulathromycin group 11 animals
259 ± 33 kg
D2D3D4D5D6D7D8D9D10D11D12D13D14
![Page 46: 10.antibiotics in brd prophylaxis and therapy](https://reader033.vdocument.in/reader033/viewer/2022042701/55a759191a28ab62458b4618/html5/thumbnails/46.jpg)
Less reLess re--treatment in treatment in zactranzactran groupgroup
![Page 47: 10.antibiotics in brd prophylaxis and therapy](https://reader033.vdocument.in/reader033/viewer/2022042701/55a759191a28ab62458b4618/html5/thumbnails/47.jpg)
TherapyTherapy
Excellent results In line with many reports from
clinicians Profitable
Less re-treatment Less manpower needed
![Page 48: 10.antibiotics in brd prophylaxis and therapy](https://reader033.vdocument.in/reader033/viewer/2022042701/55a759191a28ab62458b4618/html5/thumbnails/48.jpg)
ProphylaxisProphylaxis, , metaphylaxismetaphylaxis & & TherapyTherapy
ZACTRAN allows new BRD management strategies Thanks to it’s PK/PD parameters
Fast acting Long lasting Huge concentration above MIC
Curative Metaphylaxis
Profitable thanks to less mortality Safety
![Page 49: 10.antibiotics in brd prophylaxis and therapy](https://reader033.vdocument.in/reader033/viewer/2022042701/55a759191a28ab62458b4618/html5/thumbnails/49.jpg)
AcknowledgementsAcknowledgements
Andy ForbesYou all here
![Page 50: 10.antibiotics in brd prophylaxis and therapy](https://reader033.vdocument.in/reader033/viewer/2022042701/55a759191a28ab62458b4618/html5/thumbnails/50.jpg)
Thanks for your attention
Any questions?