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The Chemical Manufacturer’sAssociation (CMA) AlkanolaminesPanel has long been committed tounderstanding the potential healthhazards associated with products itsmembers produce, and communicat-ing hazards to customers, employees,and other interested parties.Consistent with these commitments,the Panel continues to evaluate theavailable scientific data on ethanol-amines, and, when appropriate, fundsresearch designed to identify andunderstand potential product hazards.As a result of these efforts, the Panelprovides up-to-date information onthe safe use and handling of ethanol-amine products, based on a currentunderstanding of sound scientificinformation. The following informationis a summary/overview of currenttoxicology studies on the effects ofmonoethanolamine, diethanolamineand triethanolamine.
Ethanolamines
Product Information
Monoethanolamine
Acute LD50 (oral) > 1090 mg/kg, rats.LD50 (dermal) ~ 1000 mg/kg, rats.
Skin DOT corrosive; irritating; not a sensitizer.
Eye Severe injury potential.
Inhalation Prolonged, excessive exposure may cause adverse effects.
Subchronic Studies indicate liver and kidney effects.
Chronic No information available.
Mutagenicity Negative in vitro, not mutagenic.
Repro/Teratogenicity Oral teratological study was reported positive; additional industry research showed no effect. Dermal teratology studies were negative. Repro studies were negative.
Aquatic Practically non-toxic to aquatic organisms.
Diethanolamine
Acute LD50 (oral) = 680-1820 mg/kg, rats.LD50 (oral) = 3300 mg/kg, mice.LD50 (dermal) > 8200 mg/kg, rabbits.
Skin Irritating upon repeated exposure; not a sensitizer.
Eye Severe irritation potential.
Inhalation Prolonged, excessive exposure may cause adverse effects.
Subchronic A number of studies indicate liver, kidney, and anemia effects; NTP drinking water study had no female rat NOEL (LOEL = 77-79 mg/kg/day). NTP dermal study had no female rat NOEL (LOEL = 125 mg/kg/day).
Chronic NTP dermal study. No increase in tumors wasobserved in rats; increases in liver and kidneytumors were observed in mice at high doses.The relevance of these observations for humans is questionable. Research into the possible mechanisms of carcinogenicity is ongoing.
Mutagenicity Negative in vitro, not mutagenic.
Repro/Teratogenicity Two (2) dermal studies were negative.
Aquatic Slightly toxic to aquatic organisms.
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To xicology Over view
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