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B Cell Maturation, Activation &

DifferentiationHugh B. Fackrell

Jan 4 ,1998

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B Cell Maturation, Activation &

Differentiation Assigned Reading Content Outline Performance Ojectives

– Key terms– Key Concepts

Short Answer Questions

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Assigned Reading Chapter: 8 pp 195-222 Janis Kuby’s Immunology 3rd Ed

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Content Outline B Cell Maturation B Cell Activation & Proliferation In Vivo induction of Humoral

Response B Cell Differentation Regulation of B Cell Development

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B Cell Maturation Bone marrow Ig Gene rearrangements Pre B cell receptor Selection of Immature Self

Reactive B Cells– negative selection– rescue editing of light chain genes

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B Cell Activation & Proliferation

T dependent vs T independent antigens Origins of activating signals Transduction of Activating signals B cell coreceptor complex T helper cells

– formation of T-B conjugate– mediation by CD40– induction of progression signals

Negative selection

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In Vivo Induction of Humoral Response

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B Cell Differentation Affinity maturation

– somatic hypermutation– antigen selection

Class switching Plasma cells Memory cells

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Regulation of B Cell Development

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Performance Objectives

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Key Terms affinity maturation, apotosis, avidity,

capping, carrier effect, cell mediated immunity,Cytotoxic T cells, Helper T cells, TH1 cells, TH2 cells, humoral immunity, immunologic memory, perforin, plasma cells, primary antibody, programmed cell death, secondary antibody, thymus dependent antigens, thymus independent antigens

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Key Concepts Describe the sequential development

of the humoral immune response. Draw a contemporary model for T cell B

cell macrophage interaction Describe antigen processing and

presentation by B cells

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Outline the sequence of helper (T/(TH) cell involvment in antibody production

Describe the interplay between TH1 and Th2 cells in the development of immune responses

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Short Answer Questions

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DONE!!!DONE!!!