1. Viral reproductive disorders in sows an update 2012 H. NauwynckLaboratory of Virology Faculty of Veterinary Medicine Ghent University, Belgium

2. Normal gestation in the sow 2. Cytokine/growth factor cross talk?1. CL (progesterone)3. Immune suppression 3. How do viruses cause reproductive problems? 1. General disease (fever) ~ pro-inflammatory cytokinescausing distortion of cytokine balance-> swine influenza virus, 2. Replication of pathogens in reproductive tract/embryo/fetus~ damaging the placenta and/or cytokine balance~ direct negative impact on embryo/fetus -> DNA viruses: Aujeszkys disease virus, parvovirus, porcine circovirus 2 -> RNA viruses: porcine reproductive and respiratorysyndrome virus, porcine enteroviruses,encephalomyocarditis virus, classical swine fever 4. How do viruses reach embryos/fetuses? 1. Contaminated sperm 5. How do viruses reach embryos/fetuses?2. Viremia + transplacentalspread 6. 1. Via contaminated spermVirus excretion in sperm~ viremiaDNA-viruses EmbryoADV (