1Department of Ear ,Nose and ThroatHead and Neck SurgeryMedical Faculty Padjadjaran ni!ersityBandung 2T U M O R BENIGNTYPE MALIGNANTSIZE. LOCATION.METASTASIS-LOCAL-DISTANT3ETIOLOGY SYMPTOMS SIGNS PHYSICAL EXAMINATION LAB & RAYS PATHOLOGY EXAMINATION THERAPY4ETIOLOGY (General) IONISINGRADIATION UVRADIATION AIRPOLLUTION PROFESSIONFACTOR FOOD IATROGENIC CHEMICAL HORMONAL TOBACCO SEX & REPRODUCTIVELIFE CIRCUMCISION PARASITES GENETIC IMMUNODEFICIENCY VIRUS 5RADIATION SOURCES RADIOACTIVE MINERAL MINING RADIATIONFROM MEDICAL AQUIPMENT X RAY THOROTHRAST Ra 22 ATOM BOM6PROFESSIONTAR MINERAL OIL CONTAININGDERIVATATHRACENEANILINE! BENI"IDINE!NAPHTHYLAMINE!AMINOBIPHENYLASBESTOS BEN"ENE 7V I R U S H#$an % &ell le#'e$(a ) (*%l+V!()He,a%(%(- .+V+ (H.))H#$an ,a,(ll/$a ) (*,) 012 032 40)E,-%e(n!.arr+V (e.))C*e$(&al Car&(n/5ene-(- ! V+ C*l/r(6a! A7la%/8(n8 CANCER DEVELOPMENT -INDUCTION 15 30 tahun -IN ITU5 10 tahun -INVAI1 5 tahun -DIEMINATE 1 5 tahun 9C!ROMOOME C!AN"E#1$ RECIPROCAL TRAN%ORMATION&$ ADDITION O% "EN IN PECI%IC AREAO% C!ROMOOM3$ NON RECIPROCAL C!AN"E DELETION ADDITION 10E'AMPLEAD$1 # - C!RONIC M)ELOID L B*t+**n Ch,-.-/-. && - 0- ACUTE PROM)EL)TIC L B*t+**nCh,-.-/-. 15 1 12AD$& # 11$3 13 4/ 5-6u/ 7-,ONCO"ENE#8 INT &!T 19CL 1PRAD 1AD$3 # - DELETION 3:; .a55 Ca Pa,u- DELETION -7 3: &1; 3:& >$+( FLOOR OF THE MOUTH ! N, LN > *+( - LN >$+( TONSILS < *%( > 2+( SOFT PALATE < .+ & *+(> 2+( NASOPH $%( HYPOPH %/ )% & %( PAROTIS %/ $+ & %+(