* Presenter

Orally Administered Plecanatide, a Guanylate Cyclase-C Agonist, Acts in the Lumen of the

Proximal Intestine to Facilitate Normal Bowel Movement in Mice and Monkeys

P451 Stephen J. Comiskey, John A. Foss, Gary S. Jacob and Kunwar Shailubhai* 1Synergy Pharmaceuticals, Inc, 420 Lexington Avenue, Suite 260, New York, NY 10022 and 2Research and Development Center,

Pennsylvania Biotechnology Center, Doylestown, PA 19403