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10 th and 11 th of November 2016 2 nd BALcanOSH INTERNATIONAL CONFERENCE FOR REGIONAL COLABORATION, BLED, SLOVENIA

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Page 1: 2 BALcanOSH 10 and 11 of INTERNATIONAL ...mk.balkanoshconference.org/images/dokumenti/publications/...9 Source: data of the National Cancer Register, Hungary Asbestos use and morbidity

10th and 11th of

November 2016

2nd BALcanOSH

INTERNATIONAL CONFERENCE FOR

REGIONAL COLABORATION,

BLED, SLOVENIA

Page 2: 2 BALcanOSH 10 and 11 of INTERNATIONAL ...mk.balkanoshconference.org/images/dokumenti/publications/...9 Source: data of the National Cancer Register, Hungary Asbestos use and morbidity

Occupational diseases statistics

The number of registered occupational diseases in Hungary is decreasing.

Has occupational hygiene got that better?!?

2

Source: data of OTH-MFF

Page 3: 2 BALcanOSH 10 and 11 of INTERNATIONAL ...mk.balkanoshconference.org/images/dokumenti/publications/...9 Source: data of the National Cancer Register, Hungary Asbestos use and morbidity

Reporting of occupational disease in Hungary

3

é

Physician

establishing

diagnosis

reporting

1.

OSH inspection

within the

regional

government

office

notice

feedback

4.

4.

inspection

Occupational

Health

Department

in the OCMO

expert opinion

Health Insurance Fund administrative decision

Employer /

Employee

3.

2.

5.

Page 4: 2 BALcanOSH 10 and 11 of INTERNATIONAL ...mk.balkanoshconference.org/images/dokumenti/publications/...9 Source: data of the National Cancer Register, Hungary Asbestos use and morbidity

Reasons for not reporting

Administrative burden (treating physician)

Conflict of interests (occupational physician)

Ignorance

Awareness

Indifference

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Page 5: 2 BALcanOSH 10 and 11 of INTERNATIONAL ...mk.balkanoshconference.org/images/dokumenti/publications/...9 Source: data of the National Cancer Register, Hungary Asbestos use and morbidity

What else we have?

Sources:

public health reports: e.g. infectious diseases

health care databases: e.g. health insurance

Diseases:

specific to exposure: e.g. asbestos-realted diseases

Mesothelioma:

specific to asbestos

clear diagnostics, short duration (poor prognosis)

registered in the National Cancer Registry

5

Page 6: 2 BALcanOSH 10 and 11 of INTERNATIONAL ...mk.balkanoshconference.org/images/dokumenti/publications/...9 Source: data of the National Cancer Register, Hungary Asbestos use and morbidity

National Cancer Register, Hungary

Europe Against Cancer (EU programme for MSs)

Hungarian register: National Institute of Oncology (OOI)

Since 2000

Input: from every treating medical doctor

Case: the malignant disease

Code: International Classification of Diseases (ICD-10)

C45: Mesothelioma (malignant)

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Page 7: 2 BALcanOSH 10 and 11 of INTERNATIONAL ...mk.balkanoshconference.org/images/dokumenti/publications/...9 Source: data of the National Cancer Register, Hungary Asbestos use and morbidity

Aims

Compare data of the occupational and the cancer registers (2000-2014)

Analyse mesothelioma data of the National Cancer Register

by age

by region

by date

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Page 8: 2 BALcanOSH 10 and 11 of INTERNATIONAL ...mk.balkanoshconference.org/images/dokumenti/publications/...9 Source: data of the National Cancer Register, Hungary Asbestos use and morbidity

Occupational disease register

8

Sum: 57 occupational

mesothelioma cases

Usually from asbestos

product manufacturing

Sporadicly construction

sector, manufacturing of

carriages, dredger

operator

Source: data of OTH-MFF

Page 9: 2 BALcanOSH 10 and 11 of INTERNATIONAL ...mk.balkanoshconference.org/images/dokumenti/publications/...9 Source: data of the National Cancer Register, Hungary Asbestos use and morbidity

National Cancer Register

11 cases omitted (age

<26 years)

Sum: 1539 cases

Increasing trend

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Source: data of the National Cancer Register, Hungary

Page 10: 2 BALcanOSH 10 and 11 of INTERNATIONAL ...mk.balkanoshconference.org/images/dokumenti/publications/...9 Source: data of the National Cancer Register, Hungary Asbestos use and morbidity

Asbestos use and morbidity peak

Hungarian asbestos use peaked in

the 1970-1980-ies (2.87-3.29

kg/capita/year).

(Nishikawa et al. 2008)

Number of mesothelioma cases are

on the rise worldwide. (Bianchi

& Bianchi 2014)

Mesothelioma cases have not

peaked only flattened after

several decades of ban in

Nordic countries. (FIOH 2014,

Plato et al. 2016, Tomasson et

al. 2016)

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Source: Mattenklott, M.: The socio-economic costs of asbestos in Germany. BGIA, 2010

Page 11: 2 BALcanOSH 10 and 11 of INTERNATIONAL ...mk.balkanoshconference.org/images/dokumenti/publications/...9 Source: data of the National Cancer Register, Hungary Asbestos use and morbidity

Age distribution of Hungarian mesothelioma cases

Comparison:

Peak of mortality at age 75-

84 for high-income

countries

Flat and earlier curve for

middle and low income

countries

(Delgermaa et al., 2011)

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Source: data of the National Cancer Register, Hungary

Page 12: 2 BALcanOSH 10 and 11 of INTERNATIONAL ...mk.balkanoshconference.org/images/dokumenti/publications/...9 Source: data of the National Cancer Register, Hungary Asbestos use and morbidity

Geographical distribution

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Source: data of the National Cancer Register, Hungary

Mesothelioma cases in Hungarian regions (cases/100 000 capita) in the

period 2000-2014

Page 13: 2 BALcanOSH 10 and 11 of INTERNATIONAL ...mk.balkanoshconference.org/images/dokumenti/publications/...9 Source: data of the National Cancer Register, Hungary Asbestos use and morbidity

Mesothelioma as an “indicator”

Asbestos causes mesothelioma (IARC 2012)

For mesotheliomas occupational asbestos exposure can be confirmed in 80-90% (Rake

et al. 2009, Marinaccio et al. 2015)

Indicator

for reporting awareness

of estimating asbestos related lung cancer burden (1-2 lung cancer/mesothelioma)

environmental exposures

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Page 14: 2 BALcanOSH 10 and 11 of INTERNATIONAL ...mk.balkanoshconference.org/images/dokumenti/publications/...9 Source: data of the National Cancer Register, Hungary Asbestos use and morbidity

Other register matchings

Successful Unsuccessful

Ornitosis cases 2003-2011 Regional incidence of nasal carcinomas

14

Ornithosis 2003-2011

200191

0

50

100

150

200

250

Occupational Other register

Page 15: 2 BALcanOSH 10 and 11 of INTERNATIONAL ...mk.balkanoshconference.org/images/dokumenti/publications/...9 Source: data of the National Cancer Register, Hungary Asbestos use and morbidity

Implications

Medical specialist in the curative field are not aware of occupational diseases,

cancers.

Non-occupational databases may contain information relevant for occupational

diseases.

Databases are growing but interconnections are not utilised.

Specific diseases or a specific disease+specific occupation should alarm for

suspecting occupational origin.

Interconnection of a carcinogen exposure database with the national cancer register

may yield more case discoveries.

Findings should be used in prevention measures and policy making.

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Page 16: 2 BALcanOSH 10 and 11 of INTERNATIONAL ...mk.balkanoshconference.org/images/dokumenti/publications/...9 Source: data of the National Cancer Register, Hungary Asbestos use and morbidity

Acknowledgements

Dr. István Kenessey (Nemzeti Rákregiszter és Biostatisztikai Központ)

Borbényiné Mariann Szabó and Judit Vágó (OTH-MFF)

Zsófia Kővágó (NMH TÁMOP 2.4.8-12 PVO)

Dr. Kálmán Kardos (OTH-MFF)

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Page 17: 2 BALcanOSH 10 and 11 of INTERNATIONAL ...mk.balkanoshconference.org/images/dokumenti/publications/...9 Source: data of the National Cancer Register, Hungary Asbestos use and morbidity

Thank you for your attention

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Contact:

www.omfi.hu

[email protected]