2 bc922 lec11 metab glycolysis web.ppt - zilouei.iut.ac.ir filefeed-forward activation •...
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Anabolism and catabolism
Metabolism
Forms of metabolic pathways
Linear Cyclic
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• Single-step vs multi-step pathways
• A multistep enzyme pathway releases energy in smaller amounts that can be used by the cell
Feedback inhibition
• Product of a pathway controls the rate of its own synthesis by inhibiting an early step (usually the first “committed” step (unique to the pathway)
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Feed-forward activation
• Metabolite early in the pathway activates an enzyme further down the pathway
Catabolism produces compounds for energy utilization
(1) Nucleoside triphosphates (e.g. ATP)
(2) Reduced coenzymes (NADH, FADH2,)
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Thioesters Have High Free Energies of Hydrolysis
• Thioesters are energy-rich compounds (10.22)
• Acetyl CoA has a ∆Go’ = -31 kJ mol-1 (10.23)
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The pathway for catabolism of
glucose
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Glycolysis
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Glycolysis summary
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Glycolysis in summary
How many ATP and how many e-carriers are produced?
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