2005 All Hands Meeting

Multi-Site Alzheimer’s Disease Projecta.k.a. “MAD”

Project Leaders:

C. Fennema-Notestine, R. Gollub, B. Dickerson

MAD Project Goals

Pooling datasets to increase statistical power for studying relatively rare populations or subtle neuroanatomic changes

Replicate single site results using pooled data to validate methods (Project #1)

Extend morphometric capabilities to novel observations requiring pooled samples (Projects #2&3)

Provide benchmark data sets for the use of BIRN developers for testing and validation

e.g., Freesurfer subcortical segmentation, 3D Slicer, HID, XNAT

Achievements since 10/04

Data sharing agreement among collaborating sites: UCSD, MGH/BWH, Wash U, and UCI.

Minimal dataset requirements for sharing• Diagnosis (& how generated)• Inclusion/exclusion criteria• Age, education, sex• Mini-mental state exam score (MMSE)

All data processed with most recent version of FreeSurfer subcortical segmentation and common atlas (MGH/Fischl)

Achievements cont.

Coordinated image and clinical data sharing • UCSD and MGH data combined HID storage• Added Wash U site data• UCI data currently being processed

Data employed in development and testing of HID, defacing, BIRN-DUP, SRB, mediated query tools

Collaborating with BWH/3DSlicer development of QA tool for review of final datasets

Three research projects underway resulting in conference abstracts and ultimate publication

Project #1: Morphometric Measurements in Healthy Elderly Controls

(C. Fennema-Notestine, R. Gollub, B. Dickerson)

UCSDMGH/BWHWashU

Site

60 70 80 90

AGE

2000

3000

4000

5000

Lef

t-H

ipp

oca

mp

us

Hippocampal Volume Loss in Normal Aging

Normal Elderly ControlNormal Elderly Control

Society for Neuroscience 2005

BIRN Site n Age (mean, sd) range in years

Sex Educ in Years

MMSE

UCSD 48 74.6 (5.0) 63-87

22M/ 26F 14.8 (3.3)

6-20 29.4 (0.8) 27-30

MGH/BWH 36 71.9 (4.8) 64-85

14M/ 22F 14.4 (2.3) 10-19

29.3 (1.1) 28-30

Wash U 49 75.7 (7.9) 62-89

25M/ 24F 14.5 (2.8)

8-20 29.1 (1.1) 26-30

Project #2: Clinico-anatomic Relationships

Replicate previous work in aging and AD 2 sites with similar memory measures (UCSD and MGH) Relationship between visual and verbal memory and right and

left hippocampal volume

(B. Dickerson, C. Fennema-Notestine, R. Gollub)

Normal Elderly Control Alzheimer’s IndividualNormal Elderly Control Alzheimer’s Individual

Project #3: Diagnostic Classification Healthy Elderly vs. AD Determine participant classification using hippocampus,

amygdala, ventricular volumes, & MMSE 2 sites with control and AD patients (UCSD and WashU) Linear and quadratic discriminant analysis applied .

Classification success rate on test data can approach 90%.

(C. Roddey, A. Dale, C. Fennema-Notestine, R. Gollub)

AHM 2005 Discussion Items - Morphing MAD

Should we extend existing project?• E.g., examine diagnostic specificity of classification using

morphometric results from depressed elderly with pseudodementia

• If so, what other datasets are available for study?

Should we embark on an entirely new clinical investigation (brain or beyond)?• Examine the outcomes of fully automated segmentation or

other image processing outputs?

Continue dual purpose to advance clinical knowledge and to provide substrate for testing newly developed BIRN tools

Goals for 10/06

Complete and publish quantitative study describing methodology and feasibility of pooling legacy MR data across sites (Neuroinformatics) – 3m

Complete explorations of clinico-anatomic relationships between UCSD and MGH data – 6m

Complete and publish diagnostic classification work – 6m

Descriptive exploration of MCI and AD patient data – 6m

Repository for legacy data to be used for in-house BIRN infrastructure and tool development – 6m

MAD morphed into new goals to be examined and refined for mBIRN AHM – 6m