2013mintea factor epigenetic

8/12/2019 2013Mintea Factor Epigenetic

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Minteafactorepigenetic


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Understanding the human brain and its

diseases is one of the greatest scientificand philosophical challenges. During the

last decades, brain research has made

great progress on all fronts but much

more is still to be discovered.

Advances in neuroscience are crucial to

keep our ageing societies and our

economy healthy. Brain-related disorders

will affect at least one in every three of

us during our life and treating these

disorders costs already now some 800

billion Euro in Europe every year.

Deciphering how our brain works is good

for our health, our society and our

industrial competitiveness. It has an

important role to play for the

achievement of the Europe 2020 strategy

and of the Innovation Union.


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The science behind Obamas BRAIN project.

On April 2nd, 2013 President Obama

announced the BRAIN initiative, a project aimed

at understanding brain activities at a level of

detail that is unprecedented. A lot has been saidand written about the BRAIN project but some

people feel in the dark as to what are the

precise aims of the project. Althoughannouncing the project before the aims were set

in concrete might have raised some worries
http://blog.brainfacts.org/2013/04/barack-obama-neuroscientist-in-chief/http://blog.brainfacts.org/2013/04/barack-obama-neuroscientist-in-chief/


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Mintea- fenomen informaional


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NVARE MEMORIE

GNDIRE

INSTINCT

MINTE


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Interaciuneastimul - receptor - rspuns

chimic

fizic

stimul

Re

cep

tor

Pr

ocesor

?

rspuns


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Cmpul electromagnetic este realitateaizic cu care suntem n contact permanent

i nemijlocit, dei nu avem simuri pentru ao percepe. n odaia n care stm, n parcurilen care ne plimbm, n noi nine, totul este

lin de cmp electromagnetic, n fiecaremoment, datorit cmpului electromagnetic,iecare cut a fiinei noastre este ptruns de

toate melodiile care se cnt pe Pmnt, bai de oapte din afara lui, rostite poate cumiliarde de ani n urm.

A.ugulea- Cmpul electromagnetic? Ed. Agir, 2011


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"The stuff of the world is mind-stuff.The Nature of the Physical World.

Sir Arthur Eddington

t is necessary to keep reminding

ourselves that all knowledge of ourenvironment from which the world of

hysics is constructed, has entered in

the form of messages transmitted alongthe nerves to the seat of

consciousness.


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While most neuroscientists acknowledge

that consciousness exists, and that at

resent it is something of a mystery,most of them do not attempt to study it,

mainly for one of two reasons:

1. They consider it to be a philosophicalroblem, and so best left to philosophers

2. They concede that it is a scientific

roblem, but think it is premature tostudy it now.Consciousness and Neuroscience. Francis Crick and

Christof Koch. Cerebral Cortex. 1998


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CUVNTUL - IN-FORMAIA- stla baza trmurilor manifeste

ale Cosmosului i le guverneaz-este mai important dectenergiile i materia lumiifenomenelor, prin intermediulcrora se exprim.

Toate religiile, artele itiinelsunt ramuri ale aceluiai copac

A. Einstein

E. Laszlo


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InformaiaInformaia este componenta fundamen-tala existentei. nsi contiina este oorma de informaie.

M. Drgnescu. Societatea Contiinei. 2007

Informateria este principiul creativ,care se exprim n informaiile profundeconinute n materie, cum ar fi sarcinile

electrice, leptonice, barionice, armul,stranietatea etc.


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Contiina este fundamentulexistenei (originar, autonom,

element constitutiv al tuturorlucrurilor ce se manifest casubiect care alege i experiaz

ceea ce alege, atunci cndcolapseaz autoreferenial

uncia cuantic de und nrezena contiinei minte-creierAmit Goswami. Universul contient de sine.

Contiina creeaz lumea material . Ed. Orfeu. 2000.


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n calitate de biolog, am momentecnd devin contient de un fel de

contiin atemporal, nelimitat despaiu sau de constngerilepersonalit-iimele. Aflat n aceast stare, percepcu mare claritate realitatea din faamea i devin capabil s primesc

informaii printr-un fel de osmoz sobin o cunoatere care provine de la unprincipiu mult mai vast, de la un fel de

minte ecologic global Lyall Watson


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Cheia spre mplinirea misiuniinoastre, ca oameni, ne estecontiina- dimensiune mult mai

profund i mai extins dect acrezut vreodat, majoritateadintre noi.

Existena noastra are sens i

scop. Suntem att co-creatori ailumii- ct i creaie a ei


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Informaia este esenial pentruviziunea ce se contureaz despre

lumea unitar.n noua viziune despre naturarealitii integrale, existena uman

nu este un produs secundar, acciden-tal, nu este rezultatul ntmpltor alunei mutaii genetice i al selecieinaturale, al strategiilor deconservare ale egoismului genetic

CosMos . Ervin Laszlo i Jude Currivan. Ed. For You. 2010


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Contiina form de existen ainformaiei fenomenologice cuprins n

profunzimile lumii materiale:informateria i lumatia care exist i

fiineaz una prin alta, dincolo denivelul cuatic, genernd i susinnduniversul n toate dimensiunile sale

fundamentale: materie, spaiu, timpmicare. M.Drgnescuin Medias Res. EA 2004


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C. Darwin selecia natural

R. Dawkins - gena egoist

ntreaga via evolueaz prinsupraveuirea diferenial aentitilor replicante-replicatori

Oriunde exist via trebuie sexiste replicatori

ADN junk- ADN necodant

Natura replicatorului


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cred c un nou tip de replicator aaprut recent pe aceast planet

Ne privete n fa. Este nc ncopilrie, nc plutind n deriv,neindemnatic, n supa sa primor-

dial, ns deja realizeaz schim-bri evoluionare ntr-un ritm carelas mult n urm btrna gen.

Acea sup este cultura uman;vectorul de transmitere estelimbajul; iar spaiul dem erechere este creierul


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Ele concureaz pentru resurselimitate: timp de creier saulrgime de creier. Ele concureazmai ales entru aten ie

-replicator incorporal=mem

Memele se propag n bazinulde meme srind din creier increier prin intermediul unui

roces care, n sens larg poate finumit imitatie


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Epigenetica,fenomen informaional


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Environmental exposure may causeepigenetic modifications in the germline

either directly or indirectly throughprimarily affecting the soma. The latterpossibility is most intriguing because it

contradicts the established dogma thathereditary informationflows only fromgermline to soma, not in reverse. As such,

identification of the factor(s) mediatingsoma to germline information transfer intransgenerational epigenetic inheritance

would be pathbreaking

h d h


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Factors such as RNAs and hormones,including neurohormones and neuropeptides

have previously been considered topotentially mediate soma to germlinecommunication in epigenetic inheritance

In last decade, small non-coding RNAs(sncRNAs) such as small interfering RNAs(siRNAs), microRNAs (miRNAs) and

piwiinteracting RNAs (piRNAs) haveemerged as master regulators of geneexpression in eukaryotes


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Considering only current knowledgeof these networks, and withoutextrapolating to as yet undiscovered

regulatory intricacies, theirperformance already gracefullyexceeds that of systems biology

models and mechanisms.


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It is in this context that we would liketo consider thegenomic darkmatter,one of the major mysteries of the post-

genome era. Perhaps no other topic in

contemporary genomics has inspiredsuch diverse viewpoints as the 95+%of the genome,previously known as

junkDNA,that does not code forproteins.

Transgenerational epigenetic inheritance: Focus on soma to germline information

transfer. A. Sharma. Progress in Biophysics and Molecular Biology (2012)

Th li t f l RNA ll l


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These lists of lncRNAs usually only cover aew percent of the genome, representing only a

small fraction of the original pervasiveness ofdark matter and typically, sample intergenicspace as introns of known genes are usuallyassumed to represent pre-mRNAs. Partly dueto this uncertainty, some authors have castdoubt on the importance of dark mattertranscripts, labeling them transcriptional

noise, or even arguing that they largelyrepresent fragments of known pre-mRNAsDark matter RNA: an intelligent scaffold for the dynamic regulation of the

nuclear information landscape. St.Laurent et al. Front. Genet. 2012.


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ale Pmntului,

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de Puterea

nsufleite

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2013mintea factor epigenetic

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