2014 faculty senate awards - college of pharmacy · march 12, 2014 faculty senate awards committee...

2014 Faculty Senate Awards Mission College of Pharmacy Research Award

Nominee Name: Ganesh Cherala Email: [email protected] Phone: Department: FA.OSU/OHSU College of Pharmacy

Nomination Submissions and Required Documents Included in Packet 1. Nomination Letters – 1

a. Craig Williams 2. Summary 3. CV

OSU/OHSU COLLEGE OF PHARMACY Portland Campus at OHSU, CH12C 3303 SW Bond Avenue, Portland, Oregon 97239-4501 T 503-494-5778 | F 503-494-8797 | http://pharmacy.oregonstate.edu

March 12, 2014

Faculty Senate Awards Committee OHSU Dear Awards Committee, It is my pleasure to nominate Ganesh Cherala for the OHSU Faculty Senate research award representing the college of pharmacy. Dr. Cherala has served as an excellent example of research for the college of pharmacy since his appointment in 2007. In addition to conducting his own research work, he has worked tirelessly to involve undergraduates in his lab, inspiring many to go on to graduate degrees and research projects of their own. Some of Dr. Cherala’s notable accomplishments and contributions include: 1. K12 award: Through the Office of Research on Women’s Health, Dr. Cherala was awarded his K12 grant in 2012. It is an offshoot of his work with Building Interdisciplinary Research in Women’s Health (BIRCWH) which was partly established by the National Institute of Child Health & Human Development (NICHD). Dr. Cherala has worked to assemble an interdisciplinary team of mentors to guide him through the execution of this award which focuses on the question of women’s reproductive health and oral contraceptive failure.

2. Intracollegiate Collaboration: I am pleased to detail a bit of the collaboration that Dr. Cherala has initiated. In collaboration with Dr. Craig Williams at the college of pharmacy, Dr. Cherala undertook a research project funded by the OHSU Medical research Foundation to elucidate non-genetic mechanisms that could explain inter-individual variability observed with clopidogrel (Plavix). Dr. Cherala collaborated with Dr. Matthew Ito to develop a sterol assay to investigate absorption of dietary sterols and the effects of lipid lowering therapy on those sterols. In collaboration with Dr. Myrna Munar, Dr. Cherala studied the effects inter-individual variations on the levels of tacrolimus in different patients. Tacrolimus is an important medication which helps organ transplant patients to avoid organ rejection. Along with Dr. Ali Olyeai, Dr. Cherala studied the variability of cefuroxime in pediatric cardiac surgery subjects. Cefuroxime is an important antibiotic which helps to avoid infectious complications after surgery. Dr. Cherala also has many collaborations outside of the COP at OSU. Along with Dr. Robert Tanguay, Department of Environmental and Molecular Toxicology, Dr. Cherala developed a high throughput assay in Zebra fish to serve as a research tool for drug discovery projects. 3. Research Environment: Dr. Cherala has done a wonderful job involving junior research personnel. He has established a focus on graduate students which has been particularly tough since most of the infrastructure support for lab-based work is located in Corvallis. Dr. Cherala has been successful attracting private scholarship funding for his graduate students from multiple sources, including the

P a g e | 2 Murdock Foundation. The first student from the Murdock program (2010-2011) is currently enrolled in OSU’s graduate program. To compliment these efforts, Dr. Cherala has been extremely productive in getting his work into the public realm. He is on a strong upward trajectory with corresponding author publications with one in 2011, three in 2012, and four in 2013. He has co-authored 21 papers since joining the college in 2007. Importantly, Dr. Cherala has achieved his research success with the college of pharmacy despite several early roadblocks which were beyond his control. Since there were no successful laboratory-based research faculty in Portland, Dr. Cherala faced a nearly 2-year delay in having permanent laboratory space identified for him. On a personal note, Dr. Cherala is one of the most pleasant co-workers that I have ever had the opportunity to work with. His love of his work is infectious and he never seems to have a bad day at the office. He has been a pleasure to work with from day one. Respectfully, Craig Williams, PharmD., BCPS, FNLA Professor of Pharmacy Practice Department of Pharmacy Practice College of Pharmacy

2014 Faculty Senate Awards Summary

I joined the Oregon State University /Oregon Health & Science University College of Pharmacy (CoP) to establish myself as a clinical translational science researcher and educator. My graduate training in drug metabolism, pharmacokinetics, and bioanalysis followed by postdoctoral training in clinical pharmacokinetics prepared me to undertake bench-to-bedside research. Since joining the CoP, I have developed an integrated research program that investigates perinatal programming of clinical pharmacology with a focus on women’s health.

The focus of my research program is to understand and identify sources of inter-individual variability in pharmacokinetics. The overall objective is to identify and develop easily accessible and economical tools to individualize pharmacotherapy. Ongoing research is focused on body weight as a source of inter-individual variability with a particular interest in birth weight, and its interaction with adult body weight, especially obesity. My research program includes both traditional human clinical pharmacokinetic studies as well as in vitro and animal laboratory work. I have been able to successfully establish a strong research program that has resulted in 21 peer-reviewed publications, 59 poster/podium presentations, and 15 successful extra and intramural grant applications so far.

Ganesh Cherala, B.Pharm., Ph.D. Department of Pharmacy Practice

Oregon State University / Oregon Health & Science University College of Pharmacy, Portland, OR 97239

Ph: Work: (503)-4180447; Cell: (215)-4292804 [email protected]

Education & Training 2006-07 Postdoctoral Fellowship in Clinical Pharmacokinetics Philadelphia College of Pharmacy, Philadelphia, PA 2001-06 Doctor of Philosophy (Pharmaceutical Sciences) University of the Sciences in Philadelphia, Philadelphia, PA 2003-05 Visiting Graduate Student University of Pennsylvania, Philadelphia, PA 2000-01 Master of Pharmacy (Pharmacology, Discontinued) Punjab University, India 1995-99 Bachelor of Pharmacy Osmania University, India Professional Experience 2007-present Assistant Professor of Pharmacokinetics Oregon State University, College of Pharmacy, Portland, OR 2011-present Assistant Professor Department of Obstetrics & Gynecology Oregon Health & Science University (OHSU), Portland, OR 2012-present Scientist, Moore Institute of Nutrition OHSU, Portland, OR 2013-present Scientist, Center for Developmental Health OHSU, Portland, OR

Curriculum Vitae - Ganesh Cherala, Ph.D.

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Grant Support

(a) Current

PI: Daniel Dorsa (Career Development Awardee: Ganesh Cherala) 01/2013-12/2014 NIH Office of women’s health research [K12- Building Interdisciplinary Research Career in Women’s Health] [2K12HD043488-11] $220,000 Prenatal growth programs oral contraceptive metabolism and effectiveness The guiding hypothesis is that the in utero growth restriction will permanently program drug metabolizing enzymes and transporters. This in turn might affect pharmacokinetics. In this proposal, we set out to examine alterations in pharmacokinetics with oral contraceptives as a prototype drug. PI: Ganesh Cherala 09/2013-08/2014 OHSU Oregon Clinical Translational Research Institute $16,000 [NIH NCRR 1 UL1 RR024120] Obesity and Oral Contraception: Obfuscation by Bioanalytical Method Goal of this project is to develop a highly specific and sensitive LCMS/MS assay for oral contraceptive agents. This assay will strengthen ‘innovative’ section of future grant application(s) besides providing more reliable data for pharmacokinetic data analysis. PI: Eric Horne (Co-I: Ganesh Cherala) 10/2012-03/2014 NIH/NCI (SBIR; 1R43CA165452-01A1) $291,951 Targeting a new GPCR to treat glioblastomas Pharmacokinetic support for the development of new drug molecules targeted for the treatment of glioblastomas will be provided. PI: Jeffrey Jensen (Co-I: Ganesh Cherala) 06/2013-05/2015 NIH/NICHD (HHSN2750001) $ Task order dependent Core grant for Contraceptive Clinical Trials Network site For the base contract, I will be available to offer consultation to Drs. Jensen and Edelman and to NICHD program staff in the design of future PK studies. Salary support will be provided dependent on the task orders

(b) Pending

PI: Alison Edelman (Co-I: Ganesh Cherala) 06/2014-05/2016 NIH/NICHD (R21 $330,000 Counteracting weight-based alterations in the effectiveness of emergency contraceptives The goal of the project is to identify novel therapeutic agents that could be co-administered with existing emergency contraception for enhanced efficacy.


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(c) Completed PI: Ganesh Cherala 06/2008-06/2009 13Therapeutics, Inc. $26,895 Assay development and stability studies of new drug molecules PI: Ganesh Cherala 12/2008-12/2009 Heart Drug Research Inc. $2,000 Secondary analysis of Plavix data We have determined plasma levels of clopidogrel and its metabolites and used as a measure of clopidogrel compliance among relevant patient population. These findings led a publication followed by a research grant from a foundation. This research gift has resulted in peer-reviewed publications (Original research -PMID: 20062927; Review article- PMID: 19958858). PI: Ganesh Cherala Spring 2009 Oregon State University Research Equipment Reserve Grant $15,000 Real-time PCR upgrade Real time PCR machine was upgraded using these internal funds. This equipment grant greatly facilitated significant amount of research. A peer-reviewed publication [PMID: 23507230] is a result of this funding. PI: Ganesh Cherala 01/2009-06/2010 Cubist Pharmaceuticals, Inc. $15,497 Evaluation of renal and non-renal metabolism of daptomycin in neutropenic rats In prior human studies carried out by our research team [PMID: 19015332], we suspected metabolism of daptomycin to be altered as a function of neutropenia in cancer patients. This particular project examined the above hypothesis. PI: Amira Al-Uzri (Co-I: Ganesh Cherala) 06/2009-12/2010 Doernbecher foundation $15,000 The center for Pediatric Pharmacology and Therapeutics at DCH. We were successful in attracting funds to form a pediatric research center. As a pilot study, we have examined ethnicity as a source of inter-individual variability in Tacrolimus pharmacokinetics, and developed a relatively non-invasive drug monitoring technique for pediatric population. This project has led to two publications [PMID: 22172831 and 23548676], and an invention disclosure. PI: Alison Edelman (Co-I: Ganesh Cherala) 09/2009-08/2011 NIH (R01HD061582] $460,240 Improving contraceptive effectiveness in obese women


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Collaborated with clinician researcher to investigate (a) the mechanisms of oral contraceptive failure in obese women, and (b) intervention strategies to make contraceptive regimens effective for obese women. We have successfully completed the grant, and disseminated findings in various forums including peer-reviewed journals. Furthermore, this grant has provided valuable pilot data for the successful K12 grant I received last year. PI: Ganesh Cherala 06/2010-05/2011 Medical Research Foundation of Oregon $40,000 Use of TNF-α, in addition to CYP2C19 genotype, to predict pharmacokinetics and pharmacodynamics of clopidogrel. Inter-individual variability in clopidogrel is a major hurdle in the pharmacotherapy of stroke. We have examined non-genetic factors to understand the pharmacokinetics and pharmacodynamics of clopidogrel in adult women. This work has identified a novel mechanism that could further explain the large inter-individual variability associated with clopidogrel. The study findings are disseminated in the form of peer-reviewed article [PMID: 23116430], and presentations at various national meetings. PI: Joshi Alumkal 06/2010-05/2011 Kuni Foundation $100,000 The effects of sulforaphane dose escalation in men with recurrent prostate cancer The pharmacokinetics and pharmacodynamics of sulforaphane were determined in men with recurrent prostate cancer. My contributions include PK study design, analysis, and assistance with manuscript development. Besides two poster/podium presentations on this work, a manuscript is currently under preparation. PI: Ganesh Cherala 01/2011-06/2011 GE Healthcare $5,951 Development of Dried Blood Spot technique for CYP phenotyping In addition to NIH sub-award, funds were secured from industry to develop dried blood spot technique. PI: Jeffrey Jensen 10/2012-12/2012 OHSU (NIH subcontract- HHSN275200403378I) $5,000 A Phase I Study to Evaluate Pharmacokinetic and Pharmacodynamic Profile of a Single Injection of Levonorgestrel Butanoate (LB) for Female Contraception In this project, novel contraceptive agent was clinically tested for PK and PD profile. My contributions include PK study design, analysis, and assistance with manuscript development. A manuscript is currently under preparation.


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Peer Reviewed Publications: 1. DuBois B, Pearson J, Mahmood T, Nguyen D, Thornburg K, and Cherala G. Intrauterine growth restriction decreases diuretic action of furosemide in adult rats: evidence for perinatal programming of pharmacology. European Journal of Pharmacology. 2014 Feb; 728C: 39-47. PMID: 24508521.

Role: Conceived the project, supervised data collection and analysis, and took lead in authoring manuscript.

This research article garnered lay media attention. o http://www.sciencedaily.com/releases/2014/02/140227101152.htm o http://www.firstwordpharma.com/node/1192488#axzz2ueir4g9y o http://www.parents.com/blogs/parents-news-now/2014/02/28/child-health/low-

birth-weight-may-impact-ability-to-metabolize-drugs/ 2. Huang J, Sunstrom R, Munar M, Cherala G, Olyaei A, Langley S. Are Children Undergoing Cardiac Surgery Receiving Subtherapeutic Antibiotics? Journal of Cardiovascular & Thoracic Surgery (in press, accepted on 01/16/2014). PMID: 24521951

Role: Participated in study design, and data analysis and interpretation.

3. Cherala G, Pearson J, Maslen C, Edelman A. An ethinyl estradiol-levonorgestrel containing oral contraceptives does not alter cytochrome P4502C9 in vivo activity. Drug Metab Dispos. 2014 Mar; 42(3): 323-5 PMID: 24368832.

Role: Conceived the project, supervised the experiments, and took lead in authoring manuscript.

4. Atrio J, Stanczyk FZ, Neely M, Cherala G, Kovacs A, Mishell DR Jr. Effect of protease inhibitors on steady state pharmacokinetics of oral norethindrone contraception in HIV infected women. J Acquir Immune Defic Syndr. 2014 Jan; 65(1): 72-7. PMID: 24025339

Role: Provided pharmacokinetic study design, performed pharmacokinetic data modeling and data analysis; reviewed results & discussion section.

5. Koop D, Bleyle L, Munar M, Cherala G, Al-Uzri A. Analysis of tacrolimus and creatinine from a single dried blood spot using liquid chromatography tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Mar 4; 926C: 54-61. PMID: 23548676.

Role: Conceived the project, and reviewed the final draft.

6. DuBois B, Pearson J, Hastings B, Chan T, Mahmood T, Alnakhli A, Cherala G. Maternal Low Protein Diet Alters the Expression of RT-qPCR Reference Genes in Rat Offspring. Nutrition Research. 2013 Mar 33 (3): 235-41. PMID: 23507230.


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Role: Conceived the project, supervised the experiments, and took lead in authoring results and discussion sections.

7. Edelman A, Cherala G, Munar M, Dubois B, McInnis M, Stanczyk F, Jensen J. Prolonged monitoring of ethinyl estradiol and levonorgestrel levels confirms an altered pharmacokinetic profile in obese oral contraceptives users. Contraception. 2013 Feb; 87(2):220-6. PMID: 23153898.

Role: performed pharmacokinetic data modeling and data analysis; took lead in authoring results & discussion section.

8. Ganesan S, Williams C, Maslen C, Cherala G. Clopidogrel variability: role of plasma protein binding alterations. Br J Clin Pharmacol. 2013 Jun;87(2):220-6. PMID: 23116430.


9. Cherala G, Thornburg K, Edelman A. Birthweight and cytochrome P4503A4/5 activity in obese women. Br J Clin Pharmacol. 2013 Jan;75(1):275-6. PMID: 22534035.

Role: Conceived the project, supervised the experiments, and took lead in writing manuscript.

10. Dubois B, O'Tierney-Ginn P, Pearson J, Friedman J, Thornburg K, Cherala G. Maternal obesity alters feto-placental cytochrome P4501A1 activity. Placenta. 2012 Dec;33(12):1045-51. PMID: 23046808.


11. Edelman A, Munar M, Elman M, Koop D, Cherala G. Effect of the ethinyl estradiol /levonorgestrel combined oral contraceptive on the activity of cytochrome P4503A in obese women. Br J Clin Pharmacol. 2012 Sep;74(3):510-4. PMID: 22299599.

Role: Corresponding Author. Conceived the project, supervised the experiments, and took lead in authoring results and discussion sections.

12. Bubalo J, Cherala G, McCune J, Munar M, Tse S, Maziarz R. Aprepitant pharmacokinetics and assessing the impact of aprepitant on cyclophosphamide metabolism in cancer patients undergoing hematopoietic stem cell transplantation. J Clin Pharmacol. 2012 Apr;52(4):586-94. PMID: 21415280.

Role: Performed pharmacokinetic data modeling and data analysis; took lead in authoring results & discussion section.


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13. Cherala G, Munar M, Naher A, Al-Uzri A. Tacrolimus pharmacokinetics in Hispanic children after kidney transplantation. Transplant Proc. 2011 Dec;43(10):3708-12. PMID: 22172831.

Role: Co-conceived the project, performed pharmacokinetic data modeling and data analysis, and took lead in authoring results and discussion sections.

14. Edelman A, Cherala G, Stanczyk F. Metabolism and pharmacokinetics of contraceptive steroids in obese women: a review. Contraception. 2010 Oct;82(4):314-23. Review. PMID: 20851224.

Role: Authored a section on general pharmacokinetic changes in obese subjects.

15. Qasem R, Cherala G, D'Mello A. Maternal protein restriction during pregnancy and lactation in rats imprints long-term reduction in hepatic lipid content selectively in the male offspring. Nutr Res. 2010 Jun;30(6):410-7. PMID: 20650349.

Role: Performed animal experiments and collected organs that were used in this study; reviewed final drafts of the manuscript.

16. Yadav V, Marracci G, Munar M, Cherala G, Stuber L, Alvarez L, Shinto L, Koop D, Bourdette D. Pharmacokinetic study of lipoic acid in multiple sclerosis: comparing mice and human pharmacokinetic parameters. Mult Scler. 2010 Apr;16 (4):387-97. PMID: 20150394.


17. Williams C, Cherala G, Serebruany V. Application of platelet function testing to the bedside. Thromb Haemost. 2010 Jan;103 (1):29-33. Review. PMID: 20062927.

Role: Text contribution towards understanding variability in the testing.

18. Serebruany V, Cherala G, Williams C, Surigin S, Booze C, Kuliczkowski W, Atar D. Association of platelet responsiveness with clopidogrel metabolism: role of compliance in the assessment of "resistance". Am Heart J. 2009 Dec;158 (6):925-32. PMID: 19958858.

Role: performed PK data modeling, data analysis, and data interpretation. This publication received electronic media attention.

http://www.theheart.org/article/1031989.do

19. Edelman A, Carlson N, Cherala G, Munar M, Stouffer R, Cameron J, Stanczyk F, Jensen J. Impact of obesity on oral contraceptive pharmacokinetics and hypothalamic-pituitary-ovarian activity. Contraception. 2009 Aug;80 (2):119-27. PMID: 19631786.



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This research article garnered national and international media in both print and electronic versions. Some of the electronic and print media include: -LA Times (http://latimesblogs.latimes.com/booster_shots/2009/07/the-pill-is-less-effective-in-the-obese.html ); Times of India (most circulated newspaper in India) (http://articles.timesofindia.indiatimes.com/2009-07-16/health/28160831_1_contraceptives-obese-women-drug-absorption ); The Globe and Mail (2nd most circulated newspaper in Canada); The Oregonian (most circulated newspaper in the state of Oregon); Baltimore Sun; Democrat Herald; San Diego Union tribune; Gazette Times (Corvallis based newspaper); http://www.sciencedaily.com/releases/2009/07/090714143904.htm

20. Stanczyk F, Slater C, Ramos D, Azen C, Cherala G, Hakala C, Abraham G, Roy S. Pharmacokinetics of dehydroepiandrosterone and its metabolites after long-term oral dehydroepiandrosterone treatment in postmenopausal women. Menopause. 2009 Mar-Apr;16 (2):272-8. PMID: 19098687.

Role: performed pharmacokinetic data modeling and data analysis; contributed towards results & discussion section.

21. Bubalo J, Munar M, Cherala G, Hayes-Lattin B, Maziarz R. Daptomycin pharmacokinetics in adult oncology patients with neutropenic fever. Antimicrob Agents Chemother. 2009 Feb;53 (2):428-34. PMID: 19015332.


22. Cherala G, Shapiro BH and D’mello AP (2007). Effect of perinatal low protein diet on the ontogeny of select hepatic cytochrome P450 enzymes and cytochrome P450 reductase in the rat. Drug Metabolism and Disposition, 35 (7), 1057-63. PMID: 17392395.

Role: Publication resulting from graduate studies. Responsible for execution of experiments, data analyses; Wrote first drafts and further revisions of all sections of the manuscript.

23. Cherala G, Shapiro BH and D’mello AP (2006). Two low protein diets differentially affect food consumption, and reproductive performance in pregnant and lactating rats and long term growth in their offspring. Journal of Nutrition, 136, 2827-33. PMID: 17056808.

Role: Publication resulting from graduate studies. Responsible for execution of experiments, data analyses; Wrote first drafts and further revisions of all sections of the manuscript.

24. Nimmagadda D, Cherala G, Ghatta S (2006). Cytosolic Sulfotransferases. Indian Journal of Experimental Biology, 44 (3), 171-82. PMID: 16538854.


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Role: Contributed to sections of the review article.

Papers Submitted for Publication 25. Edelman A, Cherala G, Munar M, McInnis M, Stanczyk F, Jensen J. Correcting oral contraceptive pharmacokinetic alterations due to obesity. A randomized controlled trial. Contraception (invited to revise with minor corrections)

Role: Participated in PK study design, and data analysis and interpretation. Significant contribution to all sections of the manuscript.

26. Pearson J, Edelman A, Cherala G. Birthweight and cytochrome P4502C9 activity in obese women. British Journal of Clinical Pharmacology (in review).

Role: Conceived the project, supervised data collection and analysis, and took lead in authoring manuscript.

27. DuBois N, Atrio J, Stanczyk F, Cherala G. Protease inhibitors decrease clearance as well as distribution of norethindrone in HIV positive women. Pharmacotherapy (in review).

Role: Conceived the project, supervised data analysis, and took lead in authoring manuscript.

28. Alumkal J, Slottke R, Schwartzman, Cherala G, Munar M, Koop D, Ryan C, Gao L, Flamiatos J, Tucker E, Mori T, Beer T, The Effects of Treatment with Sulforaphane-Rich Broccoli Sprout Extracts in Men with Recurrent Prostate Cancer. Clinical Cancer Research (in review)

Role: Participated in PK study design, and data analysis and interpretation..

29. DuBois B, Louey S, Giraud G, Jonker S, Cherala G. Theophylline pharmacokinetics in fetal sheep: Maternal metabolic capacity is the principle drive. Journal of Pharmacology and Experimental Therapeutics (in review).

Role: Conceived the project, supervised data analysis, and took lead in authoring manuscript.

Non-Refereed Publications (Newsletters, others). 30. Cherala G, Edelman A. BMI, Pharmacokinetics, and OCP failure. Contraception. 82(6):

582, 2010. PMID: 21074028 Role: This is a letter-to-editor I co-wrote to compare and explain discrepancies

between one of my study findings and a well-established investigator’s study.


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31. Edelman A, Cherala G, Lim J, Jensen J. Contraceptive failures in overweight and obese combined hormonal contraceptive users. Obstet Gynecol. 2013 Jul;122(1):158-9. PMID: 23787930

Role: Co-authored a letter-to-editor in response to a meta-analysis of contraceptive failure in obese women. I have highlighted the importance of dosage forms and their influence on pharmacokinetic differences.

32. Cherala G, Pearson J, DuBois B, Mahmood T. Lack of in vitro – in vivo correlation of

adulthood cytochrome p450 activities in low birth weight rats. Drug Metab Dispos. Accepted.

33. Featured in OSU Terra magazine. http://oregonstate.edu/terra/2011/05/the-birth-weight-factor/

Presentations at Professional Meetings, Symposia, and Conferences [Note: Underline indicates presenting author. If the presentation format is different than poster format, the details of the format are indicated] 1) Pearson J, DuBois B, Hastings B, Edelman A, Bagby S, Cherala G. The Effect of Low Birth Weight on Indoxyl Sulfate and Oat1/3 Expression. Annual meeting of American Association of Pharmaceutical Scientists, San Antonio, TX. Nov 2013. 2) DuBois B, Jonker S, Louey S, Giraud G, Cherala G. Pharmacokinetics of Theophylline in Fetal Sheep. Annual meeting of American Association of Pharmaceutical Scientists, San Antonio, TX. Nov 2013. 3) DuBois B, Pearson J, Mahmood T, Nguyen D, Thornburg K, and Cherala G. Intrauterine growth restriction decreases diuretic response of furosemide in rats during adulthood. Annual meeting of American Association of Pharmaceutical Scientists, San Antonio, TX. Nov 2013. 4) Mahmood T, DuBois B, Pearson J, Cherala G. Effect of maternal low protein diet on creatinine and uric acid clearances. Annual meeting of American Association of Pharmaceutical Scientists, San Antonio, TX. Nov 2013. 5) Pearson J, DuBois B, Hastings B, Edelman A, Bagby S, Cherala G. The Effect of Low Birth Weight on Indoxyl Sulfate and Oat1/3 Expression. World congress on Developmental Origins of Health & Disease, Singapore City, Singapore. Nov 2013. 6) DuBois B, Jonker S, Louey S, Giraud G, Cherala G. Pharmacokinetics of Theophylline in Fetal Sheep. World congress on Developmental Origins of Health & Disease, Singapore City, Singapore. Nov 2013.


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7) DuBois B, Pearson J, Mahmood T, Nguyen D, Thornburg K, and Cherala G. Intrauterine growth restriction decreases diuretic response of furosemide in rats during adulthood. World congress on Developmental Origins of Health & Disease, Singapore City, Singapore. Nov 2013. 8) Mahmood T, DuBois B, Pearson J, Cherala G. Effect of maternal low protein diet on creatinine and uric acid clearances. World congress on Developmental Origins of Health & Disease, Singapore City, Singapore. Nov 2013. 9) Pearson J, DuBois B, Hastings B, Cherala G. The Effect of Maternal Low Protein Diet on Uremic toxin-Indoxyl Sulfate and Oat1/3 Expression. OHSU Research Week, Portland, OR. April 2013. 10) DuBois B, Pearson J, Mahmood T, Nguyen D, Thornburg K, and Cherala G. Intrauterine growth restriction decreases diuretic response of furosemide in rats during adulthood. OHSU Research Week, Portland, OR. April 2013. 11) Alumkal J, Slottke R, Mori T, Schwartzman J, Gao L, Graff J, Beer T, Ryan C, Koop D, Cherala G, Munar M, Flamiatos J, Tucker E. Sulforaphane treatment in men with recurrent prostate cancer. ASCO Annual Meeting, Chicago, IL. June 2013 12) Pearson J, DuBois B, Hastings B, Edelman A, Bagby S, Cherala G. The Effect of Low Birth Weight on Indoxyl Sulfate and OAT1/3 Expression. Annual research retreat, College of Pharmacy, Salishan, OR. Mar 2013. 13) DuBois B, Pearson J, Mahmood T, Nguyen D, Thornburg K, and Cherala G. Intrauterine growth restriction decreases diuretic response of furosemide in rats during adulthood. Annual research retreat, college of pharmacy, Salishan, OR. Mar 2013.

Won the best podium presentation award. 14) Banh N, Lee KY, Edelman A, Cherala G, Munar M. Determination of midazolam pharmacokinetic model in obese women. Annual research retreat, College of Pharmacy, Salishan, OR. Mar 2013. 15) Nguyen P, Pearson J, DuBois B, Cherala G. Effect of Perinatal Low Protein Diet on the Expression of Renal Organic Cation Transporter 2 and Novel Organic Cation Transporter 2 in Adult Rats. Oregon State Pharmacists Association. Feb 2013. 16) Pearson J, DuBois B, Hastings B, Edelman A, Bagby S, Cherala G. The Effect of Low Birth Weight on Indoxyl Sulfate and OAT1/3 Expression. 2013 Research Retreat, Heart Research Center, OHSU. Feb 2013. 17) DuBois B, Pearson J, Mahmood T, Nguyen D, Thornburg K, and Cherala G. Intrauterine growth restriction decreases diuretic response of furosemide in rats during adulthood. 2013 research retreat, Heart research center, OHSU. Feb 2013.

Won best podium presentation award. 18) Ganesan S, Williams C, Kim A, Cherala G. Clopidogrel resistance: Role of protein binding of active metabolite. Annual Meeting of American Association of Pharmaceutical Scientists, Chicago, IL. Oct 2012.


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19) Pearson J, DuBois B, Hastings B, Cherala G. The Effect of Maternal Low Protein Diet on Uremic toxin-Indoxyl Sulfate and Oat1/3 Expression. Annual Meeting of American Association of Pharmaceutical Scientists, Chicago, IL. Oct 2012. 20) DuBois B, O’Tierney-Ginn P, Pearson J, Thornburg K, Cherala G. Maternal pre-gravid BMI and placental cytochrome P4501A1 activity. Annual Meeting of American Association of Pharmaceutical Scientists, Chicago, IL. Oct 2012. 21) Mahmood T, DuBois B, Pearson J, Cherala G. Maternal low protein diet alters urinary concentrations of uric acid and creatinine in adolescent rat offspring. Annual Meeting of American Association of Pharmaceutical Scientists, Chicago, IL. Oct 2012. 22) Sridharan d, DuBois B, O’Tierney-Ginn P, Cherala G. Maternal obesity and placental expression of carboxylesterase. 2012 Oregon Bio Association Annual Conference. Marylhurst University, Lake Oswego, OR. Sept 2012. 23) Lee KY, Munar M, Cherala G. Validation of limited sampling equations to predict midazolam AUC for CYP3A4 phenotyping in obese women. American College of Clinical Pharmacology, San Diego, CA. Sept 2012. 24) Lee KY, Munar M, Cherala G. Validation of limited sampling equations to predict midazolam AUC for CYP3A4 phenotyping in obese women. American College of Clinical Pharmacology, San Diego, CA. Sept 2012. 25) Al-Uzri A, Bleyle L, Munar M, *Cherala G, Koop D. Novel Use of One Dried Blood Spot for Tacrolimus and Creatinine Measurements in Kidney Transplant Recipients. American Transplant Congress. Boston, MA. June 2012. 26) Alumkal A, Graff J, Ryan C, Beer T, *Cherala G, Koop D, Mori T. The Effects of Sulforaphane in Patients with Biochemical Recurrence of Prostate Cancer. ASCO meeting, Chicago, IL. June 2012. 27) Salinthone S, Yadav V, Munar M, Cherala G, Shinto L, Koop D, Bourdette D, Carr D. Comparing the bioactivity of two forms of lipoic acid in multiple sclerosis. The International Research Congress on Integrative Medicine and Health 2012, Portland, OR. May 2012. 28) Pearson J, DuBois B, D’Mello A, Cherala G. Effect of Maternal Low Protein Diet During Pregnancy and Lactation in Rats on the Expression of Renal OAT3. Research Week, OHSU, Portland OR. April 2012. 29) DuBois B, O’Tierney-Ginn P, Thornburg K, Cherala G. Effect of maternal pregravid body mass index on the activity of placental Cytochrome P4501A1. Research Week, OHSU, Portland OR. April 2012. 30) Ganesan S, Williams C, Kim A, Cherala G. Clopidogrel resistance: Role of unbound concentrations of active metabolite. Research Week, OHSU, Portland OR. April 2012. 31) Al-Uzri A, Bleyle L, Munar M, Cherala G, and Dennis Koop. Novel Use of One Dried Blood Spot for Tacrolimus and Creatinine Measurements in Kidney Transplant Recipients. Pediatric Academic Society. Boston, MA. April 2012.

Podium presentation


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32) Ganesan S, Williams C, Kim A, Cherala G. Clopidogrel resistance: Role of unbound concentrations of active metabolite. Heart research center-Annual retreat, OHSU. March 2012. 33) Pearson J, DuBois B, Hastings B, Cherala G. Effect of Maternal Low Protein Diet During Pregnancy and Lactation in Rats on the Expression of Renal OAT1. Annual research retreat, Salishan resorts, Gleneden Beach. March 2012. 34) DuBois B, Pearson J, O’Tierney-Ginn P, Thornburg K, Cherala G. Effect of maternal BMI on placental expression of CYP1A1 activity. Annual research retreat, Salishan resorts, Gleneden Beach. March 2012. 35) Lee KY, Munar M, Cherala G. Validation of limited sampling equations to predict midazolam AUC for CYP3A4 phenotyping in obese women. Annual research retreat, Salishan resorts, Gleneden Beach. March 2012. 36) Hastings B, Pearson J, DuBois B, Cherala G. Effect of maternal low protein diet on the cerebral expression of organic anion transporter-3 in adult offspring. Oregon Academy of Sciences, Portland Community College-Sylvania campus, Portland, OR. Feb 2012. 37) Pearson J, DuBois B, D’Mello A, Cherala G. Effect of Maternal Low Protein Diet During Pregnancy and Lactation in Rats on the Expression of Renal OAT1. World congress of Developmental Origins of Health & Disease, Portland, OR. Oct 2011. 38) DuBois B, O’Tierney-Ginn P, Thornburg K, Cherala G. Effect of maternal pregravid body mass index on the activity of placental Cytochrome P4501A1. World congress of Developmental Origins of Health & Disease, Portland, OR. Oct 2011. 39) DuBois B, Roberts V, Grigsby P, Cherala G. Effect of Placental Vascular Restriction on Hepatic Cytochrome P4501A1 in Near Term Fetus. World congress of Developmental Origins of Health & Disease, Portland, OR. Oct 2011. 40) Roman Y, Ganesan S, Cherala G. Effect of clopidogrel and its metabolites on the activity of human carboxyl esterases in human plasma. Annual meeting of American Association of Pharmaceutical Scientists, Washington, D.C. Oct 2011. 41) Pearson J, DuBois B, D’Mello A, Cherala G. Effect of Maternal Low Protein Diet During Pregnancy and Lactation in Rats on the Expression of Renal OAT1. Annual meeting of American Association of Pharmaceutical Scientists, Washington, D.C. Oct 2011. 42) DuBois B, O’Tierney-Ginn P, Thornburg K, Cherala G. Effect of maternal pregravid body mass index on the activity of placental Cytochrome P4501A1. Annual meeting of American Association of Pharmaceutical Scientists, Washington, D.C. Oct 2011. 43) Edelman A, Cherala G, Koop D, Munar M, Jensen J, Stanczyk F. Determining differences in synthetic steroid hormone metabolism through cytochrome p450 activity – a pilot study. North American Forum on Family Planning. Washington DC, Oct 2011. 44) Edelman A, Westhoff C, Stanczyk F, Pike M, Munar M, Cherala G. Correlation between BMI and drug distribution of oral contraceptives. North American Forum on Family Planning. Washington DC, Oct 2011.


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45) Pearson J, Chan T, D’Mello A, Cherala G. The Effect of maternal low protein diet on renal OAT1. Annual Oregon Academy of Science, Portland Community College, Portland, OR. Feb 2011. 46) Chan T, Pearson J, D’Mello A, Cherala G. The Effect of maternal low protein diet on renal Pgp. American Society of Health-systems Pharmacists, 2010 Midyear meeting; Los Angeles, LA. Dec 2010 47) Pearson J, Cherala G. Effect of maternal low protein diet during pregnancy and lactation in rats on the expression of renal OAT1 and Pgp in the offspring. Oregon Health & Science University 4th Annual (2010) symposium on developmental biology, Portland OR. Dec 2010. 48) DuBois B, D’Mello A, Cherala G. Effect of maternal low protein diet during pregnancy and lactation on functional activity of renal CYP1A1 in rat offspring. Pharmaceutical Sciences World Congress, New Orleans, LA. Nov 2010. 49) Pearson J, Chan T, D’Mello A, Cherala G. Effect of maternal low protein diet during pregnancy and lactation in rats on the expression of renal OAT1 and Pgp in the offspring. Pharmaceutical Sciences World Congress, New Orleans, LA. Nov 2010.

This abstract garnered media attention: Science Daily (http://www.sciencedaily.com/releases/2010/11/101110091120.htm )

Featured on the website of 2010 Pharmaceutical Sciences World Congress. 50) Myrna Y. Munar, Cherala G, Al-Uzri A. Comparison of tacrolimus pharmacokinetics in Hispanic vs. non-Hispanic pediatric renal transplant patients. American College of Clinical Pharmacy Annual meeting, Austin, TX. Sept 2010. 51) DuBois B, D’Mello A, Cherala G. The effect of maternal low protein diet on renal CYP1A1 activity. Graduate Retreat, College of Pharmacy, Oregon State University, Silver falls, OR. Mar 2010 52) Pearson J, Chan T, D’Mello A, Cherala G. The Effect of maternal low protein diet on renal OAT1 and Pgp. Graduate Retreat, College of Pharmacy, Oregon State University, Silver falls, OR. Mar 2010. 53) Ganesan S, Ito M, Cherala G. Development of a sterol assay by Gas Chromatography Mass Spectrometry to quantify cholesterol and phytosterols in human plasma. Graduate Retreat, College of Pharmacy, Oregon State University, Silver Falls, OR. Mar 2010. 54) DUBOIS B, Hallstrand R, Cherala G. Effect of maternal low protein diet during pregnancy and lactation on functional activity of renal CYP1A1 in rat offspring. Annual Oregon Academy of Science, Concordia University, Portland, OR. Feb 2010. 55) Munar M, Cherala G, Bubalo J, Tse S, Maziarz R. Aprepitant pharmacokinetics in cancer patients undergoing hematopoietic stem cell transplantation (HSCT). American Association of Pharmaceutical Scientists National meeting, Los Angeles, CA. Nov 2009. 56) Cherala G, Williams C, Serebruany V. Predicting clopidogrel response using cytokine levels in blood. American Association of Pharmaceutical Scientists National meeting, Los Angeles, CA. Nov 2009.


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57) Yadav V, Marracci G, Cherala G, Munar M, Stuber L, Alvarez L, Shinto L, Koop D, Bourdette D. Pharmacokinetic study of different formulations of high dose oral LA in MS subjects. North American Research Conference on Complementary & Integrative Medicine. Sponsored by the Consortium of Academic Health Centers for Integrative Medicine, Minneapolis, MN. Sept 2009. 58) Yadav V, Munar M, Marracci G, Cherala G, Stuber L, Alvarez L, Shinto l, Koop D, Bourdette D. Pharmacokinetic study of lipoic acid in multiple sclerosis: Comparing mice and human pharmacokinetic parameters. 61st Annual Meeting of the American Academy of Neurology, Seattle, WA. Aug 2009. 59) Munar M, Cherala G, Bubalo J. Daptomycin PK and PD in adult oncology patients with neutropenic fever. American College of Clinical Pharmacology annual meeting 2008. Philadelphia, PA. Oct 2008. Invited Presentations National & International 09/2013 Pharmacokinetics in Obesity – Heavy on Theory, Lean on Data. Annual

meeting of American college of clinical pharmacology, Bethesda, MA. [Pre-meeting workshop-II].

10/2012 Personalized Medicine: Bring your Birth Weight. Annual Meeting of American Association of Pharmaceutical Scientists (AAPS), Chicago, IL.

11/2011 Failure of oral contraception in obese women: Role of altered pharmacokinetics of levonorgestrel. DICZFALUSY symposium on reproductive health. Szeged, Hungary.

04/2011 Fetal programming of drug pharmacokinetics. University of Southampton, UK.

State-wide and Local 01/2014 Understanding inter-individual variability in drug response through perinatal

growth. Oregon National Primate Research Center. Division of Neuroscience. 01/2014 Oral Contraceptive Failure: Blame your Birthweight. Women’s health research

retreat, OHSU. 11/2013 Perinatal determinants of drug failure: a saga of furosemide and oral

contraceptives. Department of Pharmaceutical Sciences, OSU. Nov 2013. 09/2012 Pharma-CSI; Crime Scene Investigation. Oregon State Pharmacy Association,

Portland, OR. 10/2011 Drug pharmacokinetics in intrauterine growth restricted offspring.

Bioresources Research program, College of Science, OSU. 01/2011 Cytochrome P450 phenotyping using dried blood spots.

MBA Integrated Business Project--- School of Business, Oregon State University. 10/2010 Effect of perinatal environment on drug pharmacokinetics.

Department of Environment & Molecular Toxicology, OSU.


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09/2009 Lean on Data-Heavy on Theory. Annual meeting of OSHP; Gleneden Beach-OR 02/2009 Predicting Clopidogrel platelet inhibition using cytokine levels in human

subjects. Cardiology group, School of medicine, OHSU; Hemoncology group, School of medicine, OHSU; Department of Biomedical Engineering, OHSU.

03/2008 Effect of maternal diet during gestation & lactation on body weight and hepatic drug metabolism in the offspring. Developmental origins of health and disease (DOHaD) symposium organized by the heart research center at Oregon health & Science University.

Teaching PHAR770: Advanced Pharmacokinetics (Lecturer, 25 contact hours/year) PHAR776: Pharma-CSI (Co-coordinator/lecturer, 16 contact hours/year) PHAR778: Advanced Adult Medicine (lecturer, 1 contact hour/year) PAST572: Introduction to Pharmaco-therapeutics (2.25 contact hours/year) PHAR505/705: Reading & Comprehension (20 contact hours/year) PHAR797: Research Elective (Coordinator, 30 contact hours/year)

Curriculum Development

(1) PHAR 770 Advanced Pharmacokinetics. [cross listed for graduate studies] I created and frequently update all of the lectures I provide to the students in my area of expertise. This is a continually evolving process designed to improve the student’s knowledge of pharmaceutical care in the area of preclinical and clinical pharmacokinetics. I have introduced three new topics to this course: (a) bioanalysis and PK study design, (b) inter individual variability, and (c) pharmacogenomics. These three topics address “personalized medicine,” an up and coming area in the clinical practice. I believe that these new topics will prepare professional Pharm.D. students to be at the forefront of delivering individualized/personalized medicine.

(2) PHAR 762 Pharm CSI Elective. [cross listed for graduate studies] I have been extensively involved in the development of this new elective course. We have used real world examples to combine pharmacokinetics with forensic sciences using celebrity cases as examples. We have limited student enrollment to a maximum of 12 to provide the best experience to enrolled students. We have developed didactic lectures, journal club readings, and homework problems to solve each of the celebrity death cases. The students learn about various pharmacokinetics tools available to solve such high profile cases.

(3) PHAR 505/705 Reading & Comprehension (Variability in PK) I have developed a reading & comprehension course catering to students interested in understanding inter-individual variability in PK processes. The course involves a combination of journal article readings, presentations, and wet-lab experiments to get a comprehensive understanding of the concepts. The laboratory component is geared toward awareness of common techniques and tools for undertaking research study.


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Advising I have served as academic advisor to the following students in the Doctor of Pharmacy program. Typically, I met with the entire group of students in a particular year on the day-1 of their P3 year followed by at least one additional group meeting. I met with each student individually 1-2 times per term to discuss their academic progress. Pharm.D. Class of 2009: Michelle Brown, Lindsay Holmson, Matthew Kitamura, Annie Ratliff,

Brian Zachery.

Pharm.D. Class of 2010: Zach Brown, Sydney Holt, Linda Kha, Patrick Leong, Channa Richardson, Aaron Whitten.

Pharm.D. Class of 2011: Joshua Crowe, Christopher Ferrin, Jacqueline Foster, Tiffanie Kuntz, Sarah Lam, Savanna Newlon, Erin Timony, Tony Tong.

Pharm.D. Class of 2012: Christine Boffing, Lindsey Childress, Jeremy Dinh, Mai-Hong Nguyen, Amy Speakman, Lisa Steuck, David White.

Pharm.D. Class of 2013: Denise Beasley, Michael Daher, Abby Floeter, Yuri Miura, SaraLee Molinari, Katelyn VanBrunt.

Pharm.D. Class of 2014: Tarah Authier, Jing Chen, Andrea Malos, Victoria Nguyen, Andrew Quach, Christy Ward, Vanessa Tedisch, Brad Hogg.

Pharm.D. Class of 2015: Brooke Andrews, Trinity Dam, Reem Hassanyn, Steve Lam, Linda Nguyen, Rebecca Pham.

Trainees Postdoctoral fellow Shobana Ganesan (08/2009-09/2011) Graduate students Barent DuBois (09/2011-present) Sultan M Alshahrani (09/2013-present) Marie Carone (08/2010-0/2011) Nathan Kirk (08/2010-0/2011) Richard Bruff (08/2010-0/2011) Betsy Meidinger (08/2010-0/2011) Amar Panchmatia (08/2010-0/2011) Residents (M.D.) Jason VanWinkle (01/2012-12/2012 Jessica Atrio (05/2011-05/2013)


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Ted Huang (10/2012-present) Pharm.D students Tammy Chan (09/2009-05/2010) Marina Kawaguchi (03/2010-05/2011) Youssef Roman (10/2010-05/2011) Ali Alhadab (09/2011-07/2012) Ishita Ohja (01/2013-present) Kwe Yeom Lee (01/2012-12/2012) Duc Nguyen (06/2012-present) Murdock Charitable Trust Undergraduate Scholars Barent DuBois (05/2009-09/2010) Jacob Pearson (05/2010-09/2011) Bonnie Hastings (05/2011-09/2012) Kristina Nagai (05/2013-present) Howard Hughes Medical Institute Undergraduate Scholar Paulina Nguyen (05/2010-09/2012) Undergraduate Students Tahir Mahmood (06/2010-05/2013) Alexandra Ciora (06/2010-05/2011) Shawn Mahmood (06/2010-05/2011) May-Lynn Chu (04/2009-06/2009) Christopher Harvey (04/2009-06/2009) Daniel Cosma (01/2012-06/2012) Ali Alnakhli (09/2011-06/2012) Kyle Hogan (05/2013-present) Danile Urness (11/2013-present) Pre-pharmacy Student Katie LaRue (01/2013-present) High School Student Divya Sridharan (09/2011-present) Professional Affiliations 2001-present Member, American Association of Pharmaceutical Scientists (AAPS) 2010-present Faculty Liaison, OSU student chapter of AAPS. 2013-present Member, American Society of Pharmacology & Experimental

Therapeutics 2006-present Member, American College of Clinical Pharmacology 2006-present Member, American College of Clinical Pharmacy 2007-present Member, American Association of Colleges of Pharmacy 2004-present Member, Rho Chi Society


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Journal Reviewer The Annals of Pharmacotherapy, The Journal of Clinical Pharmacology, The Journal of Pharmacy Technology, Drug Metabolism & Disposition, Indian Journal of Pharmaceutical Sciences, Toxicological Sciences, Pharmacogenomics, Current Pharmacy Review, American Journal of Obstetrics & Gynecology, Contraception, Basic & Clinical Pharmacology & Toxicology, Journal of Clinical Pharmacy and Therapeutics, Clinical Pharmacology in Drug Development, PLOS One, Journal of Cardiovascular Pharmacology, Steroids. Service University Wide 2011-2012 Member, Steering committee on the self-evaluation report for The

Northwest Commission on Colleges and Universities 2007-present Co-director, Bioanalytical Shared Resource/ Pharmacokinetics core at

OHSU. College Wide 2008-present Member, Graduate Studies Committee 2007-present Member, Research & Scholarship Committee 2009-2010 Chair, Clinical Fellowship sub-committee 2009 Member, Pharmaceutics Faculty Search Committee 2009 Member, Pharmacy Practice Faculty Search Committee 2010 Member, Pharmacogenomics Faculty Search Committee 2010-2011 Member, Accreditation Council of Pharmacy Education (ACPE) self-

study.