2015...2015/11/23 · google glass to billion dollar acquisitions and valuations, there is no...

November 23, 2015 • Advertising Supplement to the Los Angeles Business Journal

LOS ANGELES BUSINESS JOURNAL PRESENTS

PATRICK SOON-SHIONG INNOVATION AWARDS

This special advertising supplement did not involve the reporting or editing staff of the Los Angeles Business Journal.

Presenting Sponsors:

Platinum Sponsor: Community Partner:

2015

Gold Sponsors:

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26 AN ADVERTISING SUPPLEMENT TO THE LOS ANGELES BUSINESS JOURNAL NOVEMBER 23, 2015

PATRICK SOON-SHIONG INNOVATION AWARDS 2015

AS fans and supporters of home-grown innovation here at theLos Angeles Business Journal,

it’s my distinct honor and privilegeto once again present the annualPatrick Soon-Shiong InnovationAwards for 2015.

In particular, it is with great admi-ration and respect for great ideas thatwe stand alongside the great PatrickSoon-Shiong, whose very name hasbecome synonymous with ground-breaking innovation. This specialaward program was created with thevision to celebrate the organizationsthat continue to stretch boundaries.

The greater Los Angeles region haslong been a thriving home to manyof the most exciting and ground-breaking companies in the world –and today that is the case more thanever. We recognize that LA’s tremen-dous stew of ingenuity, innovationand creativity is what in many wayssparks the economic competitivenessof the region and brings a distinct andunique edge to our local economy.

Dr. Soon-Shiong himself has morethan led by example – he’s a brilliantentrepreneur who has repeatedly illus-trated how the innovative spirit candrive economic value. Moreover, heshares our desire to acknowledge andencourage innovation and has onceagain made the commitment to under-write this prestigious award program.

This year, the awards were handedout at a ceremony on November 18th

at the Four Seasons Hotel in BeverlyHills, where we were also excited tohost a half-day symposium that willbegin with breakfast and progressthrough a series of several terrificguest speakers. Our attendees had anopportunity to be inspired by localinnovators sharing their expertise ongenerating some of the great ideascoming out of California. The eveningportion of the event was highlightedby the Patrick Soon-ShiongInnovation Awards dinner, where wehonored and acknowledged the peo-ple and organizations that continueto stretch the boundaries and haveproven to be leaders in innovation.

Thanks to Dr. Soon-Shiong andthe other terrific minds that played arole in helping us select our hon-orees from a pool of fascinating andinspirational finalists.

Congratulations to this year’s fiveextraordinary honorees and sevenexceptional finalists – each of whomcontinues to inspire us and provideinvaluable contributions to keeping LosAngeles at the forefront of innovation.

Matthew A. ToledoPublisher & CEO

Letterfrom thepublisher

Aregular atop the Los Angeles Business Journal’slist of Wealthiest Angelenos, and a past recipi-ent of the LABJ’s “Business Person of the Year”

(thanks to his significant business successes and phil-anthropic contributions), Dr. Patrick Soon-Shiong isno stranger to the pages of our publication.

He knows as well as anyone that innovation, cou-pled with passion and hard work, is the engine for suc-cess in business – not to mention a catalyst for lifeenhancing, or even life-saving activity.

His groundbreaking concepts for curing diabetesled to the first nanotechnology-based breast cancerdrug, Abraxane, which is credited with saving thou-sands of lives. He’s since made time to research per-sonalized drug therapies based on people’s gene sets,one of the hottest trends in research.

Now, for the sixth year, his love of innovation hasprompted him to once again join the Business Journalin handing out Patrick Soon-Shiong InnovationAwards to deserving organizations that may in factremind Soon-Shiong a little bit of his own early stagesas a passionate entrepreneur and innovator.

We created this very special awards program toshowcase Los Angeles as a place of innovation forbusinesses – and innovation in business nearlyalways leads to growth.

Here’s a closer look at the inspiration and name-sake of our innovation award:

Dr. Patrick Soon-Shiong a physician, surgeon andscientist, has pioneered novel therapies for both dia-betes and cancer, published over 100 scientificpapers, and has over 95 issued patents on ground-breaking advancements spanning myriad fields.

Dr. Soon-Shiong performed the world’s firstencapsulated human islet transplant, the first engi-neered islet cell transplant and the first pig to manislet cell transplant in diabetic patients. He inventedand developed Abraxane, the nation’s first FDA

approved protein nanoparticle albumin-bounddelivery technology for the treatment of cancer.Abraxane was approved by the FDA for metastaticbreast cancer in 2005, lung cancer in 2012, and pan-creatic cancer in 2013. In 2014 Phase 3 trialsrevealed a 48 percent pathological complete remis-sion in triple negative breast cancer with Abraxanetreatment prior to surgery. Abraxane is nowapproved in many countries across the globe andsales are expected to reach a billion dollars in 2016.

From 1997 to 2010, Dr. Soon-Shiong served asfounder, Chairman and CEO of two global pharma-ceutical companies, American Pharmaceutical Partnersand Abraxis BioScience. Both were acquired for multi-billion dollars in 2008 and 2010. In 2011 he foundedNantWorks, an ecosystem of companies to create atransformative global health information and nextgeneration pharmaceutical development network, forthe secure sharing of genetic and medical information– empowering doctors to treat patients with provenprecision at the first point of care and, ultimately,improving the lives of individuals, everywhere.

Dr. Soon-Shiong serves as Chairman of the ChanSoon-Shiong Family Foundation and Chairman andCEO of the Chan Soon-Shiong Institute of MolecularMedicine, a non-profit medical research organiza-tion. He currently co-chairs the CEO Council forHealth and Innovation at the Bipartisan PolicyCenter and is a member of the Global AdvisoryBoard of Bank of America. He is an Adjunct Professorof Surgery at UCLA, a visiting Professor at theImperial College of London, the Executive Directorof the UCLA Wireless Health Institute, a board mem-ber of the California Telehealth Network, and globaldirector for Cancer Services and Bioinformatics atProvidence Health. The Friends of the NationalLibrary of Medicine has honored him with theirDistinguished Medical Science Award.

Dr. Patrick Soon-Shiong,Innovator

Business Journal publisher Matt Toledo and Dr. Patrick Soon-Shiong

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November 23, 2015 aN advertisiNg supplemeNt to the los aNgeles busiNess JourNal 27

Congratulations to

on receiving the 2015 Patrick Soon-Shiong

Innovation Awards

CargomaticJonathan Kessler

DAQRIRegan Wynne

LEHR LLC Bernardo Herzer, David Kostkas &

Jeff Blum

Valencia Technologies CorporationStacy Chambliss

X-Therma Inc.Xiaoxi Wei, Ph.D.

IFC-62_labj_fullpages_11_23_15.i27 27 11/18/2015 3:04:27 PM


WinnerPATRICK SOON-SHIONG INNOVATION AWARDS 2015

ARGOMATIC is a technology platformthat connects shippers with quali-fied carriers who have unutilizedcapacity on their trucks. The com-pany’s core product solves ineffi-ciencies in the less-than-full-truck-load markets within 150 miles of

Los Angeles, New York and San Francisco.The local trucking market is highly fragmented,

with 90% of carriers operating six trucks or less.Cargomatic aggregates supply and makes it availableto shippers via its desktop and mobile applications.

Shippers log onto the Cargomatic website andenter their shipment information. Two hours beforethe shipment is scheduled to be picked up, the ship-ment is displayed on an app and a nearby carriercan accept the job using their smart phone.

By tendering shipments in real time, carriersonly see shipments that are on or near their exist-ing routes and ready for immediate pickup. Thisallows them to maximize the space on their trucks

and reduce the number of vehicles a shipperneeds to have on hand to accommodate peakbusiness cycles.

Every day, tens of thousands of trucks with extracapacity are driving by businesses that have freightthat needs to move in the same direction. Simplyby connecting these parties through software,Cargomatic can reduce truck emissions by improv-ing the ratio of freight moved per vehicle-milestraveled.

Cargomatic’s app was built for the local, less-than-truckload marketplace. But the company’s engineershave developed a drayage product designed to moreefficiently move shipping containers out of the ports.

Cargomatic is working in close partnership withthe West Basin Container Terminal at the Port of LosAngeles, where it first tested Cargomatic Free Flow -a drayage product designed to more efficiently moveshipping containers out of the ports - and is build-ing out its pilot program.

Traditionally, when shipping containers come off a

ship, they are placed into long rows of 250-300 con-tainers stacked six-high. When a trucker arrives topick up a container, crane operators have to dig thatcontainer out of the pile. On average, three contain-ers must be moved for every one container delivered.Since displaced containers must be placed back intothe row after the desired container is removed, craneoperators have to make a total of seven containermoves, on average, for every one container delivered.

Cargomatic’s system aims to change that through“free flow.” If a shipper has a certain minimum num-ber of containers on one ship (typically 30-50 contain-ers), a port operator will agree to place those contain-ers in a separate “free flow” pile. Because all of thecontainers in a free flow pile are headed for one com-pany’s distribution center, it doesn’t matter whichcontainer a trucker receives. This arrangement allowstop-handlers to “peel off” the first container from thestack and place it directly on a truck, resulting in 1container delivered for every 1 container moved, or a700% improvement in operator efficiency.

CCargomaticVenice

Jonathan Kessler of Cargomatic



THE PRIVATE BANKING AND INVESTMENT GROUP AT MERRILL LYNCH SALUTES THE PATRICK SOON-SHIONG INNOVATION AWARDS, RECOGNIZING INNOVATION AND ENTREPRENEURSHIP

Merrill Lynch Wealth Management makes available products and services offered by Merrill Lynch, Pierce, Fenner & Smith Incorporated (“MLPF&S”), a registered broker-dealer and Member SIPC, and other subsidiaries of Bank of America Corporation.

The Private Banking and Investment Group is a division of MLPF&S that offers a broad array of personalized wealth management products and services.

© 2015 Bank of America Corporation. All rights reserved. | ARWDQMDW | AD-10-15-0417 | 444621PM-0615

The Gray GroupEric Gray Managing Director – Wealth Management Private Wealth Advisor

310.407.3979 • [email protected]

Merrill Lynch Private Banking and Investment Group 2049 Century Park East Suite 1100 Los Angeles, CA 90067

The Private Banking and Investment Group at Merrill Lynch is committed

to supporting individuals and organizations in our community that

contribute to enhancing the neighborhoods where we live.

Life’s better when we’re connected®



UGMENTED and virtual realities arehaving “a moment” in the techworld. From the rise and fall ofGoogle Glass to billion dollaracquisitions and valuations, there isno question that the industry isone of the most closely watched

and widely discussed. The augmented reality market is projected to gen-

erate $150 billion in revenue by 2020. Most of thehype has been around consumer-facing experiences,and not much attention has been paid to other appli-cations for both hardware and software. There is ahuge, un-tapped opportunity around using augment-ed reality in the workforce, and it is going to have adrastic impact on the way we work in the future.

DAQRI is an augmented reality company power-ing the future of work through innovative hardwareand software products. Its flagship product, theDAQRI Smart Helmet, uses augmented reality tech-nology to improve safety and efficiency for workerson the job and provides unparalleled cost savings for

Fortune 500 companies in industrial and manufac-turing settings.

DAQRI spent more than a year developing theDAQRI Smart Helmet, a professional-grade head-mounted display for industrial environments. Withthe Smart Helmet, workers are able to seamlesslyconnect to their environments, improving produc-tivity, safety and efficiency. Supported by DAQRI’s4D software, the device is completely hands-free,and allows the wearer to see work instructions in thecontext of the job being done.

With the Smart Helmet, workers in a variety ofindustries including aerospace, oil and gas, manufac-turing, transportation, power and more can now beconnected with the information and environmentaround them. Workers at complex and dangerousjob sites can receive step-by-step instructions on topof real-world objects in their field of vision, or bepinged with instant safety alerts and emergencyinstructions in the field.

Powering the Smart Helmet is “Intellitrack” theworld’s most advanced sensor package. Intellitrack

turns any industrial environment into a canvas for4D content, from in-context training applications toaugmented work instructions and beyond. UsingDAQRI’s Industrial 4D Studio, its 4D-authoring pro-gram, enterprises are able to develop their own work-flows using Intellitrack, as well as gather insights intoSmart Helmet usage behavior. With a slew of techno-logically advanced capabilities, including high-resolu-tion 3D sensors, 360 degree navigating cameras andbattery life that lasts an entire shift, the SmartHelmet’s technological capabilities are unparalleled.

From training new employees to assemblingadvanced machinery, the applications for the SmartHelmet are vast. The Smart Helmet will supply work-ers across a variety of industrial professions with thetools to make their jobs easier and more productive.

As the Los Angeles tech community continues tocome of age, DAQRI has been a leader in ensuringthat LA remains a hub for innovation. Though ARtechnology is still in its infancy, DAQRI is workingto ensure its widespread adoption, particularly inthe industrial space.

ADAQRILos Angeles

Regan Wynee of DAQRI




ECOGNIZING the need for an environ-mentally friendly addition to themarine engine industry, CaptainBernardo Herzer has created a newcategory of cleaner, more reliableoutboard engines that eliminate thegrowing concerns with ethanol

problems. With the new and stricter EPA and CARBregulations and lower cost of propane fuel, thesemore reliable outboards are making boating easierand more fun for the end user. This innovation is thefuture and one company visionary made it a reality.

In 2012, LEHR launched the 2.5HP and 5.0HPPropane Powered Outboard Engines with immediateacceptance and accolades from the boating world.The LEHR engines utilize LEHR’s award winninggaseous fuel technology to eliminate the environ-mental detriment of gasoline, extend engine life andreduce the cost of operation.

With the same power and performance andoffered at a comparable price to gasoline outboards,the propane engines are superior in that they virtu-ally eliminate particulate emissions, eliminate gaso-

line pollution in the water, and have zero evapora-tive emissions from the closed fuel system. In addi-tion, there is no danger of contamination of thewater through spillage (propane is not a marine pol-lutant) and they are cost effective to own and main-tain. Propane is a less expensive fuel that does notgo bad with time therefore avoiding fuel-related/car-bureted maintenance and repairs, particularly withtoday’s ethanol added fuels. The engines run onLEHR’s new one-pound refillable propane container,or Coleman disposables or attached to standard BBQpropane tanks or any DOT approved propane tanks.

In short, LEHR technology provides its users withequipment that offers full power and performancewith reduced emissions, reduced fuel cost, reducedmaintenance problems, and lower overall cost ofownership. Unlike gasoline-powered motors, LEHRengines can be safely and quickly refueled withoutozone depleting evaporative emissions, spilling orignition risk.

And that’s not all. Most recently, Captain Herzerand LEHR have continued their innovative successwith the release of the world’s first internal battery

propane powered outboard engine. Herzer helpeddevelop the marine application for LEHR’s new lithi-um iron phosphate chemistry technology and nowoffers this new battery technology on a range of out-boards in different horsepowers, including a 9.9Hpand 15HP. Bringing the environmentally advanta-geous aspects of this clean alternative fuel with arevolutionary starting option to a broader audience,this new internal battery model is an industry first.Traditional electric start outboards require a large,heavy lead acid or AGM type battery to be carried inthe boat along with the associated heavy cables tocarry the electrical current to the engine.

LEHR’s new innovation makes use of the latesttechnology Lithium Iron battery contained insidethe housing of the outboard motor itself, thus elimi-nating the battery and cables inside the boat. Theentire system only adds 2 lbs of weight to the out-board. The benefit to a small boat operator lookingfor portability is obvious. And with an aging activeboating population, bringing an electric start optionto small, portable self-contained engines is a god-send to many.

RLEHR LLCLos Angeles

From left: David Kostkas of LEHR LLC. and Jeff Blum of LEHR LLC



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YPERTENSION affects over one billionpeople on the planet and is one ofthe leading causes of cardiovasculardisease and stroke. Almost 50% ofadult hypertensive patients in theU.S. are uncontrolled; that is, theystill have high blood pressure.

Thus, there is a significant need for a non-drug ther-apy option that lowers blood pressure, is minimallyinvasive for patients, and is cost effective for payers.

In March of 2011, Valencia CEO Jeff Greinerreteamed with CTO Dave Peterson to evaluate ifthey could take the underlying science of elec-troacupunture and mold their Western neuromodu-lation experience with implantable pacemakers(cochlear implants and spinal cord stimulators) tofind a solution that would help improve the lives ofmillions of people not responding to their bloodpressure medications. Their solution is the radicallysmall, coin-sized Subcutaneous NeuromodulationSystem (SNS) that stimulates the median nerve inthe forearm reducing blood pressure in resistanthypertensive patients.

The underlying science was done by Drs. Li andLonghurst from UC Irvine and establishes themechanism of action for acupuncture therapy inthe treatment of hypertension. These physiciansbelieve and their decades of work show thatacupuncture is not mysterious, but neuromodula-tion. Their research indicates that a low duty cyclecan be used for the treatment of chronic conditions,which therefore allows for a once a week, thirtyminute stimulation sessions.

Placed in the forearm during a 20-minute officeprocedure, the coin-sized device stimulates themedian nerve at low frequency and low intensityelectrical pulses that are comfortable to the patient.The location is optimal because the device sits abovethe tendons and the fascia where a pocket is natural-ly formed and just 4 mm away from the target nerve(median nerve). Using local anesthetic, any surgeonor interventionalist can implant the device in a pro-cedure designed by hand surgeon Dr. Subhro Sen ofStanford University. In addition to the device, thecost of the procedure is low given limited time andfacility requirements.

Once implanted, the device works by activatingthe median nerve, sending out a relatively low-pow-ered and well-tolerated electrical stimulus to com-municate with the brain.

Valencia’s invention contains the followingadvantages over present modern technology; it isflat and disk-shaped for retention and stability justunder the skin; it is a leadless system with elec-trodes that are part of the outside housing creatingthe optimum configured electrical field; its unique-ly positioned feed-through offers protection fromthe rigors of the manufacturing process; and theelectronics enable the high impedance watch bat-tery to work.

Unlike most active medical devices on the mar-ket, Valencia’s device was also created with the goalof being low cost to produce and therefore, of lowcost to the healthcare system. CTO and primaryinventor Dave Peterson was able to collaborate withChief of Mechanical/Materials Engineering ChulaThenuwara in order to produce the device for hun-dreds of dollars instead of the thousands of dollarslarger pacemakers require.

H

Valencia Technologies CorporationValencia

Stacy Greiner Chambliss of Valencia Technologies Corporation



GUY KAWASAKIClass of ’79

Wikimedia Foundation Trustee,Technology & Marketing Guru

DENNIS SLAMONProfessor of Medicine,

Breast Cancer Treatment Pioneer

SUSAN WOJCICKIClass of ’98

CEO of YouTube,Visionary

WE CHANGE THELANDSCAPE BY LOOKING BEYOND THE HORIZON.As Optimists, we’re driven by a passion to seek new paths. To revolutionize our fi elds.

And to launch the next big thing. Because we believe opportunity lies around every corner,

we look beyond our current landscape. We stay ahead of the game. And change it for the world.

What odds will you defy? ucla.edu/optimists

UCLA-151-01d_LABJ_MECH_v3.indd 1 11/16/15 4:20 PM



-THERMA is developing a radical newhighway of non-toxic, hyper-effec-tive antifreeze agents to fightunwanted ice formation in regener-ative medicine, advanced formula-tion cosmetics, enhanced qualityfrozen food, and industrial deicing

applications using nature-inspired, biomimeticnanoscience.

Cryoprotective agents (CPAs) are critical additivesto control unwanted ice growth in the biomedicalarena and a wide array of industries (e.g. frozen food,airplane/gas pipeline deicing and engine coolants.) Amajor chemical breakthrough is demanded becauseof the limitations of the classic CPAs that have notbeen greatly improved in the last 50 years, dimethylsulfoxide (DMSO) and ethylene/propylene glycol,and their adverse toxicity. Nature provides a greatsolution for arctic species to survive an ice world byproducing natural antifreeze proteins (AFPs). Theseproteins are among the most wanted proteinsbecause of their superior antifreeze performance

compared to DMSO. However, extremely limitedresources and difficult purification hinders the com-mercialization of AFPs leading to unreliable world-wide production. AFPs also exhibit a short shelf lifeand may cause immune reactions in humans.

X-Therma has a unique solution. Biomimeticnanoscience provides advanced ice-interacting pep-tidomimetics similar to AFPs, but superior (costeffective, long lasting, non-immunogenic) to offerthe first affordable, safe and highly effective CPAsmatching AFPs. Series IPs are in formation to protectmultiple technologies in material development anda high-throughput instrument, which is a field first.

X-Therma aims to first “reshape” and “expand”rather than “disrupt” the marketplace by offeringthis new generation of antifreeze additives to drasti-cally improve the performance of current productsin the market. X-Therma has a horizontal integra-tion market strategy, which focuses on maximizingthe return and minimizing the risk for its investors.

The global market for Organ/TissueTransplantation is estimated to be $20 Billion. In the

U.S, only 1 in 5 patients can receive a new organ. InJanuary 2015, major government funding agencies(DoD, NASA, NIH, and NSF) fully realized the ulti-mate solution is an organ/tissue bank and launcheda national movement to fund cutting-edge technolo-gies to enable this vision. X-Therma’s unique devel-opment of new CPAs for safe and effective biobank-ing was awarded a DoD SBIR Phase I grant in 2015.

There are other potential markets and industriesthat can benefit from this technology as well,including the ice cream industry. U.S. annual salesof ice cream exceed $10 billion in revenue. The keyto “creamy good” ice cream is small, controlled icecrystal size. An addition of 4 mg/L of AFPs can pre-vent the formation of large ice crystals that spoil thesmooth, silky texture of premium ice cream, whichusually has 17% fat content. A small quantity of ourmaterial will allow premium ice cream to become“low fat/low carb” and increase attractiveness tohealth conscious consumers. Most importantly, byenhancing the stability of the ice cream, it could cutthe cold chain costs to 10%.

XX-Therma Inc.Vallejo

Xiaoxi Wei, Ph.D. of X-Therma Inc.


NOVEMBER 23, 2015 AN ADVERTISING SUPPLEMENT TO THE LOS ANGELES BUSINESS JOURNAL 37

finalistsPATRICK SOON-SHIONG INNOVATION AWARDS 2015

A TLANTIS Technologies has commercialized anadvanced form of capacitive deionization calledRDI, or Radial Deionization. The RDI can economi-

cally desalinate complex industrial wastewater such asoil/gas produced water, power plant (FGD scrubber blow-down, cooling tower blow-down), mining, and impairedgroundwater.

The system is based on the patented RDI super-capaci-tor cylinder. Cylinders can be placed in series to reducehigh salinity water and in parallel to treat municipal scaleflow-rates. Atlantis’ RDI system can process water withsalinity up to 150,000 ppm, high levels of hardness,heavy metals (Hg, Se, U, Ba, Sr), and other low solubilityspecies such as calcium sulfate. High flow rates, highclean water recovery, and low maintenance allow for thecost of ownership to be as much as 70% less than existingstate of the art technologies.

The base capability of the RDI system along with thepotential for improvements 30-60 times current metrics inenergy and weight is a significant breakthrough for capac-itive deionization and will allow it to meet and exceedthe performance metrics of state of the art reverse osmo-sis, electro dialysis, and thermal systems.

Atlantis has deployed multiple field pilots in the oil &gas market, including a trailer mounted system and remotecontrolled system in the Middle East. The company hasalso operated long-term studies in-house on producedwater. A 4th generation system is currently being intro-duced. This system has six times flux rate, which reducesthe size of the super capacitor needed by a factor of six,reducing the number one cost component of the system.

Atlantis Technologies Dana Point

Patrick Curran of Atlantis Technologies

EVERY short-run folding carton job faces the problem of qual-ity traded-off for cost-effective printing solutions. With thecost structure in the packaging and printing industry inher-

ently designed to favor large quantity orders; the larger theorder, the lower the price per piece. Therefore, companies thatgenerally need small quantity orders are forever disadvantagedto pay higher prices.

The world has since witnessed considerable improvements inprinting presses, numerous new printing solutions and a pletho-ra of acclaimed innovations. Despite the visible improvementsin quality due to more sophisticated machines, only few compa-nies can claim to be concurrently cost-effective and quality-con-scious. Most companies charge additional fees based on thenumber of colors printed, and most can’t sufficiently and consis-tently match Pantone colors. Hence, there has been a need for acost-effective and high quality short-run solution that can effec-tively match Pantone colors.

Thoro Packaging therefore established FoldedColor, a web-to-folding-carton solution based on its groundbreaking innovationof digital-litho technology with seven-color process. This inno-vation is cost-effective without conceding quality. It is able toconstantly match 83% of Pantone colors with color stability andconsistency on all printed cartons. On top of all this, it doesn’tcost more to print 1000+ colors on a carton than to print fourcolors. This is the first-of-its-kind.

No other technology in the world can boast of stable offsetprinted folding cartons while matching 83% of Pantone colors,high quality, one price no matter how many printed colors,online 3D proofing, immediate pricing, and fast turnaroundtime, all at once. FoldedColor saves up to 60% of the averageindustry pricings because of all these efficiencies.

FoldedColor Packaging Corona

Janet Steiner of FoldedColor Packaging




MANY of the medications that can potentially makea major improvement in the survival of patientswith life threatening lung conditions are biolog-

ics and other agents that require large doses to be deliv-ered directly to the lungs. It is the delivery of these life-saving treatments by aerosol inhalation that present criti-cal needs that are not well served by current technologies.

Dr. Donovan Yeates of KAER BiotherapeuticsCorporation took a new and untried approach. He decid-ed to generate a large liquid aerosol containing the drug,rapidly evaporate this aerosol to a dry powder and thenremove the majority of the air from the aerosol using vir-tual impaction such that a concentrated respirable aerosolwas delivered at the output. The Heart Lung and BloodInstitute of NIH through Phase I and 11 SBIR grants sup-ported this novel approach dubbed SUPRAER.

Respirable aerosols of proteins, antibodies, surfactantand other large and small molecules have been successful-ly aerosolized with SUPRAER at rates up to 200mg/minute. Molecular or biological functional degrada-tion have not been observed. A solid particle of proteingenerated by SUPRAER contains 25 times the mass of drugof an equivalent sized 4% solution of an aqueous aerosol.SUPRAER uses a single-pass low-shear nozzle. The finalparticle size and delivery rate are tailored to the need athand. Output efficiencies of 65% are attainable.

The system is scalable and can easily be manufacturedas an in-hospital device or as an aerosol generation sys-tem for home use. The universality of this system enablesit to deliver all drugs in solution or suspension.

KAER BiotherapeuticsCorporation Escondido

Donovan B. Yeates, Ph.D. of KAER Biotherapeutics Corporation

ONE in five globally suffer from skin disease, such asinfections, rashes, ulcers, moles, and cancers, andsurveys consistently show that skin disease is the

number one reason patients seek health care. Out of900,000 physicians in the US, however, only 9,600 aredermatologists. Consequently, physicians of all specialtiesare continuously confronted with the question: “what isthis mole (spot, freckle) on my skin?”

To answer this question, physicians face one of themost glaring deficiencies in modern medicine: there hasbeen no diagnostic test for skin. Lubax has now devel-oped such a test.

Lubax is a mobile app that identifies skin diseasesinstantaneously. Lubax uses a proprietary database ofdiagnosed skin-lesion images (currently 12,000 images)and a patented computer vision algorithm based on theprinciples of content-based image retrieval.

The doctor takes a photo of a skin lesion, and Lubaxreturns best-matching images and their diagnoses from aproprietary database of diagnosed lesions. No additionallenses or lighting is required, only a smart phone is need-ed. The software is potentially capable of identifying allskin lesions: if Lubax has relevant images in the database,it can identify the skin lesion. A first trial with Stanfordand Oxford showed greater than 90% sensitivity andspecificity in identifying melanomas (larger than 10mm),which is even more accurate than most dermatologists.Ultimately, Lubax will not just help doctors decide if theirpatients need to see a dermatologist, but in fact outper-form dermatologists in skin check accuracy.

Lubax, Inc. Los Angeles

Raymond Chen, MD, DPhil of Lubax, Inc



The Patrick Soon-Shiong Innovation Award2015 Honorees

Thank youfor your vision and for leading the way.

We are proud to honor some of the most innovative organizations in the country.

PROVIDENCE Salutes

PROVIDENCE FAMILY OF SERVICES

Providence Holy Cross Medical Center

Providence Little Company of Mary Medical Center San Pedro

Providence Little Company of Mary Medical Center Torrance

Providence Saint John’s Health Center

Providence Saint Joseph Medical Center

Providence Tarzana Medical Center

Providence TrinityCare

Providence Affiliated Medical Groups

california.providence.org 888-HEALING (432-5464)


NEURAL Analytics has built a working prototype of theworld’s first objective concussion diagnosis andReturn-to-Play (RTP) management device. Our

approach combines existing medical technology with cutting-edge robotics and data science.

Concussion, also known as a mild traumatic brain injury(mild TBI), impacts between 1.6 and 3.8 million people eachyear with higher rates in our military and athletic populations.

Neural Analytics’ technology utilizes non-invasive ultrasoundto assess the physiological response of patient blood flow to pro-vide an objective measure of concussion. It has been well docu-mented in academic literature that there is a strong correlationbetween impaired cerebral blood flow and mild or severe TBI.Neural Analytics developed several proprietary ways to measurethe critical components of cerebral blood flow using “off theshelf” technologies. Measuring cerebral hemodynamics objectivelyusing an accurate, portable device for mild TBI diagnosis and RTPdecisions is an innovative approach to address these challenges.

No other technology is capable of obtaining direct real-timeinformation about the physiological processes of cerebral bloodflow. Neural Analytics’ platform provides a portable, cost-effec-tive, and safe solution allowing for the mass adoption of ourtechnology. Recently, research and development by NeuralAnalytics has led to support from federal grant agencies, NASA,the US military, and professional sports organizations.

This innovative technology combines existing medicalhardware with advanced robotics and data science to address asignificant market opportunity. By providing a safe, non-inva-sive and cost-effective method to obtain objective and action-able information about the brain, Neural Analytics will help tosave lives and enable better patient care.

Neural Analytics, Inc. Los Angeles

Leo Petrossian of Neural Analytics, Inc.



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EY congratulates this year’s honoreesfor the Los Angeles Business Journal’sPatrick Soon-Shiong Innovation Awards.Your commitment to build a better workingworld inspires us all!

advise, guide and recognize entrepreneurs,visit www.ey.com/us/sgm

Building a betterworking world through innovation.


IN the past two decades, research has failed to produce a newdrug to treat Alzheimer’s disease because 1) antibodies to clearamyloid plaques and/or tau tangles from the brain were admin-

istered to patients with significant cognitive impairment/dementia— too late to reverse the brain damage; 2) gamma or beta enzymeinhibitors were administered to decrease the formation of amy-loid42 (primary cause), but these drugs have many side effects dueto other effects of the enzymes, and again it is too late for patientswith dementia. Recent evidence with two amyloid antibodies sug-gests that if administered to pre-cognitive impaired people withminimum amyloid deposits, the cognitive impairment/dementiacan be prevented along with further amyloid damage.

NeuroGenetic Pharmaceuticals’ discovery program began in2003 with the goal of selectively preventing the formation ofAb42 (the bad amyloid) without inhibiting important multifunc-tional enzymes. After screening 100,000 compounds to find oneof interest, then synthesizing more than 2000 molecules to opti-mize the mechanism and drug-like properties, the companyfound about ten with excellent potency, selectivity for modulat-ing the cleavage enzymes, orally absorbed and brain selectivity.In 2009, the company chose three compounds for toxicology anddrug disposition studies, then selected NGP 555 for further devel-opment. It has now been shown that NGP 555 selectively andsafely modulates rather than inhibits the key enzymes, is well dis-tributed in the brain, is a stable molecule which has been formu-lated into a capsule for oral dosing.

This innovation has required major persistence, and results con-tinue to be quite encouraging.

NeuroGenetic Pharmaceuticals Inc. Del Mar

William T. Comer, Ph.D. of NeuroGenetic Pharmaceuticals Inc.



HONORING THE MANBEHIND MIRACLES

The people behind medical advances can be as extraordinary as themiracles they create. We’re privileged to salute Steven T. Rosen, M.D., on his Lifetime Achievement Award from the Chicago chapter of the Israel Cancer Research Fund. Renowned as one of the best doctors in America, his talents and commitment are blazing new paths in research and treatment at City of Hope, where he serves as provost and chief scientific officer, aswell as the Irell & Manella Cancer Center Director’s Distinguished Chair.

cityofhope.org

City of Hope is a Los Angeles-based independent research and treatment center for cancer, diabetes and other life-threatening diseases. Designated as a comprehensive cancer center, the highest recognition bestowed by the National Cancer Institute, City of Hope’s research and treatment protocols advance care throughout the nation. It is ranked as one of “America’s Best Hospitals” in cancer by U.S. News & World Report.


OMNI Nano is an organization dedicated to teachingkids about cutting edge science, specifically nanotech-nology. The company envisions American students

educated and passionate about nanotechnology, and inspiredto pursue future STEM careers for the greater good of ourcommunities and our nation.

Omni Nano is on a mission to inspire our students tobecome the future scientists, engineers, and entrepreneurs ofnanotechnology, who will ultimately make significant contri-butions to the continued success and prosperity of theUnited States. The company is determined to motivate thenext generation of America’s STEM workforce by developing,producing, and distributing educational material for nan-otechnology courses.

While facing one of the most important decisions of theirlives – choosing their college major – today’s high school jun-iors and seniors typically know very little about the scienceand engineering of the 21st century. In fact, despite its grow-ing importance, nanotechnology is currently predominantlytaught in master and doctorate degree programs. Omni Nanobelieves that if junior and senior high school students (11th

and 12th grade), can be engaged and excited about the tech-nologies of the 21st Century, then they can be guidedtowards STEM majors in college, and potentially on a trajecto-ry of productive professional careers in science and engineer-ing, leading to a significant positive impact on their lives.

Omni Nano aims to disseminate nanotechnology educa-tion through three distinct projects, which are designed tofacilitate the teaching of nanotechnology classes. Although ayoung organization, Omni Nano has already achieved impor-tant milestones on all of its projects.

Omni Nano Los Angeles

Marco Curreli, Ph.D. of Omni Nano



24Hr HomeCare

El Segundo

3DT Holdings, LLC

San Diego

5D Robotics, Inc.

Carlsbad

Absolute Security

International Inc. Dba

Absolute International Security

Covina

Accurate Background

Irvine

Altus Institute

San Diego

Benefunder

San Diego

CalAsia Pharmaceuticals,

Incorporated

San Diego

Choice Technology, Inc.

Reno

CONNECT

San Diego

Cynthia Bennett & Associates

Employee Loan Solutions, Inc.

San Diego

Everyone Counts, Inc.

San Diego

EvoRx Technologies

Pasadena

Exergy Systems, Inc

Irvine

EyeSonix

Long Beach

FUGU Corporation

Aliso Viejo

GiftSnap, Inc

Irvine

Graphic Armor

Los Angeles

Greenbelt Resources Corporation

Los Angeles

InfoStreet, Inc.

Tarzana

Innovative Neuro

Technologies, Inc. (INT)

Irvine

Rick J. Caruso Founder and Chief Executive Offi cer

Caruso Affi liated

“

The community of business™

”

L.A. is the greatest city inthe world. There’s no betterway to stay updated onour region’s latest business and economic news thanwith the Los Angeles Business Journal.

Thank You!

Patrick Soon-Shiongfor nominating the creative team of

The Ultimate all-in-one TeleCare and Medical Alert System

Designed to Promote and Protect your Health

www.dailycompanion.com ~ 310.650.0264

NomineesPATRICK SOON-SHIONG INNOVATION AWARDS 2015


Medsign Internationaltional

Corporation

West Palm Beach

Molecular Assemblies

San Diego

nCore Communications, Inc.

San Diego

NeuroRecovery

Technologies, Inc

Los Angeles

New Matter

Pasadena

Pardee Properties

Venice

personalRN

Hermosa Beach

PlayWerks and WhizGirls Academy

Los Angeles

PRAXIS BIOSCIENCES, INC.

Irvine

Science 37, Inc.

Los Angeles

Secured Universe Inc.

San Diego

Sentrian

Aliso Viejo

Sevion Therapeutics

San Diego

Smart Action Company, LLC

El Segundo

Steel Glass, The

Valencia

Stelle Audio

Newport Beach

Steve Lee & Associates, LLC

Westlake Village

The Reader Magazine

Redlands

Trio Hygiene Systems, LLC

Solana Beach

Twych Innovation, Inc.

Thousand Oaks

ViaCyte, Inc.

San Diego


Congratulations

“We are reshaping brain health managementthrough innovative products and services.”

©2015 AT&T Intellectual Property. All rights reserved. AT&T and the Globe logo are registered trademarks of AT&T Intellectual Property.

AT&T is proud to support the Patrick Soon-Shiong Innovation Awards.

Inspirationstarts with you.

At AT&T we champion creative thinking

and technological advancements to

create a better, more connected life.




Event scenePATRICK SOON-SHIONG INNOVATION AWARDS 2015

From left: Eric Gray of Merrill Lynch, David Kostkas of LEHR LLC, Jeff Blum of LEHR LLC, Jonathan Kessler of Cargomatic, Stacy Greiner Chambliss of Valencia Technologies

Corporation, Matt Toledo of Los Angeles Business Journal, Dr. Patrick Soon-Shiong of NantWorks, LLC, Jim Hill of KCBS – TV, Regan Wynne of DAQRI, Dana Morgan of DAQRI,

Xiaoxi Wei, PH.D. of X-Therma Inc. and Mark Kline of X-Therma Inc.



Event scenePATRICK SOON-SHIONG INNOVATION AWARDS 2015


2015...2015/11/23 · google glass to billion dollar acquisitions and valuations, there is no...

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