20150528 smb han bio centre
TRANSCRIPT
WHY?
For well educated students
For teachers who know the ‘state of
the art’
For companies, to support in research
and innovation
Development of smart screeningssystems
antimicrobial/antifungal
– Medical
– Agro & Food
– other
C. elegans screeningssystem
– Medical (obesity)
– Safety/Toxicity
Oil from yeast
In cooperation with Wageningen UR
Companies: Nuplex, van Wijhe, Latexfalt,
Holland Colors, Parenco, Dyadic, MicCell, MVO
Biological screening systems Analytical chemistry Bio-informatics Molecular biology
PCR/qPCR
SDS-PAGE
LC-MS
HPLC
FPLC
GC
Fluorescence microscopy
Amphotericin
0
20000
40000
60000
80000
100000
120000
0:0
0
0:3
7
1:1
5
1:5
3
2:3
0
3:0
8
3:4
6
4:2
3
5:0
1
5:3
9
6:1
7
6:5
4
7:3
2
8:1
0
8:4
7
9:2
5
10:0
3
10:4
0
11:1
8
11:5
6
12:3
3
13:1
1
13:4
9
14:2
6
15:0
4
15:4
2
time (h)
Lu
min
escen
s
water
NaPb
DMSO 1:100
Amph 20 µM
Amph 10 µM
Amph 5 µM
Amph 2,5 µM
Amph 1 µM
Amph 0,5 µM
Amph 0,1 µM
Fermentation & downstream processing • From 1 to 20 L (E. coli, lactic acid bacteria, Bacillus,
Helicobacter, filamentous fungi, basidiomycetes,
yeast)
• Downstream processing
– IEX
– GPC
– Microfiltration
– Ultrafiltration
• Strain selection
• Genetic modification of m.o.
• AM-Pharma
• Aquamar
• Argos Oil
• Avatar Biotechnologies (USA)
• Avebe
• Basidiofactory
• Benilabs
• B.O.B.
• Cellution Biotech
• C4C
• Christian Hansen (DK)
• CSK Food Enrichment
• CU+TOP
• Cyto-Barr
• DMV International
• DSM
• Dyadic Nederland
• European Veterinary Laboratory
• Falco Diagnostics
• Filtex
• Innovative SeedTechnology
• TNO Quality of Life
• Koppert
• LabTie
• Meddens Diagnostics
• MicCell
• Micreos
• Nsure
• Nuplex
• NVWA
• NYtor
• Parenco
• Productschap Tuinbouw
• ProteoNic
• Quaker
• Rainbow Sustainable solutions
• RIVM
• Shell
• Uniqema/Croda
• Unilever
• Van Wijhe
• Vitaleech Bioscience
• Vivalt screening
• Xenikos
What do we offer?
- Contract research
- Cooperative research • Basidiofactory
• Vivalt screening
- Lab facilities • Basidiofactory
• Vivalt screening
- Workshops
APPLICATION DISCOVERY ANALYSIS PRODUCTION
What do companies bring?
- Knowledge/new developments
- Guest lectures
- Facility sharing
- Internships
APPLICATION DISCOVERY ANALYSIS PRODUCTION