2016 bioscwin leman china swine conference...2016 bioscwin leman china swine conference content 1....
TRANSCRIPT
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FRA® Swine 2016 Bioscwin Leman China
Swine Conference
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Content 1. Welcome: Challenge Question
2. The origin of FRA® C12 Dry
3. What is FRA® C12 Dry
4. PRRS in Swine Industry
5. FRA® C12 versus PRRS
6. Summary: Answer
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Question
PRRS infection on farm, what to do?
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Answer
Do what your mother taught you.
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• Mother milk
• +- 750 gr/day breast milk (fat 42 g/kg)
• Monolaurin content: 0,5 g/kg
• +- 6 months (180days) lactation
=> Everyone consumed approx….65 g FRA® C 12 dry!!!
We have all used FRA® C12 dry
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• Coconut oil contains alpha monolaurin
• Health supplement for humans
• Lauricidin® www.lauricidin.com
• Other plant derived oils
Where else can it be found?
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Glycerol
α
α'
β
Lauric acid (C12H24O2)
How to produce FRA® C 12 dry
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Lauric acid Glycerol Alpha monolaurin
Esterification Process
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• Porcine reproductive and respiratory syndrome
• Blue ear pig disease – (in Chinese, zhū láněr bìng 猪蓝耳病).
⇒ Weakens the overall immune system
⇒ Opens the door for other diseases
Challenge PRRS
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Porcine reproductive and respiratory syndrome
What does PRRS do to your pigs?
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• Worldwide problem – (US $650 million annually)
• Started in China in 2006 (HV-PRRSV) – Costs +- USD100,-/sow & +- USD 5,-/pig
• Secondary effect on production cost
What does PRRS do to money?
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PRRS virus structure
• Two prototype strains of PRRSV: - North American Strain
- European Strain
• In China, in 2000s, a highly virulent North American strain was found
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PRRS virus structure
PRRS
⇒Viral RNA infect host cells ⇒Virus envelops:
⇒Protection against immune cells (macrophages) ⇒Allow fusing virus membranes with host cells and transfer –multiplication of RNA
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• Route of shedding: – Blood
– Tonsil and lymphoid tissue – Nasal – Saliva – Milk/ Colostrum – Semen – Feces – Urine
Where does the virus hide?
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Transmission and propagation
• Horizontal transmission means the virus is transmitted through pathways within the herd of pigs and among different herd of pigs.
⇒ Besides the direct contact of infected pigs, it is also possible to transmit PRRSV indirectly
⇒ Indirect infection can be taken place by different types of media such insects, rodents, farm workers, tools, transporters and even air!
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Transmission and propagation
• Vertical transmission means the virus is transmitted through the parental contact:
⇒ especially from sows to piglets at fetal phase. ⇒ transmission among piglets can still be
happening to individual healthy piglets 3 months after farrowing.
⇒ semen plays a crucial role in this case as well, due to the possibility of virus shedding and the widely application of artificial insemination.
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• Transmission embryo, placenta and semen
• Propagation contact with feces, air and insects
• Secondary infections lunginfections, meningitis (Streptococcus suis)
PRRSV how does it spread?
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1. Oral application: - Is stable in acidic and neutral environment:
covalent bound
- Resist enzymatic breakdown: alfa-monoglyceride
2. Destroy lipid cell membranes (typically gram positive bacteria and fat enveloped viruses): - Based on more lipophilic MCFA (lauric acid)
- Alfa-monoglycerides are lipophilic and water dispersible
3 conditions for antiviral
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Mode of action FRA® C 12 dry
FRA® C 12 dry destabilizes and disrupts the membrane/fat envelop of viruses
Hyldgaard et al, 2012
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1. Oral application: - Is stable in acidic and neutral environment:
covalent bound
- Resist enzymatic breakdown: alfa-monoglyceride
2. Destroy lipid cell membranes (typically gram positive bacteria and fat enveloped viruses): - Based on more lipophilic MCFA (lauric acid)
- Alfa-monoglycerides are lipophilic and water dispersible
3. Product must work systemic, thus being transported via lymphatic system - Alfa-monoglycerides of MCFA, more particularly
lauric acid, are taken up by the enterocytes and preferentially transported via the lymph system
3 conditions for antiviral
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FRA® C 12 dry absorbed inside the body
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• Direct virucidal effect
• Absorbed intact in intestinal tract
(typical for MCFA-lipids)
• Lymphatic system
• Cleans the lungs and
reproductive system
FRA® C 12 works inside the body
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• Before farrowing FRA® C 12
• Lactating sows FRA® C 12
• Weaning piglets FRA® C 12
• Gilts before mating FRA® C 12
• Boars FRA® C 12
• USA: Using FRA® C12 before vaccination
Therefore… FRA® C 12 in your feed!
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• Use 3 kg FRA® C12 Dry at 3 weeks before farrowing and the whole lactation period
• Use in creep feed diet 4 kg FRA® C12 Dry at the first 2 weeks and add 3 kg FRA® C12 Dry at the last 2 weeks of starter feed
• Use 3 kg FRA® C12 Dry when gilts are at 80 kg till 120 kg
• Use 4 kg FRA® C12 Dry in Breeder Boar to reduce PRRSV
• Use 3 kg FRA® C12 Dry at the first 3 weeks in the new breeder sow before mixing in the groups
• Use 3 kg FRA®C12 Dry at 2 weeks before vaccination program in sows
FRA® C 12 Applications
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Question
PRRS infection on farm, what to do?
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Answer
Do what your mother thought you.
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Answer
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• FRA® C 12 makes sows and sow milk healthier
• Possible due to systemic action • Similar to mother baby milk • Improves protection of piglets from PRRS • Reduces infection sow to piglet ⇒ More piglets born alive ⇒ Healthier piglets = lower mortalities ⇒ Faster growing fattening pigs (7 days shorter)
Summary