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volume 310no.2

august 2016

PUBLISHED BY THE AMERICAN PHYSIOLOGICAL SOCIETY

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PUBLISHED BY THE AMERICAN PHYSIOLOGICAL SOCIETY · JAPPL.ORG

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JULY 2013

VOLUME 115

NUMBER 1 Journal of APPLIEDPHYSIOLOGY

Published by the American Physiological SocietyVolume 117 Number 4 April 2017

a multidisciplinary neuroscience journal

Neurophysiology®

Journal of

Original Research // Reviews // Editorials // Articles in Press

Overload-mediated skeletal muscle hypertrophy is not impaired by loss of myofiber STAT3Cell Physiology

featured research | read more >Lipopolysaccharide downregulates macrophage-derived IL-22 to attenuate

alcohol induced hepatocyte cell death

Sodium storage in human tissues is mediated by glycosaminoglycan expressionRenal Physiology

The human coronary vasodilatory response to acute mental stress is mediated by neuronal nitric oxide synthaseHeart and Circulatory Physiology

A novel role for primary cilia in airway remodelingLung Cellular and Molecular Physiology

Cerebral oxygenation and regional cerebral perfusion responses with resistance breathing during central hypovolemiaRegulatory, Integrative and Comparative Physiology

Development of a reliable, automated screening system to identify small molecules and biologics that promote human β cell regenerationEndocrinology and Metabolism

Roles of autophagy and metabolism in pancreatic cancer cell adaptation to environmental challengesGastrointestinal and Liver Physiology

Overload-mediated skeletal muscle hypertrophy is not impaired by loss of myofiber STAT3

Cell Physiology

Although the signal pathways mediating muscle protein synthesis and degradation are well characterized, the transcriptional processes modulating skeletal muscle mass and adaptive

growth are poorly understood. Recently, studies in mouse models of muscle wasting or acutely exercised human muscle have suggested a potential role for the transcription factor, signal transducer and activator of transcription 3 (STAT3), in adaptive growth. Hence, in the present study we sought to define the contribution of STAT3 to skeletal muscle adaptive growth. In contrast to previous work, two different resistance exercise protocols did not change STAT3 phosphorylation in human skeletal muscle. To directly address the role of STAT3 in load-induced (i.e. adaptive) growth, we studied the anabolic effects of 14 days of synergist ablation (SA) in skeletal muscle-specific STAT3 knockout (mKO) mice and their floxed, wild type (WT) littermates. Plantaris muscle weight and fibre area in the non-operated leg (Control; CON) was comparable between genotypes. As expected, SA significantly increased plantaris weight, muscle fibre cross sectional area and anabolic signaling in WT mice, although interestingly, this induction was not impaired in STAT3 mKO mice. Collectively, these data demonstrate that STAT3 is not required for overload-mediated hypertrophy in mouse skeletal muscle.

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PUBLICATIONS CATALOG2018

Empowering discovery to improve health

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AMERICAN PHYSIOLOGICAL SOCIETY

®

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The American Physiological Society (APS) is devoted to advancing scientific discovery, understanding life, and improving health. As a multidisciplinary community of scientists, APS’s goal is to solve the major problems affecting life by empowering discovery to improve health.

TABLE OF

CONTENTSJournals .........................................2

Journal Benefits ....................................3

Free Trial Information .................................3

Journals Digital Library .....................................4

American Journal of Physiology® ...........................5

Journal of Applied Physiology®..............................9

Journal of Neurophysiology® ..............................10

Physiological Genomics® ....................................10

Physiological Reviews® ........................................11

Physiology® ........................................................11

Advances in Physiology Education® ....................12

The Physiologist® ................................................12

Physiological Reports® ........................................13

Comprehensive Physiology® ................................13

Journal Legacy Content ......................................14

Book Monograph Series .....................................14

Information .......................................................15

Tier Definitions ..................................................16

JOURNALSOF THE AMERICAN PHYSIOLOGICAL SOCIETYThe American Physiological Society (APS) is a publisher of journals and books in many disciplines within physiology. The Society publishes 15 distinguished scientific journals and is dedicated to the advancement of physiological research, which has formed the basis for many biomedical advances.

The journal publishing program covers the entire spectrum of physiology. These highly regarded, peer-reviewed journals examine major physiological systems from the cellular and molecular to the organ and system levels. APS journals meet the needs of researchers, educators, fellows, students, clinicians, and others in the physiological and biological sciences.

APS journals are published and distributed solely by APS, with the exception of Physiology, which is published jointly with the International Union of Physiological Sciences; Comprehensive Physiology, which is published on behalf of APS by Wiley-Blackwell; and Physiological Reports, which is published jointly on behalf of APS and The Physiological Society by Wiley-Blackwell. Information for ordering appears on page 15 of this catalog.

APS JOURNAL TITLESAmerican Journal of Physiology (AJP) consolidated www.physiology.org

AJP–Cell Physiology ajpcell.org

AJP–Endocrinology and Metabolism ajpendo.org

AJP–Gastrointestinal and Liver Physiology ajpgi.org

AJP–Heart and Circulatory Physiology ajpheart.org

AJP–Lung Cellular and Molecular Physiology ajplung.org

AJP–Regulatory, Integrative and Comparative Physiology ajpregu.org

AJP–Renal Physiology ajprenal.org

Journal of Applied Physiology jappl.physiology.org

Journal of Neurophysiology jn.org

Physiological Genomics physiolgenomics.org

Physiological Reviews prv.org

Physiological Reports the-aps.org/prt

Physiology physiologyonline.org

Comprehensive Physiology comprehensivephysiology.com

Advances in Physiology Education advan.org

NEW online journals

platform

APS NEWSLETTERThe Physiologist the-aps.org/physiologist


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JOURNAL BENEFITSFOR LIBRARIANS AND END USERS

• In 2018, the APS journals will be hosted on Atypon’s Literatum online platform, which will offer increased functionality and intuitive navigation for an exceptional online research experience. Physiology.org will continue to offer access to a complete collection of multidisciplinary physiology content from 1898 to the present.

NEW AND IMPROVED BENEFITS• Simpler and more efficient management of all APS holdings for librarians

• A special information for librarians section of the website with important information and helpful resources, including access to real-time COUNTER compliant usage reports

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• Altmetric Attention Scores for each article that offer librarians and interested users a glimpse at where and how much articles are being discussed across various media sites

• Immediate access to accepted papers via Articles in PresS, the APS “early view” service for all 10 original research journals

• Personalized profile area for saving favorite journals, articles, and searches and managing email alerts

CONTINUED BENEFITS• Global distribution for reaching the broadest readership

• Continued indexing in Index Medicus, BIOSIS Previews, Scopus, Web of Science, and MEDLINE (Physiological Reports is not indexed in Web of Science). Journal content is also accessible through PubMed

• Perpetual electronic archiving/preservation in the LOCKSS and CLOCKSS systems for all APS journal content

FREE TRIAL Experience the APS online journals for 2 months.

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JOURNALS

DIGITAL LIBRARYThe APS Journals Digital Library is a single online package of the 10 peer-reviewed original research and two review journals of the Society. The Journals Digital Library is available at a significant discount off the individual title rates. Listed below are the journals included in the Digital Library.

AJP–Cell Physiology AJP–Endocrinology and Metabolism AJP–Gastrointestinal and Liver Physiology AJP–Heart and Circulatory Physiology AJP–Lung Cellular and Molecular PhysiologyAJP–Regulatory, Integrative and Comparative PhysiologyAJP–Renal PhysiologyJournal of Applied PhysiologyJournal of Neurophysiology Physiological Genomics Physiological ReviewsPhysiology

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BEST VALUE

for institutions

AMERICAN JOURNAL OF PHYSIOLOGY

consolidated

www.physiology.org

The consolidated American Journal of Physiology (AJP) has been in uninterrupted print publication since 1898. This publication is composed of the seven AJP specialty journals. It is printed monthly in two parts and published online as articles are ready. The most economical way for institutions to subscribe to all seven sections of the American Journal of Physiology is to purchase the consolidated version.

The consolidated American Journal of Physiology contains the following seven section journals.

• AJP–Cell Physiology• AJP–Endocrinology and Metabolism• AJP–Gastrointestinal and Liver Physiology• AJP–Heart and Circulatory Physiology• AJP–Lung Cellular and Molecular Physiology• AJP–Regulatory, Integrative and Comparative Physiology• AJP–Renal Physiology

VOLUME 314/315Individual specialty sections published online as articles are ready.Printed monthly. Two volumes per year. Approximately 1,800 articles and 17,800 pages per year. ISSN: 0002-9513

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volume 310 no.2 august 2016


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AMERICAN JOURNAL OF

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AMERICAN JOURNAL OF

PHYSIOLOGYvolume 310 no.2 august 2016


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PHYSIOLOGY



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http://ajpcell.org

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Cell Physiology

ajpcell.orgEditor: Josephine Adams, PhD, University of BristolThe American Journal of Physiology–Cell Physiology is on the cutting-edge of cell physiology research. Cell biologists, physiologists, biochemists, and biophysicists find this journal essential reading for original innovative work about normal and abnormal cell functions. Stringently reviewed, thorough, and thought-provoking papers are published on the structure and function of cell membranes, contractile systems, and cellular organelles, as well as mechanisms of development, cell-to-cell interaction, gene expression, and neural, endocrine, and metabolic control. AJP–Cell Physiology has a 2016 Impact Factor of 3.602 and a cited half-life of 9.7 years.

VOLUME 314/315Published online as articles are ready and archived as monthly issues.Printed monthly in the consolidated version of AJP. Two volumes per year.Approximately 200 articles and 2,100 pages per year. eISSN: 1522-1563 (Online)

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Endocrinology and Metabolism

ajpendo.orgEditor: André Marette, PhD, Laval UniversityThe results of original investigation pertaining to endocrine and metabolic systems on levels of organization ranging from the molecular, subcellular, and cellular levels to whole animals, including humans, appear in the American Journal of Physiology–Endocrinology and Metabolism. Areas investigated include the secretion, action, and function of hormones of the endocrine brain, anterior pituitary gland, adrenals, pancreas, thyroid, parathyroid, gonads and reproductive tissue, adipose tissue, and the paracrine and autocrine control of endocrine cell performance. AJP–Endocrinology and Metabolism has a 2016 Impact Factor of 4.142 and a cited half-life of 9.3 years.


http://ajpcell.org

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Gastrointestinal and Liver Physiology

ajpgi.orgEditor: Nigel Bunnett, PhD, Columbia UniversityA broad range of information is presented in the American Journal of Physiology–Gastrointestinal and Liver Physiology, including papers on digestion, secretion, absorption, metabolism, motility, microbiology and colonization, growth and development, and neurobiology relevant to these organs, as well as those dealing with neural, endocrine, and circulatory control mechanisms. AJP–Gastrointestinal and Liver Physiology has a 2016 Impact Factor of 3.468 and a cited half-life of 9.0 years.


Online Only Single Copies & Back IssuesTier 1 Tier 2 Tier 3 Tier 4 Tier 5 Subscriber Non-Subscriber$1,010 $1,215 $1,435 Custom Custom $75 each $150 each





Heart and CirculatoryPhysiology

ajpheart.orgEditor: Irving Zucker, PhD, University of Nebraska Medical CenterThe work published in the American Journal of Physiology–Heart and Circulatory Physiology purposefully spans a wide range of cardiovascular investigation—from genetic, molecular, and cellular physiology of the heart and vasculature to human and animal cardiovascular physiology under normal and stressed states. Studies published in AJP-Heart and Circulatory Physiology focus on uncovering underlying mechanisms of normal and abnormal cardiovascular physiology. The international editorial team ensures that the papers published undergo rigorous peer review and provide new mechanistic information to guide our continuously developing understanding of cardiovascular physiology. AJP–Heart and Circulatory Physiology has a 2016 Impact Factor of 3.348 and a cited half-life of >10.0 years.

VOLUME 314/315Published online as articles are ready and archived as monthly issues.Printed monthly in the consolidated version of AJP. Two volumes per year. Approximately 330 articles and 3,400 pages per year. eISSN: 1522-1539 (Online)

http://ajpgi.org

http://ajpheart.org

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Lung Cellular and Molecular Physiology

ajplung.orgEditor: Sadis Matalon, PhD (term ends Dec. 31, 2017), University of Alabama at Birmingham Rory Morty, PhD (term begins Jan. 1, 2018), University of Giessen and Marburg Lung CenterOriginal theoretical and research papers are published in the American Journal of Physiology–Lung Cellular and Molecular Physiology dealing with molecular, cellular, and morphological aspects of normal and abnormal function and response of cells and components of the respiratory system. AJP–Lung Cellular and Molecular Physiology has a 2016 Impact Factor of 4.281 and a cited half-life of 8.8 years.



Regulatory, Integrative and Comparative Physiology

ajpregu.orgEditor: Willis Samson, PhD, Saint Louis University School of MedicineThe American Journal of Physiology–Regulatory, Integrative and Comparative Physiology specializes in innovative articles that illuminate physiological processes at all levels of biological organization. The contents represent broad interests in regulation, integration, and homeostasis. Significant topics addressed include comparative physiology, regulation and integration in autonomic physiology, behavior, cardiovascular physiology, endocrinology, energetics, fluids and electrolytes, functional morphology, ingestion, periodicity, respiration, and temperature. AJP–Regulatory, Integrative and Comparative Physiology has a 2016 Impact Factor of 2.982 and a cited half-life of >10.0 years.


http://ajplung.org

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Renal Physiology

ajprenal.orgEditor: P. Darwin Bell, PhD, University of Alabama at BirminghamWith a sterling reputation as one of the finest journals publishing information on kidney and urinary tract physiology, epithelial cell biology, and control of body fluid volume and composition, the American Journal of Physiology–Renal Physiology appeals to scientists from many disciplines. Investigations involve human or animal models, including invertebrates, plus isolated, reconstituted, or artificial organella, or membrane systems or cells. AJP–Renal Physiology has a 2016 Impact Factor of 3.611 and a cited half-life of 8.7 years.




Journal of Applied Physiology

jappl.physiology.orgEditor: Sue Bodine, PhD, University of IowaA leader in its field, the Journal of Applied Physiology publishes original papers that deal with normal or abnormal function in six discrete, but often related, areas: 1) respiratory physiology, 2) nonrespiratory functions of the lungs, 3) environmental physiology, 4) temperature regulation, 5) exercise physiology, and 6) interdependence. Priority is given to papers dealing with integrative and adaptive mechanisms. Papers devoted to human research are encouraged. The Journal of Applied Physiology has a 2016 Impact Factor of 3.351 and a cited half-life of >10.0 years.

VOLUME 124/125Published online as articles are ready and archived as monthly issues.Printed monthly. Two volumes per year. Approximately 350 articles and 2,900 pages per year. ISSN: 8750-7587 (Print); eISSN: 1522-1601 (Online)

PUBLISHED BY THE AMERICAN PHYSIOLOGICAL SOCIETY · JAPPL.ORG

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INNOVATIVE METHODOLOGIESINNOVATIVE METHODOLOGIES

HIGHLIGHTED TOPIC:



HIGHLIGHTED TOPIC:

JULY 2013VOLUME 115NUMBER 1 Journal of APPLIED

PHYSIOLOGY




http://ajprenal.org

http://jappl.physiology.org

Journal of Neurophysiology

jn.orgEditor: Bill Yates, PhD, University of PittsburghThe Journal of Neurophysiology publishes original articles on the function of the nervous system. All levels of function are included, from the membrane and cell to systems and behavior. Experimental approaches include molecular neurobiology, cell culture and slice preparations, membrane physiology, developmental neurobiology, functional neuroanatomy, neurochemistry, neuropharmacology, systems electrophysiology, imaging and mapping techniques, and behavioral analysis. Experimental preparations may be invertebrate or vertebrate species, including humans. Theoretical studies are acceptable if they are tied closely to the interpretation of experimental data and elucidate principles of broad interest. The Journal of Neurophysiology has a 2016 Impact Factor of 2.396 and a cited half-life of >10.0 years.

VOLUME 119/120Published online as articles are ready and archived as monthly issues. Printed monthly. Two volumes per year. Approximately 530 articles and 6,200 pages per year. ISSN: 0022-3077 (Print); eISSN: 1522-1598 (Online)

Published by the American Physiological SocietyVolume 117 Number 4 April 2017

a multidisciplinary neuroscience journal

Neurophysiology®

Journal of




Physiological Genomics

physiolgenomics.orgEditor: Bina Joe, PhD, University of Toledo College of MedicinePhysiological Genomics publishes research, reviews, and rapid reports in areas of research focused on uncovering the links between genes and physiology at all levels of biological organization. Topics range from single genes to whole genome, especially concerning links to human physiology, but also any model organism, organ, tissue, or cell. Physiological Genomics has a 2016 Impact Factor of 3.044 and a cited half-life of 8.4 years.

VOLUME 50Published online as articles are ready and archived as monthly issues. One volume per year. Approximately 90 articles and 1,000 pages per year. eISSN: 1531-2267 (Online)


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http://jn.org

http://physiolgenomics.org

Physiology

physiologyonline.orgEditor: Gary Sieck, PhD, Mayo ClinicPhysiology publishes invited review articles written by leaders in their fields. These articles are peer reviewed and highlight major advances in the broadly defined field of physiology. The journal also publishes shorter articles that either highlight important emerging topics and technologies or explore differing points of view. The journal is a valuable tool for researchers, educators, and students. Published jointly by the International Union of Physiological Sciences (IUPS) and the American Physiological Society, Physiology has a 2016 Impact Factor of 6.076 and a cited half-life of 7.2 years.

VOLUME 33Published online as articles are ready and archived as bimonthly issues. Printed bimonthly—January, March, May, July, September, and November. One volume per year. Approximately 50 articles and 450 pages per year. ISSN: 1548-9213 (Print); eISSN: 1548-9221 (Online)


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Physiological Reviews

prv.orgEditor: Dennis Brown, PhD (term ends Dec. 31, 2017), Harvard Medical School Sadis Matalon, PhD (term begins Jan. 1, 2018), University of Alabama at Birmingham Physiological Reviews provides state-of-the-art coverage of timely issues in the physiological and biomedical sciences. The journal appeals to physiologists, neuroscientists, cell biologists, biophysicists, nutritionists, and clinicians with special interests in pathophysiology. Topics are covered in a broad and comprehensive manner. Ranked number one in its field, Physiological Reviews has a 2016 Impact Factor of 27.312 and a cited half-life of >10.0 years.

VOLUME 98Published online as articles are ready and archived as quarterly issues.Printed quarterly—January, April, July, and October. One volume per year.Approximately 40 reviews and 1,600 pages per year. ISSN: 0031-9333 (Print); eISSN: 1522-1210 (Online)

http://physiologyonline.org

http://prv.org

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Advances in Physiology Education

advan.orgEditor: Douglas Curran-Everett, PhD, National Jewish HealthPhysiology instructors interested in educational research find Advances in Physiology Education to be an invaluable forum for learning and exchanging new ideas. All aspects of physiology education at academic levels are covered, including research reports, scholarly essays, and practical aids to teaching. Instructors will find information on curriculum design and implementation; new approaches to discovering the diversity of solutions to common physiological problems; creative approaches, including use of technology, to teaching physiology in large and small settings; and more. Advances in Physiology Education has a 2016 Impact Factor of 1.755 and a cited half-life of 8.7 years.

VOLUME 42Published online as articles are ready and archived as quarterly issues.Printed in December only. One volume per year. Approximately 90 articles and 550 pages per year. ISSN: 1043-4046 (Print); eISSN: 1522-1229 (Online)

The Physiologist

the-aps.org/physiologistEditor: Martin Frank, PhD, American Physiological SocietyThe Physiologist, the newsletter of the APS, features articles on Society affairs and announcements, as well as articles of importance to today’s physiologist. The November and January issues may include abstracts of volunteered papers submitted for APS conferences.

VOLUME 61Published online bimonthly.Printed bimonthly—January, March, May, July, September, and November. One volume per year. ISSN: 0031-9376

THEPHYSIOLOGISTPublished by the American Physiological Society – Integrating the Life Sciences from Molecule to Organism

I certainly appreciate this opportunity to share with you some of my philosophy of teaching and briefly reflect on my own academic career as an educator. I firmly believe that teaching is a special privilege, since it has given me the opportunity to nurture, encourage, and motivate future generations of scientists, educators, and healthcare providers. However, first and most importantly, I want to convey to you how very honored I was to first be nominated for, and subsequently selected, as the recipient of the 2017 Arthur C. Guyton Educator of the Year Award. I know that most physiologists appreciate the fact that not

only was Dr. Guyton recognized as a highly respected cardiovascular physiologist with expertise in hypertension, but he was also the author of one of the world’s best-selling and most widely used textbooks of medical physiology. The fact that I have received an award that is named after this outstanding physiologist makes this recognition even more meaningful. During my career, I have been honored to receive a number of teaching awards, and those experiences have been very gratifying as well as humbling. However, for me personally, it is very important to never lose sight of the fact that I truly enjoy teaching and helping students. Over 150 years ago, President Abraham Lincoln said, “Don’t worry when you are not recognized but strive to be worthy of recognition.” Those words have inspired me throughout my academic career and have been posted above my desk for many years. They serve as a daily reminder of how fortunate I have been, both in terms of the opportunities that I have had to contribute to the education of so many diverse students, as well as to contribute to both curriculum development at my own institution and to the educational programs offered by several national and international organizations with clearly defined educational goals.

Second, I’d like to express my gratitude to the American Physiological Society (APS) for giving me numerous opportunities during my career to not only serve the Society in meaningful ways but to also promote the study of physiology at all educational levels. I hope that over the years I have made important contributions, not only by serving on the Education and Career Opportunities in Physiology Committees, but also as an invited faculty member for several APS Professional Skills Workshops and as faculty member/facilitator for the Institute on Teaching and Learning “Becoming an Effective Teacher” course. I certainly want to express my gratitude to the APS professional staff, not only for their encouragement and enthusiasm, but also for their confidence in my leadership abilities. I especially want to thank Marsha Matyas, Melinda Lowy, Brooke Bruthers, and Miranda Byse of the Education Office, and Marty Frank, APS

Guyton Award Lecture July 2017 • Vol. 60/No. 4

the-aps.org

Dinner with a Nobel LaureateTwo of the Trainee Advisory Committee members, Ryan Downey (Teaching Section) and Ijeoma Obi (Water and Electrolyte Homeostasis Section), as well as Jinae Roa (Porter Physiology Development Fellow, Eleanor Ison Franklin designee) had the pleasure of having dinner with Dr. Louis Ignarro, the 1998 co-recipient Nobel Prize winner in Physiology or Medicine for discovering the signaling role of nitric oxide in the cardiovascular system. This indeed was the highlight of the 2017 Experimental Biology conference.

The evening began with Dr. Ignarro giving his Nobel Prize award lecture followed by a long line of trainees and professors waiting to get an autograph and to have their picture taken with him. On our walk to dinner, I kept

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A Physiologist Does Retirement

APS 170th Business Meeting

ACDP Survey Results

AAMC Compensation Survey

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Thomas Schmidt2017 Arthur C. Guyton Physiology Educator of the Year Awardee

Thomas Schmidt

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Comprehensive Physiology

comprehensivephysiology.comEditor: David Pollock, PhD, University of Alabama at BirminghamComprehensive Physiology is the most authoritative and comprehensive collection of physiology information that has ever been assembled. Its starting point is more than 30,000 pages and 34 volumes of content from APS’ renowned Handbook of Physiology series, which is presented now for the first time in a dynamic online format. With the click of a mouse, researchers can instantly jump to expert reviews presenting the most current science in physiology. Comprehensive Physiology includes the latest discoveries and methods, as well as insights into what new research is needed and where the field is heading. The journal features regular issues delivering thousands of pages of new information every year. New material will not only update and expand upon the Handbook of Physiology’s classic content but also add fresh, expertly written reviews to present new and emerging topics in physiology. Comprehensive Physiology covers all of the field’s subdisciplines, including neurophysiology, heart and circulatory physiology, applied physiology, gastrointestinal and liver physiology, endocrinology and metabolism, renal physiology, and more. A valuable scientific resource for your library, Comprehensive Physiology offers new and updated materials published in a quarterly serial format. The journal is indexed in PubMed/MEDLINE, Scopus, and Clarivate Analytics Web of Science. Comprehensive Physiology has a 2016 Impact Factor of 6.949 and a cited half-life of 3.8 years.

VOLUME 8Published online as quarterly issues. One volume per year. Approximately 410 articles. ISBN: 9780470650714

Physiological Reports

the-aps.org/prtEditor: Susan Wray, PhD (term ends Dec. 31, 2017), University of Liverpool Thomas Kleyman, MD (term begins Jan. 1, 2018), University of PittsburghPhysiological Reports is an open access journal published jointly by the American Physiological Society and The Physiological Society. Physiological Reports publishes peer-reviewed research across all areas of basic, translational, and clinical physiological and allied disciplines. As a collaboration between APS and The Physiological Society, Physiological Reports is in a unique position to serve the international physiology community through quick time to publication, while upholding a quality standard of sound research that constitutes a useful contribution to the field. The journal is published on behalf of the societies by Wiley-Blackwell and is now indexed in MEDLINE.

VOLUME 6Published online as bimonthly issues. One volume per year. Approximately 380 articles. ISSN: 2051-817X

PhysiologicalReports

http://comprehensivephysiology.com

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JOURNAL

LEGACY CONTENTThe Journal Legacy Content of the American Physiological Society is an online package of 100 years of scientific research from 13 APS journals. It can be purchased separately at a one-time charge. Legacy Content is a separate program from the Subscription Program in that you pay once for perpetual access. The package includes content from 13 APS journals (see chart below). The content goes back to the first issue of each journal—including the first volume, the American Journal of Physiology, published in 1898. Legacy Content is viewable as fully searchable scanned images of the printed pages.

Journal Titles Legacy Content DatesJournal of Applied Physiology Jan. 1948 – Sept. 1996Journal of Neurophysiology Jan. 1938 – Dec. 1996American Journal of Physiology (AJP) Jan. 1898 – Dec. 1976 AJP–Cell Physiology Jan. 1977 – Sept. 1997 AJP–Endocrinology and Metabolism Jan. 1977 – Sept. 1997 AJP–Gastrointestinal and Liver Physiology Jan. 1980 – Sept. 1997 AJP–Heart and Circulatory Physiology Jan. 1977 – Sept. 1997 AJP–Lung Cellular and Molecular Physiology Aug. 1989 – Sept. 1997 AJP–Regulatory, Integrative and Comparative Physiology Jan. 1977 – Sept. 1997 AJP–Renal Physiology Jan. 1977 – Sept. 1997Physiological Reviews Jan. 1921 – Dec. 1997Physiology Feb. 1986 – Dec. 1997Advances in Physiology Education June 1989 – Nov. 1997

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Lipopolysaccharide downregulates macrophage-derived IL-22 to attenuate alcohol induced hepatocyte cell death

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Lipopolysaccharide downregulates macrophage-derived IL-22 to attenuate alcohol induced hepatocyte cell death

Sodium storage in human tissues is mediated by glycosaminoglycan expressionRenal Physiology

The human coronary vasodilatory response to acute mental stress is mediated by neuronal nitric oxide synthaseHeart and Circulatory Physiology

A novel role for primary cilia in airway remodelingLung Cellular and Molecular Physiology

Cerebral oxygenation and regional cerebral perfusion responses with resistance breathing during central hypovolemiaRegulatory, Integrative and Comparative Physiology

Development of a reliable, automated screening system to identify small molecules and biologics that promote human β cell regenerationEndocrinology and Metabolism

Roles of autophagy and metabolism in pancreatic cancer cell adaptation to environmental challengesGastrointestinal and Liver Physiology

Overload-mediated skeletal muscle hypertrophy is not impaired by loss of myofiber STAT3

Cell Physiology

Although the signal pathways mediating muscle protein synthesis and degradation are well characterized, the transcriptional processes modulating skeletal muscle mass and adaptive growth are poorly understood. Recently, studies in mouse models of muscle wasting or acutely exercised human muscle have suggested a potential role for the transcription factor, signal transducer and activator of transcription 3 (STAT3), in adaptive growth. Hence, in the present study we sought to define the contribution of STAT3 to skeletal muscle adaptive growth. In contrast to previous work, two different resistance exercise protocols did not change STAT3 phosphorylation in human skeletal muscle. To directly address the role of STAT3 in load-induced (i.e. adaptive) growth, we studied the anabolic effects of 14 days of synergist ablation (SA) in skeletal muscle-specific STAT3 knockout (mKO) mice and their floxed, wild type (WT) littermates. Plantaris muscle weight and fibre area in the non-operated leg (Control; CON) was comparable between genotypes. As expected, SA significantly increased plantaris weight, muscle fibre cross sectional area and anabolic signaling in WT mice, although interestingly, this induction was not impaired in STAT3 mKO mice. Collectively, these data demonstrate that STAT3 is not required for overload-mediated hypertrophy in mouse skeletal muscle.

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