SCIENTIFIC PLANNING COMMITTEE Nora Hansen, MD Kalliopi Siziopikou, MD, PhD Jonathan Strauss, MD, MBA

SYMPOSIUM CHAIR William Gradishar, MD SYMPOSIUM CO-CHAIR Monica Morrow, MD

22ND ANNUAL LYNN SAGE BREAST CANCER SYMPOSIUM SEPTEMBER 10 - 12, 2020

VIRTUAL FOR 2020

VISIT OUR WEBSITE lynnsagebreastcancer.org

Referred to as the most valuable breast cancer meeting worldwide for the practicing clinician, the Lynn Sage Breast Cancer Symposium provides 3 days of formal presentations and interactive case discussions. For over 20 years, this multidisciplinary CME program has been bringing together leading national and international medical, surgical, and radiation oncologists to present, debate, and evaluate cutting-edge technology and approaches in the management of breast cancer.

Progress across all aspects of patient care, including prevention, screening, detection and survivorship, as well as in the primary treatment modalities of surgery, radiation therapy, endocrine therapy, cytotoxic chemotherapy and novel biologic therapies are leading to new strategies and therapeutic options. This symposium focuses on the close cooperation required for effective multidisciplinary management of patients with breast cancer.

Educational Objectives

At the conclusion of this activity, participants will be able to:

1. Discuss optimal evaluation and management of women at increased risk for breast cancer.

2. Analyze application of neoadjuvant endocrine therapy in operable cancer.

3. Describe the role of new technology in radiology and radiotherapy.

4. Identify new approaches to systemic therapy and how they may influence surgical management.

Target Audience

The target audience for this activity includes medical oncologists, surgical oncologists, radiation oncologists, internal medicine and other health professionals who interact with or treat breast cancer patients and survivors.

PROGRAM INFORMATION

Session 1: Supportive Care Moderator: Nora Hansen, MD

9:00 am Symposium Welcome William Gradishar, MD, Symposium Chair

9:05 am Managing the Side Effects of Endocrine Therapy Dawn Hershman, MD

9:35 am New Approaches to Pain Management in Breast Surgery Tracy-Ann Moo, MD

10:05 am Current Considerations for Lymphedema Diagnosis and Treatment Sarah McLaughlin, MD

10:35 am Break

10:50 am Delivering Survivorship Care Sheetal Kircher, MD

11:20 am Q&A

11:35 am Lunch Break & Exhibits 11:35 am Optional Non-CME: Sponsored by Lilly A Treatment Option for Patients With HR+, HER2- Advanced or Metastatic Breast Cancer 12:05 pm Break

Session 2: Breast Pathology for the Non-Pathologist Moderator: Kalliopi Siziopikou, MD, PhD

12:10 pm Evaluation of Pathologic Response After Neoadjuvant Chemotherapy: A Continuing Challenge Kalliopi Siziopikou, MD, PhD

12:40 pm PDL-1 Assessment: What’s Important, What’s Not? David Rimm, MD, PhD

1:10 pm WHO Classification of Breast Tumors: The 2019 Update Luis Blanco, Jr., MD

1:40 pm Genomic Tools That Predict Response in Breast Cancer Virginia Kaklamani, MD, DSc 2:10 pm Q&A

2:25 pm Adjourn

SEPTEMBER 10 THURSDAY

Session 4: Breast Imaging and Risk Management Moderator: Seema Khan, MD

9:00 am Update on Contrast Mammography Maxine Jochelson, MD

9:30 am Machine Learning as a Tool to Improve Breast Imaging Connie Lehman, MD, PhD

10:00 am Assessing Genetic Risk 2020 Banu Arun, MD

10:30 am Break

10:45 am Controversies in Surgical Management of BRCA Carriers Mary Gemignani, MD, MPH

11:15 am Genetic Testing in Practice: Perceptions of Patients and Physicians Steven Katz, MD

11:45 am Q&A

12:00 pm Lunch Break & Exhibits

12:05 pm Optional Non-CME: Sponsored by Seattle Genetics A New Treatment in HER2+ Metastatic Breast Cancer

Session 5: New Approaches to Old Problems Moderator: Massimo Cristofanilli, MD

12:40 pm Male Breast Cancer: Is it Really Worse? Anthony Elias, MD

1:10 pm Detection and Treatment of Minimal Residual Disease: The Way Forward? Lajos Pusztai, MD, DPhil

1:40 pm Patterns of Tumor Response Following NAC: Implications for Local Therapy Stuart Schnitt, MD

2:10 pm Break

2:25 pm Proton Radiotherapy for Breast Cancer: Advance or Fad? Jonathan Strauss, MD, MBA

2:55 pm Delay in Breast Cancer Treatment: Is it Harmful? Richard Bleicher, MD

3:25 pm Q&A

3:40 pm Adjourn

SEPTEMBER 11 FRIDAY

8:15 am Optional Non-CME: Sponsored by DSI Updates on the Treatment of Patients With Unresectable or Metastatic HER2+ Breast Cancer Who Previously Received Anti-Her2 Therapies Session 6: Current Approach to Advanced Disease Moderator: William Gradishar, MD

9:00 am Novel Endocrine Agents William Gradishar, MD

9:30 am Update on Brain Metastases Carey Anders, MD

10:00 am Stereotactic Body Radiation Therapy for Oligometastases Steve Chmura, MD, PhD

10:30 am Break

10:45 am Metastatic Triple Negative Breast Cancer Kari Wisinski, MD

11:15 am Surgery of the Primary Tumor in Stage 4 Breast Cancer Seema Khan, MD

11:45 am Q&A

12:00 pm Lunch Break & Exhibits 12:05 pm Optional Non-CME: Sponsored by Genentech HER2 Positive Early Breast Cancer: Determining Adjuvant Treatment Following Neoadjuvant Therapy 12:35 pm Break

Session 7: Emerging Issues in Breast Cancer Management Moderator: Jonathan Strauss, MD, MBA

12:40 pm Financial Toxicity of Breast Cancer Treatment Reshma Jagsi, MD, DPhil

1:10 pm Will Surgery Be a Part of Breast Cancer Therapy in the Future? Monica Morrow, MD

1:40 pm Implant Associated Lymphoma Jonas Nelson, MD

2:10 pm Q&A

2:25 pm Break

Session 8: Issues in Neoadjuvant Therapy Moderator: Monica Morrow, MD

2:40 pm Decision Making for Neoadjuvant Therapy in ER+ Patients Otto Metzger, MD

3:10 pm Surgical Issues After Neoadjuvant Endocrine Therapy Tari King, MD

3:40 pm Radiotherapy Decision Making After Pathological Complete Response Julia White, MD 4:10 pm Q&A

4:25 pm Adjourn

SEPTEMBER 12 SATURDAY

Registration Advance registration is encouraged to ensure prompt access to the Virtual Symposium. The registration fee includes conference tuition, CME credits, MOC points, access to digital materials and networking opportunities. Register online at lynnsagebreastcancer.org.

Type Price

Physician $375

LMIC* Physician $100

Nurse/Nurse Practitioner/Fellow/Other Allied Health $75

LMIC* Nurse/Nurse Practitioner/Fellow/Other Allied Health $25

Industry $595

*Registrants who reside in LMIC countries as defined by the World Bank Group. Refund/Cancellation Policy Registration fees, less a $50 administrative handling fee, are refundable if written request is received on or before August 15, 2020. Please include your registration ID number when requesting a refund. No refunds will be granted after August 15, 2020. However, you may transfer your registration to a colleague. For further information, please call 312-503-7809 or email cancer@northwestern.edu.

CONFIRMED FACULTY

Carey Anders, MD Duke University School of Medicine

Banu Arun, MDUniversity of Texas MD Anderson Cancer Center

Luis Blanco, Jr., MDRobert H. LurieComprehensive Cancer Centerof Northwestern University

Richard Bleicher, MDFox Chase Cancer Center

Steven Chmura, MD, PhDUniversity of Chicago Medicine

Massimo Cristofanilli, MDRobert H. LurieComprehensive Cancer Centerof Northwestern University

Anthony Elias, MDUniversity of Colorado School of Medicine

Mary Gemignani, MD, MPH Memorial Sloan Kettering Cancer Center

William Gradishar, MD Robert H. Lurie Comprehensive Cancer Center of Northwestern University

Nora Hansen, MD Robert H. LurieComprehensive Cancer Centerof Northwestern University

Dawn Hershman, MDHerbert Irving Comprehensive Cancer CenterColumbia University Mailman School of Public Health

Reshma Jagsi, MD, DPhil University of Michigan

Maxine Jochelson, MDMemorial Sloan Kettering Cancer Center

Virginia Kaklamani, MD, DScUT Health San Antonio MD Anderson Cancer Center

Steven Katz, MDUniversity of Michigan

Seema Khan, MD Robert H. LurieComprehensive Cancer Centerof Northwestern University

Tari King, MD Harvard Medical SchoolDana-Farber Cancer Institute

Sheetal Kircher, MDRobert H. LurieComprehensive Cancer Centerof Northwestern University

Connie Lehman, MD, PhDMassachusetts General Hospital

Sarah McLaughlin, MDMayo Clinic

Otto Metzger, MDHarvard Medical School Dana-Farber Cancer Institute

Tracy-Ann Moo, MDMemorial Sloan Kettering Cancer Center

Monica Morrow, MD Memorial Sloan Kettering Cancer Center

Jonas Nelson, MDMemorial Sloan Kettering Cancer Center

Lajos Pusztai, MD, DPhil Yale Cancer CenterYale School of Medicine

David Rimm, MD, PhDYale Cancer CenterYale School of Medicine

Stuart Schnitt, MDHarvard Medical SchoolDana-Farber Cancer Institute

Kalliopi Siziopikou, MD, PhD Robert H. Lurie Comprehensive Cancer Center of Northwestern University

Jonathan Strauss, MD, MBA Robert H. LurieComprehensive Cancer Centerof Northwestern University

Julia White, MDThe Ohio State University Comprehensive Cancer Center

Kari Wisinski, MDUniversity of Wisconsin School of Medicine and Public Health

Faculty Disclosure Northwestern University FSM requires course directors, speakers, instructors, planners and other individuals who are in a position to control the content of this activity to disclose any relevant financial relationships. All identified potential conflicts of interest, scientific objectivity of studies mentioned in the materials or used as the basis for content, and appropriateness of patient care recommendations are thoroughly vetted by Northwestern University FSM for fair balance. The faculty disclosures will be indicated in the course syllabus.

625

N. M

ichi

gan

Ave,

Sui

te 1

000

Chic

ago,

Illin

ois

6061

1

Accr

edita

tion

Stat

emen

t Th

e No

rthwe

ster

n Un

iver

sity

Fei

nber

g Sc

hool

of M

edic

ine

is a

ccre

dite

d by

the

Accr

edita

tion

Coun

cil f

or C

ontin

uing

M

edic

al E

duca

tion

(ACC

ME)

to p

rovi

de c

ontin

uing

m

edic

al e

duca

tion

for p

hysi

cian

s.

Cred

it De

sign

atio

n St

atem

ent

The

North

west

ern

Univ

ersi

ty F

einb

erg

Scho

ol o

f Med

icin

e de

sign

ates

this

live

act

ivity

for a

max

imum

of 1

6.25

AM

A PR

A Ca

tego

ry 1

Cre

dit(s

)™. P

hysi

cian

s sh

ould

cl

aim

onl

y the

cre

dit c

omm

ensu

rate

with

the

exte

nt o

f th

eir p

artic

ipat

ion

in th

e ac

tivity

.

Othe

r Cre

dits

Th

e Am

eric

an A

cade

my o

f Nur

se P

ract

ition

ers

and

the

Amer

ican

Nur

ses

Cred

entia

ling

Cent

er a

ccep

t AM

A PR

A Ca

tego

ry 1

Cre

dit(s

)™ fr

om o

rgan

izatio

ns a

ccre

dite

d

by th

e AC

CME.

Mai

nten

ance

of C

ertifi

catio

n (M

OC)

Succ

essf

ul c

ompl

etio

n of

this

CM

E ac

tivity

, whi

ch

incl

udes

par

ticip

atio

n in

the

eval

uatio

n co

mpo

nent

, en

able

s th

e pa

rtici

pant

to e

arn

up to

16.

25 M

OC

poin

ts in

the

Amer

ican

Boa

rd o

f Int

erna

l Med

icin

e’s

(ABI

M) M

aint

enan

ce o

f Cer

tifica

tion

(MOC

) pro

gram

. Pa

rtici

pant

s wi

ll ea

rn M

OC p

oint

s eq

uiva

lent

to th

e am

ount

of C

ME

cred

its c

laim

ed fo

r the

act

ivity

. It i

s th

e CM

E ac

tivity

pro

vide

r’s re

spon

sibi

lity t

o su

bmit

parti

cipa

nt c

ompl

etio

n in

form

atio

n to

ACC

ME

for t

he

purp

ose

of g

rant

ing

ABIM

MOC

cre

dit.

For a

dditi

onal

info

rmat

ion

or to

regi

ster

, vi

sit l

ynns

ageb

reas

tcan

cer.o

rg o

r cal

l 312

-503

-780

9.