Antiplatelet drugs

Interfere with platelet

function

Classification1. TXA2 synthesis inhibitor: Aspirin

2. Others: Dipyridamole, clopidogrel, ticlopidine

abciximab

ASPIRIN

Low dose aspirin (75-150 mg/day)- selectively produce antiplatelet activity

Irreversibly inhibits thromboxane synthase

Reduces TXA2 production antiplatelet activity

Mechanism of action Membrane phospholipids ↓Arachidonic acid ↓cyclic endoperoxides ↓ Thromboxane synthase TXA2 (platelet aggregation)

AspirinInhibits

Therapeutic uses1. Myocardial infarction (MI)2. Prevent MI in high risk patients3. Reduce incidence of stroke in high risk patients