269, 2 the journal of biological chemistry · groenen, bengt westermnrk, and carl-henrik heldin...
TRANSCRIPT
Vol. 269, No. 2 The Journal of January 14, 1994
Biological Chemistry Copyright 0 1994 by the American Society for Biochemistry and Molecular Biology, Inc.
428 East Preston St., Baltimore, MD 21202 U.S.A.
CONTENTS*
MINIREVIEW 787 Cellular responses to cisplatin. The roles of DNA-bind-
ing proteins and DNA repair. Gilbert Chu
COMMUNICATIONS 791 Dominant negative mutants of nitric oxide-sensitive
guanylyl cyclase. Peter S. T. Yuen, Lynda K. Doolittle, and David L. Garbers
794 Removal of Rab GTP-binding proteins from Golgi membranes by GDP dissociation inhibitor inhibits in- ter-cisternal transport in the Golgi stacks. Zvulun Ela- zar, Thomas Mayer, and James E. Rothman
798 Lipid hydroperoxides induce apoptosis in T cells dis- playing a HIV-associated glutathione peroxidase defi- ciency. Paul A. Sandstrom, Paul W. Tebbey, Steve Van Cleave, and Thomas M. Buttke
802 Active site mapping of affinity-labeled rat oxidosqual- ene cyclase. Ikum Abe and Glenn D. Prestwich
860 Functional coupling of Na+/H* and Na'/Ca2' exchan- gers in the al-adrenoreceptor-mediated activation of hepatic metabolism. Elena Urcelay, Nora Butta, Guodalupe
Parrilla Cipres, Angeles Martin-Requero, Matilde S. Aywo, and Roberto
868 Identification of Lys"' at the active site of Escherichia coli glycogen synthase. Application of affinity labeling combined with site-directed mutagenesis. Koji Furu- knwa, Mitsuo Tagaya, Katsuyuki Tanizawa, and Toshio Fukui
872 Activation of Raf-1 and mitogen-activated protein kinases during monocytic differentiation of human myeloid leukemia cells. Surender Kharbanda, Ahamed Sa- leem, Yutaka Emoto, Richard Stone, Ulf Rapp, and Donnld Kufe
879 Neutral sphingomyelinase action stimulates sig- nal transduction of tumor necrosis factor-a in the syn- thesis of cholesteryl esters in human fibroblasts. Subroto Chutterjee
805 A novel cytokine exhibiting megakaryocyte potentiat- 883 The interaction of GATA-binding proteins and basal ing activity from a human pancreatic tumor cell line transcription factors with GATA box-containing core HPC-YS. Nozomi Yamnguchi, Kunihiro Hattori, Masayoshi promoters. A model of tissue-specific gene expression. Oh-eda, Tetsuo Kojima, Nobw Imai, and Norimichi Ochi William C. Aird, Jeffrey D. Paruin, Phillip A. Sharp, and Robert
D. Rosenbere 809 Inhibition of human HL-60 cell responses to chemotac-
tic factors by antisense messenger RNA depletion of G proteins. Edward J . Goetzl, Richard S. Shames, Jinhong Yaw. Franz W. Birke. Ya Fane Liu. Paul R. Albert. and
Y
890 The directly repeated RG(G/T)TCA motifs of the rat
promiscuous binding sites for RAR, RXR, HNF-4, and and mouse cellular retinol-binding protein I1 genes are
SoGzhu An I I ARP-1 homo- and beterodimers. Harikrishna Nakshatri
813 Expression of a cloned protoporphyrinogen oxidase. Tamara A. Dailey, Peter Meissner, and Harry A. Dailey
816 Phosphatidylethanolamine incorporation into vesicles selectively enhances factor Va inactivation by acti- vated protein C. Mikhail D. Smirnov and Charles T. Esmon
820 Characterization of a promiscuous GTPase-activating protein that has a Bcr-related domain from Caenorhab- ditis elegans. Weining Chen, Julian Blanc, and Louis Lim
824 Rat liver Kupffer and endothelial cells express differ- ent binding proteins for modified low density lipopro- teins. Kupffer cells express a 96-kDa membrane pro- tein as a specific binding site for oxidized low density lipoproteins. Yolanda B. de Rijke and The0 J . C. van Berkel
828 Brain-derived neurotroDhic factor increases neurotro-
and Pierre Chumbon
903 Roles of v-erbA homodimers and heterodimers in medi- ating dominant negative activity by v-erbA. Paul M. Yen, Masato Ikeda, Jill H. Brubaker, Marc Forgwne, Akira Sugawara, and William W. Chin
910 0-Glycosylation mimics N-glycosylation in the 16-kDa fragment of bovine pro-opiomelanocortin. The major 0-glycan attached to Thr-46 carries S04-4GalNAc@1- 4GlcNAcBl-, which is the archetypal non-reducing ep-
A. Siciliano, Howard R. Morris, Hugh P. J . Bennett, and Anne itope in the N-glycans of pituitary glycohormones. Rosa
Dell
921 Role of the cationic residues arginine 14 and lysine 48 in the function of the cardiotonic polypeptide antho- pleurin B. Paramjit K. Khera and Kenneth M. Blumenthal
phin-3 expression in cerebellar granule neurons. Axel Leingartner, Cad-Philipp Heisenberg, Roland Kolbeck, Hans 926 Characterization of the retention motif in the C-ter- Thoenen, and Dan Lindhnlm minal part of the long splice form of platelet-derived
831 Lys-17 is the amine-donor substrate site for transglu- growth factor A-chain. Maria Andersson, Arne &man,
taminase in BAS-crystallin. Patricia J. T. A. Groenen, Bengt Westermnrk, and Carl-Henrik Heldin
J o h n J . Grootjans, Nzcolette H. Lubsen, Hans Bloemendal, and Wilfried W. de Jong
834 Lead activation of protein kinase C from rat brain. Determination of free calcium, lead, and zinc by "F NMR. Gregory J . Long, John F. Rosen, and Francis A. X . Schanne
931 Specific heparan sulfate saccharides mediate the activ- ity of basic fibroblast growth factor. Andrew Walker, Jeremy E. Turnbull, and John T. Gallagher
936 Purified yeast RNA polymerase I1 reads through in-
TFIIS analogue, P37. Karen R. Christie, Donald E. Awrey, trinsic blocks to elongation in response to the yeast
Aled M. Edwards, and Caroline M. Kane ARTICLES 838 Activation and desensitization of phospholipase D in 944 Molecular mechanism of the synergistic phosphoryla-
intact rat hepatocytes. Giseh Moehren, Lena Gwtausson, tion of phosphatase inhibitor-2. Cloning, expression, and Jan B. Hoek and site-directed mutagenesis of inhibitor-2. In-Kyung
849 The role of cytosolic Cas', protein kinase C, and protein Park, Paris Roach, Jeffry Bondor, Stephen P. Fox, and Anna A. DeFaoli-Roach
kinase A in hormonal stimulation of phospholipase D in rat hepatocytes. Lena Gwtausson, Gisela Moehren, M. Eugenia Torres-Marquez, Christine Benistant, Raphael Rubin, and Jan B. Hoek
955 Phosphorylation of human erythrocyte band 3 by en- dogenous ~ 7 2 ~ ' . Marietta L. Harrison, Christina C. I s m - son, Debra L. Burg, Robert L. Geahlen, and Philip S. Low
* The CONTENTS arranged by Subject Categories will be found immediately following these CONTENTS. Full Instructions to Authors will be found in (1994) J. Biol. Chern. 269, 777-785, and reprints may be obtained from the editorial office.
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A mechanism for divalent cation regulation of &-inte- grins. Jeffrey W. Smith, Randolph S. Pwtrowicz, and Danielle Mathis
Noncontiguous domains of the a-factor receptor of yeasts confer ligand specificity. Malini Sen and Lorraine Marsh
Metabolic processing of cyclobutyl pyrimidine dimers and (6-4) photoproducts in UV-treated human cells.
M. Gahway, Michel Liuzi , and Malcolm C. Paterson Evidence for distinct excision-repair pathways. Anne
Characterization of the calmodulin-binding domain of rat cerebellar nitric oxide synthase. Mingjie Zhang and Hans J. Vogel
Strand displacement activity of the human immunode- ficiency virus type 1 reverse transcri tase heterodimer
Palust, Roberta L. Thimmig, Charles McHenry, and Ulrich and its individual subunits. Michael Attiger, Vludimir N.
Hcibscher
Estimation of genomic complexity, heterologous expression, and enzymatic characterization of mouse
Pwtr Zimniak, Sharad S. Singhal, Sanjay K. Sriuastaua, San- glutathione S-transferase mGSTA4-4 (GST 6.7).
jay Awasthi, Rashmi Shurma, Janet B. Hayden, and Yogesh C. Awasthr
Isolation and characterization of the mouse heme oxy-
induction by heme or heavy metals. Jawed Alam, Jing genase-1 gene. Distal 6' sequences are required for
Cui, and Ann Smith
Heme-heme oxygenase complex. Structure of the cata- lytic site and its implication for oxygen activation. Satoshi Takahashi, Jianling Wang, Denis L. Rousseau, Kazun- obu Ishiknwa, Tadashi Yoshida, Janette R. Host, and Masao Ikeda-Saito
onine y-lyase by molecular cloning. Nozomu Nishi, Hi- Identification of probasin-related antigen as cystathi-
myuki Tanabe, Haruyo @a, Masahide Urushihara, Hiroshi Miyamka, and Fumw Wada
Kinetic studies on the removal of extracellular hydro- gen peroxide by cultured fibroblasts. Nobuo Makino, Ya- suhim Mochizuki, Shim Bannai, and Yoshiki Sugita
Annexin VI, a marker protein of hepatocytic endo-
Friedrich Buck, Anke Grigoleit, Andreas Block, Ilka Groger, somes. Stefan Jlickle, Ulrike Beisiegel, Franz Rinninger,
Heiner Greten, and Eberhurd Windkr
Differential expression of an E-selectin ligand (SLex) by two Chinese hamster ovary cell lines transfected with the same a(l,3)-fucosyltransferase gene (ELFT). Susan Goelz, Rauindra Kumar, Barry Potuin, Subha Sun- daram, Margot Brickelmaier, and Pamela Stan&
Peter Bergsten, Anibal Sanchez Moura, Illani Atwater, and Ascorbic acid and insulin secretion in pancreatic islets.
Mark Leuine
by the transcription factor Spl. John W. Henson Regulation of the glial-specific JC virus early promoter
Low affinity acceleration of the phosphorylation reac- tion of the Na,K-ATPase by ATP. Ruben D. Peluffo, Ro- land0 C. Rossi, Patricw J. Garrahan, and Alcides F. Rega
virus latent origin of DNA replication by a DNA looping Stabilization of the EBNAl protein on the Epstein-Barr
mechanism. Lori Frappier, Kim Goldsmith, and Leslle Bendell
Replacement of alanine 68 by asparagine enables the
sugar transport to Na+. Hiroko Hama and T. Hastings melibiose carrier of Klebeidh pneumoniae to couple
Wilson
Identification and characterization of a novel tyrosine kinase from megakaryocytes. Brian D. Bennett, Sally Cow&, Shuriun Jiong, Roanna London, Bi'ia Deng, Jadwiga Grabarek, Jerome E. Groopman, Dauid V. doeddel, and Haua Auraham
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Enzymatic methylation of recombinant heterogeneous nuclear RNP protein Al. Dual substrate specificity for S-adenosy1methionine:histone-arginine N-methyl- transferase. Ramesh Rajpurohit, Soon Ok Lee, Jong Ok Park, Woon Ki Paik, and Sangduk Kim
structure of engineered distal myoglobin Hise' (E7) Val/ 'H NMR study of the solution molecular and electronic
ValQ ( E l l ) His double mutant. Coordination of Hise' (E l l ) a t the sixth position in both low-spin and high- spin states. Jun Qin, Gerd N. La Mar, Y i Dou, Suzanne J. Admiral, and Masao Ikeda-Saito
IFP 36 is an interferon-induced leucine zipper protein that undergoes interferon-regulated cellular redistri- bution. Franz-Christoph Bange, Ulrich Vogel, T h o r n Flohr, Monika Kiekenbeck, Bernd Denecke, and Erik C. Bottger
protein-coupled receptor kinase GRK6. Priya Kunapuli, Expression, purification, and characterization of the G
James J. Onorato, M. Marlene Hosey, and Jeffrey L. Benouic
Molecular cloning of a possible cysteine proteinase pre- dominantly expressed in osteoclasts. Ken-ichi Tezuka,
Hiroshi Kamioka, Yoshiyuki Hakeda, and Masayoshi Yoko Tezuka, Akiko Maejima, Takuya Sato, Ken Nemoto,
Kumegawa
Endothelin- 1 and fibroblast growth factors stimulate the mitogen-activated protein kinase signaling cascade
in the integration of two signaling pathways leading to in cardiac myocytes. The potential role of the cascade
myocyte hypertrophy. Marie A. Bogoyeuitch, Peter E. Glen- non, Monica B. Andersson, Angela Clerk, Antigone Lazou, Christopher J . Marshall, Peter J. Parker, and Peter H. Sugden
cow-stimulated &cells from ob/ob mice. Linda Fournier, Cyclic AMP triggers large [Cam]i oscillations in glu-
James F. Whitfield, Jean-Louis Schwartz, and Nicole Begin- Heick
Inhibition of thrombin receptor signaling by a G-pro- tein coupled receptor kinase. Functional specificity among G-protein coupled receptor kinases. Kenji Ishii, J i Chen, Maki Ishii, Walter J. Koch, Neil J. Freedman, Robert J . Lefkowitz, and S h u n R. Coughlin
Hairpin loop and second kringle domain are essential sites for heparin binding and biological activity of hep- atocyte growth factor. Kensaku Mizuno, Hayao Inoue, Mi- chw Hagiya, Shin Shimizu, Takeru Nose, Yasuyuki Shimohi- gashi, and Toshikazu Nakamura
Characterization of rhoGAP. A GTPase-activating pro-
Pamela M. Taylor-Harris, Annette J. Self, Suzanne Brill, tein for RHO-related small GTPases. Carole A. Lamaster,
Helmy E. uan Erp, and Alun Hall
Growth factors differentially stimulate the phosphoryl-
in PC-12 pheochromocytoma cells. Masahide Ohmichi, ation of Shc proteins and their association with Grb2
Koozi Matuoka, Tadmmi Takenawa, and Alan R. Saltiel
Specific binding of the peroxisomal protein targeting sequence to glyoxysomal membranes. Nathan E. Wolins and Robert P. Donaldson
I n uitro synthesis of the iron-molybdenum cofactor of nitrogenase. Purification and characterization of NifB cofactor, the product of NIFB protein. Vimd K. Shah, Jeffrey R. Allen, Nathan J. Spangler, and Paul W. Ludden
ATF-aO, a novel variant of the ATF/CREB transcrip- tion factor family, forms a dominant transcription in-
Kaszubska, James Whelan, John F. DeLamarter, and Rob hibitor in ATF-a heterodimers. Rosanna Pescini, Wiweka
Hooft uan Huijsduijnen
A novel gene, Sl7'4, encodes a phosphatidylinositol 4- kinase in the PKCl protein kinase pathway of Saccha- romyces cerevisiae. Satoshi Yoshida, Yoshikazu Ohya, Mark Goebl, Akihiko Nakano, and Yasuhiro Anraku
428 East Preston Street, Baltimore, MD 21202, U.S.A. Volume 269 for 1994: Institutions: United States, $790; Foreign, $980. Students/Postdoctoral The Journal of Biological Chemistry (ISSN 0021-9258) is published weekly by the American Society for Biochemistry and Molecular Biology, Inc.,
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to The Journal of Biological Chemistry at 428 East Preston Street, Baltimore, MD 21202, U.S.A. 130369721. Second class postage paid at Baltimore, MD 21202, U.S.A. and at additional mailing offices. Printed in the U.S.A. Send address changes
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Growth state- and cell cycle-dependent fluctuation in
and possible specific modification of the higher molec- the expression of two forms of DNA topoisomerase I1
ular weight form in the M phase. Keiji Kimura, Masafumi Sazjo, Michw Vi, and Takemi Enomoto
The transcri tion factor HNFl acts with C/EBPa to synergistical& activate the human albumin promoter through a novel domain. Kou-Jwy Wu, Deborah R. Wilson, Chiaho Shih, and Gretchen J . Darlington
The mouse osteocalcin gene cluster contains three genes with two separate spatial and temporal patterns of
Karsenty expression. Christelle Desbois, Deborah A. Hogue, and Girard
The calf 6’- to 3’-exonuclease is also an endonuclease with both activities dependent on primers annealed upstream of the point of cleavage. Richard S. Murante, Lin Hung, John J. Turchi, and Robert A. Bambara
Mevalonate kinase is predominantly localized in per- oxisomes and is defective in patients with peroxisome deficiency disorders. Lenka Biardi, Aparnu Sreedhar, A f - saneh Zokaei, Narendra B. Vartak, Renee L. Bozeat, Janis E. Shackelford, Gihrt-Andre Kelkr, and Skaidrite K. Krisans
Transcription and editing of cytochrome oxidase I1 RNAs in !&ypanosoma cruxi. Kwang S. Kim, Santuza M. R. Teixeira, Louis V. Kirchhofi and John E. Donelson
Hereditary myeloperoxidase deficiency due to a mis- sense mutation of arginine 669 to tryptophan. WiUiam M. Nauseef, Susan Brigham, and Melissa Cogley
The active site of hamster 3-hydroxy-3-methylglu- taryl-CoA reductase resides at the subunit interface and incorporates catalytically essential acidic residues from separate polypeptides. Kenneth Frimpong and Victor W. Rodwell
Primary structure, ligand binding, and localization of the human type 3 inositol 1.4,s-trisphosphate receptor expressed in intestinal epithelium. Anthony R. Maranto
Molecular characterization of a new metabotropic glu-
AMP signal transduction. Naoyuki Okamoto, Seiji Hori, tamate receptor mCluR7 coupled to inhibitory cyclic
Chihiro Akazawa, Yasunori Hayashi, Ryuichi Shigemto, No- boru Mizuno, and Shigetada Nakanishi
Identification and mutation of primary and secondary proteolytic cleavage sites in murine stem cell factor
tein. Manus K. Majumdar, Lijun Feng, Eugene Medbck, Deniz cDNA yields biologically active, cell-associated pro-
Toksoz, and Dauid A. William
Transport of an export-defective protein by a highly hydrophobic signal peptide. Sharyn L. Rusch and Debra A. Kendall
rectly activates Raf-1 in murine hematopoietic cells. Protein kinase C-mediated serine phosphorylation di-
Michael P. Carroll and W. Stratford May
cinate synthetase in a murine macrophage cell line. Coinduction of nitric oxide synthase and argininosuc-
Implications for regulation of nitric oxide production. Andreas K. Nusskr, Timothy R. Billiar, Zhi-Ze Liu, and Sidney M. Morris, Jr.
Thrombospondin 3 is a developmentally regulated hep- arin binding protein. Aziz N . Qabar, Zhiwu Lin, Frederick W. Wolf, K. Sue O’Shea, Jack Lawler, and Vishua M. Dixit
Deletion of QCR6, the gene encoding subunit six of the
ration of cytochrome c1 and causes temperature-sensi- mitochondrial cytochrome b c l complex, blocks matu-
tive petite growth in Saccharomyces cerevisiae. Meijiu Yang and Bernard L. Trumpower
Suppressed collagen gene expression and induction of a281 integrin-type collagen receptor in tumorigenic
line. Pia Santala, Hannu Larjaua, Liisa Nissinen, Terhi Rii- derivatives of human osteogenic sarcoma (HOS) cell
konen, Arto Mi&ta, and Jyrki Heino
The purification and characterization of gene 69 pro- tein from bacteriophage T4. Tetsuro Yonesaki
Pituitary adenylate cyclase activating polypeptide is an extraordinarily potent intra-pancreatlc regulator of insulin secretion from islet B-cells. Toshihiko Yadq, Ma- saya Sakurada, Kaorr Ihlda, Masanorr Nakata, Fusayoshr Mur- ata, Akira Arimura, and Masatoshi Kikuchi
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Purple acid phosphatase of the human macrophage and
crystallization of the recombinant di-iron-oxo protein osteoclast. Characterization, molecular properties, and
secreted by baculovirus-infected insect cells. Alison R. H a y m n and Timothy M. Cox
essential for heparin-catalyzed inactivation by anti- Identification of basic amino acid residues in thrombin
thrombin 111. Zhong-Ru Gun, Yiping Li, Zhongguo Chen, Sidney D. Lewis, and Jules A. Shafer
Gl/S-regulated E2F-containing protein complexes bind to the mouse thymidine kinase gene promoter. Qing-Ping
Helin, and Arthur B. Pardee Dou, Shanchwn Zhao, Andrew H. Leuin, Jian Wang, Kristian
In uitro transcriptional studies of the roles of the thy- roid hormone (T,) response elements and minimal pro- moters in Ts-stimulated gene transcription. Chen-Shian Suen, Paul M. Yen, and WiUiam W. Chin
combinatorial operation of tissue-enriched transcrip- Determination of tissue specificity of the enhancer by
tion factors. Both HNF-4 and C/EBP@ are required for liver-specific activity of the ornithine transcarbamyl-
Kimura, Kiwamu Akngi, Ken-ichi Yamamura, Masataka Mori, ase enhancer. Atsushi Nishiyori, Hidetoshi Tashiro, Akira
and Masaki Takiguchi
Biochemical and assembly properties of GluR6 and
determined with subunit-specific antibodies. Robert J. KA2, two members of the kainate receptor family,
Wenthold, Valory A. Trumpy, Wen-Si Zhu, and Ronald S. Petralia
Expression cloning and characterization of the hamster ileal sodium-dependent bile acid transporter. Melissa H. Wong, Peter Oelkers, Ann L. Craddock, and Paul A. Dawson
Association of the regulatory &adrenergic receptor ki- nase with rat liver microsomal membranes. Irene Garcia- Higuera, Petronila Penela, Cristinu Murga, Gustauo Egea, Pedro Bonay, Jeffrey L. Benouic, and Federico Mayor, Jr.
Cloning and expression of a cDNA for mouse prosta- glandin F receptor. Yukihiko Sugimoto, Ken-yuh Hasumoto,
Negishi, Akira Kakizukq Shuh Narumiya, and Atsushi Tsunehisa Namba, Atsushi Irk, Masato Katsuyama, M a d u
Ichikawa
Lipopolysaccharide induction of tissue factor expres- sion in THP-1 monocytic cells. Protein-DNA interac- tions with the promoter. Maryann Donovan-Peluso, Lisa Dawn George, and Andrea Cortese Hassett
Horseshoe crab (1,3)-8-D-glucan-sensitiVe coagulation factor G . A serine protease zymogen heterodimer with similarities to 8-glucan-binding proteins. Yorek i Seki, Tatsushi Muta, Toshw Oda, Daisuke Iwaki, Ker-ichr Kuma, Takashi Miyata, and Sadaaki Iwanuga
Two lectins from the marine sponge Hdichondria o h - dai. An N-acetyl-sugar-specific lectin (HOL-I) and an N-acetyllactosamine-specific lectin (HOL-11). Hiroknzu
Atsua Kimura, and Seiya Chrba Kawagishi, Masamichi YaFwaki , Satoko Isobe, Taichi Usui,
Identification of discrete structural domains in the ret- inoblastoma protein. Amino-terminal domain is re- quired for its oligomerization. Carmel E. Hensey, Frank Hong, T im Durfee, Yue-Wei Qian, Eva Y.-H.P. Lee, and Wen-Hwa Lee
Modulation of HIV-1 reverse transcriptase function in
Jac ues, Birgitta M. W6hr1, Kathryn J. Howard, and Stuart “selectively deleted” p66/p61 heterodimers. Pamela S.
F. Le Grice
Cloning of a novel a2,3-sialyltransferase that sialylates glycoprotein and glycolipid carbohydrate groups. Hi- roshi Kztagawa and James C. Paulson
Molecular cloning and expression of G.alNAc a2,6- sialyltransferase. Nobuyukr Kurosawa, Toshrro Hammoto, Young-Chon Lee, Taknshi Nakaoka, Naoya Kojima, and Shui- chi Tsuji
A sarco/endoplasmic reticulum CaZ+-ATPase 3-type Ca2+ pump is expressed in platelets, in lymphoid cells, and in mast cells. Frank Wuytack, Bela Papp, Hrlde Verboo- men, Luc Raeymoekers, Leonard Dode, Rigis Bobe, Jocelyne Enouf, Shaila Bokkala, Kalwant S. Authr, and Rrk Casteels
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The rat platelet 97-kDa Ca” ATPase isoform is the sarcoendoplasmic reticulum Caa+ ATPase 3 protein. RPgis Bobe, Raymonde Bredoux, Frank Wuytack, Rozenn
Magnler, and Jocelyne Enouf Quarck, Tunde Kouircs, Bela P q p , Elisabeth Coruazier, Clarice
Differential E-selectin-dependent adhesion efficiency in sublines of a human colon cancer exhibiting distinct
Minoru Fukuda metastatic potentials. Ritsuko Sawada, Shigeru Tsuboi, and
Volume-sensitive chloride currents in four epithelial cell lines are not directly correlated to the expression
Dieter C. Gruenert, and Gwvanni Romeo of the MDR-1 gene. Andrea Rasola, Luis J . V. Galietta,
plasmic reticulum to Golgi transport and trigger dis- Dominant inhibitory mutants of ARFl block endo-
assembly of the Golgi apparatus. Christiane Dascher and William E. Bakh
Repression of mouse mammary tumor virus transcrip- tion by a transcription factor complex. Binding of in- dividual components to separated DNA strands. Ward Giffin, Heather Torrance, Holly Saffran, Heather L. MacLeod, and Robert J . G. Hachi
Thyroid hormone receptor modulates the expression of the rabbit cardiac sarco(endo)plasmic reticulum Cas+- ATPase gene. Angel Zarain-Herzberg, John Marques, and Drew Sukovich
Molecular cloning and characterization of the full-
lysosomal enzyme &glucosidase in Dictyoetelium dis- length cDNA encoding the developmentally regulated
coideum. John Bush, Jan Richardson, and James Cardelli
The carboxyl-terminal domain of kinesin heavy chain is important for membrane binding. Dimitrios A. Skoufias, Douglas G. Cole, Karen P. Wedaman, and Jonathan M. Scholey
prenylcysteine-directed a carboxyl methyltransferase Characterization of a plasma membrane-associated
in human neutrophils. M i c h u e l H. Pillinger, Craig, Volker, Jeffry B. Stock, Gerald Weusmonn, and Mark R. Phrlcps
Analyses of &thalassemia mutant DNA interactions with erythroid Kriippel-like factor (EKLF), an eryth- roid cell-specific transcription factor. Waldo C. Feng, Cherie M. Southwood, and James J . Bieker
Coupled replication-translation of amplifiable messen- ger RNA. A cell-free protein synthesis system that mimics viral infection. Lubou Ryaboua, Elena Volianik, Oleg Kurnnsou, Alexander Spirin, Ying Wu, and Fred Russell Kramer
Expression of multiple somatostatin receptor genes in AtT-20 cells. Evidence for a novel somatostatin-28 selective receptor subtype. Yogesh C. Patel, Rosemarie Panetta, Ernanuel Escher, Michael Greenwood, and Coimbatore B. Srikant
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bA4-amyloid protein precursor mRNA isoforms with- out exon 15 are ubiquitously expressed in rat tissues including brain, but not in neurons. Rupert Sandbrink, Colin L. Masters, and Konrad Beyreuther
a-Actinin and vinculin are PIPz-binding proteins in- volved in signaling by tyrosine kinase. Kiyoko Fukami, Takeshi Endo, Michihiro Imamura, and Tadmmi Takenawa Mutation of the third intracellular loop of the CAMP receptor, cARl , of Dictyoetelium yields mutants im- paired in multiple signaling pathways. Michael J . Cater- zna, Jacqueline L. S. Milne, and Peter N. Deureotes
tions based on affinity of noncovalent association in Classification of az-macroglobulin-cytokine interac-
solution under apparent equilibrium conditions. Kendall P. Crookston, Donna J . Webb, Beni B. Wolf, and Steven L. Gonias Alteration of Na,K-ATPase subunit mRNA and protein levels in hypertrophied rat heart Daniele Charlemagne, John Orlowski, Patricia Oliuiero, Frawoise Rannou, Claude Sainte Beuue, Bernard Swynghedauw, and Lois K. Lane y-Aminobutyric acid-A (GABAA) agonists down-regu- late GABAhnzodiazepine receptor polypeptides from the surface of chick cortical neurons. Patricia A. Calkin and Eugene M. Barnes, Jr. Structure of the L-histidine decarboxylase gene. Kimio Yatsunami, Hiroshi Ohtsu, Motoko Tsuchikawa, Toshio Higu- chi, Kaname Ishibashi, Ayumi Shida, Youichiroh Shima, Sa- toshi Nakagawa, Kohei Yamauchi, Masayuki Yamamoto, Norio Hayashi, Takehiko Watanabe, and Atsushi Ichikawa A dual role for phosphatidylglycerol in protein trans- location across the Escherichia coli inner membrane. Ron Kusters, Eefjan Breukink, Andreas Gallusser, Andreas Kuhn, and Ben de Kruijff
ADDITIONS AND CORRECTIONS Functional domains of aromatase cytochrome P450 in-
quences and substantiated by site-directed mutagenesis ferred from comparative analyses of amino acid se-
experiments. Vol. 267 (1992) 22587-22594. Shiuan Chen and Dujin Zhou Protein kinase C-independent expression of stromely- sin by platelet-derived growth factor, ras oncogene, and phosphatidylcholine-hydrolyzing phospholipase C. Vol. 266 (1991) 22597-22602. Maria T. Diaz-Meco, Su- san Quinones, Maria M. Municw, Laura Sanz, Dolores Bernal, Esther Cabrero, Juan Sam, and Jorge Moscat Constitutively active mutants of the az-adrenergic receptor. Vol. 268 (1993) 16483-16487. Quen Ren, Hi- toshi Kurose, Robert J . Lefkowitz, and Susanna Cotecchia
Purification and characterization of an enzyme releas- ing lacto-N-biose from oligosaccharides with type 1
Kumi Hayakawa, and Ikunoshin Kat0 chain. Vol. 268 (1993) 18560-18566. Mutsumi Sam,
GENERAL INFORMATION
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The Journal of Biological Chemistry
CONTENTS Arranged by Subject Categories
January 14,1994
MINIREVIEW Cellular responses to cisplatin. The roles of DNA-bind- ing proteins and DNA repair. Gilbert Chu
CARBOHYDRATES, LIPIDS, AND OTHER NATURAL PRODUCTS
Lipid hydroperoxides induce apoptosis in T cells dis- playing a HIV-associated glutathione peroxidase defi- ciency. Paul A. Sandstrom, Paul W. Tebbey, Steve Van Cleave, and Thomas M. Buttke
Neutral sphingomyelinase action stimulates sig- nal transduction of tumor necrosis factor-cr in the syn- thesis of cholesteryl esters in human fibroblasts. Subroto Chatterjee
0-Glycosylation mimics N-glycosylation in the 18-kDa fragment of bovine pro-opiomelanocortin. The major 0-glycan attached to Thr-46 carries SO4-4GaWAcB1-
itope in the N-glycans of pituitary glycohormones. Rosa 4GlcNAcB1-, which is the archetypal non-reducing ep-
A. Siciliano, Howard R. Morris, Hugh P. J . Bennett, and Anne Dell
Specific heparan sulfate saccharides mediate the activ-
Jeremy E. Turnbull, and John T. Gallugher ity of basic fibroblast growth factor. Andrew Walker,
Differential expression of an E-selectin ligand (SLe') by two Chinese hamster ovary cell lines transfected with the same a(l,3)-fucosyltransferase gene (ELFT).
daram, Margot Brickelmaier, and Pamela Stanley Susan Goelz, Ravindra Kumar, Barry Potvin, Subha Sun-
dai. An N-acetyl-sugar-specific lectin (HOL-I) and an Two lectins from the marine sponge Halichondria oka-
Kawagishi, Masamichi Yamawaki, Satoko Isobe, Taichi Usui, N-acetyllactosamine-specific lectin (HOL-11). Hirokazu
Atsuo Kimura, and Seiya Chiba
Cloning of a novel cr2,3-sialyltransferase that sialylates glycoprotein and glycolipid carbohydrate groups. Hi- roshi Kitagawa and James C. Paulson
sialyltransferase. Nobuyuki Kurosawa, Toshiro Hammoto, Molecular cloning and expression of GalNAc a2,8-
Young-Chon Lee, Takashi Nakaoku, Naoya K o j i w and Shui- chi Tsuji
Differential E-selectin-dependent adhesion efficiency in sublines of a human colon cancer exhibiting distinct
Minoru Fukuda metastatic potentials. Ritsuko Sawada, Shigeru Tsuboi, and
ing lacto-N-biose from oligosaccharides with type 1 Purification and characterization of an enzyme releas-
chain. Vol. 288 (1993) 18580-18688. Mutsumi Sam, Kumi Hayakawa, and Ikunoshin Kat0
CELL BIOLOGY AND METABOLISM Dominant negative mutants of nitric oxide-sensitive
David L. Garbers guanylyl cyclase. Peter S. T. Yuen, Lynda K. Doolittle, and
Removal of Rab GTP-binding proteins from Golgi membranes by GDP dissociation inhibitor inhibits in- ter-cisternal transport in the Golgi stacks. Zvulun Ela- zar, Thomas Mayer, and James E. Rothman
Inhibition of human HL-80 cell responses to chemotac- tic factors by antisense messenger RNA depletion of G proteins. Edward J. Goetzl, Richard S. Shames, Jinhong
Songzhu A n Yang, Franz W. Birke, Ya Fang Liu, Paul R. Albert, and
Rat liver Kupffer and endothelial cells express differ- ent binding proteins for modified low density lipopro- teins. Kupffer cells express a 96-kDa membrane pro- tein as a specific binding site for oxidized low density lipoproteins. Yolanda B. de Rijke and The0 J . C. van Berkel
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Lead activation of protein kinase C from rat brain. Determination of free calcium, lead, and zinc by "F NMR. Gregory J. Long, John F. Rosen, and Francis A. X . Schanne
Activation and desensitization of phospholipase D in
and Jan B. Hoek intact rat hepatocytes. Gisela Moehren, Lena Gustausson,
The role of cytosolic Ca", protein kinase C, and protein kinase A in hormonal stimulation of phospholipase D in rat hepatocytes. Lena Gustausson, Gisela Moehren, M. Eugenia Torres-Marquez, Christine Benistant, Raphael Rubin, and Jan B. Hoek
Functional coupling of Na+/H+ and Na+/Ca2' exchan- gers in the crl-adrenoreceptor-mediated activation of hepatic metabolism. Elena Urcehy, Nora Butta, Guodalupe Cipres, Angeles Martin-Requero, Matilde S. Ayuso, and Roberto Parrilla
Activation of Raf-1 and mitogen-activated protein kinases during monocytic differentiation of human myeloid leukemia cells. Surender Kharbanda, Ahamed Sa- leem, Yutaka Emoto, Richard Stone, Ulf Rapp, and Donald Kufe
Characterization of the retention motif in the C-ter- minal part of the long splice form of platelet-derived growth factor A-chain. Maria Andersson, Arne &tman, Bengt Westerrnark, and Carl-Henrik Heldin
Phosphorylation of human erythrocyte band 3 by en- dogenous ~ 7 2 ~ ' . Marietta L. Harrison, Christina C. Isaac- son, Debra L. Burg, Robert L. Geahlen, and Philip S. Low
and (6-4) photoproducts in UV-treated human cells. Metabolic processing of cyclobutyl pyrimidine dimers
Evidence for distinct excision-repair pathways. Anne M. Galloway, Michel Liuzzi, and Malcolm C. Paterson
Kinetic studies on the removal of extracellular hydro-
suhiro Mochizuki, Shiro Bannai, and Yoshiki Sugita gen peroxide by cultured fibroblasts. Nobuo Makino, Ya-
Annexin VI, a marker protein of hepatocytic endo- somes. Stefan Jckkle, Ulrike Beisiegel, Franz Rinninger, Friedrich Buck, Anke Grigoleit, Andreas Block, I l k Groger, Heiner Greten, and Eberhard Windler
Ascorbic acid and insulin secretion in pancreatic islets.
Mark Levine Peter Bergsten, Anibal Sanchez Moura, Illani Atwater, and
Identification and characterization of a novel tyrosine kinase from megakaryocytes. Brian D. Bennett, Sally
Grabarek, Jerome E. Groopmn, David V. doeddel, and Hava Cowley, Shwian Jiang, Roanna London, Bi'ia Deng, Jadwiga
Auraham
Endothelin-1 and fibroblast growth factors stimulate the mitogen-activated protein kinase signaling cascade in cardiac myocytes. The potential role of the cascade in the integration of two signaling pathways leading to myocyte hypertrophy. Marie A. Bogoyeuitch, Peter E. Glen- non, Monica B. Andersson, Angela Clerk, Antigone LAZOU, Christopher J . Marshall, Peter J . Parker, and Peter H. Suga'Qn
Inhibition of thrombin receptor signaling by a G-pro- tein coupled receptor kinase. Functional specificity among G-protein coupled receptor kinases. Kenlz Ishct, J i Chen, v a k i Ishii, Walter J. Koch, Neil J. Freedman, Robert J. Lefkowztz, and S h u n R. Coughlcn
Characterization of rhoGAP. A GTPase-activating pro- tein for RHO-related small GTPases. Carole A. Lancaster, Pamela M. Taylor-Harris, Annette J. Self, Suzanne Brc11, Helmy E. van Erp, and Alan Hall Growth factors differentially stimulate the phosphoryl- ation of Shc proteins and their association with Grb2
Koozi Matuoka, Tadaomi Takenawa, and Alan R. Saltlel in PC-12 pheochromocytoma cells. Masahide Ohmichi,
Specific binding of the peroxisomal protein targeting sequence to glyoxysomal membranes. Nathan E. Wolins and Robert P. Donaldson
Indicates a Communication
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I n vitro synthesis of the iron-molybdenum cofactor of nitrogenase. Purification and characterization of NifB
Jeffrey R. Allen, Nathan J. Spangler, and Paul W. Ludden cofactor, the product of NIFB protein. Vinad K. Shah,
A novel gene, SIzT4, encodes a phosphatidylinositol 4- kinase in the PKCl protein kinase pathway of Saccha- romyces cereuisiae. Satoshi Yoshida, Yoshikazu Ohya, Mark Goebl, Akihiko Nakano, and Yasuhiro Anraku
Growth state- and cell cycle-dependent fluctuation in the expression of two forms of DNA topoisomerase I1 and possible specific modification of the higher molec-
Saijo, Michw Vi, and Takemi Enamoto ular weight form in the M phase. KeGi Kimura, Masafumi
oxisomes and is defective in patients with peroxisome Mevalonate kinase is predominantly localized in per-
deficiency disorders. Lenka Biardi, Aparna Sreedhar, Af- saneh Zokoei, Narendm B. Vartak, Renee L. Bozeat, Janis E. Shockelford, Gilbert-Andre Keller, and Skaidrite K. Krisans
Primary structure, ligand binding, and localization of
expressed in intestinal epithelium. Anthony R. Maranto the human type 3 inositol 1,4,5-trisphosphate receptor
Protein kinase C-mediated serine phosphorylation di- rectly activates Raf-1 in murine hematopoietic cells. Michael P. CarroU and W. Stratford May
Suppressed collagen gene expression and induction of a281 integrin-type collagen receptor in tumorigenic derivatives of human osteogenic sarcoma (HOS) cell line. Pia Santah, Hannu Larjaua, Liisa Nissinen, Terhi Rii- konen, Arto MGtta, and Jyrki Heino
Pituitary adenylate cyclase activating polypeptide is an extraordinarily potent intra-pancreatic regulator of insulin secretion from islet @-cells. Toshihiko Yad5 Ma- saya Sakurada, Kaori Ihida, Masanori Nakata, Fusayoshr Mur- uta, Akira Arimura, and Masatoshi Kikuchr
Association of the regulatory @-adrenergic receptor ki- nase with rat liver microsomal membranes. Irene Garcia- Higuera, Petronih Peneh, Cristina Murga, Gustavo Egea, Pedro Bonay, Jeffrey L. Benouic, and Federico Mayor, Jr.
Dominant inhibitory mutants of ARFl block endo- plasmic reticulum to Golgi transport and trigger dis- assembly of the Golgi apparatus. Christiane Dascher and WiUiam E. Bakh
Characterization of a plasma membrane-associated prenylcysteine-directed a carboxyl methyltransferase
Jeffry B. Stock, Gem2 Weissmann, and Mark R. Philips in human neutrophils. Michael H. PiUinger, Craig Volker,
a-Actinin and vinculin are PIPa-binding proteins in- volved in signaling by tyrosine kinase. Kiyoko Fukami, Takeshi Endo, Michihim Imumura, and Tadoomt Takenawa
Mutation of the third intracellular loop of the CAMP receptor, cAR1, of Dictyostelium yields mutants im- paired in multiple signaling pathways. Michael J . Cater- i n a , Jacqueline L. S. Milne, and Peter N . Deureotes
y-Aminobutyric acid-A (GABAA) agonists down-regu- late GABAAenzodiazepine receptor polypeptides from
and Eugene M. Barnes, Jr. the surface of chick cortical neurons. Patricia A. Calkin
Protein kinase C-independent expression of stromely- sin by platelet-derived growth factor, ras oncogene, and phosphatidylcholine-hydrolyzing phospholipase C. Vol. 266 (1991) 22597-22602. Maria T. Dz'uz-Meco, Su- san Quinones, Maria M. Municw, Laura Sanz, Dolores Bernal, Esther Cabrem, Juan Sam, and Jorge Moscat
Constitutively active mutants of the ap-adrenergic receptor. Vol. 268 (1993) 16483-16487. Quen Ren, Hi- toshi Kurose, Robert J. kfkowitz, and Susanna Cotecchia
ENZYMOLOGY Expression of a cloned protoporphyrinogen oxidase. Tamara A. Dailey, Peter Meissner, and Harry A. Dailey
Phosphatidylethanolamine incorporation into vesicles selectively enhances factor Va inactivation by acti- vated protein C. Mikhail D. Smirnou and Charles T. Esmon
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Lys-17 is the amine-donor substrate site for transglu- taminase in @AS-crystallin. Patricia J . T. A. Groenen, J o h n J . Grootjans, Nicolette H. Lubsen, Hans Bloemendal, and Wilfried W. de Jong
Identification of Lysa" at the active site of Escherichia coli glycogen synthase. Application of affinity labeling combined with site-directed mutagenesis. Koji Furu- kawa, Mitsuo Tagaya, Katsuyuki Tanizawa, and Toshw Fukui
Molecular mechanism of the synergistic phosphoryla- tion of phosphatase inhibitor-2. Cloning, expression, and site-directed mutagenesis of inhibitor-2. In-Kyung Park, Paris Roach, Jeffry Bondor, Stephen P. Fox, and Anna A. DePaoli-Roach
Enzymatic methylation of recombinant heterogeneous nuclear RNP protein Al. Dual substrate specificity for S-adenosy1methionine:histone-arginine N-methyl- transferase. R a m s h Rajpurohit, Soon Ok Lee, Jong Ok Park, Woon Ki Paik, and Sangduk Kim
Expression, purification, and characterization of the G protein-coupled receptor kinase GRK6. Priya Kunapuli, J a m s J . Onorato, M. Marlene Hosey, and Jeffrey L. Benouic
The active site of hamster 3-hydroxy-3-methylglu- taryl-CoA reductase resides at the subunit interface and incorporates catalytically essential acidic residues from separate polypeptides. Kenneth Frimpong and Victor W. Rodwell
Identification of basic amino acid residues in thrombin essential for heparin-catalyzed inactivation by anti- thrombin 111. Zhong-Ru Gun, Yiping Li, Zhongguo Chen, Sidney D. Lewis, and Jules A. Shafer
Expression cloning and characterization of the hamster ileal sodium-dependent bile acid transporter. Melissa H. Wong, Peter Oelkers, Ann L. Craddock, and Paul A. Dawson
Functional domains of aromatase cytochrome P460 in- ferred from comparative analyses of amino acid se- quences and substantiated by site-directed mutagenesis experiments. Vol. 267 (1992) 22587-22694. Sh iwn Chen and Dujin Zhou
MEMBRANES AND BIOENERGETICS
tion of the Na,K-ATPase by ATP. Ruben D. Peluffo, Ro- Low affinity acceleration of the phosphorylation reac-
hndo C. Rossi, Patricw J . Garrahan, and Alcides F. Rega
Replacement of alanine 58 by asparagine enables the
sugar transport to Na+. Hiroko Hama and T. Hastings melibiose carrier of Klebsiella pneumoniae to couple
Wilson
Cyclic AMP triggers large [Ca2+Ii oscillations in glu- cose-stimulated @-cells from ob/ob mice. Linda Fournier, James F. Whitfield, Jean-Louis Schwartz, and Nicole Begin- Heick
Transport of an export-defective protein by a highly hydrophobic signal peptide. Sharyn L. Rusch and Debra A. Kendall
mitochondrial cytochrome b c l complex, blocks matu- Deletion of QCRG, the gene encoding subunit six of the
ration of cytochrome c1 and causes temperature-sensi- tive petite growth in Saccharomyces cereuisiae. Meijia Yang and Bernard L. Trumpower
A sarco/endoplasmic reticulum Ca2+-ATPase 3-type Ca2+ pump is expressed in platelets, in lymphoid cells, and in mast cells. Frank Wuytack, Belo Papp, Hilde Verboo-
Emuf, S h i h Bokkah, Kalwant S. Authi, and Rik Casteels men, Luc Raeymaekers, Leonard Dode, Regis Bobe, Jocelyne
The rat platelet 97-kDa CaZ+ ATPase isoform is the sarcoendoplasmic reticulum CaZ+ ATPase 3 protein. Regis Bobe, Raymonde Bredoux, Frank Wuytack, Rozenn Qwrck, Tunde Kouircs, Beh Papp, Elisabeth Coruazier, Clarice Magnier, and Jocelyne Enauf
Volume-sensitive chloride currents in four epithelial cell lines are not directly correlated to the expression of the MDR-1 gene. Andrea Rasoh, Luis J. V. Galietta, Dieter C. Gruenert, and Giouanni Romeo
Indicates a Communication
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Expression of multiple somatostatin receptor genes in AtT-20 cells. Evidence for a novel somatostatin-28 selective receptor subtype. Yogesh C. Patel, Rosemarie Panetta, Emanuel Escher, Michael Greenwood, and Coimbatore B. Srikant
Alteration of Na,K-ATPase subunit mRNA and protein levels in hypertrophied rat heart Daniele Charlemagne, John Orlowski, Patricia Oliuiero, Fraqoise Rannou, Claude Sainte Beuue, Bernard Swynghedauw, and Lois K. Lune
A dual role for phosphatidylglycerol in protein trans- location across the Escherichia coli inner membrane. Ron Kusters, Eefjan Breukink, Andreas Gallwsser, Andreas Kuhn, and Ben de Kruijff
NUCLEIC ACIDS, PROTEIN SYNTHESIS, AND MOLECULAR GENETICS
Brain-derived neurotrophic factor increases neurotro-
Leingdrtner, Carl-Philipp Heisenberg, Roland Kolbeck, Hans phin-3 expression in cerebellar granule neurons. Axel
Thoenen, and Dan Lindholm
The interaction of CATA-binding proteins and basal
promoters. A model of tissue-specific gene expression. transcription factors with CATA box-containing core
William C. Aird, Jeffrey D. Paruin, Phillip A. Sharp, and Robert D. Rosenbeg
The directly repeated RC(C/T)TCA motifs of the rat and mouse cellular retinol-binding protein I1 genes are promiscuous binding sites for RAR, RXR, HNF-4, and ARP-1 homo- and heterodimers. Harikrishna Nakshatri and Pierre Chambon
Roles of v-erbA homodimers and heterodimers in medi- ating dominant negative activity by v-erbA. Paul M.
Sugawars and Wcllmm W. Chin Yen, Masato Ikee,. JiU H. Brubaker, Marc Forgione, Akira
Purified yeast RNA polymerase I1 reads through in- trinsic blocks to elongation in response to the yeast
Aled M. Edwards, and Caroline M. Kane TFIIS analogue, P37. Karen R. Christie, Donald E. Awrey,
Strand displacement activity of the human immunode-
and its individual subunits. Michael Hottiger, Vludimir N . ficiency virus type 1 reverse transcriptase heterodimer
Hribscher Podust, Roberta L. Thimmig, Charles McHenry, and Ulrich
expression, and enzymatic characterization of mouse Estimation of genomic complexity, heterologous
Pwtr Zimnek, Sharad S. Singhal, Sanjay K. Sriuastaua, San- glutathione S-transferase mGSTA4-4 (CST 5.7).
jay Awasthr, Rashmi Sharma, Janet B. Hayden, and Yogesh C. Awmthi
Isolation and characterization of the mouse heme oxy- genase-1 gene. Distal 5’ sequences are required for induction by heme or heavy metals. Jawed Alum, Jing Cui, and Ann Smith
by the transcription factor Spl. John W. Henson Regulation of the glial-specific JC virus early promoter
Stabilization of the EBNAl protein on the Epstein-Barr virus latent origin of DNA replication by a DNA looping mechanism. Lori Frappier, Kim Goldsmith, and Leslie Bendell
IFP 36 is an interferon-induced leucine zipper protein that undergoea interferon-regulated cellular redistri- bution. Franz-Christoph Bange, Ulrcch Vogel, Tho? Flohr, Mon ih Kiekenbeck, Bernd Denecke, and Errk C. Bottger
Molecular cloning of a possible cysteine proteinase pre- dominantly expressed in osteoclasts. Ken-ichi Tezuka, Yoko Tezuka, Akiko Maejima, Takuya Sato, Ken Nernoto,. Hiroshi Kamioh, Yoshiyuki Hak.edu, and Masayoshr Kumegawa
ATF-aO, a novel variant of the ATF/CREB transcrip- tion factor family, forms a dominant transcription in- hibitor in ATF-a heterodimers. Rosanna Pescrni, W i w e h Kaszubska, James Whelon, John F. DeLumarter, and Rob Hooft van Huijsduijnen
The transcri tion factor HNFl acts with. CEBPa to synergisticalfy activate the human albumin promoter through a,novel domain. Kou-Juey Wu, Deborah R. Wilson, Chiaho Shrh, and Gretchen J . Darlington
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The mouse osteocalcin gene cluster contains three genes with two separate spatial and temporal patterns of expression. Christelle Desbois, Deborah A. Hogue, and Gerard Karsenty
The calf 5’- to 3’-exonuclease is also an endonuclease. with both activities dependent on primers annealed upstream of the point of cleavage. Richard S. Murante, Lin Hung, John J. Turchi, and Robert A. Bambara
Transcription and editing of cytochrome oxidase I1 RNAs in !lbypanosoma cruti. Kwang S. Kim, Santuza M. R. Teixeira, Louis V. Kirchhoff, and John E. Donelson
sense mutation of arginine 669 to tryptophan. William Hereditary myeloperoxidase deficiency due to a mis-
M. Nauseef, Susan Brigham, and Melissa Cogley
Molecular characterization of a new metabotropic glu- tamate receptor mGluR7 coupled to inhibitory cyclic AMP signal transduction. Naoyuki Ohnoto, Seiji Hori,
boru Mizuno, and Shigetada Nahnishi Chihiro Akazawa, Yasunori Hayashi, Ryuichi Shigemto, No-
Identification and mutation of primary and secondary proteolytic cleavage sites in murine stem cell factor
tein. Manus K. Majumdar, Lijun Feng, Eugene Medlock, Deniz cDNA yields biologically active, cell-associated pro-
Toksoz, and David A. William
Coinduction of nitric oxide synthase and argininosuc- cinate synthetase in a murine macrophage cell line.
Andreas K. Nussler, Timothy R. Billiar, Zhi-Ze Liu, and Sulney Implications for regulation of nitric oxide production.
M. Morris, Jr.
The purification and characterization of gene 69 pro- tein from bacteriophage T4. Tetsuro Yonesaki
to the mouse thymidine kinase gene promoter. Qing-Ping Cl/S-regulated E2F-containing protein complexes bind
Doy Shanchwn Zhm, Andrew H. Leuin, Jian Wang, Kristian Helin, and Arthur B. Pardee
In vitro transcriptional studies of the roles of the thy- roid hormone (Ts) response elements and minimal pro-
S w n , Paul M. Yen, and William w. Chin moters in Ts-stimulated gene transcription. Chen-Shian
Determination of tissue specificity of the enhancer by combinatorial operation of tissue-enriched transcrip- tion factors. Both HNF-4 and C/EBP@ are required for liver-specific activity of, the ornithine transcarbamyl- ase enhancer. Atswhc Nuhiyon, Huletoshr Toshiro, Akrra Kimura, Kiwarnu Akugc, Ken-ichi Yarnamura, Masatah Mori, and Masaki Takiguchi Cloning and expression of a cDNA for mouse prosta- glandin F receptor. Yukihiko Sugimoto, Ken-yuh Hasumoto,
Negishi, Akira Kakizuka, Shuh Narurncya, and Atsushr Tsunehisa Namba, Atsushi Irie, Masato Ka,tsuyama, Manabu
Ichikawa Lipopolysaccharide induction of tissue factor expres- sion in THP-1 monocytic cells. Protein-DNA interac- tions with the promoter. Maryann Donovan-Peluso, Lisa Dawn George, and Andrea Cortese Hassett Repression of mouse mammary tumor virus transcrip- tion by a transcription factor complex. Binding of in- dividual components to separated DNA strands. Ward Giffin, Heather Torrance, Holly Saffran, Heather L. Mach&, and Robert J . G. Hachi
Thyroid hormone receptor modulates the expression of the rabbit cardiac sarco(endo)plasmic reticulum Caz+- ATPase gene. Angel Zarain-Herzberg, John Marqws, and Drew Sukovich Molecular cloning and characterization of the full- length cDNA encoding the developmentally regulated lysosomal enzyme &glucosidase in Dictyostelium dis- coideum. John Bush, Jan Rcchardson, and James CardeUc
Analyses of &thalassemia mutant DNA interactions with erythroid Kruppel-like factor (EKLF), an eryth- roid cell-specific transcription factor. Waldo C. Few, Cherie M. Southwood, and James J. Bieker Coupled replication-translation of amplifiable messen-
mimics viral infection. Lybou Ryaboua, Elena Volianik, Oleg ger RNA. A cell-free protein synthesis system that
Kramer Kurasou, Alexander Spcrzn, Yzng Wu, and Fred Russell
Indicates a Communication
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Structure of the L-histidine decarboxylase gene. Kimw Yatsunami, Hiroshi Ohtsu, Motoko Tsuchikwa, T0sh.w Higu- chi, Kaname Ishibashi, Ayumi Shida, YouFhtroh Shzm, Sa-
Hayashi, Takehiko Watanabe, and Atsushi Ichikawa toshi Nakugawq Kohei Yamuchi, Masayukt Yamnwto, Norw
PROTEIN CHEMISTRY AND STRUCTURE Active site mapping of affinity-labeled rat oxidosqual- ene cyclase. Ikuro Abe and Glenn D. Prestwzch
A novel cytokine exhibiting megakaryocyte potentiat- ing activity from a human pancreatic tumor cell line HPC-Y5. Nozomi Yamaguchi, Kunihiro Hattori, Masayoshi Oh-eda, Tetsuo Kojima, Nobua I m i , and Norimichi Ochi
Characterization of a promiscuous GTPase-activating protein that has a Bcr-related domain from Caenorhab- ditis elegan~. Weining Chen, Julian Blanc, and Louis Lim
Role of the cationic residues arginine 14 and lysine 48 in the function of the cardiotonic polypeptide antho- pleurin B. Paramjit K. Khera and Kenneth M. Blumenthal
A mechanism for divalent cation regulation of Bs-inte-
Mathis grins. Jeffrey W. Smith, Randolph S. Pktrowicz, and Danielle
Noncontiguous domains of the a-factor receptor of yeasts confer ligand specificity. Malini Sen and Lorraine Marsh
Characterization of the calmodulin-binding domain of rat cerebellar nitric oxide synthase. Mingiie Zhang and Hans J . Vogel
Heme-heme oxygenase complex. Structure of the cata- lytic site and its implication for oxygen activation. Satoshi Takahashi, Jianling Wang, Denis L. Rousseau, Kazun- obu Ishikawa, Tadashi Yoshida, Janette R. Host, and Masao Ikedn-Saito
Identification of probasin-related antigen as cystathi- onine y-lyase by molecular cloning. Nozomu Nishi, Hi-
Miyanaka, and Fumw Wada royuki Tanabe, Haruyo @a, Masahide Urushihara, Hiroshi
structure of engineered distal myoglobin Hise4 (E7) Val/ ‘H NMR study of the solution molecular and electronic
Val- ( E l l ) His double mutant. Coordination of Hise4 (E l l ) a t the sixth position in both low-spin and high- spin states. Jun Qin, Gerd N . La Mar, Yi Dou, Suzanne J. Admiraal, and Masao Ikeda-Saito
Indicates a Communication
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1370
1380
1388
1477
1510
1533
Hairpin loop and second kringle domain are essential sites for heparin binding and biological activity of hep- atocyte growth factor. Kensaku Mizum, Hayao Imue, Mi-
gashi, and Toshikazu Nakamura chi0 Hagiya, Shin Shimizy Takeru Nose, Yasuyuki Shimohi-
Thrombospondin 3 is a developmentally regulated hep- arin binding protein. Aziz N. Qabar, Zhiwu Lin, Frederick W. Wolf, K. Sue O’Shea, Jack Lawler, and Vishva M. Dixit
Purple acid phosphatase of the human macrophage and osteoclast. Characterization, molecular properties, and crystallization of the recombinant di-iron-oxo protein
H a y m n and Timothy M. Cox secreted by baculovirus-infected insect cells. Alison R.
Biochemical and assembly properties of GluR6 and KA2, two members of the kainate receptor family, determined with subunit-specific antibodies. Robert J .
Petralia Wenthold, Valory A. Trumpy, Wen-Si Zhu, and Ronald S.
Horseshoe crab (1,3)-/3-~-glucan-sensitive coagulation
similarities to j3-glucan-binding proteins. Noriaki Seki, factor G. A serine protease zymogen heterodimer with
Tatsushi Muta, Toshb Oda, Daisuke Iwaki, Kei-ichi Kuma, T a h h i Miyata, and Sadaaki Iwanaga Identification of discrete structural domains in the ret- inoblastoma protein. Amino-terminal domain is re-
Hong, Tim Durfee, Yue- Wei Qian, Eva Y . - H . P . L e , and quired for its oligomerization. Carmel E. Heme Frank
Wen-Hwa Lee
Modulation of HIV-1 reverse transcriptase function in
Jacques, Birgitta M. Wohrl, Kathryn J . Howard, and StLlart “selectively deleted” p66/p51 heterodimers. Pamela S.
F. J. Le Grice
The carboxyl-terminal domain of kinesin heavy chain
Dough G. Cole, Karen P. Wedamn, and Jonathan M. Scholey is important for membrane binding. Dimitrws A. Skoufias,
j3A4-amyloid protein precursor mRNA isoforms with- out exon 15 are ubiquitously expressed in rat tissues including brain, but not in neurons. Rupert Sandbrink, Colin L. Masters, and Konrad Beyreuther Classification of az-macroglobulin-cytokine interac- tions based on affinity of noncovalent association in
P. Crookston, Donna J. Webb, Beni B. Wolf, and Steven L. solution under apparent equilibrium conditions. Kendall
Gonins
Abe, Ikuro, 802 Admiraal, Suzanne J., 1083 Aird, William C., 883
Akazawa, Chihiro, 1231 Akagi, Kiwamu, 1323
Alam, Jawed, 1001 Albert, Paul R., 809
An, Songzhu, 809 Allen, Jeffrey R., 1154
Andersson, Monica B., 1110 Andersson, Maria, 926
Anraku, Yasuhiro, 1166 Arimura, Akira, 1290
Authi, Kalwant S., 1410 Atwater, Illani, 1041
Avraham, Hava, 1068 Awasthi, Sanjay, 992 Awasthi, Yogesh C., 992 Awrey, Donald E., 936 Apso, Matilde S., 860 Balch, William E., 1437 Bambara, Robert A., 1191 Bange, Franz-Christoph,
Bannai, Shiro, 1020 1091
Barnes, Eugene M., Jr., 1548
Beisiegel, Ulrike, 1026 BBgin-Heick, Nicole, 1120
Bendell, Leslie, 1057 Benistant, Christine, 849 Bennett, Brian D., 1068 Bennett, Hugh P. J., 910 Benovic, Jeffrey L., 1099,
Bernal, Dolores, 1565 Bergsten, Peter, 1041
Beuve, Claude Sainte, 1541 Beyreuther, Konrad, 1510 Biardi, Lenka, 1197 Bieker, James J., 1493
Birke, Franz W., 809 Billiar, Timothy R., 1257
Blanc, Julian, 820 Block, Andreas, 1026 Bloemendal, Hans, 831 Blumenthal, Kenneth M.,
Bobe, Rigis, 1410,1417 Bogoyevitch, Marie A,, 1110 Bokkala, Shaila, 1410 Bonay, Pedro, 1348
1348
921
AUTHOR INDEX
Bondor, Jeffry, 944 Bottger, Erik C., 1091 Bozeat, Renee L., 1197 Bredoux, Raymonde, 1417 Breukink, Eefjan, 1560
Brigham, Susan, 1212 Brickelmaier, Margot, 1033
Brill, Suzanne, 1137 Brubaker, Jill H., 903
Burg, Debra L., 955 Buck, Friedrich, 1026
Bush, John, 1468 Butta, Nora, 860 Buttke, Thomas M., 798 Cabrero, Esther, 1565
Calkin, Patricia A,, 1548 Cai, Jing, 1001
Cardelli, James, 1468 Carroll, Michael P., 1249
Caterina, Michael J., 1523 Casteels, Rik, 1410
Chamhon, Pierre, 890 Charlemagne, Daniele, 1541 Chatterjee, Subroto, 879 Chen, Ji, 1125
Chen, Shiuan, 1564 Chen, Weining, 820 Chen, Zhongguo, 1301
Chin, William W., 903, 1314 Chiba, Seiya, 1375
Christie, Karen R., 936 Chu, Gilbert, 787
Clerk, Angela, 1110 Ciprb, Guadalupe, 860
Cole, Douglas G., 1477 Cogley, Melissa, 1212
Corvazier, Elisabeth, 1417 Cotecchia, Susanna, 1566
Cowley, Sally, 1068 Coughlin, Shaun R., 1125
Cox, Timothy M., 1294 Craddock, Ann L., 1340 Crookston, Kendall P., 1533
Dailey, Harry A,, 813 Dailey, Tamara A,, 813 Darlington, Gretchen J., 1177
Dawson, Paul A., 1340 Dascher, Christiane, 1437
de Jong, Wilfried W., 831 de Kruijff, Ben, 1560
DeLamarter, John F., 1159 Dell, Anne, 910 Denecke, Bernd, 1091 Deng, Bijia, 1068 DePaoli-Roach, Anna A,, 944 de Rijke, Yolanda B., 824 Desbois, Christelle, 1183 Devreotes, Peter N., 1523 Dim-Meco, Maria T., 1565
Dode, Leonard, 1410 Dixit, Vishva M., 1262
Donaldson, Robert P., 1149 Donelson, John E., 1206 Donovan-Peluso, Maryann,
Dou, Qing-Ping, 1306 Doolittle, Lynda K., 791
Dou, Yi, 1083 Durfee, Tim, 1380
Egea, Gustavo, 1348 Edwards, Aled M., 936
Emoto, Yutaka, 872 Elazar, Zvulun, 794
Enomoto, Takemi, 1173 Endo, Takeshi, 1518
1361