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    Polytechnic University of the Philippines

    Sta. Mesa, Manila

    College of Engineering

    Department of Electronics and Communication Engineering

    MRI- Magnetic Resonance Imaging

    Barrion, John Ervin M.

    Gopez, Jayson B.

    Sto. Domingo, Joziel R.

    (Researchers)

    BSECE IV-2

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    Engr. Marianito P. Gallego Jr.

    (Professor)

    MRI- Magnetic Resonance Imaging

    I. Magnetic Resonance Imaging

    Magnetic resonance imaging (MRI) is a noninvasive medical test that helps

    physicians diagnose and treat medical conditions. MRI uses a powerful

    magnetic field, radio frequency pulses and a computer to produce detailed

    pictures of organs, soft tissues, bone and virtually all other internal body

    structures. MRI does not use ionizing radiation (x-rays).

    Detailed MR images allow physicians to evaluate various parts of the body

    and determine the presence of certain diseases. The images can then be

    examined on a computer monitor, transmitted electronically, printed or

    copied to a CD. It is based on the principles of nuclear magnetic resonance

    (NMR), a spectroscopic technique to obtain microscopic chemical and

    physical information about molecules. MRI has advanced beyond a

    tomographic imaging technique to a volume imaging technique.

    Magnetic resonance imaging (MRI) is a test that uses a magnetic field and

    pulses of radio wave energy to make pictures of organs and structures

    inside the body. In many cases, MRI gives different information about

    structures in the body than can be seen with anX-ray,ultrasound,

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    orcomputed tomography (CT) scan. MRI also may show problems that

    cannot be seen with other imaging methods.

    For an MRI test, the area of the body being studied is placed inside a

    special machine that contains a strong magnet. Pictures from an MRI scan

    are digital images that can be saved and stored on a computer for more

    study. The images also can be reviewed remotely, such as in a clinic or an

    operating room. In some cases,contrast materialmay be used during the

    MRI scan to show certain structures more clearly.

    You may be able to have an MRI with anopen machinethat doesn't

    enclose your entire body. But open MRI machines aren't available

    everywhere. The pictures from an open MRI may not be as good as those

    from astandard MRI machine.

    MRI can give different information about structures in the body than can

    be obtained using a standard x-ray, ultrasound, or computed tomography

    (CT) exam. For example, an MRI exam of a joint can provide detailed images

    of ligaments and cartilage, which are not visible using other study types. In

    some cases, a magnetically active material (called a contrast agent) is used

    to show internal structures or abnormalities more clearly.

    In most MRI devices, an electric current is passed through coiled wires to

    create a temporary magnetic field around a patients body. (In open-MRI

    devices, permanent magnets are used.) Radio waves are sent from and

    received by a transmitter/receiver in the machine, and these signals are

    used to produce digital images of the area of interest.

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    An MRI (or magnetic resonance imaging) scan is a radiology technique that

    uses magnetism, radio waves, and a computer to produce images of body

    structures. The MRI scanner is a tube surrounded by a giant circular

    magnet. The patient is placed on a moveable bed that is inserted into the

    magnet. The magnet creates a strong magnetic field that aligns the protons

    of hydrogen atoms, which are then exposed to a beam of radio waves. This

    spins the various protons of the body, and they produce a faint signal that

    is detected by the receiver portion of the MRI scanner. The receiver

    information is processed by a computer, and an image is produced.

    The image and resolution produced by MRI is quite detailed and can detect

    tiny changes of structures within the body. For some procedures, contrast

    agents, such as gadolinium, are used to increase the accuracy of the

    images.

    II. History

    Magnetic resonance imaging (MRI) is a sophisticated imaging technique

    that has evolved as a clinical modality over the past 30 years. The origins of

    MRI, or NMR (nuclear magnetic resonance), as it was termed in the past,

    however, can be traced back for over a century. Along the way, many

    scientists from diverse disciplines have made remarkable contributions that

    have brought the field to its present statea clinical tool capable of real

    time in-utero cardiac imaging and a research tool capable of imaging a

    single cell. As this powerful imaging modality and scientific tool continues

    to evolve, it is worthwhile to pause and look back at the evolution of MRI

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    and note the scientists who made the extraordinary contributions that have

    led to five Nobel Prizes awarded to discoveries related to NMR/MRI.

    By 1975, Peter Mansfield and Andrew Maudsley proposed a line scan

    technique, which, in 1977, led to the first image of in vivo human anatomy,

    a cross section through a finger. In 1977, Hinshaw, Bottomley, and Holland

    succeeded with an image of the wrist and Damadian et al. created a cross

    section of a human chest. More human thoracic and abdominal images

    followed, and, by 1978, Hugh Clow and Ian R. Young, working at the British

    company EMI, reported the first transverse NMR image through a human

    head. Two years later, William Moore and colleagues presented the first

    coronal and sagittal images through a human head. In 1980, Edelstein et

    al. from Aberdeen University in Scotland demonstrated imaging of the body

    using Ernsts technique. A single image could be acquired in approximately

    five minutes by this technique. By 1986, the imaging time was reduced to

    about five seconds without sacrificing too much image quality.

    A.Quick History of the MRI

    1882 Nikola Tesla discovered the Rotating Magnetic Field in Budapest,

    Hungary. This was a fundamental discovery in physics.

    1937 Columbia University Professor Isidor I. Rabi working in the Pupin

    Physic Laboratory in New York City, observed the quantum phenomenon

    dubbed nuclear magnetic resonance (NMR). He recognized that the atomic

    nuclei show their presence by absorbing or emitting radio waves when

    exposed to a sufficiently strong magnetic field.

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    1946 Felix Bloch and Edward Purcell discover magnetic resonance

    phenomenon.

    1950s Herman Carr creates a one-dimensional MR image.

    1956 The "Tesla Unit" was proclaimed in the Rathaus of Munich, Germany

    by the International Electro-technical Commission-Committee of Action. All

    MRI machines are calibrated in "Tesla Units". The strength of a magnetic

    field is measured in Tesla or Gauss Units. The stronger the magnetic field,

    the stronger the amount of radio signals which can be elicited from the

    body's atoms and therefore the higher the quality of MRI images.

    1969 Original Concept; Damadian Conceives of and proposes whole body

    MR scanner for the first time.

    1970 - Key Discovery Makes MR Scanner Possible; Damadian identifies

    T1/T2 differences between cancer and normal. He was seeking an MR

    signal difference in an important disease (cancer) that would prove his idea

    of an MR body scanner was a goal worth pursuing.

    March 1971 First Published Article; Damadian T1/T2 findings and

    scanner proposal published inScience, March 19, 1971. High pixel contrast

    provided by dramatic T1/T2 differences overcomes x-ray's century-old

    inability to see detail in vital organs.

    Spring 1971 Scanning Method Proposed; Damadian outlines voxel-by-voxel

    scanning method

    September 1971 Gradient Method Proposed; Lauterbur notebook proposal

    of gradient methods of Gabillard, Purcell & Carr for 1-dimension

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    1971 Raymond Damadian, a physician and experimenter working at

    Brooklyn's Downstate Medical Center discovered that hydrogen signal in

    cancerous tissue is different from that of healthy tissue because tumors

    contain more water. More water means more hydrogen atoms. When the

    NMR machine was switched off, the bath of radio waves from cancerous

    tissue will linger longer then those from the healthy tissue.

    1972 MRI adapted for medical purposes; Using highspeed computers,

    magnetic resonance imaging (MRI) is adapted for medical purposes, offering

    better discrimination of soft tissue than xray CAT and is now widely used

    for noninvasive imaging throughout the body. Among the pioneers in the

    development of MRI are Felix Bloch and Edward Purcell (Nobel Prize

    winners in 1952), Paul Lauterbur, and Raymond Damadian.

    March 1972 First Patent Filed; Damadian files '832 patent for 3-dimension

    voxel-by-voxel scan method and T1/T2 method.

    October 1972 2D Scan (Image) Achieved; Lauterbur submits 2-dimension

    MR scan (image) method with scan of 1mm tubes for publication

    1972 Raymond Damadian applies for a patent, which describes the concept

    of NMR being used for above purpose. He illustrates major parts of MRImachine in his patent application.

    March 1973 2D Paper Published; Lauterbur paper published in Nature,

    March 16, 1973

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    1973 Paul Lauterbur, a chemist and an NMR pioneer at the State University

    of New York, Stony Brook, produced the first NMR image. It was of a test

    tube.

    1974 3D Scan Method Proposed; Garroway, Grannell & Mansfield publish

    3-dimension scan method

    1974 Raymond Damadian receives his patent.

    1975 Phase Coding Introduced; Kumar, Welti & Ernst introduce phase

    encoding to scan method

    1975 Richard Ernst proposes using phase and frequency encoding and

    Fourier transform for acquisition of MR images.

    1977 First Human Scan Achieved; Damadian and coworkers, Minkoff and

    Goldsmith, achieve first scan (image) of the human body utilizing voxel

    method of patent.

    1977 Raymond Damadian produces MR image of the whole body. Peter

    Mansfield improves mathematics behind MRI and develops echo-planar

    technique, which allows images to be produces in seconds and later

    becomes the basis for fast MR imaging.

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    Figure 1. On July 3, 1977, nearly

    five hours after the start of

    the first MRI test, the first human

    scan was made as the first MRI prototype.

    The image above is of Dr. Damadian with the

    history- making prototype of

    his MRI scanner. This prototype is now on

    permanent display at the Smithsonian Institutions Hall of Medical Sciences.

    1980Phase Coding Applied; Aberdeen group introduces spin warp method

    1980 Phase Coding Applied; Aberdeen group introduces spin warp method

    1983 Ljunggren and Tweig introduce k-space.

    1986 Le Bihan publishes an article in Radiology, which describes diffusion

    weighted imaging (DWI).

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    1987 Real time MR imaging of the heart is developed.

    1991 Filler and colleagues describe imaging of axonal transport of

    supermagnetic metal oxide particles, a technique, which later becomes

    important in imaging of neural tracts.

    1993 Functional MR imaging of the brain is introduced.

    1994 The first intraoperative MR unit developed by GE and Harvard is

    installed in the Brigham and Women's Hospital in Boston.

    1997 Patent Upheld; High Court on U.S. Patents and U.S. Supreme Court

    enforce Damadian '832 patent.

    1990s In addition to research centers and large hospitals, small remote

    hospitals and imaging centers begin to utilize MRI predominantly for

    neuroimaging and musculoskeletal imaging.

    2000s Cardiac MRI, Body MRI, fetal imaging, functional MR imaging are

    further developed and become routine in many imaging centers. Research

    centers make significant strides forward in imaging cartilage on high field

    scanners. The number of free standing MRI centers, most of which utilize

    low or moderate field MR scanners significantly increases.

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    Figure 2. The future of MRI from 2050 2059

    2057 The ability to scan, analyse and

    diagnose the body has taken a huge

    leap forward by now. Hires, 3D

    imaging of internal structures and brain activity is now possible using

    realtime video, rather than static photos. This can be accomplished with

    devices no bigger than a camera or tablet. By the late 2050s, MRI scans

    have become as quick and easy as taking a photograph, with a

    hundredfold decrease in cost.

    Nikola Tesla discovered the Rotating Magnetic Field in 1882 in Budapest,

    Hungary.

    This was a fundamental discovery in physics.

    In 1956, the "Tesla Unit" was proclaimed in the Rathaus of Munich,

    Germany by the

    International Electrotechnical CommissionCommittee of Action. All MRI

    machines

    are calibrated in "Tesla Units". The strength of a magnetic field is measured

    in Tesla or Gauss Units. The stronger the magnetic field, the stronger the

    amount of radio signals

    which can be elicited from the body's atoms and therefore the higher the

    quality of MRI

    images.

    1 Tesla = 10,000 Gauss

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    LowField

    MRI= Under .2 Tesla (2,000 Gauss)

    MidField

    MRI= .2 to 0.6 Tesla (2,000 Gauss to 6,000 Gauss)

    HighField

    MRI= 1.0 to 1.5 Tesla (10,000 Gauss to 15,000 Gauss)

    In 1937, Columbia University Professor Isidor I. Rabi working in the Pupin

    Physic Laboratory in Columbia University, New York City, observed the

    quantum phenomenon dubbed nuclear magnetic resonance (NMR). He

    recognized that the atomic nuclei show their presence by absorbing or

    emitting radio waves when exposed to a sufficiently strong magnetic field.

    NUMBER OF MRI MACHINES WOLRDWIDE

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    III. Uses and Application of the Procedure

    MR imaging of the body is performed to evaluate, diagnose or monitor

    treatments for a variety of medical conditions, including: organs of the

    chest and abdomenincluding the heart, liver, biliary tract, kidneys,

    spleen, bowel, pancreas, and adrenal glands; pelvic organs including the

    bladder and the reproductive organs such as the uterus and ovaries in

    females and the prostate gland in males; blood vessels (including MR

    Angiography); lymph nodes; Abnormalities of the brain and spinal cord;

    Tumors, cysts, and other abnormalities in various parts of the body;

    Injuries or abnormalities of the joints; Suspected uterine abnormalities in

    women undergoing evaluation for infertility

    Physicians use an MR examination to help diagnose or monitor treatment

    for conditions such as: tumors of the chest, abdomen or pelvis; diseases of

    the liver, such as cirrhosis, and abnormalities of the bile ducts and

    pancreas; inflammatory bowel disease such as Crohns disease and

    ulcerative colitis; heart problems, such as congenital heart disease;

    malformations of the blood vessels and inflammation of the vessels

    (vasculitis); a fetus in the womb of a pregnant woman.

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    An MRI scan can be used as an extremely accurate method of disease

    detection throughout the body and is most often used after the other

    testing fails to provide sufficient information to confirm a patient's

    diagnosis. In the head, trauma to the brain can be seen as bleeding or

    swelling. Other abnormalities often found include brain aneurysms,stroke,

    tumors of the brain, as well as tumors or inflammation of the spine.

    Neurosurgeons use an MRI scan not only in defining brain anatomy but in

    evaluating the integrity of the spinal cord after trauma. It is also used when

    considering problems associated with the vertebrae or intervertebral discs

    of the spine. An MRI scan can evaluate the structure of the heart and

    aorta, where it can detect aneurysms or tears. MRI scans are not the first

    line of imaging test for these issues or in cases of trauma.

    It provides valuable information on glands and organs within the abdomen,

    and accurate information about the structure of the joints, soft tissues,

    and bones of the body. Often, surgery can be deferred or more accurately

    directed after knowing the results of an MRI scan.

    IV.Procedure

    A.Preparation

    The presence of a strong magnetic field means the metal objects of any kind

    are not permitted within the scanning room during an MRI Scan. All

    jewellery and clothing containing metal, particularly objects containing iron

    need to be removed. Internal metal objects such as metal clips, medication

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    pumps, or any internal metal items such as shrapnel or metal particles

    also present a considerable risk and must be made known to the doctor.

    Other equipment that may cause a risk include cardiac pacemakers or

    defibrillators; a catheter with metal components; aneurysm clips and

    cochlear implants. Some metal implants do not rule out using an MRI

    scanner, but some do and it is important to tell a doctor about any

    implants or metallic objects. If the patient suspects they may bepregnant,

    the doctor must be informed as little is known about the effect of MRI

    scans on an unborn baby. To improve the experience of the MRI, it is

    advised that the patient not drink for several hours before the scan. This is

    especially true of coffee and tea, as going to the toilet is not possible

    without interrupting the scan and beginning again.

    B.How does it Work?

    An MRI scanner is a cylindrical machine, used to get images of the human

    body. An MRI machine consists of a round tunnel within where the patientlies on a narrow table. An image of this is seen to the right. Surrounding

    the tube is a large cylindrical magnet. During an MRI Scan, the patient is

    within a stable magnetic field which is 10,000 30,000 times stronger than

    the earths magnetic field. Protons are tiny particles that are present in

    water molecules throughout the body. These are aligned by the incredibly

    strong magnetic field, noting that there are no water molecules in the

    human skeleton, only in bodily tissue. Radio waves are transmitted in

    pulses, and these protons produce echoes that are emitted out of the body.

    These echoes are received by theMRIscanner, and are then reconstructed

    http://www.myvmc.com/anatomy/stages-of-pregnancy-introduction/http://www.myvmc.com/anatomy/stages-of-pregnancy-introduction/
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    into images of the body by a computer. These images are very precise and

    give a clear anatomical view of the body from any angle.

    C.How does MRI performed?

    Once you are dressed in a medical gown, you will then be asked to lie down

    on a narrow table which then moves into the tunnel. An MRI can last from

    30 minutes to an hour, depending on the scans being performed. The scan

    consists of sequences, lasting from 2-15 minutes, during which the

    machine makes knocking noises, which can be loud. Patients are often

    provided with earphones to listen to music to distract them from these

    noises during the procedure. It is essential that the patient must remain

    motionless in order to produce a clear picture. For some patients

    claustrophobia may be an issue as the space within the MRI can be

    confining. Subsequently those with claustrophobicanxietyand childrenmay need light sedation. Throughout the procedure imaging technicians are

    able to communicate with the patient via intercom to ensure that the

    patient is informed and comfortable.

    After the MRI scan a radiologist, who is a physician experienced in MRI and

    other radiology examinations, will analyze the images and send a report

    with his or her interpretation to the patients personal physician. Thepatient receives MRI results from the referring physician who ordered the

    test. The image is available almost immediately, but the time from when the

    image is made available to when a report is issued will vary depending on

    the complexity of the case.

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    D.What will you experience after the procedure?

    Most MRI exams are painless. However, some patients find it uncomfortableto remain still during MR imaging. Others experience a sense of being

    closed-in (claustrophobia). Therefore, sedation can be arranged for those

    patients who anticipate anxiety, but fewer than one in 20 require

    medication.

    It is normal for the area of your body being imaged to feel slightly warm,

    but if it bothers you, notify the radiologist or technologist. It is important

    that you remain perfectly still while the images are being obtained, which is

    typically only a few seconds to a few minutes at a time. You will know when

    images are being recorded because you will hear and feel loud tapping or

    thumping sounds when the coils that generate the radiofrequency pulses

    are activated. Some centers provide earplugs, while others use headphones

    to reduce the intensity of the sounds made by the MRI machine. You will be

    able to relax between imaging sequences, but will be asked to maintainyour position without movement as much as possible.

    In some cases, intravenous injection of contrast material may be

    performed. The intravenous needle may cause you some discomfort when it

    is inserted and you may experience some bruising. There is also a very

    small chance of irritation of your skin at the site of the IV tube insertion.

    Some patients may sense a temporary metallic taste in their mouth after

    the contrast injection.

    V. Benefits and Risk

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    A.Benefits

    MRI is a noninvasive imaging technique that does not involve exposure to

    ionizing radiation. MR images of the soft-tissue structures of the body

    such as the heart, liver and many other organs is more likely in some

    instances to identify and accurately characterize diseases than other

    imaging methods. This detail makes MRI an invaluable tool in early

    diagnosis and evaluation of many focal lesions and tumors. MRI has proven

    valuable in diagnosing a broad range of conditions, including cancer, heart

    and vascular disease, and muscular and bone abnormalities. MRI enables

    the discovery of abnormalities that might be obscured by bone with other

    imaging methods. MRI allows physicians to assess the biliary system

    noninvasively and without contrast injection. The contrast material used in

    MRI exams is less likely to produce an allergic reaction than the iodine-

    based contrast materials used for conventional x-rays and CT scanning.

    MRI provides a noninvasive alternative to x-ray, angiography and CT for

    diagnosing problems of the heart and blood vessels.

    B.Risk and Disadvantages

    The MRI examination poses almost no risk to the average patient when

    appropriate safety guidelines are followed. If sedation is used, there are

    risks of excessive sedation. The technologist or nurse monitors your vital

    signs to minimize this risk. Although the strong magnetic field is not

    harmful in itself, implanted medical devices that contain metal may

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    malfunction or cause problems during an MRI exam. There is a very slight

    risk of an allergic reaction if contrast material is injected. Such reactions

    usually are mild and easily controlled by medication. If you experience

    allergic symptoms, a radiologist or other physician will be available for

    immediate assistance. Nephrogenic systemic fibrosis is currently a

    recognized, but rare, complication of MRI believed to be caused by the

    injection of high doses of gadolinium-based contrast material in patients

    with very poor kidney function. Careful assessment of kidney function

    before considering a contrast injection minimizes the risk of this very rare

    complication.

    Manufacturers of intravenous contrast indicate mothers should not

    breastfeed their babies for 24-48 hours after contrast medium is given.

    However, both the American College of Radiology (ACR) and the European

    Society of Urogenital Radiology note that the available data suggest that it

    is safe to continue breastfeeding after receiving intravenous contrast.

    Figure 1 Accidents Happen becauseof strong magnetic Field

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    The magnet may cause pacemakers, artificial limbs, and other implanted

    medical devices that contain metal to malfunction or heat up during the

    exam. Any loose metal object may cause damage or injury if it gets pulled

    toward the magnet. If a contrast agent is used, there is a slight risk of an

    allergic reaction. MRI contrast agents can cause problems in patients with

    significant kidney disease. Dyes from tattoos or tattooed eyeliner can cause

    skin or eye irritation. Medication patches can cause a skin burn. The wire

    leads used to monitor an electrocardiogram (ECG) trace or respiration

    during a scan must be placed carefully to avoid causing a skin burn.

    Prolonged exposure to radio waves during the scan could lead to slight

    warming of the body.

    Here is a news about an accident happens in MRI session.

    Aug. 1, 2001 -- Despite the horrific MRI accident that caused the death of

    6-year-old Michael Colombini earlier this week in Valhalla, N.Y., many

    medical experts reiterate that the use of the imaging test is safe when used

    appropriately. Colombini was undergoing an MRI, or magnetic resonance

    imaging, at Westchester County Medical Center last Friday when an oxygen

    canister was turned into a guided missile by the powerful MRI magnet. The

    canister was drawn into the magnet core while the boy was in the machine.

    The result was a fatal blow to the child's head. He died on Sunday. Frank

    Shellock, MD, an MRI safety expert who has been tracking MRI-related

    accidents for 16 years tells WebMD that this is the first death caused by an

    MRI projectile, and that any kind of MRI accident is "relatively rare." MRIs

    have been used regularly by doctors since "1982, and it is estimated that

    about 10 million MRI imaging studies are done in the United States each

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    year," says Shellock, who is a clinical professor of radiology at the

    University of Southern California. 2001 WebMD, Inc. All rights reserved.

    VI.Limitation

    High-quality images are assured only if you are able to remain perfectly still

    and follow breath-holding instructions while the images are being recorded.

    If you are anxious, confused or in severe pain, you may find it difficult to lie

    still during imaging.

    The presence of an implant or other metallic object sometimes makes it

    difficult to obtain clear images. Patient movement can have the same effect.A very irregular heartbeat may affect the quality of images obtained using

    techniques that time the imaging based on the electrical activity of the

    heart, such as electrocardiography (EKG).

    An MRI is a very expensive and time consuming investigation compared to

    other methods such asx-rayandCT. Some parts of the body, like bone, are

    better examined using simpler techniques such as an X-Ray. An MRI may

    not always be able to tell the difference between some disease processes. It

    is also not a very good investigation for emergencies or accidents because of

    the long time it takes and the fact that all equipment has to be removed

    from the room while the machine is running.

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    VII. The equipment

    A.Appearance and Process

    The traditional MRI unit is a large cylinder-shaped tube surrounded by a

    circular magnet. You will lie on a moveable examination table that slides

    into the center of the magnet.

    Some MRI units, calledshort-bore systems, are designed so that the

    magnet does not completely surround you. Some newer MRI machines have

    a larger diameter bore which can be more comfortable for larger size

    patients or patients with claustrophobia. Other MRI machines are open on

    the sides (open MRI). Open units are especially helpful for examining larger

    patients or those with claustrophobia. Newer open MRI units provide very

    high quality images for many types of exams; however, older open MRI

    units may not provide this same image quality. Certain types of exams

    cannot be performed using open MRI. For more information, consult your

    radiologist.

    The computer workstation that processes the imaging information is

    located in a separate room from the scanner.

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    Figure 1: Picture of MRI Equipment Figure 2: Siemens Allegra 3T

    Figure 3: A schematic representation

    of the major systems on a

    magnetic resonance imager.

    B.Comparison to other Imaging Equipment

    Unlike conventional x-ray examinations and computed tomography (CT)scans, MRI does not depend on ionizing radiation. Instead, while in the

    magnet, radio waves redirect alignment of hydrogen atoms that naturally

    exist within the body without causing any chemical changes in the tissues.

    As the hydrogen atoms return to their usual alignment, they emit energy

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    that varies according to the type of body tissue in which they lie. The MR

    scanner listens for this energy and creates a picture of the tissues scanned.

    The magnetic field is produced by passing an electric current through wire

    coils in most MRI units. Other coils, located in the machine and in some

    cases, placed around the part of the body being imaged, send and receive

    radio waves, producing signals that are detected by the coils.

    A computer then processes the signals and generates a series of images,

    each of which shows a thin slice of the body. The images can then be

    studied from different angles by the interpreting radiologist. The

    differentiation of abnormal (diseased) tissue from normal tissues is better

    with MRI than with other imaging modalities such as x-ray, CT and

    ultrasound.

    VIII.Types of MRI

    A.Magnetic Resonance Angiogram(MRA)

    An MRA, or magnetic resonance angiogram, is a type ofMRI scanthat uses

    MRI's magnetic fields and radio waves to produce pictures of blood vessels

    inside the body, allowing doctors to locate problems that may cause

    reduced blood flow. An MRI, or magnetic resonance imaging, is the

    technology behind an MRA, and it is used to examine soft ligament tissues

    and tendon injuries. Both scans are generally safe for most patients and do

    not expose them toionizing radiation.

    B. Functional MRI

    http://data.diffen.com/MRIhttp://en.wikipedia.org/wiki/Ionizing_radiationhttp://data.diffen.com/MRIhttp://en.wikipedia.org/wiki/Ionizing_radiation
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    This type of MRI is done on the brain, and not only shows the structure of

    the brain, but also how much activity is taking place in each part. This has

    been used to find out what parts of the brain are most active during certain

    situations or tasks.Cardiac MRI: This can be used for several different

    conditions and is dealt with separately.

    Types of MRI Exams

    Brain MRI

    An MRI of the brain produces very detailed pictures of the brain. It is

    commonly used

    to study patients with headaches, seizures, weakness, blurry vision, etc. It

    also can

    further evaluate an abnormality seen on a CT scan. During the brain MRI,

    a special

    device called a head coil is placed around the patient's head. It does not

    touch the

    patient, and the patient can see through large gaps in the coil. This device

    is what

    helps to produce the very detailed pictures of the brain.

    Cardiac MRI

    Cardiac MRI can evaluate the size and thickness of the chambers of the

    heart, the extent of damage caused by a heart attack or progressive heart

    disease, and buildup of plaque and blockages in the blood vessels. It is an

    invaluable tool for detecting and evaluating coronary artery disease and the

    function of the heart muscles, valves and vessels.

    http://www.myvmc.com/investigations/cardiac-mri-magnetic-resonance-imaging/http://www.myvmc.com/investigations/cardiac-mri-magnetic-resonance-imaging/
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    Spine MRI

    This test is most commonly used to look for a herniated disc or narrowing

    of the spinal canal (spinal stenosis) in patients with neck, arm, back

    and/or leg pain. It is also the best test to look for a recurrent disc

    herniation in a patient who has had prior back surgery.

    Bone and Joint MRI

    MRI can evaluate virtually all of the bones and joints, as well as the soft

    tissues. Tendon, ligament, muscle, cartilage and bone injuries can be

    diagnosed using MRI scans. It can also be used to look for infections and

    masses.

    Abdomen MRI

    MRI of the abdomen is most frequently used to further evaluate an

    abnormality seen on another test, such as an ultrasound or CT scan. Thus,

    the exam is usually tailored to look at specific organs or tissues, such as

    the liver, adrenal glands or pancreas.

    Pelvic MRI

    For women, pelvic MRI is used to evaluate the ovaries and uterus as

    followup to an ultrasound exam which showed an abnormality. It is also

    used to evaluate endometrial cancer. For men, pelvic MRI is sometimes

    used to evaluate prostate cancer.

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    Magnetic Resonance Imaging (MRI) Magnetic Resonance Andiography(MRA)

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    IX. Microscopic Property Responsible for MRI

    A.Basic Concepts and Basic Anatomy of an MRI System

    The Static Magnetic Field

    Magnetic resonance imaging requires a very strong magnetic field that has

    precisely the same magnitude and direction everywhere in the region we

    want to image. Uniformity or homogeneity is one of key properties to

    describe MRI system quality. The strength of the magnetic field can be

    difficult to understand because we rarely encounter strong magnetic field in

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    everyday life. We use unit of gauss (G) or tesla (T), where 10000 gauss is

    equal to 1 tesla, to describe the strength of the field.

    The basic concept used both for creating the magnetic fields we need for

    MRI and detecting the MR signal is that if we run an electrical current

    through a wire, then a magnetic field is created around the wire. For the

    design of MRI systems, this idea is extended further by wrapping wires in

    repeated loops along the surface of a cylinder, which makes the magnetic

    field stronger and more uniform over a larger volume at the center of the

    cylindrical coil of wire.

    Magnetic Field Gradient

    A gradient in the magnetic field is what will allow us to accomplish this. A

    magnetic field gradient is a variation in the magnetic field with respect to

    position. A one-dimensional magnetic field gradient is a variation with

    respect to one direction, while a two-dimensional gradient is a variation

    with respect to two. The most useful type of gradient in magnetic resonance

    imaging is a one- dimensional linear magnetic field gradient. A one-

    dimensional magnetic field gradient along the x axis in a magnetic field, Bo,

    indicates that the magnetic field is increasing in the x direction. Here the

    length of the vectors represents the magnitude of the magnetic field. The

    symbols for a magnetic field gradient in the x, y, and z directions are Gx, Gy,

    and Gz.

    Representing Images with Numbers and Vice-Versa

    Digital Imaging and Communications in Medicine

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    Digital Imaging and Communications in Medicine (DICOM) is a standard for

    handling, storing, printing, andtransmittinginformation inmedical

    imaging. It includes afile formatdefinition and a networkcommunications

    protocol. The communication protocol is an application protocol that

    usesTCP/IPto communicate between systems. DICOM files can be

    exchanged between two entities that are capable of receiving image and

    patient data in DICOM format.

    A DICOM data object consists of a number of attributes, including items

    such as name, ID, etc., and also one special attribute containing the image

    pixel data (i.e. logically, the main object has no "header" as such: merely a

    list of attributes, including the pixel data). A single DICOM object can have

    only one attribute containing pixel data. For many modalities, this

    corresponds to a single image. But note that the attribute may contain

    multiple "frames", allowing storage of cine loops or other multi-frame data.

    X. Bibliography and References

    https://en.wikipedia.org/wiki/Data_transmissionhttps://en.wikipedia.org/wiki/Medical_imaginghttps://en.wikipedia.org/wiki/Medical_imaginghttps://en.wikipedia.org/wiki/File_formathttps://en.wikipedia.org/wiki/Communications_protocolhttps://en.wikipedia.org/wiki/Communications_protocolhttps://en.wikipedia.org/wiki/TCP/IPhttps://en.wikipedia.org/wiki/Data_transmissionhttps://en.wikipedia.org/wiki/Medical_imaginghttps://en.wikipedia.org/wiki/Medical_imaginghttps://en.wikipedia.org/wiki/File_formathttps://en.wikipedia.org/wiki/Communications_protocolhttps://en.wikipedia.org/wiki/Communications_protocolhttps://en.wikipedia.org/wiki/TCP/IP
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    Magnetic Resonance Imaging (MRI) pages 1-8, Radiological Society of North

    America, Inc.

    Basic Principles of MRI, Simply Physics, simplyphysics.com

    Magnetic Resonance Imaging: Historical Perspective,Journal of

    Cardiovascular Magnetic Resonance(2006) 8, 573580 Copyright c_ 2006

    Taylor & Francis Group, LLC

    Basic Principles of MRI, James Voyvodic, Ph.D., Brain Imaging and

    Analysis Center

    Radiologyinfo.org, a resource produced by American College of Radiology

    and Radiological Society of North America. Magnetic Resonance Imaging

    -Body (MRI) Accessed 2/14/2014.

    Food and Drug Administration, Radiation-Emitting Products: MRI

    (Magnetic Resonance Imaging) Accessed 2/14/2014.

    Copyright 1995-2014, The Cleveland Clinic Foundation.

    Reimer P, Parizel PM, Stichnoth FA. Clinical MR Imaging: a Practical

    Approach (2ndEdition). Heidelberg. Springer-Verlag. 2003.

    Hornak, JP. The Basics of MRI. The Centre of Imaging Science. 2006.

    July 1, 2015.http://www.cis.rit.edu/htbooks/mri/

    Chernoff D, Stark P. Principles of Magnetic Resonance Imaging, UpToDate.

    July 1, 2015.http://www.uptodate.com/contents/principles-of-magnetic-

    http://www.cis.rit.edu/htbooks/mri/http://www.uptodate.com/contents/principles-of-magnetic-resonance-imaging?source=search_result&search=principles+of+magnetic+resonance+imaging&selectedTitle=1~150http://www.cis.rit.edu/htbooks/mri/http://www.uptodate.com/contents/principles-of-magnetic-resonance-imaging?source=search_result&search=principles+of+magnetic+resonance+imaging&selectedTitle=1~150
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    resonance-imaging?

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    &selectedTitle=1~150

    Magnetic Resonance Imaging: Body, Radiology Info. Radiological Society of

    North America, 2006. July 1, 2015.http://www.radiologyinfo.org/

    http://www.qmagnets.com/magnetic-field-gradients.php

    http://www.uptodate.com/contents/principles-of-magnetic-resonance-imaging?source=search_result&search=principles+of+magnetic+resonance+imaging&selectedTitle=1~150http://www.uptodate.com/contents/principles-of-magnetic-resonance-imaging?source=search_result&search=principles+of+magnetic+resonance+imaging&selectedTitle=1~150http://www.uptodate.com/contents/principles-of-magnetic-resonance-imaging?source=search_result&search=principles+of+magnetic+resonance+imaging&selectedTitle=1~150http://www.radiologyinfo.org/http://www.qmagnets.com/magnetic-field-gradients.phphttp://www.uptodate.com/contents/principles-of-magnetic-resonance-imaging?source=search_result&search=principles+of+magnetic+resonance+imaging&selectedTitle=1~150http://www.uptodate.com/contents/principles-of-magnetic-resonance-imaging?source=search_result&search=principles+of+magnetic+resonance+imaging&selectedTitle=1~150http://www.radiologyinfo.org/http://www.qmagnets.com/magnetic-field-gradients.php