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3D Health Products: Shaping Healthcare through Innovation presented by Yeong Wai Yee Assistant Professor School of Mechanical and Aerospace Engineering Nanyang Technological University, Singapore Email: [email protected] Oct 2016

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Page 1: 3D healthcare

3D Health Products: Shaping Healthcare through Innovation

presented by

Yeong Wai Yee

Assistant Professor

School of Mechanical and Aerospace Engineering

Nanyang Technological University, Singapore

Email: [email protected]

Oct 2016

Page 2: 3D healthcare

What is 3D Printing?

• Construct physical models directly from Computer-Aided Design (CAD) data.

• Other names: 3D printing, Additive Manufacturing, Rapid Prototyping, layered manufacturing, solid freeform fabrication

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3D Printing machines

4

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Different TechnologiesASTM F2792

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What can you print: Materials

6

PlasticCeramics

Biomaterials

Glass

Metal

Wood

plastic and carbon composite

Solid filament, flakes Liquid resin Powder

Different Format of Materials:

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3D Printing as Advanced Manufacturing Technology for Medical Devices

Intervertebral body fusion device(Credit: Joimax)

3D printed polymer, spinal load-bearing device

(Credit: OPM)

http://tissuesys.com/technology

TRS Scaffold Technology

Surgical guide

Porous load

bearing implant

Solid load bearing

implant

Porous

degradable

implant Hearing aid shell

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3D printing of a tracheobronchial

splint (TBS)

3D Printing meets urgent medical needs

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Umbilical cord clamps• 3D printed for direct use in local clinics at Haiti

http://reliefweb.int/report/haiti/field-ready-project-haiti

3D Printing meets global medical needs,

overcoming logistic challenges

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Home-based printed assisted devices

http://enablingthefuture.org/

Open source design file available

3D Printing enables new co-creation,

open innovation platform in healthcare

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Enables New Device Design : Customized Lattice Metal Implants for Enhanced Osteointegration

SL Sing, WY Yeong, FE Wiria. (2016). Selective laser melting of titanium

alloy with 50 wt% tantalum: Microstructure and mechanical properties.

Journal of Alloys and Compounds, 660, 461–470

SL Sing, WY Yeong, FE Wiria, BY Tay. (2015). Characterization of

Titanium Lattice Structures Fabricated by Selective Laser Melting using

an Adapted Compressive Test Method. Experimental Mechanics, ,

10.1007/s11340-015-0117-y

Sing, S. L., An, J., Yeong, W. Y. and Wiria, F. E. (2015). Laser and

electron-beam powder-bed additive manufacturing of metallic implants: A

review on processes, materials and designs. Journal of Orthopaedic

Research, Accepted, doi: 10.1002/jor.23075.

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Creating New Materials :

Patent pending

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New diagnostic and testing capability in pharma: 3D Printed Microfluidics Chip

Jia Min LEE, Meng ZHANG, Wai Yee YEONG. (2016). Characterization and evaluation of 3D printed

microfluidic chip for cell processing. Microfluidics and Nanofluidics, 20(1), 1-15

• 3D printing provides design freedom in micro-to-macro

fluidics chip features and designs.

• Enable new capabilities in cells processing, drug testing

and biosensor diagnostic testing .

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New combinational medical device: 3D Printed Biodegradable Scaffold for Tissue Engineering

Yeong WY, et al: Porous polycaprolactone scaffold for cardiac tissue engineering fabricated by selective laser sintering.

Acta Biomater; 2010 Jun;6(6):2028-34

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W.L Ng, S.Wang, W.Y.Yeong, M.W. Naing (2016) SKIN BIOPRINTING: IMPENDING REALITY

OR FANTASY, Trends in Biotechnology 2016 Sep;34(9):689-99

Emerging technologies: Bioprinting

Patterning and

printing of cells

inside/on

constructs

Cells as one of

the raw materials

to be printed

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3D Systems, TNO

Emerging technologies: 3D Printed Food

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Provide personalized food for the increasing global population ( Shape, colour, age, health requirements …)

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3D Printed Drug- Spritam

• FDA Approves Spritam (levetiracetam) as the First 3D Printed Drug Product by Aprecia Pharmaceuticals

• to be available in the first quarter of 2016

• pill can be made more porous than typical pills, rapidly disintegrate, Support dose loading up to 1,000 mg

https://www.aprecia.com/zipdose-platform/zipdose-technology.php

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Current AM Standards

• ASTM International

Committee F42 on Additive

Manufacturing

Technologies, formed in

2009 and • ISO Technical Committee

261 on Additive

Manufacturing, formed in

2011

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Summary

• 3D printing is a diverse technology with huge potential in shaping the future of healthcare.

• Enables new business operation, new business model, new technology creation and new solutions for patient and healthcare practitioners.

• Close collaboration among industry partners, healthcare practitioners and the researchers are necessary for maximum impact in the near future.

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Thank you

Images from google and articles.

For education purpose only.

https://scholar.google.com.sg/citations?user=CgowDcwAAAAJ&hl=en

Wai Yee Yeong - Google Scholar Citations