3me initiative future directions - keele university · istm, keele university 13:00 open fruo m...

3ME Initiative Future Directions

4th & 5th of July 2011De Vere: Wychwood Park

The 3ME Initiative is funded by EPSRC and Keele University

Contents 3ME Initiative Overview................................................................................................................................................ 3

Venue..................................................................................................................................................................................... 5

De Vere Wychwood Park .......................................................................................................................................... 5

Plan of Complex............................................................................................................................................................ 6

Program................................................................................................................................................................................ 7

Mo f Junday 4th o ly 2011........................................................................................................................................... 7

Session I Future Directions: Interactions with the ‘other side’ of campus............................ 7

Session II 3ME Outcomes ............................................................................................................................ 7

Session III Future Directions: Discussions............................................................................................. 7

REF and beyond, Tuesday 5th July 2011 ........................................................................................................... 8

Session I: Postgraduate Training...................................................................................................................... 8

Session II: REF 2014 .............................................................................................................................................. 8

Session III: Key Guest Speakers ........................................................................................................................ 8

Session IV: Building External Links................................................................................................................. 8

Research Theme Updates .................................................................................................................................... 8

Future Directions Workshop Delegates .................................................................................................................. 9

Staff.................................................................................................................................................................................... 9

Dr Nigel Cassidy....................................................................................................................................................... 9

Dr Charles Day....................................................................................................................................................... 10

Professor Andrew Dobson ............................................................................................................................... 10

Prof Alicia El Haj................................................................................................................................................... 11

Professor Gordon Ferns .................................................................................................................................... 12

Dr Alan Harper...................................................................................................................................................... 13

Dr Catriona Kelly.................................................................................................................................................. 14

Dr Theocharis Kyriacou .................................................................................................................................... 15

Dr Ka‐Po Lam......................................................................................................................................................... 16

Dr Shailesh Naire ................................................................................................................................................. 17

Dr Kehoe Oksana.................................................................................................................................................. 17

Professor Pauline Ong........................................................................................................................................ 18

Dr Sharon Owen ................................................................................................................................................... 18

Dr Dhaya Perumal................................................................................................................................................ 18

Dr Paul Roach ........................................................................................................................................................ 19

Dr Frank Rutten.................................................................................................................................................... 20

1

Mr Mark Smith ...................................................................................................................................................... 21

Professor David Smith ....................................................................................................................................... 22

Ms Pauline Weston.............................................................................................................................................. 23

Dr Karina Wright.................................................................................................................................................. 23

Dr Ying Yang........................................................................................................................................................... 24

PhD Students .............................................................................................................................................................. 25

Mr John Butcher ................................................................................................................................................... 25

Miss Angeliki Fouriki.......................................................................................................................................... 26

Mr Deepak Kumar................................................................................................................................................ 26

Muhammad Aslam Rao...................................................................................................................................... 27

Miss Abigail Rutter .............................................................................................................................................. 27

Mr William Smith ................................................................................................................................................. 27

Ryad Soobhany ..................................................................................................................................................... 28

Mr Rupert Wright ................................................................................................................................................ 28

REF 2014 & Beyond Delegates................................................................................................................................. 29

Keele Research News ................................................................................................................................................... 30

OTES ................................................................................................................................................................................ 31 N

2

3ME Initiative Overview

The 3ME Initiative is an inter‐disciplinary project to develop collaborative research in Modelling Methods for Medical Engineering which brings together three well established Keele research groups:

• The Institute for Science & Technology in Medicine (ISTM), including the Cellular & Neural Engineering group led by Prof Alicia El Haj and the Imaging & Diagnostics group led by Prof Jon Dobson, other members include Prof Sally Roberts, Dr Isaac Liu, Dr Sarah Cartmell, and Dr Jan‐Herman Kuiper.

• The Mathematical Modelling Group in EPSAM comprises Prof Graham Rogerson, Prof Yibin Fu, Dr Shailesh Naire and associated research staff who employ mathematical modelling including asymptotic and numerical techniques to solve problems related to industrial processes, biology and human physiology. This group enjoys an RAE 5 rating and an international profile, having become increasingly interested in emerging areas such as stem cells and cell engineering.

• The Applied and Environmental Geophysics Research Group, also in EPSAM, includes Professor Peter Styles, Dr Ian Stimpson, Dr Nigel Cassidy Dr Jamie Pringle, Dr Sam Toon, and a range of research staff who offer ultra‐high resolution geophysical techniques and numerical modelling in Environmental, Geodynamic, Hydrocarbon and Archaeological areas. Expertise covers fuel cells, clean energy, biomass utilisation, pollution control, waste management, green chemistry, clean and innovative utilisation of coal, involving academic and commercial links throughout the world. They have extensive expertise in the imaging of a parameter space, using techniques that transcend disciplines and c lly well be applied from geological to human bodies. an equa

Objectives of the 3ME Initiative are to:

1. Create an interdisciplinary environment and culture that enables Keele researchers to work together in small groups on new common interest areas

2. Host international senior research visitors to enhance the research skills of Keele and the UK's capability in medical engineering

3. Invest t up new key col e medical engineering projects o start laborativ

Beneficiaries of the 3ME Initiative will be:

1. Clinicians seeking new and cost‐effective treatments for human diseases that would benefit from tissue and cell engineered interventions, eg orthopaedic replacements using the patient's own laboratory grown tissues

2. Those patients' quality of life as a result of successful interventions

3. Industry supplying products and services to support clinical use of medically engineered solutions, and the ultimate growth of the UK research and manufacturing base in Medical Engineering.

4. Engineering researchers at a wider level, including the next generation of students seeking to apply engineering solutions to healthcare problems.

3

5. Mathematics researchers through application of modelling to novel, relevant fields.

6. Geophysics researchers through the mutual development of modelling and imaging techniques.

The 3ME Initiative is specifically intended to generate at least two new funded projects and a range of grant applications to the Research Councils and the European Commission, and further strengthen Keele's links with the UK Medical Engineering industry.

4

Venue

De Vere Wychwood Park

The 3ME Initiative Workshop is being held in the Wychwood Suite which is located in the Golf Club House.

The Drinks Reception will be held at the Bar Vista Bar in Wychwood Park Hotel and will be ollowed by Dinner. f

5

Plan of Complex

6

Program

Monday 4th of July 2011

10:00 Registration & Refreshments

Sessio Future Directions: Interactions with the ‘other side’ of campus

10:30 The journey from bench to bedside is long and windy: using implementation theory to make this journey easier

n I

Prof Bie Nio (Pauline) Ong, Professor of Health Services Research, Arthritis Research UK Primary Care Centre, Keele University

11:30 Interdisciplinary Research ESRC programme Prof Andrew Dobson, Professor of Politics, Research Institute for Law, Politics and Justice, Keele University

12:00 Refreshments

12:30 The Future of Bridging the Gaps Prof Alicia J. El Haj, Chair of Cell Engineering & Mr Mark Smith, Research Institute Manager, ISTM, Keele University

o m Discussion 13:00 Open F ru

13:30 Lunch

Session 3ME Outcomes s – Review of projects past and present from 3ME

II 14:30 Poster Display

15:30 Refreshments

16:00 Breakout Groups

Session Future Directi III ons: Discussions 17:00 Road Mapping

17:30 Driving Range

eception 18:30 Drinks R

9:30 Dinner 1

7

REF and beyond, Tuesday 5th July 2011

09.00 09.30

Registration & Coffee Introduction to the Day

Prof Gordon Ferns, RI Director, Institute for Science & Technology in Medicine (ISTM)

Sessi n09.45

o I: Postgraduate Training Future PG Training and Administration Prof Trevor Greenhough Postgra Coffee

duate Research Director (ISTM)

10.30

Sessi n10.50

o II: REF 2014 Background to REF Mr Mark Smith, RI Manager, Institute for Science & Technology in Medicin ISTM REF current position

e (ISTM)

11.10 PS

rof Gordon Ferns, RI Director, Institute for cience & Technology in Medicine (ISTM)

Sessi n11.30

o III: Key Guest Speakers Publishing in Nature Journal Dr Nicola McCarthy, Chief Editor Nature Reviews Cancer NIHR Programmes

Journal

12.15 Dr David Cox Deputy Director – Research Faculty Departm Lunch

ent of Health

13.00

Sessio13.45

n IV: Building External Links MRC Priorities and Opportunities Morven Roberts Programme Manager for Global Health and Trials, Infection and Immunity oard BMedical Research Council (MRC) Developing Future Collaborations 14.30 Iain Comley Business Development Director AstraZeneca

tancy 15.15

15.45

ConsulPeter HoCoffee

oper / Richard Toon Research & En erprise Services Keele University t

Resear16.00

ch T ates heme Updrof Alicia ElP Haj, Dr David Furness , Prof Go Hamilton & Prof Simon Davies rdon

17.00 Day Close

at Shaffers, 60 Snowhill, Shelton Dinner18.00 www.shaffers.co.uk

20.30 Close

8

http://www.shaffers.co.uk/

Future Directions Workshop Delegates

Staff

Dr Nigel Cassidy e physics Senior Lecturer in Applied G o

Telephone: 01782 733180

E‐mail: [email protected]

Selected Publications

• Crocco L, Soldovieri F, Millington T, Cassidy NJ. 2010. BISTATIC TOMOGRAPHIC GPR MAGN IMAGING FOR INCIPIENT PIPELINE LEAKAGE EVALUATION. PROG ELECTRO

RES, vol. 101, 307‐321. • Pringle JK, Cassidy NJ, Styles P, Stimpson IG, Toon SM. 2010. Training the next

lving generation of near‐surface geophysicists: team‐based, student‐led, problem‐sofield exercises, Cumbria, UK. NEAR SURF GEOPHYS, vol. 8(6), 503‐517.

• Crocco L, Prisco G, Soldovieri F, Cassidy NJ. 2009. Early‐stage leaking pipes GPR monitoring via microwave tomographic inversion. JOURNAL OF APPLIED GEOPHYSICS (vol. 67, pp. 270‐277). ELSEVIER SCIENCE BV.

• Cassidy NJ. 2009. Electrical and Magnetic Properties of Rocks, Soils and Fluids. In Ground Penetrating Radar: Theory and Applications. Jol HM (Ed.). Elsevier.

• Cassidy NJ. 2009. Ground Penetrating Radar Data Processing, Modelling and Analysis. In Ground Penetrating Radar: Theory and Applications. Jol HM (Ed.). Elsevier.

Research Interests:

My research involves the application of engineering and geophysical methods for the characterisation, investigation and remediation of environmental, geological, hydrological, archaeological, forensic and geotechnical problems and spend most of my research time on the development of practical, non‐invasive site investigation and numerical modelling tools for industry and academia.

• hematical modelling in the interpretation of near‐surface ground The application of mat

• penetrating radar. KAGe Supercomputer

• Merapi NERC Project

9

mailto:[email protected]

Dr Charles Day Lecturer in Computing

Telephone: 01782 733411

Email: [email protected]

Selected Publications:

• Austin JC, Day CR, Kearon AT, Evans DL, Haycock PW. 2010. Comparison method to ol. differentiate between painted objects using polychromatic X‐rays. INSIGHT, v

52(3), 140‐143. • Day CR, Austin JC, Butcher JB, Haycock PW, Kearon AT. 2009. Element‐specific

&E INT, determination of X‐ray transmission signatures using neural networks. NDTvol. 42(5), 446‐451.

• Austin JC, Day CR, Kearon AT, Haycock PW. 2009. Single element mapping inradiography. X‐RAY SPECTROM, vol. 38(6), 492‐504.

• Malhotra S, Pandyan AD, Day CR, Jones PW, Hermens H. 2009. Spasticity, an impairment that is poorly defined and poorly measured. Clin Rehabil, vol. 23(7), 651‐658.

• Austin JC, Day CR, Kearon AT, Valussi S, Haycock PW. 2008. Characterisation of metallic powder impregnated pastes using polychromatic X‐radiography. INSIGHT, vol. 50(10), 550‐553.

Research Interests:

Computational modelling and evaluation of human perception: vision, audition, speech processing. Data mining of very large datasets (e.g. astrophysical surveys of the night sky, electromagnetic surveys of the built environment etc.). Intelligent decision support for NHS clinicians trying to identify/treat patients with conditions such as colo‐rectal cancer or stroke. Investigator on an EPSRC funded project using neural networks to identify selected hemical elements via their x‐ray signatures. c

Professor Andrew Dobson for Law, Politics and Justice Professor of Politics, Research Institute



ebsite for a full list of his publications and CV: Please view Professor Dobson’s w

http://www.andrewdobson.com/

Research Interests:

My sre earch is in two fields:

1. Democratic theory – particularly in relation to democracy and listening. 2. Environmental political theory, with particular reference to the relationship between

‘ecologism’ and other modern political ideologies, and to the tensions between

10



http://www.andrewdobson.com/

environmental sustainability as a social objective, and other objectives such as deepening democracy and increasing social justice.

Prof Alicia El Haj eme Lead in Bioengineering & Therapeutics, ISTM Chair of Cell Engineering & Th

Telephone: 01782 554605


Publications:

• AYDIN, H.M., HU, B., SULÉ SUSO, J., EL HAJ, A. and YANG, Y. (2011) Study of tissue engineered bone nodules by Fourier transform infrared spectroscopy. Analyst, 136(4):775‐80.

• THEN, K.Y, YANG, Y., AHEARNE, M. and EL HAJ A.J. (2011) Effect of microtopographical cues on human keratocyte orientation and gene expression. Curr Eye Res, 36(2):88‐93.

• BÖLGEN, N., YANG, Y., KORKUSUZ, P., GÜZEL, E., EL HAJ, A.J. and PIŞKIN, E. (2010) 3D ingrowth of bovine articular chondrocytes in biodegradable cryogel scaffolds for cartilage tissue engineering. J Tissue Eng Regen Med. [Epub ahead of print]

• KANCZLER, J., SURA, H., MAGNAY, J. OREFFO, R., GREEN, D., DOBSON, J. and EL HAJ, A. J. (2010) Controlled Differentiation of Human Bone Marrow Stormal Cells Using Magnetic Nanoparticle Technology. Tissue Engineering 16(10):3241‐50.

• EL HAJ, A.J. and CARTMELL, S.H. (2010) Bioreactors for bone tissue engineering. Proc. IMechE, Part H: J. Engineering in Medicine, 224 (H12), 1523‐1532.

• AHEARNE, M., WILSON, S. L., LIU K., RAUZ S., EL HAJ A. J. and YANG Y., (2010) Influence of cell and collagen concentration on the cell‐matrix mechanical relationship in a corneal stroma wound healing model. Experimental Eye Research, 91(5): 584‐591.

• NGUYEN, V.B., WANG, Q.G., KUIPER, N.J., EL HAJ, A. J., THOMAS, C.R. and ZHANG, Z. (2010) Biomechanical properties of single chondrocytes and chondrons determined by micromanipulation and finite element modelling. J. R. Soc. Interface7(53):1723‐1735.

• WANG, Q.G., NGUYEN, B. C., THOMAS, R., ZHANG, Z., EL HAJ, A.J. and KUIPER, N.J. (2010) Molecular profiling of single cells in response to mechanical force: comparison of chondrocytes, chondrons and encapsulated chondrocytes. Biomaterials, 31(7): 1619‐1625.

• BAAS, E., KUIPER, J. YANG, Y. WOOD, M. A. and EL HAJ, A.J. (2010) In vitro bone growth nal of responds to local mechanical strain in three‐dimensional polymer scaffolds. Jour

Biomechanics, 43(4): 733–739. • AHEARNE, M., LIU, K.K., EL HAJ, A.J., THEN, K.Y., RAUZ, S., YANG, Y. (2010) Online

l Monitoring of the Mechanical Behaviour of Collagen Hydrogels: Influence of CorneaFibroblasts on Elastic Modulus. Tissue Eng Part C Methods, 16(2): 319‐327.

• ARAUJO, J.V., CUNHA‐REIS, C., RADA, T., ALVES, D.A., SILVA, M., GOMES, M., YANG, Y., ASHAMMAKHI, N., REIS, R.L., EL HAJ, A.J., NEVES, N.M. (2010) Dynamic culture of osteogenic cells in biomimetically coated poly(caprolactone) nanofibre mesh constructs. Tissue Eng Part A, 16(2):557‐563.

11


• WHITELEY, N.M., MAGNAY, J.L., MCCLEARY, S.J., NIA, S.K., EL HAJ, A.J. and ROCK, J. (2010) Characterisation of myosin heavy chain gene variants in the fast and slow

iol, muscle fibres of gammarid amphipods. Comp Biochem Physiol A Mol Integr Phys157(2):116‐22.

• ZHANG, H., CHEN, N.H., EL HAJ, A. J. and LIU, K.K. (2010) An optical‐manipulation technique for cells in physiological flows. J Biol Phys, 36 (2):135‐143.

• JONES, G.L, WALTON, R., CZERNUSZKA, J., GRIFFITHS, S.L., EL HAJ, A.J. and CARTMELL, ite S.H. (2010) Primary human osteoblast culture on 3D porous collagen‐hydroxyapat

scaffolds. Journal of Biomedical Materials Research Part A.94A(4):1244‐1250 • YANG, Y., IFTIMIA, A., JIA, Y.L., GOULD, T., EL HAJ, A.J. and WANG, R.K.K. (2010) The

study of effects of pore architecture in chitosan scaffolds on the fluid flow pattern by Doppler OCT. Optics in Tissue Engineering and Regenerative Medicine IV, 7566 (19):Art No. 75660J

Research:

Professor El Haj is the Research Director of an EPSRC Doctoral Training Centre in Regenerative Medicine with the aim of training 50 new PhDs in the stem cell field and is one of the co‐directors of the new EPSRC Centre for Innovative Manufacturing Centre in Regenerative Medicine, both run jointly with Loughborough and Nottingham Universities. She has published over a 100 publications in the area of cell and tissue engineering with an emphasis on engineering solutions for controlling stem cell behaviour and new orthopaedic repair strategies using novel enabling technology approaches with funding from the EPSRC, BSRC, Wellcome and EU Framework. B

Professor Gordon Ferns Professor of Metabolic Medicine; Consultant in Clinical Biochemistry;

me t & Associate Medical Director, North Staffordshire NHS Research & Develop n

s North Clinical Local Research Network Clinical Director, West Midland

Telephone: 01782 554718



• Smith D, Spaněl P, Fryer AA, Hanna F, Ferns GA. 2011. Can volatile compounds in l. exhaled breath be used to monitor control in diabetes mellitus?. J Breath Res, vo

5(2), 022001. • Alshammari E, Shafi S, Nurmi‐Lawton J, Taylor A, Lanham‐New S, Ferns G. 2010.

Altered antioxidant and trace‐element status in adolescent female gymnasts. Int J Sport Nutr Exerc Metab, vol. 20(4), 291‐298.

• Borai A, Livingstone C, Shafi S, Zarif H, Ferns G. 2010. Insulin sensitivity (Si) assessment . in lean and overweight subjects using two different protocols and updated software

Scand J Clin Lab Invest, vol. 70(2), 98‐103. • Borai A, Livingstone C, Farzal A, Kholeif M, Wang T, Ferns G. 2010. Reproducibility of

HOMA and QUICKI among individuals with variable glucose tolerance. Diabetes Metab, vol. 36(3), 247‐249.

12


• Borai A, Livingstone C, Ghayour‐Mobarhan M, Abuosa A, Shafi S, Mehta S, Heidari A, Emadzadeh A, Wark G, Ferns G. 2010. Serum insulin‐like growth factor binding protein‐1 (IGFBP‐1) phosphorylation status in subjects with and without ischaemic heart disease. Atherosclerosis, vol. 208(2), 593‐598.

Research Interests:

Professor Ferns' research and clinical interests include the causes and management of corona isorders: ry heart disease and other metabolic d

• Dietary management of coronary risk • Cellular mechanisms of atherogenesis

d antioxidants in dise• nt of Dyslipidaemia • ase Trace elements anClinical manageme

• Insulin resistance

Dr Alan Harper Lecturer in Bioscience, ISTM

Telephone: 01782‐554600



• Sage SO, Mason MJ & Harper AGS. Monitoring the intracellular store Ca2+ ). J concentration in agonist‐stimulated, intact human platelets using Fluo‐5N (2011

Thromb Haemost. Article in Press • Harper MT, Mason MJ, Sage SO & Harper AGS (2010). Phorbol ester‐evoked Ca2+

vel signaling in human platelets is via autocrine activation of P2X1 receptors, not a nonon‐capactitative Ca2+ entry. I Thromb Haemost 8, 1604‐1613.

• Harper AGS, Mason MJ & Sage SO (2009). A key role for dense granule secretion in an potentiation of the Ca2+ signal arising from store‐operated calcium entry in hum

platelets. Cell Calcium 45, 413‐420. • Harper AGS, Brownlow SL & Sage SO (2009). A role for TRPV1 in agonist‐evoked

activation of human platelets. J Thromb Haemost 7, 330‐338. • Harper AGS & Sage SO (2007). A key role for reverse Na+/Ca2+ exchange influenced by

the actin cytoskeleton in store‐operated Ca2+ entry in human platelets: evidence against the de novo conformational coupling hypothesis. Cell Calcium 42, 606‐617.

Research Interests:

My research interests lie in the calcium signalling mechanisms that control the activation and aggregation of human platelets in responses to physiological stimuli. These calcium signals are crucial to allow platelets to clot upon damage to the blood vessel wall. However platelets can also be triggered to clot inside intact, inflamed blood vessles. This aberrant clotting can lead to a person suffering from deep vein thrombosis, pulmonary embolism, heart attack and stroke. These cardiovascular disorders are the main cause of death in adults in the United Kingdom. Therefore understanding the calcium signalling mechanisms of platelets may allow us to identify novel targets for drugs to help prevent this unwanted platelet activity.

13


Calcium signalling is the result of a complex interplay between a number of direct and indirect factors that can affect the flux of calcium into and out of the cytosol, therefore solely interpreting data measuring the cytosolic calcium concentration can lead to incorrect conclusions to how this signal was brought about (Harper & Sage, 2007; Harper et al.,2009; Harper et al., 2010; Sage et al., 2011). Therefore my research has become interested in developing and utilising a systems‐level analysis of platelet calcium signalling in which all the factors that can influence platelet cytosolic calcium concentration are systematically measured. We believe this methodology will help us more reliably decode the mechanisms by which calcium signals are shaped in these cells. We want to develop this systems‐level analysis further, and in the future we hope to use it to further delineate the calcium signalling system of platelets from healthy individuals, as well as to help identify areas of the calcium signalling system which are dysregulated in situations where platelet calcium signalling is known to be abnormal such as in patients suffering from diabetes mellitus, hypertension and stroke.

Dr Catriona Kelly Lecturer in Bioscience , ISTM

Telephone: 01782 734658



• Kelly C, Shields MD, Elborn JS, Schock BC. (2011), A20 regulation of NF‐kB: Perspectives for inflammatory lung disease. AJRCMB. E‐pub

• Kelly C, McClenaghan NH, Flatt PR. (2011). Role of islet structure and cellular interactions in the control of insulin secretion. Islets (In Press)

• Kelly C, Williams MT, Elborn JS, Ennis M, Schock BC. (2010). A20 Regulation of Inflammation in the Cystic Fibrosis Epithelium. Pediatr Pulmonol 45(S33): 255

• Kelly C, Buchanan PJ, Bingham A, Elborn JS, Schock BC. (2010). The role of Endo‐Lysosomal degradation in Toll‐Like Receptor driven inflammation in the CF epithelium. Pediatr Pulmonol 45(S33): 245

• Kelly C, Guo H, McCluskey JT, Flatt PR, McClenaghan NH. (2010) Comparison of Insulin Release From MIN6 Pseudoislets and Pancreatic Islets of Langerhans Reveals Importance of Homotypic Cell Interactions. Pancreas. 39(7):1016‐23.

• Kelly C, Guo H, McCluskey JT, Flatt PR, McClenaghan NH. (2010) Establishment of a heterotypic pseudoislet model to study the role of glucagon and somatostatin‐secreting cells on insulin release. Diabetes, Metabolism Research and Reviews. 6(7):525‐33

• Kelly C, Flatt PR, McClenaghan NH. (2010). Cell‐to‐cell communication and cellularenvironment alter the somatostatin status of delta cells. BBRC 399(2):162‐166.

• Persaud SJ, Arden C, Bergsten P, Bone AJ, Brown J, Dunmore S, Harrison M, Hauge‐Evans A, Kelly C, King A, Maffucci T, Marriott CE, McClenaghan N, Morgan NG, Reers C, Russell MA, Turner MD, Willoughby E, Younis MYG, Zhi ZL, Jones PM (2010). Pseudoislets as primary islet replacements for research: Report on a symposium at King's College London, London UK. Islets 2(4): 236 ‐ 239

14


Research Interests:

My research interests are in inflammatory lung diseases such as Cystic Fibrosis and asthma and in particular, the molecular defects that lead to uncontrolled inflammation in these diseases. The work seeks to identify novel genetic predictors of inflammation in chronic airways disease at the earliest possible stage in an attempt to predict disease development and inform treatment regimes. A primary focus of the work is how the regulation of the NF‐kB pathway is altered and how this contributes to disease progression and severity.

Dr Theocharis Kyriacou AM Lecturer in Computing, EPS

Telephone: 01782 733080



• Kyriacou, T., Using an Evolutionary Algorithm to Determine the Parameters of a Biologically Inspired Model of Head Direction Cells, Journal of Computational Neuroscience, accepted in 2011, to appear.

• Kyriacou T. 2011. An Implementation of a Biologically Inspired Model of Head Direction Cells on a Robot. Towards Autonomous RObotic Systems (TAROS) 2011.

• Major L, Kyriacou T, Brereton P. 2011. Simulated Robotic Agents As Tools To Teach ent Introductory Programming. International Technology, Education and Developm

Conference (INTED 2011) (pp. 3837‐3846). Valencia, Spain. • Major L, Kyriacou T, Brereton OP. 2011. Systematic Literature Review: Teaching

Novices Programming Using Robots. Evaluation and Assessment in Software Engineering (EASE 2011). Durham, UK.

• Kyriacou T, Iglesias R, Rodríguez M, Quintía P. 2010. Unsupervised Complexity Reduction of Sensor Data for Robot Learning and Adaptation. Towards Autonomous

RObotic Systems (TAROS) 2010. Plymouth, UK. • OS T. Kyriacou, P. Styles, and S. Toon. Robot localization using seismic signals. In TAR

2008 Towards Autonomous Robotic Systems, Edinburgh, United Kingdom, 2008. • T. Kyriacou, U. Nehmzow, R. Iglesias, and S.A. Billings. Accurate robot simulation

through system identification. Robotics and Autonomous Systems, 56(12):1082‐1093, 2008.

Research Interests:

My research interests lie in fields of robotics, human‐computer interaction, computer vision, modelling of complex (non‐linear) systems, data mining and effective methods for teaching computer programming. More recently I have become interested in biologically inspired robotics and more particularly with biological mechanisms of navigation.

15


Dr KaPo Lam AM Lecturer in Computing, EPS

Telephone: 01782 734110



• Pijanka J, Sockalingum GD, Kohler A, Yang Y, Draux F, Parkes G, Lam KP, Collins D, Dumas P, Sandt C, van Pittius DG, Douce G, Manfait M, Untereiner V, Sulé‐Suso J. 2010.

n Synchrotron‐based FTIR spectra of stained single cells. Towards a clinical applicatioin pathology. Lab Invest, vol. 90(5), 797‐807.

• Lam KP, Austin JC, Day CR. 2007. A coarse‐grained spectral signature generator ‐ art. no. 63560S. In D. Fofi & F. Meriaudeau (Eds.). Eight International Conference on Quality Control by Artificial Vision (vol. 6356, p. S3560). SPIE‐INT SOC OPTICAL ENGINEERING.

• Lam KP. 2007. Towards a practical differential image processing approach of change detection. In T. Sobh, K. Elleithy, A. Mahmood & M. Karim (Eds.). INNOVATIVE

ALGORITHMS AND TECHNIQUES IN AUTOMATION, INDUSTRIAL ELECTRONICS ANDTELECOMMUNICATIONS (pp. 229‐234). SPRINGER.

• Lam KP. 1999. A component‐based design for parallel moment generators. In H. Shi & PC. Coffield (Eds.). PARALLEL AND DISTRIBUTED METHODS FOR IMAGE PROCESSING III (vol. 3817, pp. 137‐145). SPIE‐INT SOC OPTICAL ENGINEERING.

• Lam KP. 1998. High‐performance thresholding with adaptive equalisation. In HC. Shi & PC. Coffield (Eds.). PARALLEL AND DISTRIBUTED METHODS FOR IMAGE PROCESSING II (vol. 3452, pp. 148‐157). SPIE‐INT SOC OPTICAL ENGINEERING.

Research interests:

My research interests are in parallel algorithms and distributed multimedia/visual information processing. They have led to research track record exemplified in the following work:

Parallelisation of machine vision algorithms (vision cone model), including the adaptation of pattern matching techniques (Smith‐Waterman) for protein and DNA sequence database analysis on massively parallel platforms in collaboration with Edinburgh university and the AFRC (now BBSRC).

Prototypes development of high performance/concurrent computational architectures for document imaging funded under the UK/DTI AXON Initiative jointly with the Royal Mail (Future Technologies Group).

Overseas travel grants (jointly by the Royal Society and RAE) for work on the SPIE conference series in Parallel and Distributed Methods in Image Processing I‐IV ‐ c.f. Special Issues in Parallel Computing, Vol 7‐8, 2003, Elsevier Science.

Pervasive computing technology in an EPSRC funded joint project concerning the development of an embedded detection system and associated instrumentation for element specific x‐ray imaging.

16


Dr Shailesh Naire PS M Lecturer in Mathematics, E A

Telephone: 01782733268



• Naire S. 2009. Dynamics of voluntary cough maneuvers: a theoretical model. J BiomechEng, vol. 131(1), 011010.

• Whittaker RJ, Booth R, Dyson R, Bailey C, Parsons Chini L, Naire S, Payvandi S, Rong Z, Woollard H, Cummings LJ, Waters SL, Mawasse L, Chaudhuri JB, Ellis MJ, Michael V, Kuiper NJ, Cartmell S. 2009. Mathematical modelling of fibre‐enhanced perfusion inside a tissue‐engineering bioreactor. J Theor Biol, vol. 256(4), 533‐546.

• King AA, Cummings LJ, Naire S, Jensen OE. 2007. Liquid film dynamics in horizontal andtilted tubes: Dry spots and sliding drops. PHYS FLUIDS, vol. 19(4), Article 042102.

• n Jensen OE and Naire S. 2006. The spreading and stability of a surfactant‐laden drop oa prewetted substrate. J FLUID MECH, vol. 554, 5‐24.

• Naire S and Jensen OE. 2005. Epithelial cell deformation during surfactant‐mediated airway reopening: a theoretical model. J APPL PHYSIOL, vol. 99(2), 458‐471.

Research Interests:

My research interests lie in continuum mechanics of problems related to industry, biology and physiology, and specifically, problems involving strong fluid‐structure interaction and free boundaries. I am interested in mathematical modelling and in using asymptotic and numerical techniques to solve these problems. I have investigated problems in pulmonary mechanics involving lung airway reopening, cough manoeuvres and mucus transport, surfactant effects in thin‐film fluid dynamics such as in drop spreading and foam drainage. More recently, I have been involved in mathematical modelling in tissue engineering with researchers in the Institute of Science and Technology at Keele with researchers in the Institute of Science and Technology at Keele and the Robert Jones and Agnes Hunt Orthopaedic hospital in Oswestry. Projects related to this have been internally funded by the ME‐ Bridging the Gaps initiative between EPSAM and ISTM. 3

Dr Kehoe Oksana ISTM/RJAH

Telephone: 01691 404149

ksana.kehoeE‐mail: o @rjah.nhs.uk

A list of Publications and Research Interests can be provided on request

17



Professor Pauline Ong s Research, Arthritis Research UK Primary Care Centre Professor of Health Service

Telephone: 01782 734708



A list can be provided on request

Research Interests:

• Experience of pain

•

• Health needs assessment User involvement

• etween qualitative and quantitative research Relationship b• Health policy

Dr Sharon Owen ISTM/RJAH

Telephone: 01691 404660

[email protected]‐mail: s


Dr Dhaya Perumal ISTM

.Perumal@ki on.ac.ukE‐mail: d ngst


18




Dr Paul Roach ll Engineering, ISTM Lecturer in Biomedical / Ce

Telephone: 01782 555226



• ROACH P and Alexander MR. 2010. Plasma Polymers for the Chemical Modification of 3D Scaffolds. In Methods in Bioengineering: 3D Tissue Engineering. Berthiaume F and Morgan J (Eds.). Artech House Publishers.

• trol of ROACH P, Parker T, Gadegaard N, Alexander MR. 2010. Surface strategies for conneuronal cell adhesion: A review. Surface Science Reports, vol. 65(6), 145‐173.

• ROACH P, Bender F, Papadakis G, Tsortos A, Newton M, McHale G, Gizeli E. 2009. Development of a combined surface plasmon resonance/surface acoustic wave device

l. for the characterization of biomolecules. Measurement Science and Technology, vo20(12).

• ROACH P, Koe Y, De Mello AJ, McHale G, Newton MI, Shirtcliffe NJ. 2008. Nano‐scale ‐superhydrophobicity: suppression of protein adsorption and promotion of flow

induced detachment. Lab on a Chip, vol. 8(4), 582‐586. • ROACH P, Shirtcliffe NJ, Newton MI. 2008. Progess in superhydrophobic surface

development. Soft Matter, vol. 4(2), 224‐240.

Research Interests:

My research interests lie at the boundary between chemistry, physics and biology with my main focus towards understanding and developing materials and sensors for biomedical applications. My particular interest is in the design and fabrication of surfaces to invoke desired biological responses. These surfaces have defined characteristics, including but not limited to, nano/ micro topographic features, chemistry and compliance.

Surface cues can be used to control cell adhesion and proliferation as well as protein adsorption characteristics. Well defined topography from micron sized grooves that can constrain growth guidance of cells, to nano‐scale topography on the same length scales as protein molecules themselves can be engineered. The addition of and overlayer of chemistry and/or surface layer stiffness gives an additional complexity to the degree of control over biological responses. Mechanical and electrical stimuli may also be incorporated to enhance tissue growth.

19


Dr Frank Rutten tr , EPSAM Lecturer in Physical Chemis y

Telephone: 01782 733521



• Rutten FJM, Briggs D, Henderson J, Roe MJ. 2009. THE APPLICATION OF TIME‐OF‐FLIGHT SECONDARY ION MASS SPECTROMETRY (ToF‐SIMS) TO THE CHARACTERIZATION OF OPAQUE ANCIENT GLASSES*. ARCHAEOMETRY, vol. 51, 966‐986.

• Gadegaard N, Chen XY, Rutten FJM, Alexander MR. 2008. High‐energy electron beam . lithography of octadecylphosphonic acid monolayers on aluminum. LANGMUIR, vol

24(5), 2057‐2063. • Rutten FJM, Tadesse H, Licence P. 2007. Rewritable imaging on the surface of frozen

ionic liquids. ANGEW CHEM INT EDIT, vol. 46(22), 4163‐4165. • Ratcliffe LV, Rutten FJM, Barrett DA, Whitmore T, Seymour D, Greenwood C, Aranda‐

Gonzalvo Y, Robinson S, McCoustra M. 2007. Surface analysis under ambient L conditions using plasma‐assisted desorption/ionization mass spectrometry. ANA

CHEM, vol. 79(16), 6094‐6101. • RUTTEN FJM, Chalmers JM, Chesters MA, Tobin MJ. 2004. Infrared microscopy of

epithelial cancer cells in whole tissues and in tissue culture, using synchrotron radiation. Faraday Discussions, vol. 126, 27‐39.

Research Interests:

My diverse research projects all revolve around the detailed chemical characterisation of surfaces (presence as well as distribution of constituents) through advanced analytical techniques including Time‐of‐Flight Secondary Ion Mass Spectrometry (ToF‐SIMS) and an exciting new technique developed together with colleagues from Nottingham and Heriot‐Watt universities termed PADI‐MS (plasma‐assisted desorption‐ionisation mass spectrometry). As stand‐alone techniques both can be very powerful, but more often than not the application of other, complementary techniques is crucial to fully elucidate complex surface chemical issues. I therefore complement surface mass spectrometry with vibrational spectroscopy (IR and Raman) as well as X‐ray photoelectron spectroscopy (XPS). The chemical properties of surfaces are crucial in a wide range of processes. Some key applications, in collaboration with a range of research groups, are highlighted below.

I have always been very interested in archaeology and combine this with my knowledge of materials chemical characterization in collaboration with Professors Julian Henderson and David Briggs from The University of Nottingham – see publication list below. The aim of this work is to use the very powerful analytical techniques developed for surface analysis to answer key archaeological questions such as how and where certain objects were made and what materials were used. This in turn can give very valuable information not otherwise available, which will helps us to better understand ancient societies and their often surprisingly sophisticated manufacturing technologies.

20


A very exciting research project with Dr Peter Licence from the University of Nottingham has led to the selection of a paper as “Hot Topic” in Angewandte Chemie International Edition and was reported on by Nature (as a Research Highlight), Chemical and Engineering News (American Chemical Society) and Chemistry World (Royal Society of Chemistry). Research on this topic is ongoing.

Mr Mark Smith , I TM Research Institute Manager S

Telephone: 01782 555234


Publications and recent Conference Presentations:

• Ashmore C & Smith M (2010) Summarising medical research for a lay audience – what n do grant funders expect?; poster presentation at Qualilty Counts ‐ Leighton Exhibitio

2010, Leighton Hospital, Cheshire, November 2010 • Smith M & Ashmore C (2010) The Lay Summary in medical research proposals – is it

becoming more important?; poster presentation at Making an Impact ‐ Annual Conference of the Association of Research Managers and Administrators, Manchester, June 2010 (The Lay Summary in Medical Research poster 2010 pdf)

• ds Smith M (2009) The Lay Summary in Medical Research ‐ why and wherefore; MidlanMedicine Vol 25 no 5 pp191‐195 ISBN‐0269‐9796 May 2009

• Bilsbrough N & Smith M E (2008) The Challenges of running a Research Institute or Centre; presented to Exploring Similarities ‐ 2nd international conference of INORMS, Liverpool, June 2008.

Research Interests:

My role in ISTM is in supporting the research of approximately 70+ academic and clinical staff, 30+ research assistants and fellows, and up to 100 research students. To maintain our current level of activity we need to collectively achieve a grant income of around £4million per year alongside our HEFCE block grant for research, based on consistent performance in the RAE/REF assessment exercises every 5 years or so. So in fact my main role is in helping colleagues navigate their way through the fund‐raising process for grants, studentships, equipment, etc.

Research Grants held as Principal Investigator:

• BBSRC/EPSRC EP/P501237/1 Dorothy Hodgkin Postgraduate Award Oct 2005 to Sept 2009: £37,500 "Functional analysis of alternately spliced variants in cancer" (Dr P Hoban)

• MRC/EPSRC EP/P503019/1 Dorothy Hodgkin Postgraduate Award Oct 2007 to Sept 2011: £45,000 "Investigation of gene‐smoking interactions in rheumatoid arthritis" (Dr D Mattey)

• MRC/EPSept 2

SRC EP/P504546/1 Dorothy Hodgkin Postgraduate Awards (x2) Oct 2008 to 012: £90,000

o "Peritoneal dialysis and the evaluation of fluid status in advanced renal failure" (Prof S Davies)

21


o "Exploring Progenitor Cell Regeneration Methods for the Repair of Lung Fibrosis" (Prof M Spiteri, Dr N Forsyth)

Professor David Smith ics ISTM Professor of Chemical Phys ,

Telephone: 01782 555228


Selected Journal Publications

(Prof David Smith has published some 350 research and review papers, including approx 90 since 2001. Below is a comprehensive set of references from 2006 onwards and a selection from 200105).

• David Smith, Patrik Španel, Beth Enderby, Warren Lenney, Claire Turner and Simon J Davies Isoprene levels in the exhaled breath of 200 healthy pupils within the age range 7–18 years studied using SIFT‐MS. J. Breath Res. 4 (2010) 017101 (7pp)

• Beth Enderby, David Smith, W Carroll and W Lenney Hydrogen Cyanide as a Biomarker atric for Pseudomonas Aeruginosa in the Breath of Children With Cystic Fibrosis. Pedi

Pulmonology; 44 (2009) 142–147 • Cian Chan, Christopher McIntyre, David Smith, Patrik Španel, and Simon J. Davies

in Combining Near‐Subject Absolute and Relative Measures of Longitudinal HydrationHemodialysis. Clin J Am Soc Nephrol;4 (2009) 1791–1798

• Josep Sule‐Suso, Andriy Pysanenko, Patrik Španel and David Smith.Quantification of ignant acetaldehyde and carbon dioxide in the headspace of malignant and non‐mal

lung cells in vitro by SIFT‐MS; Analyst 134 (2009) 2419–2425. • K. Dryahina, F. Pehal, D. Smith, P. Španel.Quantification of methylamine in the

headspace of ethanol of agricultural origin by selected ion flow tube mass spectrometry.International Journal of Mass Spectrometry;286 (2009) 1–6

• Andriy Pysanenko, Patrik Španel, David Smith. Analysis of the isobaric compounds propanol, acetic acid and methyl formate in humid air and breath by selected ion flow tube mass spectrometry, SIFT‐MS.International Journal of Mass Spectrometry;285 (2009) 42‐48.

• B Enderby,W Lenney, M Brady, C Emmett, P Španel, D Smith. Concentrations of some metabolites in the breath of healthy children aged 7–18 years measured using selected ion flow tube mass spectrometry (SIFT‐MS).J. Breath Res. 3 (2009) 036001 (11pp)

• David Smith, Andriy Pysanenko, Patrik Španel.The quantification of carbon dioxide in humid air and exhaled breath by selected ion flow tube mass spectrometry.Rapid Commun. Mass Spectrom. 23 (2009) 1419–1425.

• Andriy Pysanenko, Tianshu Wang, Patrik Španel and David Smith.Acetone, butanone, pentanone, hexanone and heptanone in the headspace of aqueous solution and urine studied by selected ion flow tube mass spectrometry. Rapid Commun. Mass Spectrom. 23 (2009) 1097‐1104.

22


• David Smith, Andriy Pysanenko, Patrik Španel. Ionic diffusion and mass discrimination effects in the new generation of short flow tube SIFT‐MS instruments. International Journal of Mass Spectrometry; 281 (2009) 15‐23.

• Patrik Španel, David Smith. Influence of weakly bound adduct ions on breath trace gas analysis by selected ion flow tube mass spectrometry (SIFT‐MS).International Journal of Mass Spectrometry;280 (2009) 128‐13.

Research Interests:

Physics and chemistry of ionised gases with special reference to ion‐molecule reaction.

Development of analytical instruments that exploit gas phase ionic reactions for the analysis of trace gases in air (for environmental monitoring) and breath analysis (for non‐invasive

apeutic monitoring). clinical diagnosis and ther

Current Projects include:

• Quantification of metabolites in breath of patients with end‐stage renal failure, pre‐ and post‐dialysis.

• ath Determination of total body water by measuring the deuterium content of single breexhalations following ingestion of D2O.

• Identifying and quantifying metabolites emitted by tumour cells, both in vivo and in vitro.

Ms Pauline Weston r, E SAM Research Institute Manage P

Telephone: 01782734339

[email protected]‐mail: p ele.ac.uk

A

list of Research Interests can be provided on request

Dr Karina W ir ght ISTM/RJAH

arina.Wright h.nhs.ukE‐mail: K @rja

A

list of Publications and Research Interests can be provided on request

23


Dr Ying Yan gISTM/RJAH

Telephone: 01782 554606



• Ahearne M, Wilson SL, Liu KK, Rauz S, El Haj AJ, Yang Y. 2010. Influence of Cell and troma Collagen Concentration on the Cell‐Matrix Mechanical Relationship in a Corneal S

Wound Healing Model. Exp Eye Res. • Aydin HM, Hu B, Suso JS, El Haj A, Yang Y. 2011. Study of tissue engineered bone

nodules by Fourier transform infrared spectroscopy. Analyst, vol. 136(4), 775‐780. • Jozwiak A, Gates MA, Liu Y, Yang Y. 2010. A novel technology and stereotactic accessory

for implanting engineered tissues, cells, and scaffold materials into the brain. Tissue Eng Part C Methods, vol. 16(3), 469‐470.

• Ashammakhi N, Wimpenny I, Nikkola L, Yang Y. 2009. Electrospinning: Methods and Development of Biodegradable Nanofibres for Drug Release. J BIOMED NANOTECHNOL, vol. 5(1), 1‐19.

• Aydin HM, El Haj AJ, Piskin E, Yang Y. 2009. Improving pore interconnectivity in polymeric scaffolds for tissue engineering. J TISSUE ENG REGEN M, vol. 3(6), 470‐476.

Research Interests:

Currently, my research interests focus on two directions: develop multifunctional scaffolds or template for regenerative medicine including novel nanofabrication techniques; explore non‐destructive online monitoring techniques for diagnosis and characterization of engineered tissues. The on‐going projects including

Establishment of full thickness corneal model for drug screening

Exploring novel nanofabrication protocols for regeneration medicine of cornea, CNS, spine, tendon

Development and characterization of new protocols for stimulation of rapid bone formation

Identification of the pathway of pathological calcification in heart valve and establishment of an in vitro calcification model for drug screening

Application of FTIR techniques as diagnostic and characterization tool for disease and regenerative tissues

Development implantable 3D neuron circuits for treatment of disorder in CNS

Development of multi‐functional scaffolds including mechano‐active scaffolds

Establishment of novel non‐destructive monitoring technique for tissue regeneration

24


PhD Students

Mr John Butcher EPSAM PhD Student

Telephone: 01782 733435


Publications:

• Butcher, J.B., Verstraeten, D., Schrauwen, B., Day, C.R. and Haycock, P.W., 2011, s data "Investigating the properties of reservoir computing for non‐linear time‐serie

analysis", In progress • Butcher, J.B., Verstraeten, D., Schrauwen, B., Day, C.R. and Haycock, P.W., 2010,

"Pruning reservoirs with random static projections", IEEE workshop on Machine Learning for Signal Processing (MLSP)

• Butcher, J., Verstraeten, D., Schrauwen, B., Day, C. and Haycock, P., 2010, "Extending reservoir computing with random static projections: a hybrid between extreme learning and RC", European Symposium on Neural Networks (ESANN)

• Butcher, J.B., Lion, M., Day, C.R., Haycock, P.W., Hocking, M.J., Bladon, S., 2009, "A Low Frequency Electromagnetic Probe for Detection of Corrosion in Steel‐Reinforced Concrete", In Grantham, M., Majorana, C. and Valentina, S. (eds), / Concrete Solutions /, pages 417 24, CRC Press ‐4

Research Interests:

My main interests lie in understanding how the many processes of the brain work in order to try and model these computationally. Modelling these processes does not only provide solutions to real‐world problems, but also has the potential to learn more about how processes in biological organs function. From this interest I went on to study recurrent neural networks for my PhD which were successfully applied to a variety of time‐series tasks including speech recognition as well as an engineering application. Now at the end of my PhD research, I am looking to use more biologically plausible models, not only to replicate functions in the brain, but also to apply them to domains such as speech recognition and obotics. r

25


Miss Angelik Fourikii PhD Student ISTM

E‐mail [email protected]

Research Synopsis:

Angeliki is completing the final year of her PhD in Keele University under the supervision of Professor Jon Dobson. Her research interest is focused on biomedical engineering and in particular on nanomagnetic gene transfection for non‐viral gene delivery on a single cells asis. b

Publications

• Journals:

Fouriki A, Farrow N, Clements M, Dobson J (2010). Evaluation of the magnetic field gnetic gene transfection. Nanoreviews 1: 5167. requirements for nanoma

• Book Chapter (in press):

Chapter 12. Nanomagnetic Gene Transfection

ticles: From fabrication to clinical applications’. For the book: ‘Magnetic Nanopar

Edited by Dr. Nguyen TK Thanh

To be published by CRC Press/Taylor and Francis in 1/1/2012.

Angeliki Fouriki1 and Professor Jon Dobson1,2 *, (1) Institute for Science and Technology in Medicine, Keele University, UK, (2) Departments of Biomedical Engineering and Materials Science & Engineering, University of Florida, USA

Mr Deepak Kumar PhD Student ISTM


Research:

A 3rd year PhD student under the supervision of Dr N R Forsyth, investigating the ability of non‐biological substrates to support the adhesion and expansion of human embryonic stem cells whilst retaining their pluripotency and their typical hESC characteristics; alongside the underlying molecular mechanisms which are encouraging this phenomena.

Publications List

• D. Kumar D, J.P. Gittings, I.G.Turner, C.R.Bowen, A.Bastilgo‐Hidalgo, S.H.Cartmell. Polarisation of hydroxyapatite: Influence on osteoblast cell proliferation. Acta Biomaterialia, 2009

• Jacek Klaudiusz Pijanka, Deepak Kumar, Tina Dale, Ibraheem Yousef, Gary Parkes, Valerie Untereiner, Ying Yang, Paul Dumas, David Collins, Michel Manfait, Ganesh Dhruvananda Sockalingum, Nicholas Robert Forsyth and Josep Sule‐Suso. Vibrational spectroscopy differentiates between multipotent and pluripotent stem cells. Analyst, 2010

26



Muhammad Aslam Rao MSc Student, ISTM


Personal Profile

I am an overseas pharmacy graduate with over five years experience in the pharmaceutical industry. I enjoy meeting new people, overcoming challenges and constantly seek to extend y knowledge by learning new skills and developing existing skills. m

Miss Abigail Rutter ISTM PhD Student


Personal profile can be provided on request. A

Mr William Smith PhD Student EPSAM


Research:

PhD Supervisor: KP Lam

Co‐supervisor: JB Richardson

Visual inspection of cells is a fundamental tool for discovery in biological science. My PhD studies concerns the investigation of computational vision procedures that seek to automate the analysis of large scale image‐based biology experiments.

A principal goal is to extract high‐quality measurements of the cells in digital microscopy mages from each sample and identify samples with phenotypes of interest. i

Publication:

• Smith WA & Lam KP, "Exploratory Analysis of UV‐Vis Absorption Spectra", IEEE/IETA er 2010 (Int'l Conf on Industrial Electronics, Technology & Automation 2010), Octob

2010. • Smith WA, Lam KP, Collins D & Tarvainen J, "Estimation of Depth Map using Image

Focus: A Scale‐Space Approach for Shape Recovery", Int'l Joint Conf on Comp, Info & Sys Sci Eng, December 2010.

27



Ryad Soobhany PhD Student EPSAM


Research:

PhD Supervisor: KP Lam

o‐supervisor: P. Fletcher C

My PhD is an industry CASE project (funded by Keele/ACORN) and pertains to the investigation of robust forensic identification techniques for portable camera sources and the classification of images generated by these devices. The research principally involves the development of reliable extraction procedures of a reference digital fingerprint of images in he form of the so‐called sensor pattern noise (SPN) of a camera. t

Publications:

• Soobhany A.R., Lam K.P. & Fletcher P. (2009)."Exploratory Visual Search of Image th , Sensor Noise in High‐Dimensional Space". 13 Information Visualization Conference

Barcelona, Spain • Soobhany A.R., Leary R. & Lam K.P. (2011). "On the performance of Li’s unsupervised

image classifier and the optimal cropping position of images for forensic investigations". International Journal on Digital Crime and Forensics, 3(1)

Mr Rupert Wright PhD Student ISTM

[email protected]‐mail: c

A list of Publications and Research Interests can be provided on request.

28



REF 2014 & Beyond Delegates

Alcock, Beryl Horrocks, Paul Bin, Hu Hubball, Emma Berkson, Rachel Kehoe, Oksana Carter, Pam Kelly, Catriona Chakravorty, Srabasti Lam, KP Chari, Divya Longshaw, Laura Chen, Ruo‐Li Maarabouni, Mirna Clement, Darren Maingon, Rhayza Comley, Iain Mattey, Derek Cox, David McCarthy, Nicola Davies, Simon Morris, Glenn Dent, Gordon Moss, Gary Driskell, Owen Redford, Amanda Dobson, Jon Richardson, Alan Dudley, Lynn Roach, Paul Eggleston, Paul Roberts, Sally El Haj, Alicia Roberts, Morven Ferns, Gordon Rotherham, Mike Fricker‐Gates, Rosemary Skidmore, Mark Fryer, Tony Smith, David Furness, Dave Telling, Neil Glazewski, Stas Tripet, Frederic Griffiths, Sarah Rooney, Angie Hamilton, Gordon Rutten, Frank Han, Jihong Smith, Mark Harper, Alan Sule‐Suso, Josep Hart, Sarah Toon, Richard Hawkins, Clive Watts, Keira Henstock, James Williams, Gwyn Hooper, Peter Yang, Ying

29

Ke ele Research News

Ages and stages research project at Keele

Researchers at Keele University are looking for people who were interviewed for the Victoria eatre's famous social documentaries or docudramas. Th

Improving honeybee health by enhancing the palatability of food supplements

An £80,00 study which aims to improve the taste of artificial diets fed to honey bees has been arded annual ‘seed‐core’ funding from the British Beekeepers Association. aw

Spinstars: the first polluters of the Universe?

An international team of astronomers, including Dr Raphael Hirschi of Keele University, has sented new clues on the nature of the first stellar generations in our Universe. pre

Swearing relieves pain but don’t overdo it

New research from Keele University has fund that swearing can relieve pain – but only for ople who swear infrequently. pe

£1million MRC award to fight malaria

The aim of £1million MRC funded project is to better understand male mosquito mating haviour, enabling new strategies to eliminate malaria. be

Keele astrophysicist in discovery of red giant and two red dwarfs

A Keele University astrophysicist is a member of an international group of European, Australian and American researchers who have reported on the discovery of a unique system stars. of

Keele research into aluminium and Alzheimer's disease

New research is being carried out at Keele university to examine links between aluminium nd Alzheimer's disease. a

30

NOTES

31

3ME Initiative Steering Group committee:

Prof. Alicia El Haj, ISTM, Keele University Prof. Graham Rogerson, EPSAM, Keele University

Prof. Jon Dobson ISTM, Keele University Prof. Peter Styles, EPSAM, Keele University Dr Nigel Cassidy, EPSAM, Keele University Mr. Mark Smith, ISTM, Keele University

Mrs Pauline Weston, EPSAM, Keele University

For any queries please contact: Mrs Maria Kyriacou

ISTM, Keele University, GHRC, Thornburrow Drive Hartshill Campus

Phone: +44 1782 554605 Fax: +44 1782 747319


The 3ME Initiative is funded by EPSRC and Keele University


3me initiative future directions - keele university · istm, keele university 13:00 open fruo m...

Documents