3rd annual global summit on...

3rd Annual Global Summit on

GENITOURINARYO CTOBER 10-13 , 2019BANFF | CANADA

MALIGNANCIES

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SUMMIT CHAIRS:Daniel Petrylak, MDYale UniversityNew Haven, CT

Charles Ryan, MDUniversity of MinnesotaMinneapolis, MN

Oliver Sartor, MDTulane Medical SchoolNew Orleans, LA


GENITOURINARY MALIGNANCIESO CTOBER 10-13 , 2019

BANFF | CANADA

NIMIRA ALIMOHAMED, MD, FRCPCClinical Associate ProfessorDepartment of OncologyCumming School of MedicineUniversity of CalgaryCalgary, Alberta, Canada

PEDRO BARATA, MD, MSC Assistant Professor of MedicineInternal Medicine/Hematology-Oncology Section/Genitourinary

Cancers Tulane Cancer CenterNew Orleans, LA

MATTHEW R. COOPERBERG, MD, MPHProfessor of Urology and Epidemiology & BiostatisticsAssociate Chair, Clinical Research, Department of UrologyHelen Diller Family Chair in UrologyUniversity of California, San FranciscoSan Francisco, CA

HAMID EMAMEKHOO, MDAssistant ProfessorUniversity of Wisconsin Carbone Cancer CenterUniversity of Wisconsin School of Medicine and Public HealthMadison, WI

ANNA C. FERRARI, MDProfessor of Medicine, OncologyAlbert Einstein College of MedicineMontefiore Medical CenterBronx, NY

TERENCE FRIEDLANDER, MDAssociate Professor of MedicineUCSF Medical CenterSan Francisco, CA

PETROS GRIVAS, MD, PHDAssociate ProfessorClinical Director of Genitourinary Cancers ProgramFred Hutchinson Cancer Research CenterUniversity of WashingtonSeattle, WA

SHILPA GUPTA, MDAssociate Professor of Medicine Genitourinary Oncology Department of Hematology and Oncology Cleveland Clinic Taussig Cancer InstituteCleveland, OH

HANS HAMMERS, MD, PHDAssociate ProfessorThe University of Texas Southwestern Medical CenterDallas, TX

CELESTIA HIGANO, MD, FACPProfessor of MedicineUniversity of WashingtonSeattle, WA

ANDREW HONG, MDInstructor of PediatricsHarvard Medical SchoolDana-Farber Cancer InstituteBoston, MA

GOPA IYER, MDAssistant AttendingGenitourinary Oncology ServiceMemorial Sloan Kettering Cancer CenterNew York, NY

ROHIT JAIN, MBBS, MPHAssistant Member, Department of Genitourinary OncologyMoffitt Cancer CenterTampa, FL

ERIC JONASCH, MDProfessor of MedicineUniversity of Texas MD Anderson Cancer CenterHouston, TX

ANIL KAPOOR, MD, FRCSCDirector, Urologic Cancer Centre for Research & Innovation Head, Genito-Urinary Oncology Program Juravinski Cancer CentreProfessor of Surgery (Urology) and OncologyMcMaster UniversityHamilton, Ontario, Canada

STACEY KENFIELD, SCDAssociate Professor of UrologyHelen Diller Family Chair in Population Science for Urologic

CancerDepartment of UrologyUniversity of California, San FranciscoSan Francisco, CA

DEEPAK KILARI, MDAssociate ProfessorMedical College of WisconsinMilwaukee, WI

JOSEPH KIM, MDAssociate ProfessorYale UniversityNew Haven, CT

FACULTY



BANFF | CANADA

NEYSSA MARINA, MDExecutive Medical DirectorSynthorxLa Jolla, CA

BENJAMIN MAUGHAN, MD, PHARMDAssistant Professor, Division of Medical OncologyHuntsman Cancer InstituteUniversity of UtahSalt Lake City, Utah

RON PECK, MDChief Medical OfficerArvinasNew Haven, CT

DANIEL PETRYLAK, MD CHAIRProfessor of MedicineCo-Director, Signal Transduction Research ProgramYale UniversityNew Haven, CT

ARPIT RAO, MDAssistant Professor, Division of Hematology, Oncology and

TransplantationChair, M Health/Fairview Oncology Quality and Safety

CommitteeUniversity of Minnesota Masonic Cancer CenterMinneapolis, MN

CHARLES RYAN, MD CHAIRProfessor of MedicineBJ Kennedy Professor of Clinical Cancer ResearchDirector, Division of Hematology, Oncology, and

TransplantationAssociate Director, Masonic Cancer CenterUniversity of MinnesotaMinneapolis, MN

OLIVER SARTOR, MD CHAIRC.E. and Bernadine Laborde Professor of Cancer ResearchMedical Director, Tulane Cancer CenterTulane Medical SchoolNew Orleans, LA

ABHISHEK SOLANKI, MDAssistant ProfessorDirector of Clinical Research & Quality Medical DirectorDepartment of Radiation OncologyStritch School of Medicine, Loyola UniversityMaywood, IL

SRIKALA SRIDHAR, MD, MSC, FRCPCAssociate ProfessorPrincess Margaret Cancer CenterToronto, Ontario, Canada

WALTER STADLER, MD, FACPFred C. Buffett ProfessorDepartments of Medicine & SurgeryDean for Clinical ResearchDeputy Director, Comprehensive Cancer CenterUniversity of Chicago Medicine & Biological SciencesChicago, IL

SUMIT SUBUDHI, MD, PHDAssistant ProfessorDepartment of Genitourinary Medical OncologyThe University of Texas MD Anderson Cancer CenterHouston, TX

WILLIAM TESTER, MD, FACP Clinical Professor of Medical OncologyMedical Director of Outpatient OperationsJefferson Sidney Kimmel Cancer CenterThomas Jefferson UniversityPhiladelphia, PA

ULKA VAISHAMPAYAN, MDChair, Division of Solid Tumor OncologyDirector of Phase I TherapeuticsKarmanos Cancer Institute Charles Martin Endowed ChairProfessor of OncologyWayne State UniversityDetroit, MI

CHRISTOPHER WEIGHT, MDDirector, Urologic Oncology FellowshipAssociate ProfessorDepartment of UrologyUniversity of MinnesotaMinneapolis, MN

ALEXANDER WYATT, PHDSenior Research ScientistVancouver Prostate CentreAssistant Professor, Department of Urologic SciencesUniversity of British ColumbiaVancouver, British Columbia, Canada

FACULTY



BANFF | CANADA

Thursday, October 10, 20195:45 PM Welcome and Introductions

KEYNOTE ADDRESS

6:00 PM GU Malignancies: Perspectives and a Peer Into the Future

Eric Jonasch

SETTING THE STAGE

Moderator: Charles Ryan 6:30 PM Can We Make Prostate Cancer a

Chronic Disease?Oliver Sartor

6:45 PM Can We Cure Metastatic Renal Cell Carcinoma?

Hans Hammers

7:00 PM How Do We Integrate New Therapies into the Treatment of Bladder Cancer?

Walter Stadler

7:15 PM Next Steps for Immunotherapy in GU Malignancies

Srikala Sridhar

7:30 PM Using Genomics to Select Patients for Organ Preservation

William Tester

7:45 PM DISCUSSION8:00 PM ADJOURN TO WELCOME RECEPTION

Friday, October 11, 20196:00 AM BREAKFAST

ADVANCES IN IMAGING AND SURGERY

Moderator: Oliver Sartor 7:00 AM Non-invasive Monitoring of Urothelial

CancersRohit Jain

7:15 AM New Perspectives in PET Imaging in Prostate Cancer

Oliver Sartor

7:30 AM Deep Learning in Kidney Cancer Imaging: How AI Will Revolutionize Kidney Cancer Care

Christopher Weight

7:45 AM DISCUSSION8:00 AM The Role of Genomic Risk in Prostate

Cancer Surveillance Matthew

Cooperberg

8:15 AM The Role of Nephrectomy in the Age of Modern Therapeutics

Ulka Vaishampayan

8:30 AM DISCUSSION8:45 AM BREAK

PROGRESS IN RENAL CELL CARCINOMA THERAPIES

Moderator: Charles Ryan 9:05 AM VEGFR TKI and PD-1/PD-L1

Combinations for First-line RCCHamid

Emamekhoo

9:20 AM Next-generation Immunotherapy in RCC Hans Hammers

9:35 AM Anti-tumor Activity of Small Molecule Glutaminase Inhibitors

Benjamin Maughan

9:50 AM How to Choose First-line Therapy for RCC

Hamid Emamekhoo

10:05 AM DISCUSSION AND CASE STUDIES

NOVEL TARGETS AND APPROACHES FOR GU MALIGNANCES

Moderator: Oliver Sartor 10:30 AM Novel Immunoconjugates in Bladder

CancerSrikala Sridhar

10:45 AM PSMA Targeted Therapies in Advanced Prostate Cancer

Oliver Sartor

11:00 AM Using Synthetic Biology to Design and Manufacture Optimized Medicines for the Treatment of Cancer

Neyssa Marina

11:15 AM DISCUSSION11:35 AM BREAK11:55 AM Targeting the DNA Repair Pathway Charles

Ryan12:10 PM Development of an Androgen Receptor

PROTAC® in Prostate CancerRon Peck

12:25 PM Targeting PTEN Loss and PI3K in Prostate Cancer Therapeutics

Pedro Barata

12:40 PM DISCUSSION1:00 PM ADJOURN

DEBATING TECHNOLOGY: IS THERE A ROLE FOR CHEMOTHERAPY IN METASTATIC CSPC?

5:00 PM Hormonal Therapy: The Future of mCSPC Treatment

Anil Kapoor

5:10 PM Chemotherapy is Not Dead in Prostate Cancer

Daniel Petrylak

5:20 PM PANEL DISCUSSION: Walter Stadler, Charles Ryan, Oliver Sartor, and Anna Ferrari

THE SPECTRUM OF DISEASE IN PROSTATE CANCER

Moderator: Oliver Sartor 5:40 PM New Perspectives in Non-metastatic

CRPCCelestia Higano

5:55 PM Defining Oligometastatic Disease in Prostate Cancer

Terence Friedlander

6:10 PM The Role of Treating the Primary in Metastatic Prostate Cancer

Matthew Cooperberg

6:25 PM Addressing Neuroendocrine Differentiation in Prostate Cancer

Nimira Alimohamed

6:40 PM DISCUSSION7:05 PM BREAK

TARGETED THERAPY IN BLADDER CANCERModerator: Daniel Petrylak

7:25 PM Neoadjuvant Therapy for Muscle Invasive Bladder Cancer

Deepak Kilari

7:40 PM Targeting FGFR in Bladder Cancer Petros Grivas

7:55 PM Sitravatinib in GU Malignancies Gopa Iyer

8:10 PM DISCUSSION AND CASE STUDIES8:30 PM ADJOURN TO POSTER RECEPTION



BANFF | CANADA

Saturday, October 12, 20196:00 AM BREAKFAST

THE ROLE OF IMMUNO AND RADIOTHERAPY

Moderator: Charles Ryan

7:00 AM Immunotherapy in Prostate Cancer Sumit Subudhi

7:15 AM Targeting the IL2 Pathway to Engage the Immune Response

Daniel Petrylak

7:30 AM DISCUSSION7:45 AM Combination Immunotherapy and

Radiotherapy in Bladder CancerAbhishek

Solanki

8:00 AM Immune Checkpoint Inhibitors and Cytokine Combinations in GU Malignancies

Rohit Jain

8:15 AM Stereotactic Body Radiation Therapy in Oligometastatic Cancer

Abhishek Solanki


LEARNING FROM GENOMICS AND BIOMARKERS

Moderator: Daniel Petrylak 9:05 AM The Relationship Between the

Microbiome and GU MalignanciesCharles

Ryan

9:20 AM Molecular Assessments of Resistance to Hormonal Therapies in Prostate Cancer

Benjamin Maughan

9:35 AM Epigenetic Modulation of Antiandrogen Resistance

Anna Ferrari

9:50 AM DISCUSSION10:10 AM Assessing Biomarkers for Bladder

CancerPetros Grivas

10:25 AM Non-invasive Genotyping and Stratification using Cell-free DNA

Alexander Wyatt

10:40 AM Utility of Circulating Tumor Cells in GU Malignancies

Terence Friedlander


TARGETING THE ANDROGEN RECEPTOR IN PROSTATE CANCER

Moderator: Oliver Sartor 11:35 AM Evolution of Androgen Receptor

Alterations During Sequential InhibitionAlexander

Wyatt

11:50 AM Role of AR-V7 in Sequencing Therapeutic Agents for CRPC

Arpit Rao

12:05 PM Strategies for Targeting the Androgen Receptor Axis in Prostate Cancer

Ulka Vaishampayan

12:20 PM Apalutamide: New Approaches and Future Directions

Anil Kapoor

12:35 PM DISCUSSION AND CASE STUDIES1:00 PM ADJOURN

SETTING THE STAGE

5:00 PM The Era of Personalized Therapy for GU Tumors

Daniel Petrylak

ADDRESSING THERAPEUTIC CHALLENGES IN GU MALIGNANCIESModerator: Oliver Sartor

5:15 PM The Potential of High-dose Testosterone: Re-sensitizing Patients to Hormonal Therapy

Pedro Barata

5:30 PM Future of mTOR Inhibitors in GU Malignancies

Joseph Kim

5:45 PM Clinical Development of PARP Inhibitors for Genitourinary Cancers

Shilpa Gupta

6:00 PM DISCUSSION

6:20 PM Progress in Pediatric Renal Tumors Andrew Hong

6:35 PM Diet and Lifestyle Modifications in Prostate Cancer

Stacey Kenfield

6:50 PM DISCUSSION

7:10 PM ADJOURN

Sunday, October 13, 20196:00 AM BREAKFAST

ORAL ABSTRACTS7:00 AM A Population Based Analysis of Incidence

and Predictors of Germline DNA Damage Repair Gene Mutations (gDDRm) in Patients with Metastatic Castration Resistant Prostate Cancer (CRPC)

Steven Yip

7:15 AM Phase II Trial of a Novel Immunotherapy Combination of Pembrolizumab and HER2Bi-armed Activated T Cells (BATS) in Metastatic Castration Resistant Prostate Cancer

Meera Patel

7:30 AM A Pilot Trial of Neoantigen Vaccine in Combination with Nivolumab/Ipilimumab and PROSTVAC in Metastatic Hormone-sensitive Prostate Cancer

Russell Pachynski

7:45 AM Outcomes of Patients with Metastatic Urothelial Cancer (mUC) and Poor Performance Status (PS) Receiving Anti-PD(L)1 Agents

Ali Khaki

8:00 AM Clinical and Immunologic Features of Immune Checkpoint Therapy (ICT)-Associated Neuromuscular and Cardiac Toxicities

Bilal Siddiqui

8:15 AM Machine Learning to Predict Recurrence of Localized Renal Cell Carcinoma

Yanbo Guo

8:30 AM MEETING CONCLUDES

3rd annual global summit on...

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