5 ht receptor

8/2/2019 5 HT Receptor

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5-HT receptor

Serotonin

The serotonin receptors, also known as 5-hydroxytryptamine receptors or 5-HT receptors,

are a group of G protein-coupled receptors (GPCRs) and ligand-gated ion channels (LGICs)found in thecentralandperipheralnervous systems.[1][2]They mediate bothexcitatoryand

inhibitoryneurotransmission. The serotonin receptors are activated by theneurotransmitter

serotonin, which acts as their naturalligand.

The serotonin receptors modulate the release of many neurotransmitters, includingglutamate,

GABA,dopamine,epinephrine/norepinephrine, andacetylcholine, as well as many hormones,includingoxytocin,prolactin,vasopressin,cortisol,corticotropin, andsubstance P, among others.

The serotonin receptors influence various biological and neurological processes such as

aggression, anxiety, appetite,cognition, learning, memory,mood, nausea, sleep, and

thermoregulation. The serotonin receptors are the target of a variety of pharmaceutical and illicitdrugs, including manyantidepressants,antipsychotics,anorectics,antiemetics,gastroprokinetic

agents,antimigraine agents,hallucinogens, andentactogens.[3]

Classification

With the exception of the5-HT3 receptor, aligand-gated ion channel, all other serotoninreceptors areG protein-coupled receptorsthat activate anintracellularsecond messengercascade

to produce an excitatory or inhibitory response.

Families

FamilyType Mechanism Potential5-HT1 Gi/Go-protein coupled. Decreasing cellular levels ofcAMP. Inhibitory

5-HT2 Gq/G11-protein coupled.Increasing cellular levels ofIP3andDAG.

Excitatory

5-HT3Ligand-gatedNa

+andK

+cation

channel.Depolarizingplasma membrane. Excitatory

5-HT4 Gs-protein coupled. Increasing cellular levels ofcAMP. Excitatory
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p://en.wikipedia.org/wiki/Ligand-gated_ion_channelhttp://en.wikipedia.org/wiki/Ligand-gated_ion_channelhttp://en.wikipedia.org/wiki/G_protein-coupled_receptorhttp://en.wikipedia.org/wiki/G_protein-coupled_receptorhttp://en.wikipedia.org/wiki/G_protein-coupled_receptorhttp://en.wikipedia.org/wiki/Intracellularhttp://en.wikipedia.org/wiki/Intracellularhttp://en.wikipedia.org/wiki/Second_messengerhttp://en.wikipedia.org/wiki/Second_messengerhttp://en.wikipedia.org/wiki/Second_messengerhttp://en.wikipedia.org/wiki/5-HT1http://en.wikipedia.org/wiki/5-HT1http://en.wikipedia.org/wiki/Gi_alpha_subunithttp://en.wikipedia.org/wiki/Gi_alpha_subunithttp://en.wikipedia.org/wiki/Gi_alpha_subunithttp://en.wikipedia.org/wiki/Gi_alpha_subunithttp://en.wikipedia.org/wiki/Gi_alpha_subunithttp://en.wikipedia.org/wiki/Cyclic_adenosine_monophosphatehttp://en.wikipedia.org/wiki/Cyclic_adenosine_monophosphatehttp://en.wikipedia.org/wiki/Cyclic_adenosine_monophosphatehttp://en.wikipedia.org/wiki/5-HT2http://en.wikipedia.org/wiki/5-HT2http://en.wikipedia.org/wiki/Gq_proteinhttp://en.wikipedia.org/wiki/Gq_proteinhttp://en.wikipedia.org/wiki/Gq_proteinhttp://en.wikipedia.org/wiki/Gq_proteinhttp://en.wikipedia.org/wiki/Gq_proteinhttp://en.wikipedia.org/wiki/Inositol_trisphosphatehttp://en.wikipedia.org/wiki/Inositol_trisphosphatehttp://en.wikipedia.org/wiki/Inositol_trisphosphatehttp://en.wikipedia.org/wiki/Inositol_trisphosphatehttp://en.wikipedia.org/wiki/Diglyceridehttp://en.wikipedia.org/wiki/Diglyceridehttp://en.wikipedia.org/wiki/5-HT3http://en.wikipedia.org/wiki/5-HT3http://en.wikipedia.org/wiki/Sodiumhttp://en.wikipedia.org/wiki/Sodiumhttp://en.wikipedia.org/wiki/Sodiumhttp://en.wikipedia.org/wiki/Sodiumhttp://en.wikipedia.org/wiki/Potassiumhttp://en.wikipedia.org/wiki/Potassiumhttp://en.wikipedia.org/wiki/Potassiumhttp://en.wikipedia.org/wiki/Ion_channelshttp://en.wikipedia.org/wiki/Ion_channelshttp://en.wikipedia.org/wiki/Ion_channelshttp://en.wikipedia.org/wiki/Ion_channelshttp://en.wikipedia.org/wiki/Depolarizationhttp://en.wikipedia.org/wiki/Plasma_membranehttp://en.wikipedia.org/wiki/Plasma_membranehttp://en.wikipedia.org/wiki/Plasma_membranehttp://en.wikipedia.org/wiki/5-HT4http://en.wikipedia.org/wiki/5-HT4http://en.wikipedia.org/wiki/G%28s%29alphahttp://en.wikipedia.org/wiki/G%28s%29alphahttp://en.wikipedia.org/wiki/G%28s%29alphahttp://en.wikipedia.org/wiki/Cyclic_adenosine_monophosphatehttp://en.wikipedia.org/wiki/Cyclic_adenosine_monophosphatehttp://en.wikipedia.org/wiki/Cyclic_adenosine_monophosphatehttp://en.wikipedia.org/wiki/File:Serotonin_(5-HT).svghttp://en.wikipedia.org/wiki/File:Serotonin_(5-HT).svghttp://en.wikipedia.org/wiki/File:Serotonin_(5-HT).svghttp://en.wikipedia.org/wiki/File:Serotonin_(5-HT).svghttp://en.wikipedia.org/wiki/Cyclic_adenosine_monophosphatehttp://en.wikipedia.org/wiki/G%28s%29alphahttp://en.wikipedia.org/wiki/5-HT4http://en.wikipedia.org/wiki/Plasma_membranehttp://en.wikipedia.org/wiki/Depolarizationhttp://en.wikipedia.org/wiki/Ion_channelshttp://en.wikipedia.org/wiki/Ion_channelshttp://en.wikipedia.org/wiki/Potassiumhttp://en.wikipedia.org/wiki/Sodiumhttp://en.wikipedia.org/wiki/5-HT3http://en.wikipedia.org/wiki/Diglyceridehttp://en.wikipedia.org/wiki/Inositol_trisphosphatehttp://en.wikipedia.org/wiki/Gq_proteinhttp://en.wikipedia.org/wiki/5-HT2http://en.wikipedia.org/wiki/Cyclic_adenosine_monophosphatehttp://en.wikipedia.org/wiki/Gi_alpha_subunithttp://en.wikipedia.org/wiki/5-HT1http://en.wikipedia.org/wiki/Second_messengerhttp://en.wikipedia.org/wiki/Intracellularhttp://en.wikipedia.org/wiki/G_protein-coupled_receptorhttp://en.wikipedia.org/wiki/Ligand-gated_ion_channelhttp://en.wikipedia.org/wiki/5-HT3_receptorhttp://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid18476671-2http://en.wikipedia.org/wiki/Empathogen-entactogenhttp://en.wikipedia.org/wiki/Hallucinogenhttp://en.wikipedia.org/wiki/Antimigrainehttp://en.wikipedia.org/wiki/Gastroprokinetic_agenthttp://en.wikipedia.org/wiki/Gastroprokinetic_agenthttp://en.wikipedia.org/wiki/Antiemetichttp://en.wikipedia.org/wiki/Anorectichttp://en.wikipedia.org/wiki/Antipsychotichttp://en.wikipedia.org/wiki/Antidepressanthttp://en.wikipedia.org/wiki/Thermoregulationhttp://en.wikipedia.org/wiki/Mood_%28psychology%29http://en.wikipedia.org/wiki/Cognitionhttp://en.wikipedia.org/wiki/Substance_Phttp://en.wikipedia.org/wiki/Corticotropinhttp://en.wikipedia.org/wiki/Cortisolhttp://en.wikipedia.org/wiki/Vasopressinhttp://en.wikipedia.org/wiki/Prolactinhttp://en.wikipedia.org/wiki/Oxytocinhttp://en.wikipedia.org/wiki/Acetylcholinehttp://en.wikipedia.org/wiki/Norepinephrinehttp://en.wikipedia.org/wiki/Epinephrinehttp://en.wikipedia.org/wiki/Dopaminehttp://en.wikipedia.org/wiki/Gamma-Aminobutyric_acidhttp://en.wikipedia.org/wiki/Glutamic_acidhttp://en.wikipedia.org/wiki/Ligand_%28biochemistry%29http://en.wikipedia.org/wiki/Serotoninhttp://en.wikipedia.org/wiki/Neurotransmitterhttp://en.wikipedia.org/wiki/Synaptic_transmissionhttp://en.wikipedia.org/wiki/Neurotransmitter#Excitatory_and_inhibitoryhttp://en.wikipedia.org/wiki/Neurotransmitter#Excitatory_and_inhibitoryhttp://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid7938165-0http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid7938165-0http://en.wikipedia.org/wiki/Peripheral_nervous_systemhttp://en.wikipedia.org/wiki/Central_nervous_systemhttp://en.wikipedia.org/wiki/Ligand-gated_ion_channelhttp://en.wikipedia.org/wiki/G_protein-coupled_receptorhttp://en.wikipedia.org/wiki/Serotonin


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5-HT5 Gi/Go-protein coupled.[4] Decreasing cellular levels ofcAMP. Inhibitory



[edit] Subtypes

Within these general classes of serotonin receptors, a number of specific types have beencharacterized:[5][6][7]

Overview of Serotonin Receptors

Rece

ptorGene(s)

Distribu

tionFunction Agonists Antagonists

5-

HT1A

HTR1A

Blo

o

dV

es

sels

CNS

Addiction[8][9][10]

Aggression[11]

Anxiety[12] Appetite[13

]

BloodPressure

[14]

[15]

CardiovascularFunction[16

]

Emesis[17] Heart

Rate[14][15]

Impulsivity

[18]

Memory[19][20]

Mood[21] Nausea[17] Nociceptio

n[22]

PenileErection[23]

PupilDilation

[24]

Respiration[25]

SexualBehavior

[2

5-CT 8-OH-DPAT Aripiprazole Buspirone[31]

(anxiolyticand

antidepressant)[31]

Cannabidiol Clozapine Dihydroergota

mine

Eltoprazine Ergotamine Flesinoxan Flibanserin Gepirone Ipsapirone Methysergide Nefazodone Psilocin Quetiapine RU 24969 Tandospirone Trazodone Urapidil Xaliproden Yohimbine Ziprasidone

Alprenolol Asenapine BMY 7378 Cyanopindolol Iodocyanopindol

ol

Lecozotan Methiothepin NAN-190 Nebivolol Oxprenolol Pindolol Propanolol Robalzotan S15535 Spiperone TFMPP UH-301 WAY-100,135 WAY-100,635 Mefway
http://en.wikipedia.org/wiki/5-HT5Ahttp://en.wikipedia.org/wiki/5-HT5Ahttp://en.wikipedia.org/wiki/Gi_alpha_subunithttp://en.wikipedia.org/wiki/Gi_alpha_subunithttp://en.wikipedia.org/wiki/Gi_alpha_subunithttp://en.wikipedia.org/wiki/Gi_alpha_subunithttp://en.wikipedia.org/wiki/Gi_alpha_subunithttp://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid9865521-3http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid9865521-3http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid9865521-3http://en.wikipedia.org/wiki/Cyclic_adenosine_monophosphatehttp://en.wikipedia.org/wiki/Cyclic_adenosine_monophosphatehttp://en.wikipedia.org/wiki/Cyclic_adenosine_monophosphatehttp://en.wikipedia.org/wiki/5-HT6http://en.wikipedia.org/wiki/5-HT6http://en.wikipedia.org/wiki/G%28s%29alphahttp://en.wikipedia.org/wiki/G%28s%29alphahttp://en.wikipedia.org/wiki/G%28s%29alphahttp://en.wikipedia.org/wiki/Cyclic_adenosine_monophosphatehttp://en.wikipedia.org/wiki/Cyclic_adenosine_monophosphatehttp://en.wikipedia.org/wiki/Cyclic_adenosine_monophosphatehttp://en.wikipedia.org/wiki/5-HT7http://en.wikipedia.org/wiki/5-HT7http://en.wikipedia.org/wiki/G%28s%29alphahttp://en.wikipedia.org/wiki/G%28s%29alphahttp://en.wikipedia.org/wiki/G%28s%29alphahttp://en.wikipedia.org/wiki/Cyclic_adenosine_monophosphatehttp://en.wikipedia.org/wiki/Cyclic_adenosine_monophosphatehttp://en.wikipedia.org/wiki/Cyclic_adenosine_monophosphatehttp://en.wikipedia.org/w/index.php?title=5-HT_receptor&action=edit&section=3http://en.wikipedia.org/w/index.php?title=5-HT_receptor&action=edit&section=3http://en.wikipedia.org/w/index.php?title=5-HT_receptor&action=edit&section=3http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-urlSerotonin_Receptor_Subtypes_and_Ligands-4http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-urlSerotonin_Receptor_Subtypes_and_Ligands-4http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-Wesolowska_2002-6http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-Wesolowska_2002-6http://en.wikipedia.org/wiki/Agonisthttp://en.wikipedia.org/wiki/Agonisthttp://en.wikipedia.org/wiki/Receptor_antagonisthttp://en.wikipedia.org/wiki/Receptor_antagonisthttp://en.wikipedia.org/wiki/5-HT1A_receptorhttp://en.wikipedia.org/wiki/5-HT1A_receptorhttp://en.wikipedia.org/wiki/5-HT1A_receptorhttp://www.genenames.org/data/hgnc_data.php?match=HTR1Ahttp://www.genenames.org/data/hgnc_data.php?match=HTR1Ahttp://www.genenames.org/data/hgnc_data.php?match=HTR1Ahttp://www.genenames.org/data/hgnc_data.php?match=HTR1Ahttp://www.genenames.org/data/hgnc_data.php?match=HTR1Ahttp://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid7862892-7http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid15713268-9http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid15713268-9http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid16310183-10http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid16310183-10http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid16310183-10http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid9724773-11http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid9724773-11http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid9724773-11http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid17609739-12http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid17609739-12http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid17609739-12http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid2842163-13http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid2842163-13http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid18667366-14http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid18667366-14http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid15802554-15http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid15802554-15http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid15802554-15http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid8013549-16http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid8013549-16http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid8013549-16http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid2842163-13http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid2842163-13http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid2842163-13http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid15688093-17http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid15688093-17http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid15688093-17http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid18394726-18http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid12562581-19http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid12562581-19http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid2883013-20http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid2883013-20http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid8013549-16http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid8013549-16http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid12595749-21http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid12595749-21http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid12595749-21http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid9085055-22http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid9085055-22http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid8982715-23http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid8982715-23http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid16166206-24http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid16166206-24http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid16166206-24http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid11965359-25http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid11965359-25http://en.wikipedia.org/wiki/5-Carboxamidotryptaminehttp://en.wikipedia.org/wiki/5-Carboxamidotryptaminehttp://en.wikipedia.org/wiki/8-OH-DPAThttp://en.wikipedia.org/wiki/8-OH-DPAThttp://en.wikipedia.org/wiki/Aripiprazolehttp://en.wikipedia.org/wiki/Aripiprazolehttp://en.wikipedia.org/wiki/Buspironehttp://en.wikipedia.org/wiki/Buspironehttp://en.wikipedia.org/wiki/Buspironehttp://en.wikipedia.org/wiki/Anxiolytichttp://en.wikipedia.org/wiki/Anxiolytichttp://en.wikipedia.org/wiki/Anxiolytichttp://en.wikipedia.org/wiki/Antidepressanthttp://en.wikipedia.org/wiki/Antidepressanthttp://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pharmamotion-30http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pharmamotion-30http://en.wikipedia.org/wiki/Cannabidiolhttp://en.wikipedia.org/wiki/Cannabidiolhttp://en.wikipedia.org/wiki/Clozapinehttp://en.wikipedia.org/wiki/Clozapinehttp://en.wikipedia.org/wiki/Dihydroergotaminehttp://en.wikipedia.org/wiki/Dihydroergotaminehttp://en.wikipedia.org/wiki/Dihydroergotaminehttp://en.wikipedia.org/wiki/Dihydroergotaminehttp://en.wikipedia.org/wiki/Dihydroergotaminehttp://en.wikipedia.org/wiki/Eltoprazinehttp://en.wikipedia.org/wiki/Eltoprazinehttp://en.wikipedia.org/wiki/Ergotaminehttp://en.wikipedia.org/wiki/Ergotaminehttp://en.wikipedia.org/wiki/Flesinoxanhttp://en.wikipedia.org/wiki/Flesinoxanhttp://en.wikipedia.org/wiki/Flibanserinhttp://en.wikipedia.org/wiki/Flibanserinhttp://en.wikipedia.org/wiki/Gepironehttp://en.wikipedia.org/wiki/Gepironehttp://en.wikipedia.org/wiki/Ipsapironehttp://en.wikipedia.org/wiki/Ipsapironehttp://en.wikipedia.org/wiki/Methysergidehttp://en.wikipedia.org/wiki/Methysergidehttp://en.wikipedia.org/wiki/Nefazodonehttp://en.wikipedia.org/wiki/Nefazodonehttp://en.wikipedia.org/wiki/Psilocinhttp://en.wikipedia.org/wiki/Psilocinhttp://en.wikipedia.org/wiki/Quetiapinehttp://en.wikipedia.org/wiki/Quetiapinehttp://en.wikipedia.org/wiki/RU_24969http://en.wikipedia.org/wiki/RU_24969http://en.wikipedia.org/wiki/Tandospironehttp://en.wikipedia.org/wiki/Tandospironehttp://en.wikipedia.org/wiki/Trazodonehttp://en.wikipedia.org/wiki/Trazodonehttp://en.wikipedia.org/wiki/Urapidilhttp://en.wikipedia.org/wiki/Urapidilhttp://en.wikipedia.org/wiki/Xaliprodenhttp://en.wikipedia.org/wiki/Xaliprodenhttp://en.wikipedia.org/wiki/Yohimbinehttp://en.wikipedia.org/wiki/Yohimbinehttp://en.wikipedia.org/wiki/Ziprasidonehttp://en.wikipedia.org/wiki/Ziprasidonehttp://en.wikipedia.org/wiki/Alprenololhttp://en.wikipedia.org/wiki/Alprenololhttp://en.wikipedia.org/wiki/Asenapinehttp://en.wikipedia.org/wiki/Asenapinehttp://en.wikipedia.org/wiki/BMY_7378http://en.wikipedia.org/wiki/BMY_7378http://en.wikipedia.org/wiki/Cyanopindololhttp://en.wikipedia.org/wiki/Cyanopindololhttp://en.wikipedia.org/wiki/Iodocyanopindololhttp://en.wikipedia.org/wiki/Iodocyanopindololhttp://en.wikipedia.org/wiki/Iodocyanopindololhttp://en.wikipedia.org/wiki/Iodocyanopindololhttp://en.wikipedia.org/wiki/Iodocyanopindololhttp://en.wikipedia.org/wiki/Lecozotanhttp://en.wikipedia.org/wiki/Lecozotanhttp://en.wikipedia.org/wiki/Methiothepinhttp://en.wikipedia.org/wiki/Methiothepinhttp://en.wikipedia.org/wiki/NAN-190http://en.wikipedia.org/wiki/NAN-190http://en.wikipedia.org/wiki/Nebivololhttp://en.wikipedia.org/wiki/Nebivololhttp://en.wikipedia.org/wiki/Oxprenololhttp://en.wikipedia.org/wiki/Oxprenololhttp://en.wikipedia.org/wiki/Pindololhttp://en.wikipedia.org/wiki/Pindololhttp://en.wikipedia.org/wiki/Propanololhttp://en.wikipedia.org/wiki/Propanololhttp://en.wikipedia.org/wiki/Robalzotanhttp://en.wikipedia.org/wiki/Robalzotanhttp://en.wikipedia.org/wiki/S15535http://en.wikipedia.org/wiki/S15535http://en.wikipedia.org/wiki/Spiperonehttp://en.wikipedia.org/wiki/Spiperonehttp://en.wikipedia.org/wiki/TFMPPhttp://en.wikipedia.org/wiki/TFMPPhttp://en.wikipedia.org/wiki/UH-301http://en.wikipedia.org/wiki/UH-301http://en.wikipedia.org/wiki/WAY-100,135http://en.wikipedia.org/wiki/WAY-100,135http://en.wikipedia.org/wiki/WAY-100,635http://en.wikipedia.org/wiki/WAY-100,635http://en.wikipedia.org/wiki/Mefwayhttp://en.wikipedia.org/wiki/Mefwayhttp://en.wikipedia.org/wiki/Mefwayhttp://en.wikipedia.org/wiki/WAY-100,635http://en.wikipedia.org/wiki/WAY-100,135http://en.wikipedia.org/wiki/UH-301http://en.wikipedia.org/wiki/TFMPPhttp://en.wikipedia.org/wiki/Spiperonehttp://en.wikipedia.org/wiki/S15535http://en.wikipedia.org/wiki/Robalzotanhttp://en.wikipedia.org/wiki/Propanololhttp://en.wikipedia.org/wiki/Pindololhttp://en.wikipedia.org/wiki/Oxprenololhttp://en.wikipedia.org/wiki/Nebivololhttp://en.wikipedia.org/wiki/NAN-190http://en.wikipedia.org/wiki/Methiothepinhttp://en.wikipedia.org/wiki/Lecozotanhttp://en.wikipedia.org/wiki/Iodocyanopindololhttp://en.wikipedia.org/wiki/Iodocyanopindololhttp://en.wikipedia.org/wiki/Cyanopindololhttp://en.wikipedia.org/wiki/BMY_7378http://en.wikipedia.org/wiki/Asenapinehttp://en.wikipedia.org/wiki/Alprenololhttp://en.wikipedia.org/wiki/Ziprasidonehttp://en.wikipedia.org/wiki/Yohimbinehttp://en.wikipedia.org/wiki/Xaliprodenhttp://en.wikipedia.org/wiki/Urapidilhttp://en.wikipedia.org/wiki/Trazodonehttp://en.wikipedia.org/wiki/Tandospironehttp://en.wikipedia.org/wiki/RU_24969http://en.wikipedia.org/wiki/Quetiapinehttp://en.wikipedia.org/wiki/Psilocinhttp://en.wikipedia.org/wiki/Nefazodonehttp://en.wikipedia.org/wiki/Methysergidehttp://en.wikipedia.org/wiki/Ipsapironehttp://en.wikipedia.org/wiki/Gepironehttp://en.wikipedia.org/wiki/Flibanserinhttp://en.wikipedia.org/wiki/Flesinoxanhttp://en.wikipedia.org/wiki/Ergotaminehttp://en.wikipedia.org/wiki/Eltoprazinehttp://en.wikipedia.org/wiki/Dihydroergotaminehttp://en.wikipedia.org/wiki/Dihydroergotaminehttp://en.wikipedia.org/wiki/Clozapinehttp://en.wikipedia.org/wiki/Cannabidiolhttp://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pharmamotion-30http://en.wikipedia.org/wiki/Antidepressanthttp://en.wikipedia.org/wiki/Anxiolytichttp://en.wikipedia.org/wiki/Buspironehttp://en.wikipedia.org/wiki/Buspironehttp://en.wikipedia.org/wiki/Aripiprazolehttp://en.wikipedia.org/wiki/8-OH-DPAThttp://en.wikipedia.org/wiki/5-Carboxamidotryptaminehttp://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid11965359-25http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid16166206-24http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid8982715-23http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid9085055-22http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid12595749-21http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid8013549-16http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid2883013-20http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid12562581-19http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid18394726-18http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid18394726-18http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid15688093-17http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid2842163-13http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid2842163-13http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid8013549-16http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid15802554-15http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid15802554-15http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid18667366-14http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid2842163-13http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid17609739-12http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid17609739-12http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid9724773-11http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid16310183-10http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid15713268-9http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid7862892-7http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid7862892-7http://www.genenames.org/data/hgnc_data.php?match=HTR1Ahttp://www.genenames.org/data/hgnc_data.php?match=HTR1Ahttp://en.wikipedia.org/wiki/5-HT1A_receptorhttp://en.wikipedia.org/wiki/5-HT1A_receptorhttp://en.wikipedia.org/wiki/Receptor_antagonisthttp://en.wikipedia.org/wiki/Agonisthttp://en.wikipedia.org/wiki/5-HT_receptor#cite_note-Wesolowska_2002-6http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-urlSerotonin_Receptor_Subtypes_and_Ligands-4http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-urlSerotonin_Receptor_Subtypes_and_Ligands-4http://en.wikipedia.org/w/index.php?title=5-HT_receptor&action=edit&section=3http://en.wikipedia.org/wiki/Cyclic_adenosine_monophosphatehttp://en.wikipedia.org/wiki/G%28s%29alphahttp://en.wikipedia.org/wiki/5-HT7http://en.wikipedia.org/wiki/Cyclic_adenosine_monophosphatehttp://en.wikipedia.org/wiki/G%28s%29alphahttp://en.wikipedia.org/wiki/5-HT6http://en.wikipedia.org/wiki/Cyclic_adenosine_monophosphatehttp://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid9865521-3http://en.wikipedia.org/wiki/Gi_alpha_subunithttp://en.wikipedia.org/wiki/5-HT5A


3/8

6]

Sleep[27] Sociability

[28]

Thermoregulation

[29]

Vasoconstr

iction[30]

5-

HT1B

HTR1B

Bloo

d

Vesse

ls

CN

S

Addiction[32]

Aggression

[11]

Anxiety[33][34][35]

Learning[36]

Locomotio

n[37]

Memory[36]

Mood[35] Penile

Erection[23]

SexualBehavior[26]

Vasoconstriction

5-CT CP-93,129 CP-94,253 Dihydroergota

mine

Eltoprazine Ergotamine Methysergide RU 24969 TFMPP Triptans[31]

(antimigraine[3

1])

o Zolmitriptan

o Eletriptan

o Sumatriptan

Alprenolol AR-A000002 Asenapine Cyanopindolol GR 127935 Iodocyanopindol

ol

Isamoltane Metergoline Methiothepin Oxprenolol Pindolol Propanolol SB-216,641 Yohimbine

5-

HT1D

HTR1D

Bloo

d

V

es

sels

CNS

Anxiety[38][39]

Locomotion[37]

Vasoconstriction

5-CT Dihydroergota

mine

Ergotamine Methysergide Triptans[31]

(antimigraine[3

1])

o Almotriptan

o Eletriptan

o Frovatriptan

o Naratriptan

BRL-15572 GR 127935 Ketanserin Metergoline Methiothepin Rauwolscine Ritanserin
http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid11965359-25http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid11965359-25http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid10607047-26http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid10607047-26http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid17383105-27http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid17383105-27http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid2951611-28http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid2951611-28http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid16455061-29http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid16455061-29http://en.wikipedia.org/wiki/5-HT1B_receptorhttp://en.wikipedia.org/wiki/5-HT1B_receptorhttp://en.wikipedia.org/wiki/5-HT1B_receptorhttp://www.genenames.org/data/hgnc_data.php?match=HTR1Bhttp://www.genenames.org/data/hgnc_data.php?match=HTR1Bhttp://www.genenames.org/data/hgnc_data.php?match=HTR1Bhttp://www.genenames.org/data/hgnc_data.php?match=HTR1Bhttp://www.genenames.org/data/hgnc_data.php?match=HTR1Bhttp://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid10027505-31http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid10027505-31http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid16310183-10http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid16310183-10http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid16310183-10http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid15720791-32http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid15720791-32http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid11888549-33http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid11888549-33http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid18394658-35http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid18394658-35http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid18394658-35http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid10454466-36http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid10454466-36http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid10454466-36http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid18394658-35http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid18394658-35http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid18394658-35http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid15577451-34http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid15577451-34http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid9085055-22http://en.wikipedia.org/wiki/Zolmitriptanhttp://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid11965359-25http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid11965359-25http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid11965359-25http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid11965359-25http://en.wikipedia.org/wiki/5-Carboxamidotryptaminehttp://en.wikipedia.org/wiki/5-Carboxamidotryptaminehttp://en.wikipedia.org/wiki/CP-93,129http://en.wikipedia.org/wiki/CP-93,129http://en.wikipedia.org/wiki/CP-94,253http://en.wikipedia.org/wiki/CP-94,253http://en.wikipedia.org/wiki/Dihydroergotaminehttp://en.wikipedia.org/wiki/Dihydroergotaminehttp://en.wikipedia.org/wiki/Dihydroergotaminehttp://en.wikipedia.org/wiki/Dihydroergotaminehttp://en.wikipedia.org/wiki/Dihydroergotaminehttp://en.wikipedia.org/wiki/Eltoprazinehttp://en.wikipedia.org/wiki/Eltoprazinehttp://en.wikipedia.org/wiki/Ergotaminehttp://en.wikipedia.org/wiki/Ergotaminehttp://en.wikipedia.org/wiki/Methysergidehttp://en.wikipedia.org/wiki/Methysergidehttp://en.wikipedia.org/wiki/RU_24969http://en.wikipedia.org/wiki/RU_24969http://en.wikipedia.org/wiki/TFMPPhttp://en.wikipedia.org/wiki/TFMPPhttp://en.wikipedia.org/wiki/Triptanshttp://en.wikipedia.org/wiki/Triptanshttp://en.wikipedia.org/wiki/Triptanshttp://en.wikipedia.org/wiki/Antimigrainehttp://en.wikipedia.org/wiki/Antimigrainehttp://en.wikipedia.org/wiki/Antimigrainehttp://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pharmamotion-30http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pharmamotion-30http://en.wikipedia.org/wiki/Zolmitriptanhttp://en.wikipedia.org/wiki/Zolmitriptanhttp://en.wikipedia.org/wiki/Zolmitriptanhttp://en.wikipedia.org/wiki/Zolmitriptanhttp://en.wikipedia.org/wiki/Zolmitriptanhttp://en.wikipedia.org/wiki/Eletriptanhttp://en.wikipedia.org/wiki/Eletriptanhttp://en.wikipedia.org/wiki/Eletriptanhttp://en.wikipedia.org/wiki/Eletriptanhttp://en.wikipedia.org/wiki/Eletriptanhttp://en.wikipedia.org/wiki/Sumatriptanhttp://en.wikipedia.org/wiki/Sumatriptanhttp://en.wikipedia.org/wiki/Sumatriptanhttp://en.wikipedia.org/wiki/Sumatriptanhttp://en.wikipedia.org/wiki/Sumatriptanhttp://en.wikipedia.org/wiki/Alprenololhttp://en.wikipedia.org/wiki/Alprenololhttp://en.wikipedia.org/wiki/AR-A000002http://en.wikipedia.org/wiki/AR-A000002http://en.wikipedia.org/wiki/Asenapinehttp://en.wikipedia.org/wiki/Asenapinehttp://en.wikipedia.org/wiki/Cyanopindololhttp://en.wikipedia.org/wiki/Cyanopindololhttp://en.wikipedia.org/w/index.php?title=GR_127935&action=edit&redlink=1http://en.wikipedia.org/w/index.php?title=GR_127935&action=edit&redlink=1http://en.wikipedia.org/wiki/Iodocyanopindololhttp://en.wikipedia.org/wiki/Iodocyanopindololhttp://en.wikipedia.org/wiki/Iodocyanopindololhttp://en.wikipedia.org/wiki/Iodocyanopindololhttp://en.wikipedia.org/wiki/Iodocyanopindololhttp://en.wikipedia.org/wiki/Isamoltanehttp://en.wikipedia.org/wiki/Isamoltanehttp://en.wikipedia.org/wiki/Metergolinehttp://en.wikipedia.org/wiki/Metergolinehttp://en.wikipedia.org/wiki/Methiothepinhttp://en.wikipedia.org/wiki/Methiothepinhttp://en.wikipedia.org/wiki/Oxprenololhttp://en.wikipedia.org/wiki/Oxprenololhttp://en.wikipedia.org/wiki/Pindololhttp://en.wikipedia.org/wiki/Pindololhttp://en.wikipedia.org/wiki/Propanololhttp://en.wikipedia.org/wiki/Propanololhttp://en.wikipedia.org/wiki/SB-216,641http://en.wikipedia.org/wiki/SB-216,641http://en.wikipedia.org/wiki/Yohimbinehttp://en.wikipedia.org/wiki/Yohimbinehttp://en.wikipedia.org/wiki/5-HT1D_receptorhttp://en.wikipedia.org/wiki/5-HT1D_receptorhttp://en.wikipedia.org/wiki/5-HT1D_receptorhttp://www.genenames.org/data/hgnc_data.php?match=HTR1Dhttp://www.genenames.org/data/hgnc_data.php?match=HTR1Dhttp://www.genenames.org/data/hgnc_data.php?match=HTR1Dhttp://www.genenames.org/data/hgnc_data.php?match=HTR1Dhttp://www.genenames.org/data/hgnc_data.php?match=HTR1Dhttp://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid15820416-37http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid15820416-37http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid8736648-38http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid8736648-38http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid10454466-36http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid10454466-36http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid10454466-36http://en.wikipedia.org/wiki/5-Carboxamidotryptaminehttp://en.wikipedia.org/wiki/5-Carboxamidotryptaminehttp://en.wikipedia.org/wiki/Dihydroergotaminehttp://en.wikipedia.org/wiki/Dihydroergotaminehttp://en.wikipedia.org/wiki/Dihydroergotaminehttp://en.wikipedia.org/wiki/Dihydroergotaminehttp://en.wikipedia.org/wiki/Dihydroergotaminehttp://en.wikipedia.org/wiki/Ergotaminehttp://en.wikipedia.org/wiki/Ergotaminehttp://en.wikipedia.org/wiki/Methysergidehttp://en.wikipedia.org/wiki/Methysergidehttp://en.wikipedia.org/wiki/Triptanshttp://en.wikipedia.org/wiki/Triptanshttp://en.wikipedia.org/wiki/Triptanshttp://en.wikipedia.org/wiki/Antimigrainehttp://en.wikipedia.org/wiki/Antimigrainehttp://en.wikipedia.org/wiki/Antimigrainehttp://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pharmamotion-30http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pharmamotion-30http://en.wikipedia.org/wiki/Almotriptanhttp://en.wikipedia.org/wiki/Almotriptanhttp://en.wikipedia.org/wiki/Almotriptanhttp://en.wikipedia.org/wiki/Almotriptanhttp://en.wikipedia.org/wiki/Almotriptanhttp://en.wikipedia.org/wiki/Eletriptanhttp://en.wikipedia.org/wiki/Eletriptanhttp://en.wikipedia.org/wiki/Eletriptanhttp://en.wikipedia.org/wiki/Eletriptanhttp://en.wikipedia.org/wiki/Eletriptanhttp://en.wikipedia.org/wiki/Frovatriptanhttp://en.wikipedia.org/wiki/Frovatriptanhttp://en.wikipedia.org/wiki/Frovatriptanhttp://en.wikipedia.org/wiki/Frovatriptanhttp://en.wikipedia.org/wiki/Frovatriptanhttp://en.wikipedia.org/wiki/Naratriptanhttp://en.wikipedia.org/wiki/Naratriptanhttp://en.wikipedia.org/wiki/Naratriptanhttp://en.wikipedia.org/wiki/Naratriptanhttp://en.wikipedia.org/wiki/Naratriptanhttp://en.wikipedia.org/wiki/BRL-15572http://en.wikipedia.org/wiki/BRL-15572http://en.wikipedia.org/w/index.php?title=GR_127935&action=edit&redlink=1http://en.wikipedia.org/w/index.php?title=GR_127935&action=edit&redlink=1http://en.wikipedia.org/wiki/Ketanserinhttp://en.wikipedia.org/wiki/Ketanserinhttp://en.wikipedia.org/wiki/Metergolinehttp://en.wikipedia.org/wiki/Metergolinehttp://en.wikipedia.org/wiki/Methiothepinhttp://en.wikipedia.org/wiki/Methiothepinhttp://en.wikipedia.org/wiki/Rauwolscinehttp://en.wikipedia.org/wiki/Rauwolscinehttp://en.wikipedia.org/wiki/Ritanserinhttp://en.wikipedia.org/wiki/Ritanserinhttp://en.wikipedia.org/wiki/Ritanserinhttp://en.wikipedia.org/wiki/Rauwolscinehttp://en.wikipedia.org/wiki/Methiothepinhttp://en.wikipedia.org/wiki/Metergolinehttp://en.wikipedia.org/wiki/Ketanserinhttp://en.wikipedia.org/w/index.php?title=GR_127935&action=edit&redlink=1http://en.wikipedia.org/wiki/BRL-15572http://en.wikipedia.org/wiki/Naratriptanhttp://en.wikipedia.org/wiki/Naratriptanhttp://en.wikipedia.org/wiki/Frovatriptanhttp://en.wikipedia.org/wiki/Frovatriptanhttp://en.wikipedia.org/wiki/Eletriptanhttp://en.wikipedia.org/wiki/Eletriptanhttp://en.wikipedia.org/wiki/Almotriptanhttp://en.wikipedia.org/wiki/Almotriptanhttp://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pharmamotion-30http://en.wikipedia.org/wiki/Antimigrainehttp://en.wikipedia.org/wiki/Antimigrainehttp://en.wikipedia.org/wiki/Triptanshttp://en.wikipedia.org/wiki/Triptanshttp://en.wikipedia.org/wiki/Methysergidehttp://en.wikipedia.org/wiki/Ergotaminehttp://en.wikipedia.org/wiki/Dihydroergotaminehttp://en.wikipedia.org/wiki/Dihydroergotaminehttp://en.wikipedia.org/wiki/5-Carboxamidotryptaminehttp://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid10454466-36http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid8736648-38http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid15820416-37http://www.genenames.org/data/hgnc_data.php?match=HTR1Dhttp://www.genenames.org/data/hgnc_data.php?match=HTR1Dhttp://en.wikipedia.org/wiki/5-HT1D_receptorhttp://en.wikipedia.org/wiki/5-HT1D_receptorhttp://en.wikipedia.org/wiki/Yohimbinehttp://en.wikipedia.org/wiki/SB-216,641http://en.wikipedia.org/wiki/Propanololhttp://en.wikipedia.org/wiki/Pindololhttp://en.wikipedia.org/wiki/Oxprenololhttp://en.wikipedia.org/wiki/Methiothepinhttp://en.wikipedia.org/wiki/Metergolinehttp://en.wikipedia.org/wiki/Isamoltanehttp://en.wikipedia.org/wiki/Iodocyanopindololhttp://en.wikipedia.org/wiki/Iodocyanopindololhttp://en.wikipedia.org/w/index.php?title=GR_127935&action=edit&redlink=1http://en.wikipedia.org/wiki/Cyanopindololhttp://en.wikipedia.org/wiki/Asenapinehttp://en.wikipedia.org/wiki/AR-A000002http://en.wikipedia.org/wiki/Alprenololhttp://en.wikipedia.org/wiki/Sumatriptanhttp://en.wikipedia.org/wiki/Sumatriptanhttp://en.wikipedia.org/wiki/Eletriptanhttp://en.wikipedia.org/wiki/Eletriptanhttp://en.wikipedia.org/wiki/Zolmitriptanhttp://en.wikipedia.org/wiki/Zolmitriptanhttp://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pharmamotion-30http://en.wikipedia.org/wiki/Antimigrainehttp://en.wikipedia.org/wiki/Antimigrainehttp://en.wikipedia.org/wiki/Triptanshttp://en.wikipedia.org/wiki/Triptanshttp://en.wikipedia.org/wiki/TFMPPhttp://en.wikipedia.org/wiki/RU_24969http://en.wikipedia.org/wiki/Methysergidehttp://en.wikipedia.org/wiki/Ergotaminehttp://en.wikipedia.org/wiki/Eltoprazinehttp://en.wikipedia.org/wiki/Dihydroergotaminehttp://en.wikipedia.org/wiki/Dihydroergotaminehttp://en.wikipedia.org/wiki/CP-94,253http://en.wikipedia.org/wiki/CP-93,129http://en.wikipedia.org/wiki/5-Carboxamidotryptaminehttp://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid11965359-25http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid11965359-25http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid9085055-22http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid15577451-34http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid18394658-35http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid18394658-35http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid10454466-36http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid18394658-35http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid18394658-35http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid11888549-33http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid11888549-33http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid15720791-32http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid16310183-10http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid10027505-31http://www.genenames.org/data/hgnc_data.php?match=HTR1Bhttp://www.genenames.org/data/hgnc_data.php?match=HTR1Bhttp://en.wikipedia.org/wiki/5-HT1B_receptorhttp://en.wikipedia.org/wiki/5-HT1B_receptorhttp://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid16455061-29http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid2951611-28http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid17383105-27http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid10607047-26http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid11965359-25


4/8

o Rizatriptan

o Sumatriptan

o Zolmitriptan

Yohimbine

5-

HT1e

puta

tive

rece

ptor

HTR1E

Bloo

d

V

esse

ls

CN

S

Eletriptan Methysergide Tryptamine

Methiothepin

5-

HT1F

HTR1F

CN

S Migraine LY334370

COL-144

5-

HT2A

HTR2A

Blo

o

dV

es

sels

CNS

GI

T

ract

Plat

el

et

s

P

Addiction(potentiall

ymodulating)[40]

Anxiety[41] Appetite Cognition Imaginatio

n

Learning Memory Mood Perception Sexual

Behavior[42]

Sleep[43] Thermoreg

ulation[44]

Vasoconstr

2C-B 5-MeO-DMT BZP Bufotenin DMT DOM Ergonovine Lisuride LSD Mescaline Myristicin Psilocin Psilocybin TFMPP

(partial agonist

or antagonist)

Yohimbine

Atypicalantipsychotics

o Clozapine[31]

o Olanzapine

o Quetiapine

o Risperidone

o Ziprasidone

Aripiprazole Asenapine Amitriptyline Clomipramine Cyproheptadine Eplivanserin Etoperidone Iloperidone Ketanserin[31]

(antihypertensiv
http://en.wikipedia.org/wiki/Rizatriptanhttp://en.wikipedia.org/wiki/Rizatriptanhttp://en.wikipedia.org/wiki/Rizatriptanhttp://en.wikipedia.org/wiki/Rizatriptanhttp://en.wikipedia.org/wiki/Rizatriptanhttp://en.wikipedia.org/wiki/Sumatriptanhttp://en.wikipedia.org/wiki/Sumatriptanhttp://en.wikipedia.org/wiki/Sumatriptanhttp://en.wikipedia.org/wiki/Sumatriptanhttp://en.wikipedia.org/wiki/Sumatriptanhttp://en.wikipedia.org/wiki/Zolmitriptanhttp://en.wikipedia.org/wiki/Zolmitriptanhttp://en.wikipedia.org/wiki/Zolmitriptanhttp://en.wikipedia.org/wiki/Zolmitriptanhttp://en.wikipedia.org/wiki/Zolmitriptanhttp://en.wikipedia.org/wiki/Yohimbinehttp://en.wikipedia.org/wiki/Yohimbinehttp://en.wikipedia.org/w/index.php?title=5-HT1e&action=edit&redlink=1http://en.wikipedia.org/w/index.php?title=5-HT1e&action=edit&redlink=1http://en.wikipedia.org/w/index.php?title=5-HT1e&action=edit&redlink=1http://en.wikipedia.org/w/index.php?title=5-HT1e&action=edit&redlink=1http://www.genenames.org/data/hgnc_data.php?match=HTR1Ehttp://www.genenames.org/data/hgnc_data.php?match=HTR1Ehttp://www.genenames.org/data/hgnc_data.php?match=HTR1Ehttp://www.genenames.org/data/hgnc_data.php?match=HTR1Ehttp://www.genenames.org/data/hgnc_data.php?match=HTR1Ehttp://en.wikipedia.org/wiki/Eletriptanhttp://en.wikipedia.org/wiki/Eletriptanhttp://en.wikipedia.org/wiki/Methysergidehttp://en.wikipedia.org/wiki/Methysergidehttp://en.wikipedia.org/wiki/Tryptaminehttp://en.wikipedia.org/wiki/Tryptaminehttp://en.wikipedia.org/wiki/Methiothepinhttp://en.wikipedia.org/wiki/Methiothepinhttp://en.wikipedia.org/wiki/5-HT1Fhttp://en.wikipedia.org/wiki/5-HT1Fhttp://en.wikipedia.org/wiki/5-HT1Fhttp://www.genenames.org/data/hgnc_data.php?match=HTR1Fhttp://www.genenames.org/data/hgnc_data.php?match=HTR1Fhttp://www.genenames.org/data/hgnc_data.php?match=HTR1Fhttp://www.genenames.org/data/hgnc_data.php?match=HTR1Fhttp://www.genenames.org/data/hgnc_data.php?match=HTR1Fhttp://en.wikipedia.org/wiki/5-HT2A_receptorhttp://en.wikipedia.org/wiki/5-HT2A_receptorhttp://en.wikipedia.org/wiki/5-HT2A_receptorhttp://www.genenames.org/data/hgnc_data.php?match=HTR2Ahttp://www.genenames.org/data/hgnc_data.php?match=HTR2Ahttp://www.genenames.org/data/hgnc_data.php?match=HTR2Ahttp://www.genenames.org/data/hgnc_data.php?match=HTR2Ahttp://www.genenames.org/data/hgnc_data.php?match=HTR2Ahttp://en.wikipedia.org/wiki/5-HT_receptor#cite_note-Bubar-39http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-Bubar-39http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-Bubar-39http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid9539263-40http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid9539263-40http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid9539263-40http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid12097814-41http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid12097814-41http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid12097814-41http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid12097814-41http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid16339018-42http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid16339018-42http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid9106912-43http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid9106912-43http://en.wikipedia.org/wiki/2C-Bhttp://en.wikipedia.org/wiki/2C-Bhttp://en.wikipedia.org/wiki/5-MeO-DMThttp://en.wikipedia.org/wiki/5-MeO-DMThttp://en.wikipedia.org/wiki/Benzylpiperazinehttp://en.wikipedia.org/wiki/Benzylpiperazinehttp://en.wikipedia.org/wiki/Bufoteninhttp://en.wikipedia.org/wiki/Bufoteninhttp://en.wikipedia.org/wiki/Dimethyltryptaminehttp://en.wikipedia.org/wiki/Dimethyltryptaminehttp://en.wikipedia.org/wiki/2,5-Dimethoxy-4-methylamphetaminehttp://en.wikipedia.org/wiki/2,5-Dimethoxy-4-methylamphetaminehttp://en.wikipedia.org/wiki/Ergonovinehttp://en.wikipedia.org/wiki/Ergonovinehttp://en.wikipedia.org/wiki/Lisuridehttp://en.wikipedia.org/wiki/Lisuridehttp://en.wikipedia.org/wiki/LSDhttp://en.wikipedia.org/wiki/LSDhttp://en.wikipedia.org/wiki/Mescalinehttp://en.wikipedia.org/wiki/Mescalinehttp://en.wikipedia.org/wiki/Myristicinhttp://en.wikipedia.org/wiki/Myristicinhttp://en.wikipedia.org/wiki/Psilocinhttp://en.wikipedia.org/wiki/Psilocinhttp://en.wikipedia.org/wiki/Psilocybinhttp://en.wikipedia.org/wiki/Psilocybinhttp://en.wikipedia.org/wiki/TFMPPhttp://en.wikipedia.org/wiki/TFMPPhttp://en.wikipedia.org/wiki/Yohimbinehttp://en.wikipedia.org/wiki/Yohimbinehttp://en.wikipedia.org/wiki/Atypical_antipsychotichttp://en.wikipedia.org/wiki/Atypical_antipsychotichttp://en.wikipedia.org/wiki/Atypical_antipsychotichttp://en.wikipedia.org/wiki/Atypical_antipsychotichttp://en.wikipedia.org/wiki/Atypical_antipsychotichttp://en.wikipedia.org/wiki/Clozapinehttp://en.wikipedia.org/wiki/Clozapinehttp://en.wikipedia.org/wiki/Clozapinehttp://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pharmamotion-30http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pharmamotion-30http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pharmamotion-30http://en.wikipedia.org/wiki/Olanzapinehttp://en.wikipedia.org/wiki/Olanzapinehttp://en.wikipedia.org/wiki/Olanzapinehttp://en.wikipedia.org/wiki/Olanzapinehttp://en.wikipedia.org/wiki/Olanzapinehttp://en.wikipedia.org/wiki/Quetiapinehttp://en.wikipedia.org/wiki/Quetiapinehttp://en.wikipedia.org/wiki/Quetiapinehttp://en.wikipedia.org/wiki/Quetiapinehttp://en.wikipedia.org/wiki/Quetiapinehttp://en.wikipedia.org/wiki/Risperidonehttp://en.wikipedia.org/wiki/Risperidonehttp://en.wikipedia.org/wiki/Risperidonehttp://en.wikipedia.org/wiki/Risperidonehttp://en.wikipedia.org/wiki/Risperidonehttp://en.wikipedia.org/wiki/Ziprasidonehttp://en.wikipedia.org/wiki/Ziprasidonehttp://en.wikipedia.org/wiki/Ziprasidonehttp://en.wikipedia.org/wiki/Ziprasidonehttp://en.wikipedia.org/wiki/Ziprasidonehttp://en.wikipedia.org/wiki/Aripiprazolehttp://en.wikipedia.org/wiki/Aripiprazolehttp://en.wikipedia.org/wiki/Asenapinehttp://en.wikipedia.org/wiki/Asenapinehttp://en.wikipedia.org/wiki/Amitriptylinehttp://en.wikipedia.org/wiki/Amitriptylinehttp://en.wikipedia.org/wiki/Clomipraminehttp://en.wikipedia.org/wiki/Clomipraminehttp://en.wikipedia.org/wiki/Cyproheptadinehttp://en.wikipedia.org/wiki/Cyproheptadinehttp://en.wikipedia.org/wiki/Eplivanserinhttp://en.wikipedia.org/wiki/Eplivanserinhttp://en.wikipedia.org/wiki/Etoperidonehttp://en.wikipedia.org/wiki/Etoperidonehttp://en.wikipedia.org/wiki/Iloperidonehttp://en.wikipedia.org/wiki/Iloperidonehttp://en.wikipedia.org/wiki/Ketanserinhttp://en.wikipedia.org/wiki/Ketanserinhttp://en.wikipedia.org/wiki/Ketanserinhttp://en.wikipedia.org/wiki/Antihypertensivehttp://en.wikipedia.org/wiki/Antihypertensivehttp://en.wikipedia.org/wiki/Antihypertensivehttp://en.wikipedia.org/wiki/Ketanserinhttp://en.wikipedia.org/wiki/Ketanserinhttp://en.wikipedia.org/wiki/Iloperidonehttp://en.wikipedia.org/wiki/Etoperidonehttp://en.wikipedia.org/wiki/Eplivanserinhttp://en.wikipedia.org/wiki/Cyproheptadinehttp://en.wikipedia.org/wiki/Clomipraminehttp://en.wikipedia.org/wiki/Amitriptylinehttp://en.wikipedia.org/wiki/Asenapinehttp://en.wikipedia.org/wiki/Aripiprazolehttp://en.wikipedia.org/wiki/Ziprasidonehttp://en.wikipedia.org/wiki/Ziprasidonehttp://en.wikipedia.org/wiki/Risperidonehttp://en.wikipedia.org/wiki/Risperidonehttp://en.wikipedia.org/wiki/Quetiapinehttp://en.wikipedia.org/wiki/Quetiapinehttp://en.wikipedia.org/wiki/Olanzapinehttp://en.wikipedia.org/wiki/Olanzapinehttp://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pharmamotion-30http://en.wikipedia.org/wiki/Clozapinehttp://en.wikipedia.org/wiki/Clozapinehttp://en.wikipedia.org/wiki/Atypical_antipsychotichttp://en.wikipedia.org/wiki/Atypical_antipsychotichttp://en.wikipedia.org/wiki/Yohimbinehttp://en.wikipedia.org/wiki/TFMPPhttp://en.wikipedia.org/wiki/Psilocybinhttp://en.wikipedia.org/wiki/Psilocinhttp://en.wikipedia.org/wiki/Myristicinhttp://en.wikipedia.org/wiki/Mescalinehttp://en.wikipedia.org/wiki/LSDhttp://en.wikipedia.org/wiki/Lisuridehttp://en.wikipedia.org/wiki/Ergonovinehttp://en.wikipedia.org/wiki/2,5-Dimethoxy-4-methylamphetaminehttp://en.wikipedia.org/wiki/Dimethyltryptaminehttp://en.wikipedia.org/wiki/Bufoteninhttp://en.wikipedia.org/wiki/Benzylpiperazinehttp://en.wikipedia.org/wiki/5-MeO-DMThttp://en.wikipedia.org/wiki/2C-Bhttp://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid9106912-43http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid16339018-42http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid12097814-41http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid12097814-41http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid9539263-40http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-Bubar-39http://www.genenames.org/data/hgnc_data.php?match=HTR2Ahttp://www.genenames.org/data/hgnc_data.php?match=HTR2Ahttp://en.wikipedia.org/wiki/5-HT2A_receptorhttp://en.wikipedia.org/wiki/5-HT2A_receptorhttp://www.genenames.org/data/hgnc_data.php?match=HTR1Fhttp://www.genenames.org/data/hgnc_data.php?match=HTR1Fhttp://en.wikipedia.org/wiki/5-HT1Fhttp://en.wikipedia.org/wiki/5-HT1Fhttp://en.wikipedia.org/wiki/Methiothepinhttp://en.wikipedia.org/wiki/Tryptaminehttp://en.wikipedia.org/wiki/Methysergidehttp://en.wikipedia.org/wiki/Eletriptanhttp://www.genenames.org/data/hgnc_data.php?match=HTR1Ehttp://www.genenames.org/data/hgnc_data.php?match=HTR1Ehttp://en.wikipedia.org/w/index.php?title=5-HT1e&action=edit&redlink=1http://en.wikipedia.org/w/index.php?title=5-HT1e&action=edit&redlink=1http://en.wikipedia.org/wiki/Yohimbinehttp://en.wikipedia.org/wiki/Zolmitriptanhttp://en.wikipedia.org/wiki/Zolmitriptanhttp://en.wikipedia.org/wiki/Sumatriptanhttp://en.wikipedia.org/wiki/Sumatriptanhttp://en.wikipedia.org/wiki/Rizatriptanhttp://en.wikipedia.org/wiki/Rizatriptan


5/8

NS

Smo

othM

u

sc

le

iction[45] e[31])

Methysergide Mianserin Mirtazapine Nefazodone Pimavanserin Pizotifen Ritanserin Trazodone

5-

HT2B

HTR2B

Bloo

d

Ves

se

ls

CN

S

GI

T

ra

ct Pl

at

elet

s

PN

S

Sm

oot

h

Mu

sc

le

Anxiety[46][47][48]

Appetite[49]

Cardiovascular

Function

GIMotility[50]

Sleep[43] Vasoconstr

iction

BW-723C86 Fenfluramine MDMA Norfenflurami

ne

Ro60-0175

Agomelatine Asenapine BZP Ketanserin Methysergide Ritanserin Tegaserod Yohimbine
http://en.wikipedia.org/wiki/Antihypertensivehttp://en.wikipedia.org/wiki/Antihypertensivehttp://en.wikipedia.org/wiki/Antihypertensivehttp://en.wikipedia.org/wiki/Antihypertensivehttp://en.wikipedia.org/wiki/Antihypertensivehttp://en.wikipedia.org/wiki/Antihypertensivehttp://en.wikipedia.org/wiki/Antihypertensivehttp://en.wikipedia.org/wiki/Antihypertensivehttp://en.wikipedia.org/wiki/Antihypertensivehttp://en.wikipedia.org/wiki/Antihypertensivehttp://en.wikipedia.org/wiki/Antihypertensivehttp://en.wikipedia.org/wiki/Antihypertensivehttp://en.wikipedia.org/wiki/Antihypertensivehttp://en.wikipedia.org/wiki/Antihypertensivehttp://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid12654345-44http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid12654345-44http://en.wikipedia.org/wiki/Antihypertensivehttp://en.wikipedia.org/wiki/Antihypertensivehttp://en.wikipedia.org/wiki/Antihypertensivehttp://en.wikipedia.org/wiki/Methysergidehttp://en.wikipedia.org/wiki/Methysergidehttp://en.wikipedia.org/wiki/Mianserinhttp://en.wikipedia.org/wiki/Mianserinhttp://en.wikipedia.org/wiki/Mirtazapinehttp://en.wikipedia.org/wiki/Mirtazapinehttp://en.wikipedia.org/wiki/Nefazodonehttp://en.wikipedia.org/wiki/Nefazodonehttp://en.wikipedia.org/wiki/Pimavanserinhttp://en.wikipedia.org/wiki/Pimavanserinhttp://en.wikipedia.org/wiki/Pizotifenhttp://en.wikipedia.org/wiki/Pizotifenhttp://en.wikipedia.org/wiki/Ritanserinhttp://en.wikipedia.org/wiki/Ritanserinhttp://en.wikipedia.org/wiki/Trazodonehttp://en.wikipedia.org/wiki/Trazodonehttp://en.wikipedia.org/wiki/5-HT2B_receptorhttp://en.wikipedia.org/wiki/5-HT2B_receptorhttp://en.wikipedia.org/wiki/5-HT2B_receptorhttp://www.genenames.org/data/hgnc_data.php?match=HTR2Bhttp://www.genenames.org/data/hgnc_data.php?match=HTR2Bhttp://www.genenames.org/data/hgnc_data.php?match=HTR2Bhttp://www.genenames.org/data/hgnc_data.php?match=HTR2Bhttp://www.genenames.org/data/hgnc_data.php?match=HTR2Bhttp://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid8730737-45http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid8730737-45http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid9225285-46http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid9225285-46http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid9144661-48http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid9144661-48http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid9144661-48http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid11877320-49http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid11877320-49http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid16339018-42http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid16339018-42http://en.wikipedia.org/wiki/BW-723C86http://en.wikipedia.org/wiki/BW-723C86http://en.wikipedia.org/wiki/Fenfluraminehttp://en.wikipedia.org/wiki/Fenfluraminehttp://en.wikipedia.org/wiki/MDMAhttp://en.wikipedia.org/wiki/MDMAhttp://en.wikipedia.org/wiki/Norfenfluraminehttp://en.wikipedia.org/wiki/Norfenfluraminehttp://en.wikipedia.org/wiki/Norfenfluraminehttp://en.wikipedia.org/wiki/Norfenfluraminehttp://en.wikipedia.org/wiki/Norfenfluraminehttp://en.wikipedia.org/wiki/Ro60-0175http://en.wikipedia.org/wiki/Ro60-0175http://en.wikipedia.org/wiki/Agomelatinehttp://en.wikipedia.org/wiki/Agomelatinehttp://en.wikipedia.org/wiki/Asenapinehttp://en.wikipedia.org/wiki/Asenapinehttp://en.wikipedia.org/wiki/Benzylpiperazinehttp://en.wikipedia.org/wiki/Benzylpiperazinehttp://en.wikipedia.org/wiki/Ketanserinhttp://en.wikipedia.org/wiki/Ketanserinhttp://en.wikipedia.org/wiki/Methysergidehttp://en.wikipedia.org/wiki/Methysergidehttp://en.wikipedia.org/wiki/Ritanserinhttp://en.wikipedia.org/wiki/Ritanserinhttp://en.wikipedia.org/wiki/Tegaserodhttp://en.wikipedia.org/wiki/Tegaserodhttp://en.wikipedia.org/wiki/Yohimbinehttp://en.wikipedia.org/wiki/Yohimbinehttp://en.wikipedia.org/wiki/Yohimbinehttp://en.wikipedia.org/wiki/Tegaserodhttp://en.wikipedia.org/wiki/Ritanserinhttp://en.wikipedia.org/wiki/Methysergidehttp://en.wikipedia.org/wiki/Ketanserinhttp://en.wikipedia.org/wiki/Benzylpiperazinehttp://en.wikipedia.org/wiki/Asenapinehttp://en.wikipedia.org/wiki/Agomelatinehttp://en.wikipedia.org/wiki/Ro60-0175http://en.wikipedia.org/wiki/Norfenfluraminehttp://en.wikipedia.org/wiki/Norfenfluraminehttp://en.wikipedia.org/wiki/MDMAhttp://en.wikipedia.org/wiki/Fenfluraminehttp://en.wikipedia.org/wiki/BW-723C86http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid16339018-42http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid11877320-49http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid9144661-48http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid9144661-48http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid9225285-46http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid9225285-46http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid8730737-45http://www.genenames.org/data/hgnc_data.php?match=HTR2Bhttp://www.genenames.org/data/hgnc_data.php?match=HTR2Bhttp://en.wikipedia.org/wiki/5-HT2B_receptorhttp://en.wikipedia.org/wiki/5-HT2B_receptorhttp://en.wikipedia.org/wiki/Trazodonehttp://en.wikipedia.org/wiki/Ritanserinhttp://en.wikipedia.org/wiki/Pizotifenhttp://en.wikipedia.org/wiki/Pimavanserinhttp://en.wikipedia.org/wiki/Nefazodonehttp://en.wikipedia.org/wiki/Mirtazapinehttp://en.wikipedia.org/wiki/Mianserinhttp://en.wikipedia.org/wiki/Methysergidehttp://en.wikipedia.org/wiki/Antihypertensivehttp://en.wikipedia.org/wiki/Antihypertensivehttp://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid12654345-44


6/8

5-HT2C

HTR2C

Blo

o

dV

essels

CN

S

GI

T

ract

Platel

et

s

PN

S

Sm

o

oth

M

u

scle

Addiction.(potentiallymodulatin

g)[40]

Anxiety[51][52][53]

Appetite GI

Motility[54]

Locomotion

Mood

[52][53

]

PenileErection

[55]

[56]

SexualBehavior[42]

Sleep[57] Thermoreg

ulation[44]

Vasoconstriction

A-372,159 AL-38022A Aripiprazole Ergonovine Lorcaserin Ro60-0175 TFMPP Trazodone[31]

(hypnotic[31])

YM-348

Agomelatine[31](antidepressant

[3

1])

Amitriptyline Asenapine Clomipramine Clozapine[31]

(antipsychotic[31]

)

Cyproheptadine Dimebolin Eltoprazine Etoperidone Fluoxetine

Iloperidone Ketanserin[31]

(antihypertensiv

e[31]

)

Lisuride Methysergide[58] Mianserin Mirtazapine Nefazodone Olanzapine Quetiapine

Risperidone Ritanserin Trazodone Ziprasidone

5-

HT3

HTR3A

HTR3B

HTR3C

HTR3D

HTR3E

CN

S

GIT

ra

ct

PN

S

Addiction Anxiety Emesis GI

Motility Learning[59

]

Memory[59]

Nausea

2-Methyl-5-HT

BZP Quipazine RS-56812

Alosetron Several

antiemetics[31]

o Dolasetron

o Ondansetron

[31]

o Granisetron

o Tropisetron

Clozapine
http://en.wikipedia.org/wiki/5-HT2C_receptorhttp://en.wikipedia.org/wiki/5-HT2C_receptorhttp://en.wikipedia.org/wiki/5-HT2C_receptorhttp://www.genenames.org/data/hgnc_data.php?match=HTR2Chttp://www.genenames.org/data/hgnc_data.php?match=HTR2Chttp://www.genenames.org/data/hgnc_data.php?match=HTR2Chttp://www.genenames.org/data/hgnc_data.php?match=HTR2Chttp://www.genenames.org/data/hgnc_data.php?match=HTR2Chttp://en.wikipedia.org/wiki/5-HT_receptor#cite_note-Bubar-39http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-Bubar-39http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-Bubar-39http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid9225286-50http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid9225286-50http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid15289999-51http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid15289999-51http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid19058784-53http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid19058784-53http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid15289999-51http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid18523738-52http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid18523738-52http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid9151932-54http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid8001637-55http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid8001637-55http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid12097814-41http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid12097814-41http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid12097814-41http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid12097814-41http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid12431861-56http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid12431861-56http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid9106912-43http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid9106912-43http://en.wikipedia.org/wiki/A-372,159http://en.wikipedia.org/wiki/A-372,159http://en.wikipedia.org/wiki/AL-38022Ahttp://en.wikipedia.org/wiki/AL-38022Ahttp://en.wikipedia.org/wiki/Aripiprazolehttp://en.wikipedia.org/wiki/Aripiprazolehttp://en.wikipedia.org/wiki/Ergonovinehttp://en.wikipedia.org/wiki/Ergonovinehttp://en.wikipedia.org/wiki/Lorcaserinhttp://en.wikipedia.org/wiki/Lorcaserinhttp://en.wikipedia.org/wiki/Ro60-0175http://en.wikipedia.org/wiki/Ro60-0175http://en.wikipedia.org/wiki/TFMPPhttp://en.wikipedia.org/wiki/TFMPPhttp://en.wikipedia.org/wiki/Trazodonehttp://en.wikipedia.org/wiki/Trazodonehttp://en.wikipedia.org/wiki/Trazodonehttp://en.wikipedia.org/wiki/Hypnotichttp://en.wikipedia.org/wiki/Hypnotichttp://en.wikipedia.org/wiki/Hypnotichttp://en.wikipedia.org/wiki/Hypnotichttp://en.wikipedia.org/wiki/YM-348http://en.wikipedia.org/wiki/YM-348http://en.wikipedia.org/wiki/Agomelatinehttp://en.wikipedia.org/wiki/Agomelatinehttp://en.wikipedia.org/wiki/Agomelatinehttp://en.wikipedia.org/wiki/Antidepressanthttp://en.wikipedia.org/wiki/Antidepressanthttp://en.wikipedia.org/wiki/Antidepressanthttp://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pharmamotion-30http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pharmamotion-30http://en.wikipedia.org/wiki/Amitriptylinehttp://en.wikipedia.org/wiki/Amitriptylinehttp://en.wikipedia.org/wiki/Asenapinehttp://en.wikipedia.org/wiki/Asenapinehttp://en.wikipedia.org/wiki/Clomipraminehttp://en.wikipedia.org/wiki/Clomipraminehttp://en.wikipedia.org/wiki/Clozapinehttp://en.wikipedia.org/wiki/Clozapinehttp://en.wikipedia.org/wiki/Clozapinehttp://en.wikipedia.org/wiki/Antipsychotichttp://en.wikipedia.org/wiki/Antipsychotichttp://en.wikipedia.org/wiki/Antipsychotichttp://en.wikipedia.org/wiki/Cyproheptadinehttp://en.wikipedia.org/wiki/Cyproheptadinehttp://en.wikipedia.org/wiki/Dimebolinhttp://en.wikipedia.org/wiki/Dimebolinhttp://en.wikipedia.org/wiki/Eltoprazinehttp://en.wikipedia.org/wiki/Eltoprazinehttp://en.wikipedia.org/wiki/Etoperidonehttp://en.wikipedia.org/wiki/Etoperidonehttp://en.wikipedia.org/wiki/Fluoxetinehttp://en.wikipedia.org/wiki/Fluoxetinehttp://en.wikipedia.org/wiki/Iloperidonehttp://en.wikipedia.org/wiki/Iloperidonehttp://en.wikipedia.org/wiki/Ketanserinhttp://en.wikipedia.org/wiki/Ketanserinhttp://en.wikipedia.org/wiki/Ketanserinhttp://en.wikipedia.org/wiki/Antihypertensivehttp://en.wikipedia.org/wiki/Antihypertensivehttp://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pharmamotion-30http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pharmamotion-30http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pharmamotion-30http://en.wikipedia.org/wiki/Lisuridehttp://en.wikipedia.org/wiki/Lisuridehttp://en.wikipedia.org/wiki/Methysergidehttp://en.wikipedia.org/wiki/Methysergidehttp://en.wikipedia.org/wiki/Methysergidehttp://en.wikipedia.org/wiki/Mianserinhttp://en.wikipedia.org/wiki/Mianserinhttp://en.wikipedia.org/wiki/Mirtazapinehttp://en.wikipedia.org/wiki/Mirtazapinehttp://en.wikipedia.org/wiki/Nefazodonehttp://en.wikipedia.org/wiki/Nefazodonehttp://en.wikipedia.org/wiki/Olanzapinehttp://en.wikipedia.org/wiki/Olanzapinehttp://en.wikipedia.org/wiki/Quetiapinehttp://en.wikipedia.org/wiki/Quetiapinehttp://en.wikipedia.org/wiki/Risperidonehttp://en.wikipedia.org/wiki/Risperidonehttp://en.wikipedia.org/wiki/Ritanserinhttp://en.wikipedia.org/wiki/Ritanserinhttp://en.wikipedia.org/wiki/Trazodonehttp://en.wikipedia.org/wiki/Trazodonehttp://en.wikipedia.org/wiki/Ziprasidonehttp://en.wikipedia.org/wiki/Ziprasidonehttp://en.wikipedia.org/wiki/5-HT3_receptorhttp://en.wikipedia.org/wiki/5-HT3_receptorhttp://en.wikipedia.org/wiki/5-HT3_receptorhttp://www.genenames.org/data/hgnc_data.php?match=HTR3Ahttp://www.genenames.org/data/hgnc_data.php?match=HTR3Ahttp://www.genenames.org/data/hgnc_data.php?match=HTR3Ahttp://www.genenames.org/data/hgnc_data.php?match=HTR3Ahttp://www.genenames.org/data/hgnc_data.php?match=HTR3Ahttp://www.genenames.org/data/hgnc_data.php?match=HTR3Bhttp://www.genenames.org/data/hgnc_data.php?match=HTR3Bhttp://www.genenames.org/data/hgnc_data.php?match=HTR3Bhttp://www.genenames.org/data/hgnc_data.php?match=HTR3Bhttp://www.genenames.org/data/hgnc_data.php?match=HTR3Bhttp://www.genenames.org/data/hgnc_data.php?match=HTR3Chttp://www.genenames.org/data/hgnc_data.php?match=HTR3Chttp://www.genenames.org/data/hgnc_data.php?match=HTR3Chttp://www.genenames.org/data/hgnc_data.php?match=HTR3Chttp://www.genenames.org/data/hgnc_data.php?match=HTR3Chttp://www.genenames.org/data/hgnc_data.php?match=HTR3Dhttp://www.genenames.org/data/hgnc_data.php?match=HTR3Dhttp://www.genenames.org/data/hgnc_data.php?match=HTR3Dhttp://www.genenames.org/data/hgnc_data.php?match=HTR3Dhttp://www.genenames.org/data/hgnc_data.php?match=HTR3Dhttp://www.genenames.org/data/hgnc_data.php?match=HTR3Ehttp://www.genenames.org/data/hgnc_data.php?match=HTR3Ehttp://www.genenames.org/data/hgnc_data.php?match=HTR3Ehttp://www.genenames.org/data/hgnc_data.php?match=HTR3Ehttp://www.genenames.org/data/hgnc_data.php?match=HTR3Ehttp://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid8115433-58http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid8115433-58http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid8115433-58http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid8115433-58http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid8115433-58http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid8115433-58http://en.wikipedia.org/wiki/2-methyl-5-hydroxytryptaminehttp://en.wikipedia.org/wiki/2-methyl-5-hydroxytryptaminehttp://en.wikipedia.org/wiki/2-methyl-5-hydroxytryptaminehttp://en.wikipedia.org/wiki/2-methyl-5-hydroxytryptaminehttp://en.wikipedia.org/wiki/2-methyl-5-hydroxytryptaminehttp://en.wikipedia.org/wiki/Benzylpiperazinehttp://en.wikipedia.org/wiki/Benzylpiperazinehttp://en.wikipedia.org/wiki/Quipazinehttp://en.wikipedia.org/wiki/Quipazinehttp://en.wikipedia.org/wiki/RS-56812http://en.wikipedia.org/wiki/RS-56812http://en.wikipedia.org/wiki/Alosetronhttp://en.wikipedia.org/wiki/Alosetronhttp://en.wikipedia.org/wiki/Antiemeticshttp://en.wikipedia.org/wiki/Antiemeticshttp://en.wikipedia.org/wiki/Antiemeticshttp://en.wikipedia.org/wiki/Dolasetronhttp://en.wikipedia.org/wiki/Dolasetronhttp://en.wikipedia.org/wiki/Dolasetronhttp://en.wikipedia.org/wiki/Dolasetronhttp://en.wikipedia.org/wiki/Dolasetronhttp://en.wikipedia.org/wiki/Ondansetronhttp://en.wikipedia.org/wiki/Ondansetronhttp://en.wikipedia.org/wiki/Ondansetronhttp://en.wikipedia.org/wiki/Ondansetronhttp://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pharmamotion-30http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pharmamotion-30http://en.wikipedia.org/wiki/Granisetronhttp://en.wikipedia.org/wiki/Granisetronhttp://en.wikipedia.org/wiki/Granisetronhttp://en.wikipedia.org/wiki/Granisetronhttp://en.wikipedia.org/wiki/Granisetronhttp://en.wikipedia.org/wiki/Tropisetronhttp://en.wikipedia.org/wiki/Tropisetronhttp://en.wikipedia.org/wiki/Tropisetronhttp://en.wikipedia.org/wiki/Tropisetronhttp://en.wikipedia.org/wiki/Tropisetronhttp://en.wikipedia.org/wiki/Clozapinehttp://en.wikipedia.org/wiki/Clozapinehttp://en.wikipedia.org/wiki/Clozapinehttp://en.wikipedia.org/wiki/Tropisetronhttp://en.wikipedia.org/wiki/Tropisetronhttp://en.wikipedia.org/wiki/Granisetronhttp://en.wikipedia.org/wiki/Granisetronhttp://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pharmamotion-30http://en.wikipedia.org/wiki/Ondansetronhttp://en.wikipedia.org/wiki/Ondansetronhttp://en.wikipedia.org/wiki/Dolasetronhttp://en.wikipedia.org/wiki/Dolasetronhttp://en.wikipedia.org/wiki/Antiemeticshttp://en.wikipedia.org/wiki/Antiemeticshttp://en.wikipedia.org/wiki/Alosetronhttp://en.wikipedia.org/wiki/RS-56812http://en.wikipedia.org/wiki/Quipazinehttp://en.wikipedia.org/wiki/Benzylpiperazinehttp://en.wikipedia.org/wiki/2-methyl-5-hydroxytryptaminehttp://en.wikipedia.org/wiki/2-methyl-5-hydroxytryptaminehttp://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid8115433-58http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid8115433-58http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid8115433-58http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid8115433-58http://www.genenames.org/data/hgnc_data.php?match=HTR3Ehttp://www.genenames.org/data/hgnc_data.php?match=HTR3Ehttp://www.genenames.org/data/hgnc_data.php?match=HTR3Dhttp://www.genenames.org/data/hgnc_data.php?match=HTR3Dhttp://www.genenames.org/data/hgnc_data.php?match=HTR3Chttp://www.genenames.org/data/hgnc_data.php?match=HTR3Chttp://www.genenames.org/data/hgnc_data.php?match=HTR3Bhttp://www.genenames.org/data/hgnc_data.php?match=HTR3Bhttp://www.genenames.org/data/hgnc_data.php?match=HTR3Ahttp://www.genenames.org/data/hgnc_data.php?match=HTR3Ahttp://en.wikipedia.org/wiki/5-HT3_receptorhttp://en.wikipedia.org/wiki/5-HT3_receptorhttp://en.wikipedia.org/wiki/Ziprasidonehttp://en.wikipedia.org/wiki/Trazodonehttp://en.wikipedia.org/wiki/Ritanserinhttp://en.wikipedia.org/wiki/Risperidonehttp://en.wikipedia.org/wiki/Quetiapinehttp://en.wikipedia.org/wiki/Olanzapinehttp://en.wikipedia.org/wiki/Nefazodonehttp://en.wikipedia.org/wiki/Mirtazapinehttp://en.wikipedia.org/wiki/Mianserinhttp://en.wikipedia.org/wiki/Methysergidehttp://en.wikipedia.org/wiki/Methysergidehttp://en.wikipedia.org/wiki/Lisuridehttp://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pharmamotion-30http://en.wikipedia.org/wiki/Antihypertensivehttp://en.wikipedia.org/wiki/Antihypertensivehttp://en.wikipedia.org/wiki/Ketanserinhttp://en.wikipedia.org/wiki/Ketanserinhttp://en.wikipedia.org/wiki/Iloperidonehttp://en.wikipedia.org/wiki/Fluoxetinehttp://en.wikipedia.org/wiki/Etoperidonehttp://en.wikipedia.org/wiki/Eltoprazinehttp://en.wikipedia.org/wiki/Dimebolinhttp://en.wikipedia.org/wiki/Cyproheptadinehttp://en.wikipedia.org/wiki/Antipsychotichttp://en.wikipedia.org/wiki/Antipsychotichttp://en.wikipedia.org/wiki/Clozapinehttp://en.wikipedia.org/wiki/Clozapinehttp://en.wikipedia.org/wiki/Clomipraminehttp://en.wikipedia.org/wiki/Asenapinehttp://en.wikipedia.org/wiki/Amitriptylinehttp://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pharmamotion-30http://en.wikipedia.org/wiki/Antidepressanthttp://en.wikipedia.org/wiki/Antidepressanthttp://en.wikipedia.org/wiki/Agomelatinehttp://en.wikipedia.org/wiki/Agomelatinehttp://en.wikipedia.org/wiki/YM-348http://en.wikipedia.org/wiki/Hypnotichttp://en.wikipedia.org/wiki/Hypnotichttp://en.wikipedia.org/wiki/Trazodonehttp://en.wikipedia.org/wiki/Trazodonehttp://en.wikipedia.org/wiki/TFMPPhttp://en.wikipedia.org/wiki/Ro60-0175http://en.wikipedia.org/wiki/Lorcaserinhttp://en.wikipedia.org/wiki/Ergonovinehttp://en.wikipedia.org/wiki/Aripiprazolehttp://en.wikipedia.org/wiki/AL-38022Ahttp://en.wikipedia.org/wiki/A-372,159http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid9106912-43http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid12431861-56http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid12097814-41http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid12097814-41http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid8001637-55http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid9151932-54http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid18523738-52http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid15289999-51http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid15289999-51http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid19058784-53http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid15289999-51http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid15289999-51http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid9225286-50http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-Bubar-39http://www.genenames.org/data/hgnc_data.php?match=HTR2Chttp://www.genenames.org/data/hgnc_data.php?match=HTR2Chttp://en.wikipedia.org/wiki/5-HT2C_receptorhttp://en.wikipedia.org/wiki/5-HT2C_receptor


7/8

Memantine Metoclopramide Mianserin Mirtazapine Olanzapine Quetiapine

5-

HT4

HTR4

CN

S

GIT

ra

ct P

N

S

Anxiety[60][61]

Appetite[62][63]

GIMotility

Learning[64][65]

Memory[64][65][66]

Mood[67][68]

Respiration

[25][69]

5-MT BIMU-8 Cinitapride Cisapride[31]

(gastroprokine

tic)

Dazopride Metocloprami

de

Mosapride Prucalopride RS-67333 Renzapride Tegaserod Zacopride

L-Lysine[60] Piboserod

5-

HT5A

HTR5A

CN

S

Locomotion[70]

Sleep

[71]

5-CT Ergotamine Valerenic

Acid[71]

Asenapine Dimebolin Methiothepin Ritanserin SB-699,551 SB-699,551-A

5-

HT6

HTR6

CN

S

Anxiety[72][73]

Cognition[74]

Learning[75]

Memory[75

]

Mood[73][76]

EMD-386,088 EMDT

Amitriptyline Aripiprazole Asenapine Clomipramine Clozapine Dimebolin EGIS-12233 Iloperidone MS-245 Olanzapine Ro04-6790 SB-258,585 SB-271,046[77] SB-357,134 SB-399,885
http://en.wikipedia.org/wiki/Clozapinehttp://en.wikipedia.org/wiki/Clozapinehttp://en.wikipedia.org/wiki/Memantinehttp://en.wikipedia.org/wiki/Memantinehttp://en.wikipedia.org/wiki/Metoclopramidehttp://en.wikipedia.org/wiki/Metoclopramidehttp://en.wikipedia.org/wiki/Mianserinhttp://en.wikipedia.org/wiki/Mianserinhttp://en.wikipedia.org/wiki/Mirtazapinehttp://en.wikipedia.org/wiki/Mirtazapinehttp://en.wikipedia.org/wiki/Olanzapinehttp://en.wikipedia.org/wiki/Olanzapinehttp://en.wikipedia.org/wiki/Quetiapinehttp://en.wikipedia.org/wiki/Quetiapinehttp://en.wikipedia.org/wiki/5-HT4_receptorhttp://en.wikipedia.org/wiki/5-HT4_receptorhttp://en.wikipedia.org/wiki/5-HT4_receptorhttp://www.genenames.org/data/hgnc_data.php?match=HTR4http://www.genenames.org/data/hgnc_data.php?match=HTR4http://www.genenames.org/data/hgnc_data.php?match=HTR4http://www.genenames.org/data/hgnc_data.php?match=HTR4http://www.genenames.org/data/hgnc_data.php?match=HTR4http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-Meneses_A.2C_Hong_E_1997_347.E2.80.9351-63http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid14676321-59http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid14676321-59http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid9225297-60http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid9225297-60http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid17913892-61http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid15146954-62http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid15146954-62http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-Meneses_A.2C_Hong_E_1997_347.E2.80.9351-63http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid9225295-64http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid9225295-64http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-Meneses_A.2C_Hong_E_1997_347.E2.80.9351-63http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid9225295-64http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid9225295-64http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid17785179-66http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid17785173-67http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid17785173-67http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid16166206-24http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid16166206-24http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid16166206-24http://en.wikipedia.org/wiki/5-Methoxytryptaminehttp://en.wikipedia.org/wiki/5-Methoxytryptaminehttp://en.wikipedia.org/wiki/BIMU-8http://en.wikipedia.org/wiki/BIMU-8http://en.wikipedia.org/wiki/Cinitapridehttp://en.wikipedia.org/wiki/Cinitapridehttp://en.wikipedia.org/wiki/Cisapridehttp://en.wikipedia.org/wiki/Cisapridehttp://en.wikipedia.org/wiki/Cisapridehttp://en.wikipedia.org/wiki/Prokinetic_agenthttp://en.wikipedia.org/wiki/Prokinetic_agenthttp://en.wikipedia.org/wiki/Prokinetic_agenthttp://en.wikipedia.org/wiki/Prokinetic_agenthttp://en.wikipedia.org/wiki/Dazopridehttp://en.wikipedia.org/wiki/Dazopridehttp://en.wikipedia.org/wiki/Metoclopramidehttp://en.wikipedia.org/wiki/Metoclopramidehttp://en.wikipedia.org/wiki/Metoclopramidehttp://en.wikipedia.org/wiki/Metoclopramidehttp://en.wikipedia.org/wiki/Metoclopramidehttp://en.wikipedia.org/wiki/Mosapridehttp://en.wikipedia.org/wiki/Mosapridehttp://en.wikipedia.org/wiki/Prucalopridehttp://en.wikipedia.org/wiki/Prucalopridehttp://en.wikipedia.org/wiki/RS-67333http://en.wikipedia.org/wiki/RS-67333http://en.wikipedia.org/wiki/Renzapridehttp://en.wikipedia.org/wiki/Renzapridehttp://en.wikipedia.org/wiki/Tegaserodhttp://en.wikipedia.org/wiki/Tegaserodhttp://en.wikipedia.org/wiki/Zacopridehttp://en.wikipedia.org/wiki/Zacopridehttp://en.wikipedia.org/wiki/L-Lysinehttp://en.wikipedia.org/wiki/L-Lysinehttp://en.wikipedia.org/wiki/L-Lysinehttp://en.wikipedia.org/wiki/Piboserodhttp://en.wikipedia.org/wiki/Piboserodhttp://en.wikipedia.org/wiki/5-HT5A_receptorhttp://en.wikipedia.org/wiki/5-HT5A_receptorhttp://en.wikipedia.org/wiki/5-HT5A_receptorhttp://www.genenames.org/data/hgnc_data.php?match=HTR5Ahttp://www.genenames.org/data/hgnc_data.php?match=HTR5Ahttp://www.genenames.org/data/hgnc_data.php?match=HTR5Ahttp://www.genenames.org/data/hgnc_data.php?match=HTR5Ahttp://www.genenames.org/data/hgnc_data.php?match=HTR5Ahttp://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid14965244-69http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid14965244-69http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid14965244-69http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid15921820-70http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid15921820-70http://en.wikipedia.org/wiki/5-Carboxamidotryptaminehttp://en.wikipedia.org/wiki/5-Carboxamidotryptaminehttp://en.wikipedia.org/wiki/Ergotaminehttp://en.wikipedia.org/wiki/Ergotaminehttp://en.wikipedia.org/wiki/Valerenic_acidhttp://en.wikipedia.org/wiki/Valerenic_acidhttp://en.wikipedia.org/wiki/Valerenic_acidhttp://en.wikipedia.org/wiki/Valerenic_acidhttp://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid15921820-70http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid15921820-70http://en.wikipedia.org/wiki/Asenapinehttp://en.wikipedia.org/wiki/Asenapinehttp://en.wikipedia.org/wiki/Dimebolinhttp://en.wikipedia.org/wiki/Dimebolinhttp://en.wikipedia.org/wiki/Methiothepinhttp://en.wikipedia.org/wiki/Methiothepinhttp://en.wikipedia.org/wiki/Ritanserinhttp://en.wikipedia.org/wiki/Ritanserinhttp://en.wikipedia.org/wiki/SB-699,551http://en.wikipedia.org/wiki/SB-699,551http://en.wikipedia.org/wiki/SB-699,551-Ahttp://en.wikipedia.org/wiki/SB-699,551-Ahttp://en.wikipedia.org/wiki/5-HT6_receptorhttp://en.wikipedia.org/wiki/5-HT6_receptorhttp://en.wikipedia.org/wiki/5-HT6_receptorhttp://www.genenames.org/data/hgnc_data.php?match=HTR6http://www.genenames.org/data/hgnc_data.php?match=HTR6http://www.genenames.org/data/hgnc_data.php?match=HTR6http://www.genenames.org/data/hgnc_data.php?match=HTR6http://www.genenames.org/data/hgnc_data.php?match=HTR6http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid18096153-71http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid18096153-71http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid17320917-72http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid17320917-72http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid17069795-73http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid17069795-73http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid17069795-73http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid17069795-73http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid15964617-74http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid15964617-74http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid15964617-74http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid15964617-74http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid15964617-74http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid15964617-74http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid17320917-72http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid18234190-75http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid18234190-75http://en.wikipedia.org/wiki/EMD-386,088http://en.wikipedia.org/wiki/EMD-386,088http://en.wikipedia.org/wiki/2-Ethyl-5-methoxy-N,N-dimethyltryptaminehttp://en.wikipedia.org/wiki/2-Ethyl-5-methoxy-N,N-dimethyltryptaminehttp://en.wikipedia.org/wiki/Amitriptylinehttp://en.wikipedia.org/wiki/Amitriptylinehttp://en.wikipedia.org/wiki/Aripiprazolehttp://en.wikipedia.org/wiki/Aripiprazolehttp://en.wikipedia.org/wiki/Asenapinehttp://en.wikipedia.org/wiki/Asenapinehttp://en.wikipedia.org/wiki/Clomipraminehttp://en.wikipedia.org/wiki/Clomipraminehttp://en.wikipedia.org/wiki/Clozapinehttp://en.wikipedia.org/wiki/Clozapinehttp://en.wikipedia.org/wiki/Dimebolinhttp://en.wikipedia.org/wiki/Dimebolinhttp://en.wikipedia.org/wiki/EGIS-12233http://en.wikipedia.org/wiki/EGIS-12233http://en.wikipedia.org/wiki/Iloperidonehttp://en.wikipedia.org/wiki/Iloperidonehttp://en.wikipedia.org/wiki/MS-245http://en.wikipedia.org/wiki/MS-245http://en.wikipedia.org/wiki/Olanzapinehttp://en.wikipedia.org/wiki/Olanzapinehttp://en.wikipedia.org/wiki/Ro04-6790http://en.wikipedia.org/wiki/Ro04-6790http://en.wikipedia.org/wiki/SB-258,585http://en.wikipedia.org/wiki/SB-258,585http://en.wikipedia.org/wiki/SB-271,046http://en.wikipedia.org/wiki/SB-271,046http://en.wikipedia.org/wiki/SB-271,046http://en.wikipedia.org/wiki/SB-357,134http://en.wikipedia.org/wiki/SB-357,134http://en.wikipedia.org/wiki/SB-399,885http://en.wikipedia.org/wiki/SB-399,885http://en.wikipedia.org/wiki/SB-399,885http://en.wikipedia.org/wiki/SB-357,134http://en.wikipedia.org/wiki/SB-271,046http://en.wikipedia.org/wiki/SB-271,046http://en.wikipedia.org/wiki/SB-258,585http://en.wikipedia.org/wiki/Ro04-6790http://en.wikipedia.org/wiki/Olanzapinehttp://en.wikipedia.org/wiki/MS-245http://en.wikipedia.org/wiki/Iloperidonehttp://en.wikipedia.org/wiki/EGIS-12233http://en.wikipedia.org/wiki/Dimebolinhttp://en.wikipedia.org/wiki/Clozapinehttp://en.wikipedia.org/wiki/Clomipraminehttp://en.wikipedia.org/wiki/Asenapinehttp://en.wikipedia.org/wiki/Aripiprazolehttp://en.wikipedia.org/wiki/Amitriptylinehttp://en.wikipedia.org/wiki/2-Ethyl-5-methoxy-N,N-dimethyltryptaminehttp://en.wikipedia.org/wiki/EMD-386,088http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid18234190-75http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid17320917-72http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid17320917-72http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid15964617-74http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid15964617-74http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid15964617-74http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid15964617-74http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid17069795-73http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid17069795-73http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid17320917-72http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid18096153-71http://www.genenames.org/data/hgnc_data.php?match=HTR6http://www.genenames.org/data/hgnc_data.php?match=HTR6http://en.wikipedia.org/wiki/5-HT6_receptorhttp://en.wikipedia.org/wiki/5-HT6_receptorhttp://en.wikipedia.org/wiki/SB-699,551-Ahttp://en.wikipedia.org/wiki/SB-699,551http://en.wikipedia.org/wiki/Ritanserinhttp://en.wikipedia.org/wiki/Methiothepinhttp://en.wikipedia.org/wiki/Dimebolinhttp://en.wikipedia.org/wiki/Asenapinehttp://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid15921820-70http://en.wikipedia.org/wiki/Valerenic_acidhttp://en.wikipedia.org/wiki/Valerenic_acidhttp://en.wikipedia.org/wiki/Ergotaminehttp://en.wikipedia.org/wiki/5-Carboxamidotryptaminehttp://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid15921820-70http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid14965244-69http://www.genenames.org/data/hgnc_data.php?match=HTR5Ahttp://www.genenames.org/data/hgnc_data.php?match=HTR5Ahttp://en.wikipedia.org/wiki/5-HT5A_receptorhttp://en.wikipedia.org/wiki/5-HT5A_receptorhttp://en.wikipedia.org/wiki/Piboserodhttp://en.wikipedia.org/wiki/L-Lysinehttp://en.wikipedia.org/wiki/L-Lysinehttp://en.wikipedia.org/wiki/Zacopridehttp://en.wikipedia.org/wiki/Tegaserodhttp://en.wikipedia.org/wiki/Renzapridehttp://en.wikipedia.org/wiki/RS-67333http://en.wikipedia.org/wiki/Prucalopridehttp://en.wikipedia.org/wiki/Mosapridehttp://en.wikipedia.org/wiki/Metoclopramidehttp://en.wikipedia.org/wiki/Metoclopramidehttp://en.wikipedia.org/wiki/Dazopridehttp://en.wikipedia.org/wiki/Prokinetic_agenthttp://en.wikipedia.org/wiki/Prokinetic_agenthttp://en.wikipedia.org/wiki/Cisapridehttp://en.wikipedia.org/wiki/Cisapridehttp://en.wikipedia.org/wiki/Cinitapridehttp://en.wikipedia.org/wiki/BIMU-8http://en.wikipedia.org/wiki/5-Methoxytryptaminehttp://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid16166206-24http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid16166206-24http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid17785173-67http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid17785179-66http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid17785179-66http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid9225295-64http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-pmid9225295-64http://en.wikipedia.org/wiki/5-HT_receptor#cite_note-Meneses_A.2C_Hong_E_1997_347.E2.80.9351-63ht

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