document
DESCRIPTION
TRANSCRIPT
![Page 1: Document](https://reader035.vdocument.in/reader035/viewer/2022062617/54bf45354a7959c43d8b467d/html5/thumbnails/1.jpg)
FIGURE 5- 1Exposure routes for chemical agents in hazardous waste.
![Page 2: Document](https://reader035.vdocument.in/reader035/viewer/2022062617/54bf45354a7959c43d8b467d/html5/thumbnails/2.jpg)
FIGURE 5-2
Overview of absorption, distribution, storage, transformation, and elimination of a toxic substance in the human body.
![Page 3: Document](https://reader035.vdocument.in/reader035/viewer/2022062617/54bf45354a7959c43d8b467d/html5/thumbnails/3.jpg)
FIGURE 5-3Types of doses for dermal contact with contaminated soil.
![Page 4: Document](https://reader035.vdocument.in/reader035/viewer/2022062617/54bf45354a7959c43d8b467d/html5/thumbnails/4.jpg)
FIGURE 5-4Correlation of atmospheric benzene concentrations with urinary phenol levels in workers in a rubber coating plant.
![Page 5: Document](https://reader035.vdocument.in/reader035/viewer/2022062617/54bf45354a7959c43d8b467d/html5/thumbnails/5.jpg)
FIGURE 5-5
Effect of dose fractionalization on accumulation of a toxic compound.
![Page 6: Document](https://reader035.vdocument.in/reader035/viewer/2022062617/54bf45354a7959c43d8b467d/html5/thumbnails/6.jpg)
FIGURE 5-6
Sequence of events leading up to a toxic response.
![Page 7: Document](https://reader035.vdocument.in/reader035/viewer/2022062617/54bf45354a7959c43d8b467d/html5/thumbnails/7.jpg)
FIGURE 5-7
Representative cellular targets for toxic action.
![Page 8: Document](https://reader035.vdocument.in/reader035/viewer/2022062617/54bf45354a7959c43d8b467d/html5/thumbnails/8.jpg)
FIGURE 5-8
Lock-and-key model for toxic action.
![Page 9: Document](https://reader035.vdocument.in/reader035/viewer/2022062617/54bf45354a7959c43d8b467d/html5/thumbnails/9.jpg)
FIGURE 5-9Example of compounds with identical molecular formula but different toxicity.
![Page 10: Document](https://reader035.vdocument.in/reader035/viewer/2022062617/54bf45354a7959c43d8b467d/html5/thumbnails/10.jpg)
FIGURE 5-10
Inhibition of enzyme acetylcholinesterase (AChE) by organophosphorus.
![Page 11: Document](https://reader035.vdocument.in/reader035/viewer/2022062617/54bf45354a7959c43d8b467d/html5/thumbnails/11.jpg)
FIGURE 5-11
Dose-response relationship (dose versus mortality).
![Page 12: Document](https://reader035.vdocument.in/reader035/viewer/2022062617/54bf45354a7959c43d8b467d/html5/thumbnails/12.jpg)
FIGURE 5-12
Dose-response relationship for erythrocyte protoporphyrin (EP) in blood as a function of the blood lead level in subpopulations.
![Page 13: Document](https://reader035.vdocument.in/reader035/viewer/2022062617/54bf45354a7959c43d8b467d/html5/thumbnails/13.jpg)
FIGURE 5-13
Effect of EGM on the relative organ weights of testes and prostate.
![Page 14: Document](https://reader035.vdocument.in/reader035/viewer/2022062617/54bf45354a7959c43d8b467d/html5/thumbnails/14.jpg)
FIGURE 5-14
Health effects from breathing and/or ingesting lead.
![Page 15: Document](https://reader035.vdocument.in/reader035/viewer/2022062617/54bf45354a7959c43d8b467d/html5/thumbnails/15.jpg)
FIGURE 5-15
Health effects from breathing benzene.
![Page 16: Document](https://reader035.vdocument.in/reader035/viewer/2022062617/54bf45354a7959c43d8b467d/html5/thumbnails/16.jpg)
FIGURE 5-16
Adequacy of human exposure data on health effects of benzene.
![Page 17: Document](https://reader035.vdocument.in/reader035/viewer/2022062617/54bf45354a7959c43d8b467d/html5/thumbnails/17.jpg)
FIGURE 5-17
Adequacy of animal test data on health effects of benzene.
![Page 18: Document](https://reader035.vdocument.in/reader035/viewer/2022062617/54bf45354a7959c43d8b467d/html5/thumbnails/18.jpg)
FIGURE 5-18
Location of NOAEL and LOAEL doses with respect to the threshold on a typical dose-response curve.
![Page 19: Document](https://reader035.vdocument.in/reader035/viewer/2022062617/54bf45354a7959c43d8b467d/html5/thumbnails/19.jpg)
FIGURE 5-19
Three stages in carcinogenesis.
![Page 20: Document](https://reader035.vdocument.in/reader035/viewer/2022062617/54bf45354a7959c43d8b467d/html5/thumbnails/20.jpg)
FIGURE 5-20
Metabolic activation of benzo(a)pyrene.
![Page 21: Document](https://reader035.vdocument.in/reader035/viewer/2022062617/54bf45354a7959c43d8b467d/html5/thumbnails/21.jpg)
FIGURE 5-21
Example of a point mutation through base pair substitution.
![Page 22: Document](https://reader035.vdocument.in/reader035/viewer/2022062617/54bf45354a7959c43d8b467d/html5/thumbnails/22.jpg)
FIGURE 5-22
2,3,7,8-tetrachlorodibenzo(p)dioxin.
![Page 23: Document](https://reader035.vdocument.in/reader035/viewer/2022062617/54bf45354a7959c43d8b467d/html5/thumbnails/23.jpg)
FIGURE 5-23
Hypothetical dose-response curve for a typical complete carcinogen.
![Page 24: Document](https://reader035.vdocument.in/reader035/viewer/2022062617/54bf45354a7959c43d8b467d/html5/thumbnails/24.jpg)
FIGURE 5-24
Extrapolation of dose-response relationship for liver tumors induced by 2- cetylaminofluorene in the low-dose range.
![Page 25: Document](https://reader035.vdocument.in/reader035/viewer/2022062617/54bf45354a7959c43d8b467d/html5/thumbnails/25.jpg)
FIGURE 5-25
Toxicological/ecological relevance and time scale of toxic responses for levels of biological organization.
![Page 26: Document](https://reader035.vdocument.in/reader035/viewer/2022062617/54bf45354a7959c43d8b467d/html5/thumbnails/26.jpg)
FIGURE 5-26
Idealized plot of dose-responserelationship.
![Page 27: Document](https://reader035.vdocument.in/reader035/viewer/2022062617/54bf45354a7959c43d8b467d/html5/thumbnails/27.jpg)
FIGURE 5-27
Graphical interpolation of time- ependent LC50values for sodium selenite.
![Page 28: Document](https://reader035.vdocument.in/reader035/viewer/2022062617/54bf45354a7959c43d8b467d/html5/thumbnails/28.jpg)
FIGURE 5-28
Biomagnification of pesticides in aquatic food chains.
![Page 29: Document](https://reader035.vdocument.in/reader035/viewer/2022062617/54bf45354a7959c43d8b467d/html5/thumbnails/29.jpg)
FIGURE 5-29
Possible movement and fate of a contaminant after absorption
into the bloodstream of fish.