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5G for personalized health and ambient assisted living prof. dr ir. Hermie J. Hermens University of Twente Enschede the Netherlands Roessingh Research and Development, Enschede, the Netherlands Introduction There is an increasing awareness that healthcare in the western countries cannot be continued in the way it has developed in the past; It is just not sustainable due to the increasing demand for volume of care, limits to the amount of qualified people to work in care and limits to the amount of money we can spend on healthcare. A main trend that is contributing to this need for change, is the increased life expectancy of our western society. As the years that are added, come with longer period of time in which we have to cope with chronic conditions, the volume of required health care services is rapidly rising. This increase in volume of care needed cannot be met with a proportional increase in professional personnel and money. There is a strong belief that technology, especially information and communication technology can make a significant contribution to make care more sustainable, by supporting people in their wish for independent living and increase of self management capabilities. Areas that are especially relevant in this context are: - Unobtrusive monitoring of health related conditions and behavior - Home based interventions. Enabling people to do therapy like physical and cognitive training at home, remotely supervised - Personalised Health Systems that provide people in real-time personalized advices about their health, based on multimodal sensing - Caring homes, supportive environment that intuitively feels the needs of its user and is able to react properly These areas are coming up fast due to rapid developments in sensing technology, artificial intelligence and improved communication infrastructures [7]. In this chapter, I would like to describe some recent developments in these areas of health care supporting technology, both from a technical and functional point of view and then, based on the present developments try to imagine how 5G will support and/or accelerate these. Technology to support personalized health and ambient assisted living 2.1 exercising at home When patients are able to do their training at home, this would have great benefits for all stakeholders. Patients can do their training where and what time they want, not being obliged to go e.g. three times a week to a physical therapy

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5Gforpersonalizedhealthandambientassistedliving

prof.drir.HermieJ.HermensUniversityofTwenteEnschedetheNetherlandsRoessinghResearchandDevelopment,Enschede,theNetherlands

IntroductionThereisanincreasingawarenessthathealthcareinthewesterncountriescannotbecontinuedinthewayithasdevelopedinthepast;Itisjustnotsustainableduetotheincreasingdemandforvolumeofcare,limitstotheamountofqualifiedpeopletoworkincareandlimitstotheamountofmoneywecanspendonhealthcare.Amaintrendthatiscontributingtothisneedforchange,istheincreasedlifeexpectancyofourwesternsociety.Astheyearsthatareadded,comewithlongerperiodoftimeinwhichwehavetocopewithchronicconditions,thevolumeofrequiredhealthcareservicesisrapidlyrising.Thisincreaseinvolumeofcareneededcannotbemetwithaproportionalincreaseinprofessionalpersonnelandmoney.Thereisastrongbeliefthattechnology,especiallyinformationandcommunicationtechnologycanmakeasignificantcontributiontomakecaremoresustainable,bysupportingpeopleintheirwishforindependentlivingandincreaseofselfmanagementcapabilities.Areasthatareespeciallyrelevantinthiscontextare:

- Unobtrusivemonitoringofhealthrelatedconditionsandbehavior- Homebasedinterventions.Enablingpeopletodotherapylikephysical

andcognitivetrainingathome,remotelysupervised- PersonalisedHealthSystemsthatprovidepeopleinreal-time

personalizedadvicesabouttheirhealth,basedonmultimodalsensing- Caringhomes,supportiveenvironmentthatintuitivelyfeelstheneedsof

itsuserandisabletoreactproperlyTheseareasarecomingupfastduetorapiddevelopmentsinsensingtechnology,artificialintelligenceandimprovedcommunicationinfrastructures[7].Inthischapter,Iwouldliketodescribesomerecentdevelopmentsintheseareasofhealthcaresupportingtechnology,bothfromatechnicalandfunctionalpointofviewandthen,basedonthepresentdevelopmentstrytoimaginehow5Gwillsupportand/oracceleratethese.

Technologytosupportpersonalizedhealthandambientassistedliving

2.1exercisingathomeWhenpatientsareabletodotheirtrainingathome,thiswouldhavegreatbenefitsforallstakeholders.Patientscandotheirtrainingwhereandwhattimetheywant,notbeingobligedtogoe.g.threetimesaweektoaphysicaltherapy

practiceorarehabilitationcentre[8].Ifitispartlyreplacingtheintramuraltherapysessions,itisalsobecomingmorecosteffectiveandenlargingthecapacityofintramuralcare.Ifitisusedasanextensionofintramuralrehabilitation,itwillhelpindecreasingthefallbackofcapacitiesinthehomesituation.

Figure1.Exampleofapatientplatform,supportingwebbasedexercising,videoteleconsultation,selfmanagementandactivitycoaching(ContinuousCareandCoachingPlatform,RRD)IntheECprojectClear,intheperiod2011-2013,1000patientsin4Europeancountrieswereusingasystemthatwasabletodelivervideosofexercises,anexercisescheme,remotesupervisionandteleconsultationservices.Intheextensivehealthtechnologyassessmentitwasshownthatthisremotelysupervisedtreatmentwascosteffectiveandefficientwhenappliedaspartialreplacementoftheregularintramuraltherapy.Moreover,itwasshownthatthepatients,whoexercisedmore,improvedmore.Thisunderlinesthatthepatientisinthedriverseatandisabletotakecontrol.Theadvantageofthisapproachisthatitisfullywebbased,makingitindependentofplaceandtimeandrelativelylow-tech,meaningthatyouonlyneedapcorasimilardevicetogettheserviceworking.Assuch,itisagoodfirststeptointroducethiskindoftechnologyindailyhealthcare.Anextstepinthetrainingathomeinvolvesmuchmorecomplexsystemsinvolvinggamestomaketheexercisesmoreenjoyableandpersuasive,combinedwithpassiveoractiveroboticsupportsystemstocorrectthemovementand/orsupportthepatientsincarryingoutthedesiredmovementwhenmuscleforceisstillnotsufficient.Anexampleofsuchacombinedsystem,istheScriptsystem[1],developedintheEuropeanScriptproject,targetingupperextremitytrainingforstrokepatients.Itinvolvesanarm/handsupportsystemthatallowspersonaladjustmentoftheamountofsupport,sensorstocontrolthegameandanumber

Selfmanagement

Webbasedexercising

Self-management Ac5vitycoaching

WebbasedexercisingTele-consulta5on

ofgamesthatvaryindifficultyandadecisionsupportsystemthatrecommendsindividualgamesettingandachoiceofthegames.

Figure2.Upperextremityexercisesystemincludingroboticsupportforthehandfunctioning,gravitycompensationandindividuallytailoredvideogames(Scriptproject.eu)Withrespecttorequiredbandwidth,andtechnicalcomplexity,systemslikeScriptaremuchmoredemanding.Optimally,onewouldallowexperiencedclinicianstolookattheperformanceofthepatientexercisingremotely,butalsohavereal-timecontroloftheroboticdeviceaswellasthevirtualworldwherethepatientisexperiencing.TheevaluationstudiesoftheScriptsystemshowthatsuchsystemsarepromisingwithrespecttoindependentandmotivatingexercisingathome,butstillratherfragile.

2.2MovementanalysisandmonitoringMovementanalysisisanimportantstepinthefunctionaldiagnosisinrehabilitation.Itfocusesonquantificationofthemovementpatternandtoinvestigatetheunderlyingdeviationsinneuromuscularcontrolandthecompensationmechanismsthatoccur.Gaitanalysishasbeenrestrictedtolaboratories,wheregaitwasquantifiedusingoptical,markerbasedsystems.Reflectingmarkersareplacedatspecificplacesonthebodyandassessedusingvideocamerasplacedaroundthesubjectthatpulsewithinfraredlightstoobtainathreedimensionalimage.Off-linetheseimagesarethencombinedwithathree-dimensionalmodelandforceplatesto

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calculatejointforces.Inthepastyears,thisisbeingseenmoreandmoreasaso-calledcapacitymeasurementasthelaboratorysituationisaratherperfectenvironmentwithaverycleancontext,wherethepatientcanbetotallyfocusedonthetaskathand.Aneedhasarisentobeabletohavequantitativemovementdatafromrealisticsituations,likeathome.Inthepastyearsthishasbeenenabledbyrapiddevelopmentofinertialsensortechnologyandprocessingalgorithmstogeneratethemovementsfromthedata.ArecentexampleofprogressmadeinthisareaconcernstheInteractionproject.

Figure3.ThedifferentcomponentsoftheInteractionmonitoringsystem(https://www.xsens.com/news/interaction-project/)Hereacompletemovementrecordingandanalysissystemhasbeendevelopedwithmotionsensorsembeddedinsmarttextiles,abletomonitortheactivitiesofapersoninhisownenvironment.Itinvolvesdifferentmodalitiesofsensinglikeinertialsensorstodetectpostureandmovements,surfaceEMGsensorstomeasuremuscleactivationpatternsand3Dforcemeasurementunderthefoot.Thesystemispresentlybeingappliedinstrokepatientstomonitorhowtheyusetheirmovementcapacitiesindailylife,afteraperiodofrehabilitation.Theresponsesfrombothpatientsandcliniciansareingeneralverypositive,underliningthatthesekindofunobtrusivemonitoringsystemshavegreatpromiseforfutureintegratedcare.

2.3PersonalcoachingsystemsTheamountofpeoplewithchronicconditionsisrapidlygrowingespeciallybecausewelivesubstantiallylongerbutthisextensionofourlivesisunfortunatelygoinghandinhandwithdealingwithchronicconditionsthataffectourqualityoflife.Chronicconditionscannotbecuredbutithasbeenshowninmanystudiesthatqualityoflifeandtheoccurrenceofco-morbiditiesisstronglyrelatedtotheextendwebehavehealthy,intermsofphysicalactivity,

Legenda:

EMGsensor

CEstrain

CEGoniometer

Xsens/Xsens+UDP Interface/

Xsens+EMG interface

healthyfoodandavoidanceofstress.We,humanarenotgoodinchangingourbehavior,properandintensivecoachingisessential.Aswedonothavetheabilitytodothiswithpersons,theideawasborntodothiswithtechnicalsystemsusingonbodyandcontextsensing,smartcontextawarereasoninganduser-friendly,persuasiveinteraction[6].TheconceptofsuchPersonalCoachingSystem(PCS)isshowninfigure4.

Figure4.SchematicpresentationofanartificialPersonalcoachingSystem,involvingon-bodysensing,contextawarereasoningandpersuasivefeedback.SeveralPCShavebeenrealizedinthepastyears.Figure5showssomeexamplesofpastandon-goingwork.ProbablythefirstPCSwasasystemtotreatneck/shoulderpainduringactivitiesofdailyliving[13,14].ItinvolvedmeasurementofthemuscleactivityintheTrapeziusmuscles,wellknowntobesensitiveforstressandpain,processingthesignalintermsofamountofrelaxationandgivingpersonalfeedbackviavibrationtowarnthesubjectwhenthereisnotsufficientrelaxation.ThissystemwassuccessfullyevaluatedinaEuropeantrial,showingthesystemcanbeappliedinneck/shoulderpainpatients,withoutaffectingtheiractivitiesofdailyliving[9,12].Asecondsystemisasmartactivitycoach,developedtocoachpeoplewithchronicconditionstowardsamorehealthyactivitypatternthroughtheday.Thisoftenconcernsahigherlevelofactivitybutalsoinmanycasesbetterbalancingtheamountofactivityovertheday,toavoidatooearlyexhaustion.Itmeasurestheamountofactivityduringtheday,usinga3Dinertialsensor.Thismeasurementiscontinuouslycomparedwithadesiredactivitypatternandbasedontheresultitprovidesencouraging,discouragingorneutralmessages.Boththecontentandtimingofthemessagesaredynamicallypersonalized,usingamodelwhichtakesintoaccountmanyactivityvariablesandcontextinformation[2,3].Thesystemisundercontinuousdevelopmentbutinparallel,ithasbeensuccessfullyappliedinover100patientswithdifferentchronicconditions,likechronicpainandCOPD[10,11].Thethirdexampleisastressmanagementsystem[15,16].Stressappearstobeacomplex,notwell-definedphenomenon.Peoplealsorespondindifferentwaysto

The future coach

Model based reasoning & Interactive learning

Context aware Feedback via various devices

Context information

Self learning from responses

Wearable sensors

stress,whichmakesthatforaPCSapersonalsetofsensorsarerequiredandapersonalizedmodelthatisabletoweightthedifferentinputsintooneestimateofstress.Experimentalstudiesinthelabshowthatthisapproachisfeasible.Experimentsinfree-livingconditionsshowthatagreatamountofcontextinformationhastobetakenintoaccounttoprovideagoodreal-timestressestimateandtoenableaproperinterpretation.

Figure5.ThreeexamplesofPersonalCoachingsystems,thatusesensorandcontextinformationtoreasonaboutahealthconditioninordertoprovidepersonalizedandpersuasivefeedback.

2.4Thecaringhome;supportivehomeenvironmentsInordertoenablepeopletoliveaslongaspossibleintheirownenvironment,thereisaneedforintelligentsupportsystems.Ideally,thesystemshould“feel”theneedsoftheuserintuitivelyandabletoreactwhenrequired.Inadditionitisimportantthatthesystemispersonalizedandabletoofferawiderangeofservicesintheareaofhealth,well-beingandcomfort.Presently,manyprojectsaregoingoninthisareadealingwithseveralsubgoalsinthecontextofthecaringhome.ForexampleProjectsthataimtodeterminethebehaviorofthepersonusingdifferentmodalitiesofsensing.KeytargetpopulationhereispeoplewithMCIordementiaasthereisagreatandrapidlygrowingneedtosupervisethemaslongastheyliveintheirownhouses.AgoodexampleofanoverallapproachtothischallengeistheeWallproject.TheconceptofeWallistoofferservicesinauser-friendlywayusingalargeinteractivescreen,runinabrowserandsupportedbyanextensivecloudserviceinfrastructure.Thewaytheservicesarepresentedisinnovativebyusinga50’shomeroomenvironment.Itoffersapersonalizedsetofservicesincludinghealthserviceslikeanactivitycoach,videobasedexercising,asleepqualificationsystemandapersonalizedguidancethroughtheday.

Personalcoachingsystems

Flickr-Kaptain Kobold

Rest Rest Rest Rest RestStress Stress Stress

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Stress management Coach

Figure6.Anintegratedcaringhomeenvironment,offeringhealth,wellnessandsafetyservicestopeoplewithchronicconditions(http://ewallproject.eu/)Integratedapproaches,likeeWall,requireconsiderablebandwidthfortheseservicesasthereislotofsensing,real-timedataprocessingandhumancomputerinteractionwithanimations.Itisgenerallyexpectedthatsuchapproachwithanintegrationofservicesandusingacloud-basedinfrastructurewillbecomecommonsoon.

Opportunitiesdueto5GOverlookingthedescribedupcomingareasthatwillhaveimpactonthehealthcare,especiallythecareforpeoplewithchronicconditions,ontheonhandandtryingtounderstandandforecastthecontribution5Gcanhavetotheseareas,onecouldmakethefollowingpredictions.

MovementanalysisandmonitoringFormonitoringpurposes,especiallyintheareaoftheanalysisoffunctionalmovements,moreandmorerathercomplexmultimodalsensorsareused,likecombinationsofgyroscopes,accelerometers,magnetometersandultrasoundtogetacomplete3Dpictureofthesubjectandhismovements.WhenthesearecombinedwithEMGmeasurementsofseveralmuscles,aconsiderablebandwidthisrequired.5Gwouldallowsuchsimultaneousmeasurementsinafreeconditionoutsidethelab.Andprobablyalsobeyondthepresentsetofmeasurements,likeadditionofEEGtoassessmotorcontrolandmoodinreal-timewouldbecomepossible,makingaholisticmonitoringofallrelevanthealthandbehaviouraspectspossible.Attheotherside,theviewingofallthesesensordatainanunderstandableandcomprehensiveway,isaconsiderablechallenge,especiallywhenthedatasetisexpandedextensively.Anupcomingtechnicalopportunityistheuseof

holographicprojections.Thiswouldallowthepresentationofthedatatothecareprofessionalinawayhe/sheisusedto,likeinhisdailypractice.Seeingthesubjectmove,whileinformationisaddedlikeinenhancedreality.The5Gbandwidthwouldhaveabigimpactinmakingthisfeasible.

PersonalcoachingsystemsPersonalcoachingsystemsareattractingmoreandmoreattentionasthewayforwardtosupportpeopleinchangingtheirbehaviour.Anearreal-timeresponseofthePCSisessential,astheuserhastobeabletolinkhisbehaviourtotherecommendationsthesystemisproviding,soheisabletobeawareofhisbehaviorandabletochangeitdirectly.MorecomplexPCSlikeoneforstressdorequireanindividuallymodeledcombinationofseveralsensorstogetanestimateofstressforfeedback.Thecapacitiesof5Gwouldsupportreal-timedatacollectionandprocessingcentrally,enablingtheuseofcomplexbehaviormodeling.

ThecaringhomeThecaringhomeisjustatthebeginningofitstime.TheupcomingInternetofthings(IoT)willextendthesensingandinteractioncapabilitiesofthehomeenvironmentconsiderablyand5Gwillenablereal-timedatacollectionofalltheon-bodyandcontextualIoTdata,enablingabetterintuitiveidentificationoftheuserneedsandrequiredresponsesofthehomeenvironment.Itwillalsoenabletheincorporationofnewsensingmethodsthatinvolvemoredata;likemooddetectionusingreal-timevideoprocessing.

DiscussionHealthcareisslowlybecomingawareofboththeneedtochangeandthepotentialbenefitsofe-healthandtelemedicineservices.Thereisalsoanincreasingawarenessofthedeterminantsofsuccessfulimplementation[4,5],basedonthemanyexperiencesgainedinthepastdecade.Presenthealthcareisnotyetfullyexploitingthecapacityofthepresent3Gand4Gnetworks.Electronicpatientrecordsdousealimitedamountoftrafficand,apartfromtheimagingdata,involvesmallamountsofdata.Onlyrehabilitationexercisingathomewherevideosareusedtoenableindependentexercisingdoesrequiresomesubstantialbandwidth.Nevertheless,itisexpectedthatthiswillchangetheupcomingyears,nowthatmanyhealthcareinstituteshavetheirEPDreadyandarenowlookingfortechnologysupportedinnovationsoftheircareservices.Andthiswillmeanthatthedescribedareaswillreceiveincreasingattention.Itisexpectedthat5Gwillenablesignificantstepsforwardintheareas.Theexpectedlargebandwidthcombinedwithhighreliabilityandavailability,willenablereal-timedatacollectionfromlargeamountofsensors(onbody,IoT),theuseofcomplexusermodelingandnewwaysofuserinteraction.Itwillalsoincreasetrustintheseareasbothbytheend-usersandcareprofessionalcommunity,speedingupthelargescaledeploymentofthesecaresupportingsolutions.

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