5th um-nus-cu trilateral mini symposium and scientific meeting 2014

5TH UM-NUS-CU TRILATERAL MINI SYMPOSIUM AND SCIENTIFIC MEETING 2014 11-12 FEBRUARY 2014, UNIVERSITY OF MALAYA, KUALA LUMPUR

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5th UM-NUS-CU TRILATERAL MINI SYMPOSIUM

AND SCIENTIFIC MEETING 2014

PROGRAMME AND

ABSTRACTS

DEPARTMENT OF CHEMISTRY, FACULTY OF SCIENCE,

UNIVERSITY OF MALAYA, 50603 KUALA LUMPUR

Welcome


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Table of Contents Page

Welcome note 3

Organizing committee 5

Delegation from Chulalongkorn University 6

Delegation from National University of Singapore 7

Scientific programme 8

Abstracts of invited speakers 11

Abstracts of poster presentations 24

Sponsors 114

Welcome


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Welcome note

Prof. Dr. Mhd. Radzi Abas

Welcome to the 5th UM-NUS-CU Trilateral Mini Symposium and Scientific Meeting

2014!! We are especially proud to be given the opportunity to organize this

symposium in the Department of Chemistry, UM this year.

Since the initiation of this symposium in 2009 in Bangkok, Thailand, we have strived

both to focus and broaden the scope of the symposium. The focus has been to

establish collaborative research and networking among the academics from the top

research universities in Malaysia, Singapore, and Thailand.

This year, the symposium is held on the 11th and 12th February 2014. The program

on the first day of the event is packed with oral presentations by 12 distinguished

speakers from the three univeristies. As before, the symposium is structured to allow

close interaction among the participants; hence together with the formal

presentations, there will be social occasions such as dinner at Eastin Hotel, where

the academics and attendees will get together and know each other better to

enhance opportunities for scientific intercourse. Besides, we have also arranged a

short tour for our guests to Rimba Ilmu, which means Forest of Knowledge in the

malay language. Rimba Ilmu is a tropical botanical garden, set up in the University of

Malaya campus in Kuala Lumpur. It is modelled after a rain forest garden concept

rather than a formal flower garden. It emphasises the flora of the Asean region with

living collections of over 1,600 species. The Rimba Ilmu also houses the University of

Malaya herbarium (acronym KLU) and has its own Environmental Education

Programme.

An administrative or annual meeting between the three institutes has also been

arranged and it will be held on the second day of this event to discuss matters

associated to research student exchange, collaboration, MoU, etc. With all these

programs in line, I greatly hope that we can make full use of our time and resources

in the next two days to discuss and deliberate on research issues, and at the same

time paving the way towards a more sustainable and resilient research

collaborations.

Welcome


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To our friends from Singapore and Thailand, the Department of Chemistry, UM

welcomes you, encourages you to visit and stay with us and hope that this trilateral

seminar will bond us even more strongly for our mutual benefit. I hope you will enjoy

yourself in the sympossium and have a wonderful time!!

Prof. Dr. Mhd. Radzi Abas,

Chairman of the Organizing Committee,

5th UM-NUS-CU Trilateral Mini Symposium 2014

Department of Chemistry,

University of Malaya.

Organisers


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Members of Organising Committee

Patron : Prof. Dato’ Dr. Mohd. Sofian Azirun

Dean, Faculty of Science, Univeristy of Malaya

Advisor : Prof. Dr. Sharifuddin Md. Zain

Chairman : Prof. Dr. Mhd. Radzi Abas

Secretary : Dr. Cheng Sit Foon

Treasurer : Dr. Teo Yin Yin

Liason officer : Dr. Cheng Sit Foon (UM – NUS)

Assoc. Prof. Dr. Vannajan Sanghiran Lee (UM – CU)

Members

(i) Dr. Desmond Ang Teck Chye

(ii) Dr. Low Kah Hin

(iii) Dr. Noraini Ahmad

(iv) Dr. Siti Nadiah Abdul Halim

(v) En. Mohd. Azli Ishak

(vi) En. Hashim Mohammad Salleh

(vii) En. Norafandi Tamar

(viii) En. Nor Mazni bin Jahari

(ix) En. Saifulrullah Abd. Rahim

(x) En. Yusriadie Mohd. Azmi

(xi) Pn. Norhaida Mohd. Nor

(xii) Pn. Norzainariah bt. Mat Zaid

(xiii) Pn. Siti Alimah Makmon

(xiv) Pn. Zailawati Mohamad Zakaria

CU Delegates


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Honorable Delegation from Chulalongkorn University

Assoc. Prof. Dr. Vudhichai Parasuk

Assoc. Prof. Dr. Paitoon Rashatasakhon

Assist. Prof. Dr. Worawan Bhantumnavin

Prof. Dr. Orawon Chailapakul

Assist. Prof. Dr. Sumrit Wacharasindhu

Dr. Numpon Insin

Assist. Prof. Dr. Viwat Vchirawongwin

Assist. Prof. Dr. Fuangfa Unob

Dr. Puttaruksa Varanusupakul

Dr. Rojrit Rojanathanes

Dr. Pannee Leeladee

Assist. Prof. Dr. Soamwadee Chaianansutcharit

Dr. Kanet Wongravee

Dr. Prompong Pienpinijtham

NUS Delegates


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Honorable Delegation from National University of Singapore

Prof. Dr. Chang Young Tae

Assoc. Prof. Dr. Valiyaveettil Suresh

Assoc. Prof. Dr. Kang Hway Chuan

Assoc. Prof. Dr. Chen Wei

Programme


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Scientific Programme Day 1 - 11th February 2014 Activity : Oral and poster presentations Venue : D112 (Oral) and Dataran Kimia (Poster) 8.30 – 9.30 a.m. Registration

9.30 a.m. Opening ceremony

9.30 – 9.45 a.m. Welcoming remarks and Briefing

Prof. Dr. Sharifuddin Md. Zain

Head, Department of Chemistry, Faculty of Science,

University Malaya, Malaysia

9.45 – 10.00 a.m. Speech and Briefing

Prof. Dr. Chang Young Tae

Head of Delegation,

National University of Singapore

10.00 – 10.15 a.m. Speech and Briefing

Assoc. Prof. Dr. Vudhichai Parasuk

Head, Department of Chemistry,

Chulalongkorn University, Thailand

10.15 – 10.30 a.m. Welcoming and Opening Speech

Prof. Dato’ Dr. Mohd. Sofian Azirun

Dean, Faculty of Science, University Malaya

10.30 – 10.40 a.m. Group photography session

All delegates

10.40 – 11.00 a.m. Coffee break and poster presentation

Venue: Dataran Kimia

11.00 a.m. Session 1

Chairperson : Prof. Dr. Chang Young Tae

11.00 –11.20 a.m. Speaker 1

Prof. Dr. Rauzah Hashim (UM)

Guerbet Glycoside: The New Lipid in Town

11.20 – 11.40 a.m. Speaker 2

Assoc. Prof. Dr. Chen Wei (NUS)

Atomic-Scale Interface Controlled Two-Dimensional Molecular

Dipole Dot Arrays

11.40 – 12.00 p.m. Speaker 3

Prof. Dr. Orawon Chailapakul (CU)

The Novel Electrochemical Systems For Environmental And

Clinical Applications

12.00 – 12.20 p.m. Speaker 4 UM

Prof. Dr. Khalijah Awang (UM)

Bioactive Phytochemicals From The Malaysian Flora And

Programme


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Medicinal Plants

12.20 – 12.40 p.m. Speaker 5

Assoc. Prof. Dr. Kang Hway Chuan (NUS)

Conductance And Electronic Structure Across Graphene

Nanoribbon Junctions

12.40 – 1.00 p.m. Speaker 6

Assist. Prof. Dr. Sumrit Wacharasindhu (CU)

Direct Synthesis of Acetylenic Compounds from Calcium

Carbide: a New Sustainable Chemical Feedstock

1.00 – 2.00 p.m. Lunch

Venue: Multipurpose room

Poster presentation


2.00 p.m. Session 2

Chairperson: Assoc. Prof. Dr. Paitoon Rashatasakhon

2.00 – 2.20 p.m. Speaker 7

Dr. Sharifah Mohamad (UM)

Application of β-cyclodextrin Functionalized With Ionic Liquid

For Extraction And Separation Of Organic Compounds

2.20 – 2.40 p.m. Speaker 8

Assoc. Prof. Dr. Valiyaveettil Suresh (NUS)

Understanding The Environmental Impact And Developing A

Remediation Method For Nanopollutants

2.40 – 3.00 p.m. Speaker 9

Dr. Numpon Insin (CU)

Surface Modifications and Environmental Applications of

Magnetic Nanoparticles and Quantum Dots

3.00 – 3.20 p.m. Speaker 10

Dr. Woi Pei Meng (UM)

Development of Non-Enzymatic Portable Body Metabolites

Sensor

3.20 - 3.40 p.m. Speaker 11

Prof. Dr. Chang Young Tae (NUS)

Caffeine Sensor and Bioimaging Probe Development

3.40 – 4.00 p.m. Speaker 12

Assist. Prof. Dr. Viwat Vchirawongwin (CU)

Evaluations of Vibration Spectra from Molecular Dynamics

Simulation of Hydrated Sulfoxy Anions

4.00 p.m. End of mini sympossium

Light refreshment


8.00 p.m. Dinner at Eastin Hotel (by invitation)

Programme


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Day 2 – 12th February 2014 Activity : Scientific meeting and discussion Venue : Rimba Ilmu and K017 8.30 – 9.45 a.m. Rimba Ilmu tour

9.45 –12.15 noon Discussion on academic staff exchange programme

Discussion on student exchange programme for

undergraduates and postgraduates

Venue: K017

12.15 – 12.30 p.m. Closing ceremony

12.30 p.m. Lunch

Venue: Multipurpose room

Abstract - Speakers


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ABSTRACTS OF

ORAL PRESENTATIONS

(Content unedited)

Abstract - Speakers


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Guerbet Glycoside: The New Lipid in Town

Rauzah Hashim

Chemistry Department, University of Malaya, Kuala Lumpur, Malaysia

*Email: [email protected]

Abstract

Here, we discuss some results from the study of self-assembly phenomena on a special class

of poly-hydroxy sugar surfactant, the branched chain Guerbet glycoside (BCGG). Surfactants

from this class of material are also classified as amphitropic liquid crystals since they exhibit

both thermotropic and lyotropic liquid crystalline properties. Hence the potential applications

of these non-ionic surfactants are far wider than the conventional lyotropic liquid crystals

encompassing both areas of high-technology industry and life science. From uniting the

approaches in experiment, theory and computation, we have developed some basic

understanding of the phase behavior. In turn, the self-assembly property may be manipulated

using external factors to give rise many innovative ideas. This review covers the effect of

stereochemical diversity of the sugar on the thermotropic/lyotropic phases formed. The

structure to property relationship compares different chain designs and other popular

polyhydroxy compounds, such as monooleins and alkylpolyglucosides. The structural

advantages of these Guerbet glycosides due to large chain hydrophobicity, tunable, chiral,

asymmetric and stable ether linking group are discussed with respect to their self-assembly

organization and potential applications, such as drug delivery, protein crystallization and

membrane mimetic study.

Keywords: Glycolipid, Guerbet Glycoside, Lyotropic, Non-ionic surfactant

Speaker 1

Abstract - Speakers


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Atomic-Scale Interface Controlled Two-Dimensional Molecular Dipole Dot

Arrays

Wei CHEN1,2*

1Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore,

117543

2Department of Physics, National University of Singapore, 2 Science Drive 3, Singapore,

117542

*E-mail: [email protected]

Abstract

Creation of well-ordered functional molecular arrays at the nanometer scale is one of the key

issues in the development for future molecular- or nano-electronic devices, solid-state

quantum computation, single-electron devices, and biosensors. Molecular self-assembly on

surfaces or surface nanotemplates via selective and directional covalent or non-covalent

interactions offers a promising bottom-up approach to fabricating molecular nanostructure

arrays with desired functionalities over macroscopic areas. The directionality and selectivity

of intermolecular hydrogen bonding, metal-ligand interactions as well as covalent bonding

can facilitate the formation of ordered supramolecular assemblies with good structural

stability. In this talk, we highlight our recent progress in the fabrication of self-assembled

molecular nanostructures on surface and surface nanotemplates, as investigated by in-situ

scanning tunneling microscopy, with particular emphasis on the fabrication of 2D molecular

dipole dot arrays, as well as the reversible switching of individual dipole molecule in

hydrogen-bonded 2D networks.

Keywords: Single Molecule, STM, Self-Assembly

Speaker 2

Abstract - Speakers


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The novel electrochemical systems for environmental and clinical

applications

Orawon Chailapakul1,*

, Thara Nurak1, Narong Praphairaksit

1, Nipapan Ruecha

2, Nadnudda

Rodthongkum3, Ratthapol Rangkupan

3

1Electrochemistry and Optical Spectroscopy Research Unit (EOSRU), Department of

Chemistry, Faculty of Science, Chulalongkorn University,10330, Thailand

2Program in Macromolecular Science, Faculty of Science, Chulalongkorn University, 10330,

Thailand

3Metallurgy and Materials Science Research Institute, Chulalongkorn University, 10330,

Thailand


Abstract

Our research topic focuses on a development of new electrochemical systems for the

detection of elemental species and biomakers of interest for the environmental and clinical

applications. The first project, we report a spraying method with lacquer developed for a

novel fabrication of paper-based devices. The paper-based devices were used to determine

nickel using anodic stripping voltammetry. Cu-enhancer solution was employed to increase

sensitivity of nickel determination with the optimal concentration of 4.5 ppm. Under the

optimal conditions, linear range was found to be in the range of 1 to 50 ppm with a coefficient

of determination of 0.9971. The limit of detection (LOD) and the limit of quantitation (LOQ)

were found to be 0.5 and 1.97 ppm, respectively. M oreover, these paper -based

electrochemical devices were applied to determine nickel in waste water from a jewelry

factory.

The second project, graphene-polymer nanodroplets are developed and used to modify

paper-based electrode for electrochemical detection of cholesterol. Nanodroplets of

Graphene-polymer were fabricated using electrospraying technique to increase the electrode

surface. The modified electrode was characterized for morphology and electroactivity by

using scanning electron microscope and cyclic voltammetry. This proposed method has been

used to detect cholesterol using chronoamperometry.

Keywords: Electrochemical sensor, Anodic stripping voltammetry, Amperometry, heavy

metal, biomarker

Speaker 3

Abstract - Speakers


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Bioactive Phytochemicals from the Malaysian flora and medicinal plants

Khalijah Awang

Department of Chemistry, Faculty of Science, University Malaya,

50603 Kuala Lumpur

Abstract

Since the dawn of civilisation, plants have been used as medicine and until today there are still the

main source for therapeutic agents especially the anti cancer drugs such as taxol and the indole

alkaloids vinblastine and vincristine. Malaysia is the home to one of the oldest and most diverse

flora in the world. It is the host of more than 15,000 plant species. Therefore, the Malaysian flora

is an excellent resource for bioactive and rare phytochemicals that could be potential candidates

for drug development. In view of the these factors, our laboratory is focussing our research on

bioactive natural products. Our findings on phytochemicals from various plant species shall be

presented. Examples of bioactive compounds possessing complex skeletons from plant families

such as Annonaceae, Apocynaceae, Meliaceae, Guttifereae shall be presented. In addition,

Malaysia is also rich with its traditional medicine heritage from three different cultures: Malay,

Chinese and Indian. Findings from the traditional medicinal plants studied in our laboratory shall

also be discussed briefly.Since the dawn of civilisation, plants have been used as medicine and

until today there are still the main source for therapeutic agents especially the anti cancer drugs

such as taxol and the indole alkaloids vinblastine and vincristine. Malaysia is the home to one of

the oldest and most diverse flora in the world. It is the host of more than 15,000 plant species.

Therefore, the Malaysian flora is an excellent resource for bioactive and rare phytochemicals that

could be potential candidates for drug development. In view of the these factors, our laboratory is

focussing our research on bioactive natural products. Our findings on phytochemicals from

various plant species shall be presented. Examples of bioactive compounds possessing complex

skeletons from plant families such as Annonaceae, Apocynaceae, Meliaceae, Guttifereae shall be

presented. In addition, Malaysia is also rich with its traditional medicine heritage from three

different cultures: Malay, Chinese and Indian. Findings from the traditional medicinal plants

studied in our laboratory shall also be discussed briefly.

Speaker 4

Abstract - Speakers


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Conductance and electronic structure across graphene

nanoribbon junctions

Kang Hway Chuan

Department of Chemistry, NUS

Division of Science, Yale-NUS College

Abstract

The antiferromagnetic electronic structure of zig-zag graphene nanoribbons is well-known,

leading to possible spin-polarized electron transport with a transverse electric field. We

explore an alternative way of achieving spin-polarized electron transport through a junction

consisting of zig-zag graphene nanoribbon leads and a small molecular link such as polyenes

and cumulenes. We will present our results discuss the effects on conductance of the

adsorption position for the linker molecule, edge decoration and relative rotations of the

graphene-nanoribbon leads.

Speaker 5

Abstract - Speakers


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Direct Synthesis of Acetylenic Compounds from Calcium Carbide: a New

Sustainable Chemical Feedstock

Sumrit Wacharasindhu, Padon Chuentragool, Nopparat Thavornsin, Narongpol

Kaewchangwad and Mongkol Sukwattanasinitt

Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330


Abstract

Acetylenic compounds are important building blocks for natural products,

pharmaceuticals and molecular materials. At the start of our research program, we explored

one of well-known acetylenenic derivatives: polydiacetylene (PDA) in sensor application. The

success of these works led to the development of point of care colorimetric sensors for

detecting temperature anionic surfactants and volatile organic compounds. To promote wider

adoption of PDA-based materials, we aim to develop a more cost efficient and safer method

to synthesize acetylenic derivatives in the second part of our project. In this presentation, we

demonstrated the use of calcium carbide, which is a low price primary feedstock from heavy

chemical industry for the synthesis of acetylenic compounds such as diarylethynes, poly-

phenyleneethylene and arylpyroles in one step fashion. The processes provide high yields of

acetylenic derivatives in comparable or better yield than conventional methods. It is also less

complicate and cheaper to carry out. The optimization and scope of the reaction will be

discussed in this presentation.

Keywords: Sonogashira, acetylene, conjugated polymer and calcium carbide

Speaker 6

mailto:[email protected]

Abstract - Speakers


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Application of β-cyclodextrin functionalized with ionic liquid for extraction

and separation of organic compounds.

Sharifah Mohamad*, Mhd Radzi Abas, Nor Kartini Abu Bakar, Tay Kheng Soo, Nur

Nadhirah binti Mohamad Zain, Muggundha Raoov a/L Ramachandran, Tay Kheng Soo

Department of Chemistry, Faculty of Science, University of Malaya, Kuala Lumpur 50603,

Malaysia


Abstract

The growing interest in cyclodextrin (CD) and ionic liquid (IL) in separation study, has

allowed us to combine these two domains of research to apply in extraction and separation of

organic compounds. In the first part of the presentation, I will focus on how the combination

of properties offered by both domains may be combined usefully for extraction and separation

of organic compounds. Cyclodextrin offer hydrophobic in nature can entrap different kinds of

compounds including organic, inorganic, organometallic and metaloorganic, while ionic

liquids offer unique properties such as negligible volatility, thermal stability, and non-

flammability make them acceptable as new green solvents. Owing to the properties of

cylcodextrin and ionic liquid, the functionalization of β-CD with IL has fostered our interest

in preparing a new generation of material that may demonstrate some interesting phenomena

in extraction and separation studies. In this paper, synthesize and characterization of β-

cyclodextrin functionalized with ionic liquid (β-CD-IL) will be presented and the application

of (β-CD-IL) in extraction and separation of organic compounds will be discussed.

Keywords: Cyclodextrin, Ionic Liquid, Extraction, Separation

Speaker 7


Abstract - Speakers


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Understanding the environmental impact and developing a remediation

method for nanopollutants

Suresh Valiyaveettil

Department of Chemistry, Faculty of Science,

National University of Singapore,

3 Science Drive 3, Singapore, 117543.

E-mail: [email protected]

Abstract

Nanoscience and nanotechnologies are expected to revolutionize our life in the coming years.

Engineered nanomaterials are already present in many consumer products such as cosmetics,

biomedical materials, detergents, antimicrobial paints, surface modifiers, food additives and

packaging materials, to name a few. Such increased usage of nanomaterials has caused

concerns from various quarters of our society, including government organizations and public

in general. The main reason for such concern involves the lack of our knowledge on the fate

of such nanomaterials inside the living organism. Recent studies have shown that metallic

nanoparticles are toxic to living systems. We have been examining such adverse impact of

nanomaterials in human cell lines and zebrafish models. On the other hand, if the

environments are contaminated with nanomaterials, there must be efficient materials and

methods to remove such pollutants from environment, especially potable water. Recently, we

tried to develop new renewable adsorbents for water purification. The current presentation

will give full details on environmental impact of nanomaterials and also look a t the future

remediation of contaminated environment.

Keywords: Nanotoxicity, zebrafish, metal nanoparticles, Water purification

Acknowledgement: The authors thank the Environment and Water Industry Programme

Office (EWI) under the National Research Foundation of Singapore (PUBPP 21100/36/2,

NUS WBS no. R-706-002-013-290, R-143-000-458-750, R-143-000-458-731) for the

financial support of the work. The authors also thank Faculty of Science, Department of

Chemistry, NUS Environmental Research Institute (NERI) for funding and technical support.

Speaker 8

Abstract - Speakers


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Surface Modifications and Environmental Applications of

Magnetic Nanoparticles and Quantum Dots

Numpon Insin

Department of Chemistry, Faculty of Science, Chulalongkorn University

Email: [email protected]

Abstract

Magnetic nanoparticles (MNPs) and semiconductor quantum dots (QDs) are two classes of

inorganic nanomaterials with unique properties. MNPs exhibit superparamagnetism, the

phenomenon of nanoscale ferromagnetic and ferrimagnetic materials that can stay colloidal

stable with strong response in presence of magnetic fields. QDs are known for their intense

and tunable fluorescence with broad range of excitation wavelength. In this presentation, we

will discuss about various surface modification processes that have been studied in our lab in

order to use these nanomaterials to solve and prevent some environmental problems.

Pollutants such as oil, heavy metals, and organic dyes were removed from water by

superparamagnetic sorbents. Moreover, QDs were used to monitor the level of some heavy

metals in waste water. From these studies, we found that these nanomaterials, after undergone

suitable surface modification processes, show their potential to be used in many applications

efficiently.

Keywords: Magnetic nanoparticles, superparamagnetic, quantum dots, fluorescent, pollutants

Speaker 9

Abstract - Speakers


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Development of Non-Enzymatic Portable Body Metabolites Sensor

Pei Meng Woi,1,* Ahmad Nazmi bin Rosli,1,2 , Yatimah Alias1 and Mohd Rais Ahmad2

1Department of Chemistry, Faculty of Science, University of Malaya, 50603 Lembah Pantai,

Kuala Lumpur, Malaysia.

2NEMS & Photonics Laboratory, MIMOS Berhad, Technology Park Malaysia, 57000



Abstract

Our research relates to prototype construction of molecular sensing devices of bio-chemical

nanosensors for bio-medical and health applications. This nanosensor can be used to monitor

health conditions by monitoring binding affinity of the metabolites thus possessing recognitive

ability geared towards ionic metabolites such as potassium, sodium, ammonium, hydrogen ions,

chloride, phosphate and carbonate of medical interest [1,2]. Similarly, biomolecule recognising

substituents are of importance for glucose and living body fluid such as blood and uric acid

determination. Our nanosensors can be used to monitor health conditions by monitoring the

calcium and magnesium level, with preferable selectivity towards calcium. This prototype which

is an integrated miniaturised sensor array along with readout circuitry and microcontroller on the

same platform provides fast and accurate measurement of the targeting analytes via potentiometric

method. The prototype we have here is based on nano-electrodes which are fabricated using

chemical vapour deposition (CVD) method, through selective deposition, nano-lithography and

etching. Alternatively, carbonised polymeric poles, carbon nano-tubes and graphenes can be

grown to function as electrodes [3]. This is an added advantage compared to other available

sensors on the market in terms of lifetime/reliability, accuracy, mobility, cost and manufactured

ability.

Keywords: Bio-chemical nanosensor, portable detection kit, USB terminal, functionalized

monomer

Suggested Reading:

1. Apodaca, D.C.; Pernites, R.B.; Ponnapati, R.R.; Del Mundo, F.R.; Advincula, R.C. ACS Applied Materials

& Interfaces, 2011 3(2), 191-203.

2. Workman, J.; Lavine, B.; Chrisman, R.; Koch, M. Anal. Chem., 2011, 83(12), 4557-4578.

3. Nayagam, D.A.X.; Williams, R.A.; Irwin, J.; Tan, J.; Innis, P.; Leung, R.T.; Finch, S.; Williams, C.E.;

Clark, G.M.; Wallace, G.G. Small 2011, 7 (8), 1035.

Speaker 10


Abstract - Speakers


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Caffeine Sensor and Bioimaging Probe Development

Young-Tae Chang

National University of Singapore

Department of Chemistry


Abstract

The conventional bioprobe design has been carried out by so-called hypothesis-driven

approach. The basic assumption of hypothesis-driven approach is that the scientist “knows

the target” in advance, and then design the recognition motif for it. An alternative approach is

diversity-driven approach, in which a broad range of fluorescence molecules in a library

format are constructed by combinatorial chemistry, as a tool box for unbiased screening.

Among several diversity sources, “Diversity Oriented Fluorescence Library Approach

(DOFLA)” using fluorophore core with diverse recognition motives around has been the most

fruitful in novel bioprobe generations. Using DOFLA, various sensors including caffeine

orange, and also colorful bioimaing probes from stem cells to Neurons will be demonstrated.

Keywords: Fluorescence, Sensor, Bioimaging, Probe

Speaker 11

Abstract - Speakers


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Evaluations of Vibration Spectra from Molecular Dynamics Simulation of

Hydrated Sulfoxy Anions

Viwat Vchirawongwin

Department of Chemistry, Faculty of Science, Chulalongkorn University, Phayathai Road,

Patumwan, Bangkok 10330, Thailand


Abstract

The sulfoxy anions consist of sulfur and oxygen atoms utilized in ubiquitous chemical

processes, resulting contamination in freshwater environments as evidence of water pollution

and in atmospheric aerosol particles. The aqueous solutions of sulfate, bisulfate, sulfonate and

thiosulfate anions were simulated by the ab initio quantum mechanical charge field molecular

dynamics (QMCF MD) formalism. The evaluation of vibration spectra from the trajectory of

simulations is a challenge to verify the dynamics property comparison with the experimental

data. This process uses the normal vector analysis on the molecular solute and the velocity

autocorrelation function (VACF) coupling with Fourier transformation, converting the MD

results into the power spectra. This evaluation provided the positions and patterns of

calculated spectra in very good agreements with available IR and Raman data, which can

confirm the appropriation of the selected theoretical level in the simulation protocol to acquire

the properties of these hydrated anions.

Keywords: Molecular Dynamics, Sulfoxy anion, Velocity autocorrelation function, Vibration

spectra

Speaker 12

Abstract -Poster


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ABSTRACTS OF

POSTER PRESENTATION

(CONTENT UNEDITED)

Abstract -Poster


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Index

Abstracts of Posters

Section Author Title Designation

Inorganic

Chemistry

Fadhil Lafta Faraj, Hapipah

Mohd Ali, Hamid Khaledi and

Noraini Ahmad

A meso-substituted β-

dialdiminate-bis(phenolate)

ligand in MnIII, Co

III , Co

II,, Ni

II

and CuII complexes

INORG 1

Nurul Azimah Ikmal Hisham,

Hamid Khaledi, and Hapipah

Mohd Ali

Di- and trinuclear metal

complexes derived from

pyrazolylindolenine

INORG 2

Ainnul Hamidah Syahadah

Azizan, Nurfarhanim Abu

Bakar, Teh Kai Ni, Gwaram

Nura Suleiman, Hapipah Mohd

Ali and Hamid Khaledi

Reduction of carbon-carbon

double bonds of Chalcone

using phenylsulfonyl

hydrazide

INORG 3

Mok Piew Heng, Kong Wai

Tan, Seik Weng Ng, Yoke

Kqueen Cheah, Sabrina

Sukardi

Synthesis and

characterization of nickel (II)

complex bearing a Schiff

base with a testosterone

moiety and its biological

properties

INORG 4

Farhatun Najat Maluin,

Sharifah Mohamad, Ninie S. A.

Manan

Ionic Liquid as the

morphology template for

polyaniline/ nano-hematite

composite

INORG 5

Subathra Sinniah, Sharifah

Mohamad, Ninie S.A. Manan

Synthesis and

Characterization of Fe3O4

Nanoparticles Coated with β-

CD-IL

INORG 6

Norbani Abdullah and Noha

Said A. Bedowr

Single-molecule magnet and

magnetic coordination

polymers with mesogenic

properties

INORG 7

Abeer Abduljaleel Ibrahim,

Hapipah Mohd Ali, Hamid

Khaledi

Spectroscopic and X-ray

crystallographic studies on

Pd+2

and Pt+2

complexes of

flexidentate Schiff base

ligand derived from indole-7-

thiosemicarbazone and their

anticancer activity

INORG 8

Shin Thung Chew, Kong Mun

Lo and Kong Wai Tan

Synthesis, Structural

Characterization And

Biological Properties Of

Copper Complexes With

Ligands Containing

Phosphonium Substituents

INORG 9

Sze Koon Lee, Kong Wai Tan,

Hoi Ling Seng

Zinc (II) Complex Bearing A

Cationic Schiff Base With A

Bromomethyl Group:

INORG 10

Abstract -Poster


Pag

e26

Synthesis, Spectroscopic

Characterizations And

Biological Study On E.Coli

Topoisomerase I Activity

Hana Bashir Shawish, Mohd

Jamil Maah

Synthesis and

Characterization of Nickel

complexes - New Insights

into the Structure and

Bonding of Thiourea Diamine

Derivatives

INORG11

Ishak, D. H. A., Ooi, K. K., Ang,

K. P., Akim, A. M., Cheah, Y.

K., Nordin, N., Halim, S. N. A.,

Seng, H. L. & Tiekink, E. R. T.1

A bismuth

diethyldithiocarbamate

compound promotes

apoptosis in HepG2

carcinoma, cell cycle arrest

and inhibits cell invasion

through modulation of the

NF-κB activation pathway

INORG12

Kit May Chow and Kong Mun

Lo

Organometallic Chemistry INORG13

Pannee Leeladee, Guy N. L.

Jameson, Maxime Siegler and

David Goldberg

A High-Valent Iron Imido

Corrolazine: Generation and

Evidence of NR Group

Transfer

INORG14

Richard C.S. Wong and Mei Lee Ooi

Isolation And Characterisation Of Novel Organometallic Derivatives Of Multidentate Phosphine

Bis[(o-methylthio)phenyl]phenylpho

sphine and Tris[(o-methylthio)phenyl]phosphine

INORG15

Wang Chunyan and Suresh Valiyaveettil

Study of cytotoxic effects of green synthesized silver

nanoparticles with different capping agents on tumor

cells

INORG16

Aina Mardia Akhmad Aznan, A. P. Safwan, Zanariah

Abdullah, Trupta Kaulgud, Hadi D. Arman, Matthew Mahindaratne, Laurie E.

McNeil, and Edward R. T. Tiekink

Supramolecular metathesis: cation exchange in salts

derived from the sulfa-drug, sulfathiazole

INORG17

Abstract -Poster


Pag

e27


Organic /

Natural

products

Nur Atiqah Mohd Nasuha and

Yeun-Mun Choo

Dyes From Natural

Resources ORG 1

Katrina Mohamad Khidzir, Sit

Foon Cheng and Cheng Hock

Chuah

Volatile Components of

Fresh Jasminum sambac

Buds and the Potential

Antioxidant Activities of its

Methanolic Extract

ORG 2

Chun Hui Ang, Sit Foon

Cheng, Chavasiri Warinthorn

and Cheng Hock Chuah

Antioxidant Potential of

Tannin-rich n-Butanol Extract

from Elaeis guineensis Leaf

ORG 3

Wei Seng Ng, Sit Foon Cheng,

Choy Sin Lee and Cheng Hock

Chuah

Synthesis of Palm Oil-Based

Polyester Polyols ORG 4

Wai-Ming Kok, Sit-Foon Cheng

and Cheng-Hock Chuah

Long Chain Saturated

Structured Lipids via

Enzymatic Interesterification

using Lipase Rhizomucor

miehei (Lipozyme RM IM)

ORG 5

Lim Jun Lee, Gan Chew Yan,

Low Yun Yee, Lim Siew Huah

and Kam Toh Seok

Alkaloid from Alstonia

rostrata ORG 6

Rojrit Rojanathanes, Kobkun

Saepang, Supakit

Seawpakorn, Patchanita

Thamyongkit, and Wittawat

Keawsongsang

Pyridine-Based Molecular

Pincer for Transition Metal

Complexation

ORG 7

Shah Bakhtiar Nasir and

Noorsaadah Abd Rahman

Aza Diels-Alder Rection of

Cyclic Imine with

Danishefsky’s Diene

ORG 8

Chun Keng Thy, Chin Fei Chee

and Noorsaadah Abd Rahman

Total Synthesis of (±)-

Cyclollicinone ORG 9

Jia Ti Tee, Chin Fei Chee and

Noorsaadah Abd Rahman

Total synthesis of (+)-

Morusalbanol A and (+)-

Sorocein B

ORG 10

Nurul Izzatil Aisya Asri, Issha Nadirah Ismail, Hairul Anuar

Tajuddin, and Zanariah Abdullah

Preparation and Fluorescence Behaviour Of

Coumarin Terminated Monolayer On Silver Particle

ORG11

Mohd Helmi Hussaini Dullah, Zanariah Abdullah, Hairul

Anuar Tajuddin

Synthesis and Fluorescence Characterization Of Azo-

Coumarin And Azo-Naphthol ORG12

Issha Nadirah Ismail, Nurul Izzatil Aisya Asri, Hairul Anuar

Tajuddin, and Zanariah Abdullah.

Alkyl Disulfide as an Alternative Absorbate for Monolayer Formation on

Silver Particles

ORG13

Abstract -Poster


Pag

e28


Physical /

Polymer /

Composites /

Material

chemistry

Nirosa Raman, Kavirajaa

Pandian Sambasevam and

Phang Sook Wai

Comparison studies of

polyaniline nanocomposite

with & without TiO2 for

hydrazine detection

PHY 1

Misni Misran, Teo Yin Yin,

Woo Juin Onn, Vicit Rizal Eh

Suk, and Yew Han Choi

Fatty acid nanoparticle for

topical and oral delivery

applications

PHY 2

T. H. Ali, R. S. D. Hussen and T. Heidelberg

Y-shaped Carbohydrate Surfactants by ‘Click

Chemistry’ for Oil-in-Water Emulsions

PHY 3

Nurshafiza Shahabudin, Rosiyah Yahya and Seng

Neon Gan

Preparation of microcapsules containing alkyd resin as

core

PHY 4

M.S. Nusari and A. Mainal

Adsorption of Methylene blue onto Chitosan-Based

Activated Carbon: Isotherm and Kinetic Studies

PHY 5

Vannajan Sanghiran Lee, Vertika Gautam, Wei Lim

Chong, Sharifuddin M. Zain, Noorsaadah Abd. Rahman

Hot-Spot Motif Characterization of Interface between a Designed Ankyrin-Repeat Protein and Its Target

Kinase

PHY 6

Pedram Azari, Haris Akram, Gan Seng Neon, Rosiyah Yahya, Wong Chiow San, Belinda-Pingguan Murphy

An in vitro biological evaluation of electrospun

poly(3-hydroxybutyrate) and bovine hydroxyapatite

composite scaffold for bone tissue engineering

PHY 7

Pameswari Subramani,Yeong Siang Chiam, Seng Neon Gan,

Sook Wai Phang

Synthesis, Characterization And Application Of

Polyaniline (PAni) Optical Sensor For pH Detection

PHY 8

Zahrabatoul Mosapour Kotena, Reza Behjatmanesh–Ardakani,

Rauzah Hashim

Hydrogen bonds formation in α/β-D-mannose and n-octyl-

α/β-D-mannopyranoside using AIM and NBO analyses

PHY 9

Abbas Abdulameer Salman and Thorsten Heidelberg

Bio-Functionalization of Inorganic Nanoparticles

PHY 10

Vannajan Sanghiran Lee, Kanchanok Kodchakorn, Jitrayut Jitonnom, Piyarat Nimmanpipug, Prachya Kongtawelert, Bhusana

Premanode, Wei Lim Chong, Sharifuddin M. Zain,

Noorsaadah Abd. Rahman

Exploration on the Role of Metal Cofactors and Water on the Catalytic Mechanism of Creatininase-Creatinine in

Aqueous Solution from Molecular Dynamics

Simulation/Quantum Study

PHY11

Shabnam Bakhshaei, Sharifah Mohamad, Sharifuddin Md

Zain

Synthesis and characterization of of new

sol–gel titanium(IV) butoxide–

cyanopropyltriethoxysilane in cooperated with imidazolium-

based ionic liquids

PHY12

Naimah Haron, Nor Asrina Sairi, Mohamed Kheireddine

Aroua, Yatimah Alias

Effect of Water Concentration on the Structural and

Diffusion Properties of

PHY13

Abstract -Poster


Pag

e29

Guanidinium Trifluoromethanesulfonate

Ionic Liquid− Mixture

Nor Asrina Sairi, Mohd Azlan

Kassim, Rozita Yusoff,

Mohamed Kheireddine Taieb

Aroua

CO2 Capture in Ionic Liquid:

A review on mixed solvent

systems PHY14

Zati Ismah Ishak, Nor Asrina

Sairi, Yatimah Alias, Mohamed

Kheireddine Taieb Aroua

Transesterification reaction:

Facile reaction by ionic

liquids as catalyst – A review PHY15

Wan Melissa Diyana Wan

Normazlan, Vijaya

Ranganathan, Usman Ali

Rana, Nor Asrina Sairi,

Yatimah Alias and Douglas

MacFarlane

The Role of Hydrogen

Bonding by New Protic Ionic

Liquids in Driving Phase

Separation or Phase

Miscibility in UCST Ternary

Mixtures.

PHY16

Prompong Pienpinijtham, Xiao Xia Han, Sanong Ekgasit, and

Yukihiro Ozaki

A Fabrication of Surface-Enhanced Raman Scattering (SERS) Substrate Using an Ionic Surfactant-Mediated Langmuir-Blodgett Method

PHY17

Supamas Kanjanakunthon, Nipaka Sukpirom and

Puttaruksa Varanusupakul

Electrospun Titanium Dioxide Fibers as Stationary Phase in Thin Layer Chromatography

PHY18

Anucha Koedtruad, Koichiro Mitsuke and Soamwadee

Chaianansutcharit

Effects of Sintering Temperature on Conductivity and Oxygen Permeation of

La0.3Sr0.7Co0.9Fe0.1O3 Perovskite

PHY19

Norazlinaliza Salim, Rauzah Hashim and Noraini Ahmad

Formation of Branched-Chain Glycolipids Nano-Emulsions

for Topical Drug Delivery Systems

PHY20

Faheem Ahmed Qaid, Abdul Hamid bin Yahaya and

Rosiyah binti Yahya

Kinetic and isotherm adsorption of phenol from

wastewater using activated carbons prepared from

jatropha seed husks by KOH activation

PHY21

Yee Ting Chong, Norazilawati Muhamad Sarih, Sie Tiong Ha,

Rezaul Karim Sheikh

Synthesis and Mesomorphic Properties of Schiff’s Base

Ester with Terminal Methoxy Substituent

PHY22

Olla .H.Sharhan, Abdul Hamid Yahaya and Mohamed

Mahmoud Nasef

Preparation and characterization of poly (3-

hydroxybutyric acid)/poly(vinyl acetate) thin

films

PHY23

Sung-Jin Park, Nam-Young Kang, Anandhkumar Raju, Xiao Wei Emmiline Ang,

Animesh Samanta, Seong-Wook Yun and Young-Tae

Chang

Development of in vivo Inflammation Imaging Probes

PHY24

Nam-Young Kang, Sung-Chan Lee, Sung-Jin Park, Seong-

Development of in vivo imaging probes for

PHY25

Abstract -Poster


Pag

e30

Wook Yun, and Young-Tae Chang

pancreatic islets by Diversity Oriented Fluorescence

Library Approach (DOFLA)

Young-Tae Chang and Seong-Wook Yun

Fluorescent chemical imaging probes for live stem

cells PHY26

Animesh Samanta,Kaustabh Kumar Maiti, U. S. Dinish and

Young-Tae Chang

Near-Infrared Raman Reporters for SERS-based in

vivo Cancer detection PHY27

Wan Hamdah Wan Ahmad

Effect Of Pure Cationic Micelle ([Ctabr]T On The Rate Of Alkaline Hydrolysis Of N-(2-Aminophenyl)Phthalimide

PHY28

Norazizah A. Razak, Nor Saadah M. Yusof and M. Niyaz

Khan

Quantitative Correlation Between Counterion (X)

Affinity to Cationic Micelles and X-Induced Micellar

Growth for X = 2,6-Dichlorobenzoate Ions

PHY29

Ashok Keerthi, Yeru Liu, Qing

Wang, Suresh Valiyaveettil

Multidonor Substituted Perylene Dyes through Unusual Bromination of

Perylene Monoimide

PHY30

Perakassh veloo, Yen Nee Koh, Sook Wai Phang

Morphology Studies of Doped Polyaniline

Nanocomposites Containing TiO2 Nanoparticles and Graphene Nanoplatelets

PHY31

Muhammad Adil Mansoor, Muhammad Mazhar and

Zainudin Artfin.

Development of Photosensitive Ceramic Thin

Films for Photovoltaic Applications

PHY32

Abstract -Poster


Pag

e31


Analytical /

Environmental

Adam Henry Sivapatham,

Nadiya Taha Darwish, Mai Mai

Khoo and Sook Mei Khor

Development of a Reusable

Biosensor for Small

Molecules

AN-EV 1

Mehwish Jamil Noor, Muhammad Aqeel Ashraf,

Mushtaq Ahmad,Amber latif, Sonia Fatima

Identification and Evaluation of Air Pollution Tolerance

Index of Plant Species under the Impacts of Marble Industry Pollutants of

AN-EV 2

Rizwana Naureen, Imran Hashmi, Mohd, Jamil Maah, Ismail Yusoff, Muhammad

Aqeel Ashraf

Biodegradation Studies of Dichlorvos under Different

Sets of Conditions

AN-EV 3

Shiau Yi Tan and Kah Hin Low

Prediction of cetirizine hydrochloride content in

medication tablet using ATR-FTIR and PLS

AN-EV 4

Mehrnaz Ashrafi, Sharifah Mohamad, Ismail Yusoff, Fauziah Shahul Hamid

Remediation of Heavy Metal Contaminated Soil Using

Banana Stem as the Organic Fixing Additive

AN-EV 5

Fathiah Zubaidi, Guan Huat Tan, Choo Yeun Mun

Development and Validation of Liquid Chromatography

Tandem Mass Spectrometer (LCMSMS) for the

Simultaneous Determination of Common Drugs of Abuse

in Forensic Cases in Malaysia: Application to Dried Blood Stain (DBS)

AN-EV 6

Ummi Noor Salhah Masseren, Tay K.S, Abas M.R.B

Preliminary Result On Screening Of

Pharmaceuticals In Hospital Sungai Buloh Wastewater

Treatment Plant

AN-EV 7

Jarinya Sittiwong, Fuangfa

Unob

Detection of creatinine in

urine samples by gold

nanoparticles

AN-EV 8

Kanet Wongravee, Tewalak

Parnklang, Yukihiro Ozaki,

Chuchaat Thammacharoen,

Sanong Ekgasit

Chemometric Analysis of

Spectroscopic Data on

Shape Evolution of Silver

Nanoparticles Induced by

Hydrogen Peroxide

AN-EV 9

H.H. Mohammad, Khalisanni

Khalid, Kheng Soo Tay,

Sharifuddin Md. Zain, Rashid

Atta Khan

The Influence of Triton-X on

the Evaporation Rate of

Methanol- An analysis using

Reversed-Flow Gas

Chromatography (RF-GC)

Methodologies

AN-EV 10

Ramakrishna Mallampati, Ong Pin Jin, Suresh Valiyaveettil

Efficient removal of engineered nanoparticles from water using renewable resources

AN-EV11

Abstract -Poster


Pag

e32


UM

Undergraduate

poster

Final Year

Project

and

Internship

Mak Oi Wei, Maheswari D/O

Paliyanny

Multi-residue Analysis of β-

Agonists in Tissues by LC-

MS/MS

UP 1

Ong Pei Pei and Dr. Ng Mei

Han

Extraction Of Phytonutrients

From Crude Palm Oil And

Red Palm Oil Using Ionic

Liquid

UP 2

Su-Han Ng and Toh-Seok

Kam Alkaloids from Alstonia sp. UP 3

Sim-Yee Cha, Bonnie Yen-

Ping Tay, and Pei-Meng Woi

Analysis of Compound P, A

By-Product of Palm-Based

Ester

Using HPLC-MWD

UP 4

Abstract -Poster


Pag

e33

A meso-substituted β-dialdiminate-bis(phenolate) ligand in MnIII

, CoIII ,

CoII

, NiII

and CuII

complexes

Fadhil Lafta Faraj*, Hapipah Mohd Ali, Hamid Khaledi and Noraini Ahmad

Department of Chemistry, Faculty of Science, University of Malaya,

Kuala Lumpur 50603, Malaysia


Abstract

Copper, nickel, manganese and cobalt complexes have been synthesized from a new ligand

derived from condensation reaction of 2-aminophenol and 2-(3,3-dimethylindolin-2-ylidene)

malonaldehyde. The structures of ligand and complexes were characterized by FT-IR, UV–

Vis, TGA, 1

H and 13

C-NMR spectroscopy and magnetic susceptibility measurements,

elemental analysis and X-ray crystallographic analysis.

Keywords: 2-(3,3-dimethylindolin-2-ylidene) malonaldehyde, 2-aminophenol, complexes

INORG 1

Abstract -Poster


Pag

e34

Di- and trinuclear metal complexes derived from pyrazolylindolenine

Nurul Azimah Ikmal Hisham*, Hamid Khaledi, and Hapipah Mohd Ali.

1Department of Chemistry University of Malaya, 50603 Kuala Lumpur,Malaysia


Abstract

Reactions of the 2,3,3-trimethylindolenine with Vilsmeier reagent (DMF/POCl3) produced

aminomethylene-malonaldehyde which reacted with hydrazine to obtain the corresponding

pyrazolylindolenine. The heterocycle was used in the synthesis of a series of di- and

trinuclear metal complexes. The structures were characterized by single crystal X-ray

diffraction and magnetic susceptibility.

Keywords: Dinuclear, Trinuclear, Metal complexes, Pyrazolylindolenine

Suggested Reading :

1. R. M. Aghdam, M. M. Baradarani & A. Afghan, Curr. Chem. Lett. 2 (2013) 13.

2. J.E. Cosgriff, G.B. Deacon, Angew. Chem., Int. Ed. 37 (1998) 286.

3. O. Kahn, Molecular Magnetism, Wiley-VCH, Weinheim, 1993.

INORG 2

Abstract -Poster


Pag

e35

Reduction of carbon-carbon double bonds of Chalcone using phenylsulfonyl

hydrazide

Ainnul Hamidah Syahadah Azizan*, Nurfarhanim Abu Bakar, Teh Kai Ni, Gwaram Nura

Suleiman, Hapipah Mohd Ali and Hamid Khaledi

Department of chemistry, Faculty of Science, University of Malaya.


Abstract

The reactions of substituted chalcones with phenylsulfonyl hydrazide in ethanol resulted in

the reduction of the carbon-carbon double bond of the chalcones. While in the presence of

sodium acetate, the reactions gave the corresponding ketones as the sole product, in acidic

conditions, along with the ketones, sulfones were generated. The reactions were also carried

out in solvent-free conditions were the ketones were obtained as the sole-products. The

products were all characterized by IR and NMR spectroscopy and also X-ray crystallographic

analysis.

Keywords: Chalcones, Phenylsulfonyl hydrazide, carbon-carbon reduction

Suggested Reading:

1. Smit C., Fraaije M.W. and Minnaard A. J. (2008). Reduction of Carbon−Carbon Double Bonds Using

Organocatalytically Generated Diimide, J. Org. Chem., 73, 9482–9485

2. Li, J.P.; Zhang, Y.X.; Ji, Y. (2008). Selective 1,4-reduction of chalcones with Zn/NH4Cl/C2H5OH/ H2O. J.

Chin. Chem. Soc., 55, 390–393.

INORG 3

http://pubs.acs.org/doi/abs/10.1021/jo801588d

http://pubs.acs.org/doi/abs/10.1021/jo801588d

Abstract -Poster


Pag

e36

Synthesis and characterization of nickel (II) complex bearing a Schiff base

with a testosterone moiety and its biological properties

Mok Piew Heng1,2

, Kong Wai Tan2, Seik Weng Ng

2, Yoke Kqueen Cheah

1, Sabrina Sukardi

1

1Department of Biomedical Sciences, Universiti Putra Malaysia, 43400 Serdang, Malaysia

2Department of Chemistry, University of Malaya, 50603 Kuala Lumpur, Malaysia.


Abstract

A Schiff base ligand L was prepared by refluxing equimolar amount of testosterone and

thiosemicarbazide in boiling ethanol with continuous stirring for 6 hours. Crystal of L was

obtained from slow evaporation ethanol at room temperature. Its nickel (II) complex 1 were

synthesized and precipitated upon addition of nickel acetate into ethanolic solution of L.

Complex 1 was recrystallized from mixture of DMF:methanol (3:8).

These compounds sythesized were characterized by using FTIR, CHN, 1H-NMR, and X-ray

crystallography. These spectroscopic methods confirmed the formation of L from

condensation of testosterone and thiosemicarbazide. Besides, X-ray study also proved that

complex 1 is in a slightly distorted square planar environment. L acts as a bidentate OS-donor

ligand, whereby a mononuclear complex 1 is coordinated to 2 L via 2 imine nitrogens and 2

tautomeric thiol sulfurs.

The inhibitory effects of L and 1 on E. coli topoisomerase I were evaluated by agarose gel

electrophoresis. However, both compounds failed to inhibit topoisomerase I even at high

compound concentration (500 µM). The DNA binding ability of these compounds were

determined by UV-vis spectroscopy and the intrinsic binding constants (Kb) for the interaction

of the compounds with calf thymus DNA were determined by employing Wolfe-Shimmer

equation. Complexation with nickel dramatically increased the binding ability.

Keywords: Testosterone, Thiosemicarbazide, Nickel, Schiff base, DNA binding

INORG 4

Abstract -Poster


Pag

e37

Ionic Liquid as the morphology template for polyaniline/ nano-hematite

composite

Farhatun Najat Maluin*, Sharifah Mohamad, Ninie S. A. Manan

Department of Chemistry, University Malaya, 50603 Kuala Lumpur.


Abstract

The synthesis and morphology of polyaniline/hematite(α-Fe2O3) was explored using an

imidazolidium base ionic liquids (ILs). A series of ILs with different length of alkyl chain

with several types of anions (Cl, BF4, PF6 and NTf2) have been tested. A direct chemical

synthesis of polyaniline-ferric oxide was prepared via interface polymerization. This

polymerization occurs between the layer of ionic liquid and immiscible solvent. The reactions

were simple and fast as the green thin layer of polyaniline in the interface can be observed

immediately. The composite were subjected to the structural characterization by Infrared

spectroscopy (FT-IR), X-ray Diffraction (XRD) and UV spectroscopy. The FT-IR result

confirmed the formation of polyaniline in the composite while the XRD result confirmed the

presence of hematite in the composite. The morphology of the nanocomposites was confirmed

with Field Emission Scanning Microscopy (FESEM) and Transmission Electron Microscopy

(TEM). The size, shape and distribution of nanoparticle of hematite loading in nanocomposite

of polyaniline-ferric oxide were determined. In addition, the magnetic susceptibility of

polyaniline/nano-hematite composite has been investigated by using Guoy balance

magnetometer.

Keywords: Ionic Liquid, Polyaniline, nano-hematite

INORG 5

Abstract -Poster


Pag

e38

Synthesis and Characterization of Fe3O4 Nanoparticles Coated

with β-CD-IL

Subathra Sinniah*, Sharifah Mohamad, Ninie S.A. Manan

Department of Chemistry, Faculty of Sciences,

University Malaya, 50603 Kuala Lumpur, Malaysia


Abstract

Beta Cyclodextrin-Ionic liquid (β-CD-IL) coated with iron oxide nanoparticles (FeNPs) were

synthesized by chemical co-precipitation method. The structure and morphology of prepared

complex was characterized using X Ray Diffaction (XRD), Tramission Electron Microscope

(TEM), Fourier Transform Infrared Spectroscopy (FT-IR), Thermal Gravimetric Analysis

(TGA) and Field Emission Scanning Electron Microscopy (FESEM). The results of analysis

confirmed the proposed complex as the product. The FESEM showed β-CD-IL-FeNPs have

mean diameter (between 10 to 30nm).

Keywords: Beta Cyclodextrin, Ionic liquid, Fe3O4 Nanoparticles

INORG 6

http://www.photometrics.net/fesem.html

Abstract -Poster


Pag

e39

Single-molecule magnet and magnetic coordination polymers with

mesogenic properties

Norbani Abdullah and Noha Said A. Bedowr*

Chemistry Department, University of Malaya, 50603 Kuala Lumpur, Malaysia


Abstract

Single molecule magnets and magnetic coordination polymers are examples of advanced low-

dimensional materials, especially for spintronic applications. They may be constructed from

copper(II) ion and ditopic ligands, such as 2,2’-bipyridine and 4,4’-bipyridine. This paper

reports the synthesis and characterization of a single molecule magnet,

[Cu2(ɳ2-(OOCR)2(ɳ

1-(OOCR)2(2,2'-bpy)].H2O (1), and a coordination polymer,

{[Cu2(ɳ2-(OOCR)2(ɳ

1-(OOCR)2(2,2'-bpy)(4,4'-bpy)].H2O}n (2), where R = CH3(CH2)14.

These complexes were characterized by elemental analyses, FTIR and UV-vis spectroscopies,

magnetic susceptibility, differential scanning calorimetry (DSC) and optical polarized

microscopy (OPM). Both complexes showed weak antiferromagnetic interactions between the

square pyramidal Cu(II) centres, and exhibit mesomorphisms.

Keywords: Cu(II), Single molecule magnet, Coordination polymer, Magnetic,

Mesomorphism

INORG 7


Abstract -Poster


Pag

e40

Spectroscopic and X-ray crystallographic studies on Pd+2

and

Pt+2

complexes of flexidentate Schiff base ligand derived from indole-7-

thiosemicarbazone and their anticancer activity

Abeer Abduljaleel Ibrahim*, Hapipah Mohd Ali, Hamid Khaledi

Chemistry Department, Faculty of science, University of Malaya,

50603 Kuala Lumpur, Malaysia

*Email : [email protected]

Abstract

A new indolyl-imine ligand was synthesized by the condensation reaction of indole-7-

carbaldehyde with thiosemicabazide . This ligand was reacted with Pd+2

and Pt+2

. The

chemical structures and purities of the complexes were evaluated by 1HNMR and X-ray

crystalloghraphy. In the palladium complex, the Schiff base molecule acts as a tridantate-

N,N,S ligand to chelate the metal center via its indole and azomethine nitrogens and thiolate

sulfur atoms to afford a complex of the type 2:1 (ligand/metal ratio) in square planner

coordination geometry. Also,the Schiff base coordinates Pt+2

ion as a tridentate ligand via

N,N,S atoms to form a complex of the type 1:1(ligand/metal) in square planner geometry.

Anticancer activity of the ligand and its complexes are investigated in vitro assay.

Suggested Pathway:

Keywords: Thiosemicarbazone, Platinum complex, Palladium complex, Crystal structure,

Anticancer assay

INORG 8

Abstract -Poster


Pag

e41

Synthesis, Structural Characterization And Biological Properties Of

Copper Complexes With Ligands Containing Phosphonium Substituents

Shin Thung Chew*, Kong Mun Lo and Kong Wai Tan

Department of Chemistry, Faculty of Science, University of Malaya, 50603 Kuala Lumpur,

Malaysia

* E-mail: [email protected]

Abstract

The interaction between anticancer drugs and nucleic acids has attracted much attention in

molecular pharmacology, pharmaceutical chemistry and biological chemistry. It is commonly

believed that DNA is one of the main target of many antitumor agents. In this connection, a

series of copper complexes containing phosphonium substituted hydrazones was synthesized

and further reacted with diamine ligands. All the compounds were characterized by elemental

analysis and spectroscopic methods (FT-IR, NMR and UV-Vis) and in the case of crystalline

products by X-ray crystallography. In addition, the DNA binding and nucleolytic properties

of these Schiff base complexes were evaluated by using spectroscopic methods and gel

electrophoresis. The topoisomerase I inhibition was also carried out in an attempt to

investigate the ability of complexes to inhibit the topoisomerase I enzyme.

Keywords: Hydrazones, DNA binding, topoisomerase I inhibitor, copper complexes

INORG 9


Abstract -Poster


Pag

e42

Zinc (II) Complex Bearing A Cationic Schiff Base With A Bromomethyl

Group: Synthesis, Spectroscopic Characterizations And Biological Study

On E.Coli Topoisomerase I Activity

Sze Koon Lee, Kong Wai Tan, Hoi Ling Seng

Department of Chemistry, Faculty of Science, University of Malaya, 50603, Kuala Lumpur,

Malaysia.


Abstract

A new cationic schiff base (STB) was synthesized by refluxing (3-Formyl-4-hydroxybenzyl)

triphenylphosphonium chloride with 2-bromoethylamine.HBr. The ligand treated with zinc

acetate salts in 1:1 molar ratios afforded the new metal complex, ZnSTB. Schiff base and its

zinc complex formation have been confirmed by using IR, NMR, CHN and x-ray diffraction

analysis. STB can be dissolved in most of the polar solvent, whereas ZnSTB only dissolve in

DMF and DMSO. X-ray diffraction study shows that ZnSTB is four coordinated and the

coordination geometry around zinc (II) is tetrahedral. Two bromine atoms are attached to the

central zinc in cis-position and the singly deprotonated STB acts as an ON-donor ligand. The

inhibition effect of STB and ZnSTB on E.coli topoisomerase I have been evaluated by gel

electrophoresis. Results show that the inhibitory effect of STB is further enhanced upon

complexation with zinc.

Figure 1: Structure of STB

INORG 10


Abstract -Poster


Pag

e43

Figure 2: Structure of ZnSTB

Figure 3: Effect of various concentrations of STB on the inhibition of E.coli topoisomerase I

activity

Figure 4: Effect of various concentrations of ZnSTB on the inhibition of E.coli

topoisomerase I activity

Keywords: Zinc, cationic, schiff base, triphenylphosphine, topoisomerase

Abstract -Poster


Pag

e44

Synthesis and Characterization of Nickel complexes - New Insights into the

Structure and Bonding of Thiourea Diamine Derivatives

Hana Bashir Shawish*, Mohd Jamil Maah

Department of Chemistry, University of Malaya, 50603 Kuala Lumpur, Malaysia

* Email: [email protected]

Abstract

Three series of nickel(II) complexes with thiourea ligands have been synthesized. Complexes

of the formula [Ni(RNHCSNHRR̀)2] and [Ni2(RNHCSNHRR̀)2(NN)2]X where R= phenyl,

R̀= o-phenylamine, p-phenylamine and o-aminopyridine, NN= N,N bidentate ligand, X= NO3-

; Cl-, have been characterized by elemental analysis, UV-Vis, IR, NMR spectroscopic studies

as well as single crystal X-ray diffraction. Thiourea diamine ligands have been coordinated to

nickel(II) and the differing binding modes of the ligands in the absence and presence of co-

ligands have been investigated. The crystal structures of the complexes show that the reaction

of thiourea ligands with nickel(II) salts yields mononuclear diamagnetic complexes with

thiourea ligand coordinates as bidentate NS donors, while the reaction of nickel salts with the

thiourea ligands in the presence of 1,10-phenanthroline or 2,2-bipyridine affords binuclear

paramagnetic complexes with the thiourea ligands coordinate as tridentate NNS donors. The

ligands and their nickel complexes were subjected to test their DNA topoisomerase I

inhibition efficiency.

Keywords: Nickel(II) complexes, Thiourea, Diamine Derivatives, Binuclear complexes,

DNA Topoisomerase I

INORG 11

Abstract -Poster


Pag

e45

A bismuth diethyldithiocarbamate compound promotes apoptosis in HepG2

carcinoma, cell cycle arrest and inhibits cell invasion through modulation of

the NF-κB activation pathway

Ishak, D. H. A.1, Ooi, K. K.

2, Ang, K. P.

2, Akim, A. M.

2*, Cheah, Y. K.

2, Nordin, N.

3, Halim,

S. N. A.1, Seng, H. L.

1 & Tiekink, E. R. T.

1**

1Department of Chemistry, University of Malaya, 50603, Kuala Lumpur, Malaysia.

2Department of Biomedical Science, Faculty of Medicine and Health Sciences, University

Putra Malaysia, 43400, Serdang, Selangor, Malaysia.

3Department of Obstetrics and Gynaecology, Faculty of Medicine and Health Sciences,

University Putra Malaysia, 43400, Serdang, Selangor, Malaysia.


**Email: [email protected]

Abstract

The compound with R = CH2CH3 in Bi(S2CNR2)3 (1) is highly cytotoxic against a range of

human carcinoma, whereas that with R = CH2CH2OH (2) is considerably less so. Both 1 and

2 induce apoptosis in HepG2 cells with some evidence for necrosis induced by 2. Based on

DNA fragmentation, caspase activities and human apoptosis PCR-array analysis, both the

extrinsic and intrinsic pathways of apoptosis have been shown to occur. While both

compounds activate mitochondrial and FAS apoptotic pathways, compound 1 was also found

to induce another death receptor-dependent pathway by induction of CD40, CD40L and TNF-

R1 (p55). Further, 1 highly expressed DAPK1, a tumour suppressor, with concomitant down-

regulation of XIAP and NF-κB. Cell cycle arrest at the S and G2/M phases correlates with the

inhibition of the growth of HepG2 cells. The cell invasion rate of 2 is 10-fold higher than that

of 1, a finding correlated with the down-regulation of survivin and XIAP expression by 1.

Compounds 1 and 2 interact with DNA through different binding motifs with 1 interacting

with AT- or TA-specific sites followed by inhibition of restriction enzyme digestion; 2 did not

interfere with any of the studied restriction enzymes.

Keywords: Bismuth, Apoptosis, Metallopharmaceuticals, Cell cycle, NF-κB

INORG 12



Abstract -Poster


Pag

e46

Organometallic Chemistry

Kit May Chow* and Kong Mun Lo

University Malaya, Faculty of Science, Department of Chemistry,

Kuala Lumpur, 50603, Malaysia.


Abstract

Organotin(IV) complexes have received considerable attention because of their biological

properties, particularly antitumor, antibacterial and antifungal activity. An important class of

organotin(IV) complexes with potential biological activities are those derived from ligands

containing nitrogen and oxygen donor atoms. The easily accessibility and structural features

made them the target of numerous biological and catalytic studies. New diorganotin(IV) and

monoorganotin(IV) complexes have been synthesized from the reaction of the corresponding

diorganotin(IV) dichloride or diorganotin(IV) dibromide with tridentate ligands such as (E)-

4-chloro-N’-(2-hydroxy-4-methoxybenzylidene)benzohydrazide and (E)-4-chloro-N’-(3,5-

dichloro-2-hydroxybenzylidene)benzohydrazide in methanol. All the complexes were

characterized by elemental analysis, IR and NMR (1H and

13C) spectroscopic studies, and

their molecular structures have been confirmed by single crystal X-ray diffraction analysis.

Keywords: Organotin Compounds (OTCs), Mononuclear organotin(IV) complexes, Crystal

structure

INORG 13


Abstract -Poster


Pag

e47

A High-Valent Iron Imido Corrolazine: Generation and Evidence of NR

Group Transfer

Pannee Leeladee1,3

, Guy N. L. Jameson2, Maxime Siegler

1 and David Goldberg

1,*

1Department of Chemistry, The Johns Hopkins University, Baltimore, 21218, USA

2Department of Chemistry and MacDiarmid Institute for Advanced Materials and

Nanotechnology, University of Otago, Dunedin 9054, New Zealand

Present Address: 3Department of Chemistry, Faculty of Science, Chulalongkorn University,

Bangkok 10330, Thailand


Abstract

Iron-nitrogen multiply bonded compounds have been postulated as key intermediates in

biological transformation (e.g. dinitrogen reduction in nitrogenase) and industrial processes

(e.g. Haber-Bosch process). However, synthesis and characterization of such species remains

challenging. Herein, generation of a new high-valent Fe-imido corrolazine complex is

reported. Reaction of FeIII

(TBP8Cz) (TBP8Cz = octakis(4-tert-butylphenyl)corrolazinato) and

commercially available chloramine-T afforded a new species assigned as

[FeIV

(TBP8Cz+•

)(NTs)] (Ts = 4-toluenesulfonyl) at room temperature. This new compound

was characterized by UV-vis, EPR (X-band (15 K), g = 2.10, 2.00) and Mössbauer ( = -0.05

mm s-1

, EQ = -2.95 mm s-1

) spectroscopies. [FeIV

(TBP8Cz+•

)(NTs)] was shown to perform

stoichiometric and catalytic NTs transfer to triphenylphosphine (PPh3) giving the phospharane

product, Ph3P=NTs, monitored by 31

P-NMR. Kinetic data were also consistent with the

proposed NTs transfer mechanism. The reaction mixture of FeIII

(TBP8Cz) + chloramine-T +

PPh3 gave two new Fe corrolazine compounds i.e. [FeIV

(TBP8Cz)(NPPh3)] and

[FeIII

(TBP8Cz)(OPPh3)], which were determined by X-ray crystallography. Full

characterization of the [FeIII

(TBP8Cz)(OPPh3)] structure was obtained by independently

preparing the compound from FeIII

(TBP8Cz) and OPPh3. This pure [FeIII

(TBP8Cz)(OPPh3)]

offers a benchmark for spectroscopic study on FeIII

corrolazine in a structurally defined

compound.

INORG 14

Abstract -Poster


Pag

e48

Isolation And Characterisation Of Novel Organometallic Derivatives Of

Multidentate Phosphine Bis[(o-methylthio)phenyl]phenylphosphine

and Tris[(o-methylthio)phenyl]phosphine

Richard C.S. Wong* and Mei Lee Ooi



Abstract

Multidentate phosphine ligands containing thiolaryl groups have been in the limelight in

recent years because of its lability towards soft metal complexes via its σ-donor and π-

acceptor properties. Phosphine complexes are common in a variety of catalytic reactions, and

the ability to control cis/trans isomerism via attractive interactions opens up possibilities for

controlling the mechanisms of homogeneous catalytic reactions.

In this work, we report the reactivity of bis(o-methylthiophenyl)phenylphosphine and tris(o-

methylthiophenyl)phenylphosphine, acting as bidentate, tridentate and tetradentate ligands,

respectively. Herein, we reported the syntheses and isolation of 8 novel complexes which

were fully characterized by 1H,

13C and

31P NMR, I.R. spectroscopy and single crystal X-ray

crystallography.

Keywords: multidentate, thioaryl, lability, synthesis, isolation.

INORG 15


Abstract -Poster


Pag

e49

Study of cytotoxic effects of green synthesized silver nanoparticles with

different capping agents on tumor cells

Wang Chunyan and Suresh Valiyaveettil*

Department of Chemistry, Faculty of Science, 3 Science Drive 3,

National University of Singapore, Singapore 117543

Abstract

Metal nanoparticles (NPs) have been found in a wide range of commercially available

consumer products ranging from cosmetics to household detergents. This is especially true for

silver (Ag) NPs, which showed antimicrobial effects. Recently, various green approaches have

been used for preparing Ag NPs, as they may reduce or eliminate the toxic effects towards the

environment and ultimately to human being. In our study, we explore preparation of Ag NPs

using ginger, coffee and mint extracts at room temperature. The as-synthesized nanostructures

were characterized using transmission electron microscopy and UV spectroscopy. The toxicity

of Ag NPs with respective capping agents was studied using human cervical cancer cells

(HeLa) and hepatocellular carcinoma cells (HepG2). Furthermore, the level of toxicity was

evaluated using changes in cell morphology, cell viability and oxidative stress. Toxicity of Ag

NPs is dependent on both concentration and chemical nature of capping agents. Ag-mint NPs

induced significant toxicity as competed to the other three NPs, with a viability of only 30%

at a concentration of 25 µg/ml. The poster will discuss the synthesis, characterization and

toxicity studies of AgNPs in detail.

Acknowledgement: The authors acknowledge the support from Department of Chemistry,

National University of Singapore for funding and technical support. WC thanks the National

University for a graduate scholarship.

INORG 16

Abstract -Poster


Pag

e50

Supramolecular metathesis: cation exchange in salts derived from the sulfa-

drug, sulfathiazole

Aina Mardia Akhmad Aznan,a A. P. Safwan,

a Zanariah Abdullah,

a Trupta Kaulgud,

b Hadi D.

Arman,b Matthew Mahindaratne,

b Laurie E. McNeil,

c and Edward R. T. Tiekink*

a

aDepartment of Chemistry, University of Malaya, 50603 Kuala Lumpur, Malaysia.

b Department of Chemistry, The University of Texas at San Antonio, San Antonio,

Texas 78249-0698, USA

c Department of Physics and Astronomy, University of North Carolina at Chapel Hill,

Chapel Hill, North Carolina 27599-3255, USA

*E-mail: [email protected]; Fax: +60 3 79674204; Tel: +60 3 7967 6775

Abstract

Co-crystallisation of equimolar quantities of sulfathiazole (STL) with each of 1,4-

diazabicyclo[2.2.2]octane (DABCO) and piperazine (PIP) lead to the facile formation of salts

[DABCOH][STL_H] (1) and [PIPH][STL_H] (2), respectively. Crystallography shows the

formation of aniline-N–H...O(sulfonyl) hydrogen bonds between anions to form undulating

and zig-zag layers, respectively, with the cations being connected to these by charge-assisted

N–H...N(thioazole) interactions. The salts were also investigated by 1H NMR, IR and Raman

spectroscopies as well as by DSC. Solid-state grinding competition experiments were

monitored by PXRD. When 2 was ground with an equimolar amount of DABCO,

substitution of the PIPH+ cation by DABCOH

+ was proven, i.e. supramolecular metathesis

had occurred, an observation correlated with the more efficient crystal packing observed in 1

cf. 2.

INORG 17


Abstract -Poster


Pag

e51

Dyes From Natural Resources

Nur Atiqah Mohd Nasuha* and Yeun-Mun Choo

Department of Chemistry, University of Malaya, Kuala Lumpur, Malaysia


Abstract

Roots of Morinda citrifolia (Mengkudu, Engkudu, or Noni) have been used traditionally by

Iban community from Sarawak, Malaysia as a natural dye to produce yellow-orange shades.

M. citrifolia is known to have a broad range of therapeutic effects due to its antioxidant

activities. These include antiviral, antibacterial, anticancer activities as well as analgesics

effects. In the present study, the chemical components were separated using various

chromatographic methods. The structures were established by spectroscopic methods,

particularly 2D NMR and MS.

Keywords: Morinda citrifolia; Anthraquinones; Antioxidants

ORG 1

Abstract -Poster


Pag

e52

Volatile Components of Fresh Jasminum sambac Buds and the Potential

Antioxidant Activities of its Methanolic Extract

Katrina Mohamad Khidzir, *Sit Foon Cheng and Cheng Hock Chuah.

Unit of Research on Lipids, Department of Chemistry, Faculty of Science, University of

Malaya,50603, Kuala Lumpur, Malaysia.

* E-mail: [email protected]

Abstract

We report on the volatile components of the methanolic extract from the fresh buds of

Jasminum sambac which is categorized under the olive family, Oleaceae. A headspace solid -

phase micro extraction (HS-SPME) method was utilized for profiling the volatile compounds

released from fresh buds of Jasminum sambac. A 100 µm polydimethylsiloxane fibre was

used to absorb and desorb the volatile compounds from the equilibrium headspace generated

by the fresh buds. A gas chromatography-mass spectrometry coupled with the HS-SPME was

employed for the confirmation of identity and quantification of volatiles extracted. Volatile

components found include farnesene, linalool, cadiene and muurolene. The antioxidant

properties of the methanolic extract at different concentrations (50, 100, 250, 500 and 1000

ppm) were then examined by estimating the capability to scavenge DPPH free radicals. It was

interestingly found that the methanolic extract has an IC50 value of 208.33 µg/mL compared

to Butylated hydroxytoluene (BHT) which is 13.67 µg/mL.

Keywords: Jasminum sambac, buds, solid phase micro extraction, antioxidant

ORG 2

Abstract -Poster


Pag

e53

Antioxidant Potential of Tannin-rich

n-Butanol Extract from Elaeis guineensis Leaf

Chun Hui Ang1, *Sit Foon Cheng

1, Chavasiri Warinthorn

2 and Cheng Hock Chuah

1

1 Unit of Research on Lipids, Department of Chemistry, Faculty of Science, University of

Malaya, Lembah Pantai, 50603 Kuala Lumpur, Malaysia

2 Natural Products Research Unit, Department of Chemistry, Faculty of Science,

Chulalongkorn University, Bangkok 10330, Thailand


Abstract

Aqueous fraction partitioned from methanolic extract of fresh Elaeis guineensis leaf

was found to exhibit antioxidant activity in various in-vitro bioactivity evaluation

assays including DPPH radical-scavenging activity assay, lipid peroxidation (LPO)

inhibition assay and beta-carotene bleaching assay, as compared to butylated

hydroxytoluene (BHT) as standard. This active aqueous fraction was subjected to

further fractionation to gain n-butanol tannin-rich sticky solid, then purified

chromatographically by Sephadex LH-20 and RP C-18 silica gel columns.

Phytochemical screening on these purified fractions suggested that Elaeis guineensis

leaf has great potential to be used as natural antioxidant and worthy of further

investigations.

Keywords: Elaeis guineensis, antioxidant, tannins, n-butanol

ORG 3

Abstract -Poster


Pag

e54

Synthesis of Palm Oil-Based Polyester Polyols

Wei Seng Ng1,

*Sit Foon Cheng

1, Choy Sin Lee

2 and Cheng Hock Chuah

1

1Unit of Research on Lipids (URL), Department of Chemistry, Faculty of Science, University

of Malaya, 50603 Kuala Lumpur, Malaysia.

2Department of Pharmaceutical Chemistry, School of Pharmacy and Health Sciences,

International Medical University, Bukit Jalil, Kuala Lumpur, Malaysia.


Abstract

Palm oil-based polyester polyols were prepared from palm oil-based glycerol monostearate

(GMS) and glutaric acid in a solvent free and non-catalyzed condition. The effect of

temperature and effect of ratio of functionality (OH:COOH) were studied. This reaction

involved esterification reaction with evolving water. Deacidification of GMS was carried out

before proceeding to synthesis of polyester polyol. The acid value and hydroxyl value of

polyester polyol were measured according to AOCS Official Method Te 2a-64 and AOCS

Official Method Cd 13-60 (1993) respectively. From the study of the effect of

temperature, the acid value decreased from 163.67 to 28.38 mg NaOH/g sample at the

temperature of 190℃. Further decrement of acid value to 24.19 mg NaOH/g sample was

recorded at the temperature of 200℃. Hydroxyl values of polyester polyols were

measured in the range of 82 to 225 mg KOH/g sample. The polyester polyol were also

characterized with 1H &

13C NMR, FTIR, GPC, LCMS and HPLC. Polyester polyol

exhibited the characteristic peaks at about 3550 and 1732 cm-1

which attributed to -OH & -

C=O stretching of ester group, respectively, confirming the formation of polyester polyols.

The molecular weights of polyester polyols were recorded in the range of 560 to 34039

Dalton.

Keywords: dicarboxylic acid; palm oil-based monoglyceride; polyester polyol

Suggested Reading:

1. Lee, C. S., Lee, S. C. (2011). Preparation of polyester polyol from epoxidized palm olein. Chinese Journal

of Chemistry, 29(4), 840-846.

2. Abdel Hakim, A. A., Mosa Nassar, Aisha Emam, Maha Sultan. (2011). Preparation and

characterization of rigid polyurethane foam prepared from sugar-cane bagasse polyol. Materials Chemistry

and Physics, 129, 301-307.

3. Lin, S., Zhou, J.,Chen, J. (2009). Microwave synthesis of polyester polyol used for polyurethane soles.

Faming Zhuanli Shenqing, CN 101538358 A 20090923.

ORG 4

Abstract -Poster


Pag

e55

Long Chain Saturated Structured Lipids via

Enzymatic Interesterification using Lipase Rhizomucor miehei (Lipozyme

RM IM)

Wai-Ming Kok, *Sit-Foon Cheng. and Cheng-Hock Chuah.

Unit of Research on Lipids (URL), Department of Chemistry, Faculty of Science, University

of Malaya.


Abstract

There were several reports relating positional fatty acid distributions and fatty acids

composition of triacyglycerols with obesity. Unsaturated fatty acid at sn-2 position is

absorbed through intestinal mucosa in the form of monoacyglycerol, while the free saturated

fatty acids from sn-1 and sn-3 positions are hardly absorbed and easily excreted. That is

especially evidenced for long and saturated fatty acids. In the present study, structured lipids

of long and saturated fatty acids were synthesized. High oleic sunflower oil (HOS) and

behenic acid ethyl ester were interesterified using sn-1,3-specific lipase (10 m/m% of total

substrates), Rhizomucor miehei (Lipozyme RM IM), at 65°C for 2 hours. The synthesized

structured lipids were characterized and quantified using 13

C NMR as containing 65.1 mol%

of SFA, 28.7 mol% of MUFA, 6.2 mol% of PUFA at sn-1,3 positions and 81.8% of MUFA,

18.2% of PUFA at sn-2 position. Overall, there were 42.9 mol% of SFA, 46.8 mol% of

MUFA and 10.2 mol% of PUFA at sn-1,2,3 positions.

Keywords: Enzymatic interseterification, lipase, triacyglycerols, qCNMR.

ORG 5

Abstract -Poster


Pag

e56

Alkaloid from Alstonia rostrata

Lim Jun Lee1,

*, Gan Chew Yan2, Low Yun Yee

1, Lim Siew Huah

1 and Kam Toh Seok

1

1Department of Chemistry, Faculty of Science, University Malaya,

50603 Kuala Lumpur, Malaysia.

2University Malaysia of Computer Science & Engineering, Ground Floor, Menara Z10, No.2,

Jalan Alamanda 2, Presint 1, 62000 Putrajaya, Wilayah Persekutuan, Malaysia.


Abstract

A total of 20 alkaloids were isolated and characterized from the bark extract of Malayan

Alstonia Rostrata (Apocynaceae), including six leuconolam-rhazinilam alkaloids, four

strychnan alkaloids, two vallesiachotaman alkaloids, a corynanthean alkaloid, an

asipidospermatan alkaloid, an uleine alkaloid, a vallesamine alkaloid, an akuammiline

alkaloid, two skythantine alkaloids and a 2,7-napthiridine alkaloid. The structures were

determined using NMR and MS analysis.

Keywords: Alstonia Rostrata; Apocynaceae; Alkaloids

ORG 6

http://www.unimy.edu.my/

Abstract -Poster


Pag

e57

Pyridine-Based Molecular Pincer for Transition Metal Complexation

Rojrit Rojanathanes*1

, Kobkun Saepang2, Supakit Seawpakorn

2, Patchanita Thamyongkit

1,

and Wittawat Keawsongsang1

1Department of Chemistry, Faculty of Science, Chulalongkorn University

2Program in Petrochemistry and Polymer Science, Faculty of Science, Chulalongkorn

University


Abstract

Two novel molecular pincers was successfully synthesized from chelidamic acid. Both

molecular pincers contains 5 nitrogen atoms forming two different pocket sizes. The

nitrogen-rich cavities are designed for complexation with some transition metal ions.

Carboxylic group was introduced onto the 4- position of the central pyridine core as a linker

for further application in solar cell technology. The carboxylic group was successfully

fabricated by two different methods, chromate oxidation and copper-free Sonogashira

coupling.

Keywords: pincer, chelidamic, picolinic, complexation

ORG 7

Abstract -Poster


Pag

e58

Aza Diels-Alder Rection of Cyclic Imine with Danishefsky’s Diene

Shah Bakhtiar Nasir and Noorsaadah Abd Rahman

Department of Chemistry, Faculty of Science, University of Malaya

*Email: [email protected], [email protected]

Abstract

Danishefsky’s diene is a diene with a formal name trans-1-methoxy-3-trimethylsilyloxy-1,3-

butadiene. It has been known for its efficiency in Diels-Alder reactions. Calculation of the

energy for the reaction between cyclic imine derivatives and Danishefsky’s Diene were

carried out to determine the energy level and the selectivity for the Aza Diels-Alder reaction.

The calculation used density functional theory (DFT) basis set to discern the selectivity and

the transition state of the reactions. This information then will further use for the total

synthesis of Mitraphylline.

Keywords: Aza Diels-Alder, Danishefsky’s Diene, Density Functional Theory (DFT)

ORG 8



Abstract -Poster


Pag

e59

Total Synthesis of (±)-Cyclollicinone

Chun Keng Thy, Chin Fei Chee and Noorsaadah Abd Rahman



Abstract

Cycloillicinone and illicarborene A were isolated from the Illicium anisatum1 and Illicium

arborescens2. This compound belongs to the class of phytoquinoids which are known for their

antitumor and cytotoxic activities. In this presentation, the total synthesis of a racemic

cycloillicinone is described. The key step is Diels-Alder cycloaddition reaction between a β-

trans-ocimene and a racemic illicinone A. A chiral Corey-Bakshi-Shibata (CBS)

oxazaborolidine was used as catalyst in the reaction. The β-trans-ocimene is commercially

available and the racemic illicinone A was prepared in 4 steps from commercially available

sesamol via alkylation, Claisen rearrangement, prenylation and finally prenyl migration3. In

summary, the (±)-cyclollicinone was prepared in 5 steps with a total yield of 19.0%

ORG 9

Abstract -Poster


Pag

e60

Keywords: cycloillicinone; illicarborene A; Diels-Alder cycloaddition reaction

References

1. Kubo, M., Shima, N., Harada, K., Hioki, H., & Fukuyama, Y. (2011). New prenylated C6-C3 compounds from

the twigs of Illicium anisatum. Chemical and Pharmaceutical Bulletin, 59, 898-901.

2. Liaw, C. C., Chen, Y. C., Fazary, A. E., Hsieh, J. L., Chen, S. Y., & Chien, C. T. (2013). A novel prenylated

C6-C3 compound with estrogen-like activity from the fruits of Illicium arborescens. Phytochemistry letters, 6,

397-402.

3. Lei, X., Dai, M., Hua, Z., & Danishefsky, S. J. (2008). Biomimetic total synthesis of tricycloillicinone and

mechanistic studies toward the rearrangement of prenyl phenyl ethers. Tetrahedron Letters, 49, 6383-6385.

Abstract -Poster


Pag

e61

Total synthesis of (+)-Morusalbanol A and (+)-Sorocein B Jia Ti Tee, Chin Fei Chee and Noorsaadah Abd Rahman

Chemistry Department, Faculty of Science, University of Malaya, 68100,

Kuala Lumpur, MALAYSIA.

*Email: jennytee12302um.edu.my

Abstract

Morusalbanol A and sorocein B are biologically active oxabicyclic compounds which appear to

originate from an intramolecular cyclisation /ketalisation of a cis-trans mulberry Diels-Alder

adduct (i.e. 1 & 2). Due to its sparse distribution of its natural plant source, there has been no

report on the synthesis of these compounds since its first isolation in 1991.

Our work involved the synthesis of Morulsalbanol A (1) and Sorocein (2). In this presentation,

we describe the synthesis of the key intermediates (3) and (4) leading to Morulsalbanol A (1) and

Sorocein (2), respectively through the Diels-Alder reaction (DA) (Scheme 1). To investigate the

effect of different substituents on the DA reaction, model studies have been carried out using

various chalcones containing hydroxy (OH), methoxy (OMe) and ethoxymethoxy (EOM) groups.

The presence of hydroxyl group at C2’ position was found to be essential for the intermolecular

cycloaddition reaction. However, the low yield of product was obtained when the hydroxyl group

at C2’ position was replaced with a methoxy group and no product observed for the one without

hydroxyl group at C2’ position.

Further efforts toward the total synthesis of morusalbanol A and Sorecein B are underway.

Keywords: Diels-Alder reaction, Morusalbanol A, Sorocein B

ORG 10

Abstract -Poster


Pag

e62

Preparation and Fluorescence Behaviour Of Coumarin Terminated

Monolayer On Silver Particle

Nurul Izzatil Aisya Asri*, Issha Nadirah Ismail, Hairul Anuar Tajuddin, and Zanariah

Abdullah

Chemistry Department, Faculty of Science, University of Malaya,


*Corresponding author: [email protected]

Abstract

Coumarin and their derivatives are known fluorescent compounds potentially used for

chemical sensors and biosensors. In this work, self-assembled monolayer with coumarin

terminated was successfully prepared from chemisorptions of (1) onto silver particles. The

method was applied according to Brust et.al with minor modification. The adsorbate structure

(1) was purified and confirmed under 1H NMR,

13C NMR, FTIR and LCMS. The formation

of the monolayer was investigated using FTIR, UV-visible and Fluorescence Spectrometers.

The size of the particle suspension was determined at around 141.7 nm. The fluorescence of

the monolayer was similar to with the emission of adsorbate in Ethanol indicates that

monolayer of coumarin successfully formed on the silver surface.

O OO

S

O OO

S

(1)

Keywords: coumarin, self-assembled monolayer, fluorescence.

ORG 11


Abstract -Poster


Pag

e63

Synthesis and Fluorescence Characterization Of

Azo-Coumarin And Azo-Naphthol

Mohd Helmi Hussaini Dullah, Zanariah Abdullah, Hairul Anuar Tajuddin

Department of Chemistry, Faculty of Science, University of Malaya, 50603 Kuala Lumpur


Abstract

Azo compounds are widely used as dyes and colorants. They are also used as laser dyes,

optical brighteners and fluorescent. In this work, azo-coumarin and azo-naphthol have been

synthesized by coupling of 7-hydroxycoumarin and 2-naphthol with diazonium salts

intermediate. The products were purified and confirmed by 1H NMR,

13C NMR, FTIR, UV-

visible absorption and elemental analysis. The presence of IR transmission at 1470-1508 cm-1

indicates the formation of -N=N- in both products. Their absorption and fluorescence

behavior were also characterized. Absorption occurred between 320-350 nm either in ethanol

or chloroform suggesting that the products are chromophores. Azo linkages was found as

reliable way to modify both naphthol and coumarin including their fluorescence character.

Keywords: azo-coumarin, azo-naphthol, diazotization, fluorescence

ORG 12


Abstract -Poster


Pag

e64

Alkyl Disulfide as an Alternative Absorbate for Monolayer Formation on

Silver Particles

Issha Nadirah Ismail, Nurul Izzatil Aisya Asri, Hairul Anuar Tajuddin, and Zanariah

Abdullah.

Chemistry Department , Faculty of Science, University of Malaya,



Abstract

Two types of self-assembled monolayers on silver particles have been derived from alkyl

disulfides with methyl and hydroxyl terminals. Both alkyl disulfides were synthetically

prepared and purified before further analyzed using spectroscopic methods. Silver particles

were then prepared from reduction of silver nitrate using phase transfer method in the

presence of the alkyl disulfides. The products were purified either by solvent extraction or

filtration with copious amount of solvents. Alkyl disulfide with hydroxyl terminal produced

highly hydrophilic monolayer protected silver particles and the other absorbate with methyl

terminal produced highly hydrophobic monolayer. The similar method was repeated with

common alkyl thiols for background experiment. All samples were analyzed from FTIR and

UV-visible absorption. The presence of strong -CH2- band indicated the formation of organic

monolayers. Broad signal for alkyl disulfide with hydroxyl terminal was observed at around

3100 cm-1

, evident of hydroxyl terminated monolayer that consistent with our prediction and

the background experiment. The formation of silver particles was indicated from absorption

band above 400 nm. The results suggesting that disulfide group is also practical for anchoring

group for the formation of self-assembled monolayer on silver particles.

ORG 13

Abstract -Poster


Pag

e65

Comparison studies of polyaniline nanocomposite with & without TiO2 for

hydrazine detection

Nirosa Raman*, Kavirajaa Pandian Sambasevam and Phang Sook Wai

Department of Chemistry, Faculty of Science, University of Malaya


Abstract

This work presents the comparison of PANI and PANI/TiO2 nanocomposite chemical sensors

for hydrazine detection. The PANI and PANI/TiO2 films were prepared by chemical oxidative

polymerization of aniline by ammonium persulfate in the presence of dioctyl sulfosuccinate

sodium salt (AOT) as a dopant. The polymers were characterized by UV-Vis, FT-IR, FESEM

and conductivity study. Besides, the response of the chemical sensors in terms of conductivity

was measured at room temperature by using four point probe method. PANI and PANI/TiO2

sensor response for hydrazine detection was evaluated based on the wavelength shift of

conducting and non-conducting states of PANI upon exposure to hydrazine at different

concentrations. PANI/TiO2 exhibited better performance compared to PANI due to the

complementary behaviour of TiO2 nanoparticles. As conclusion, PANI/TiO2 nanocomposite

can be potentially applied for hydrazine detection.

Keywords: Polyaniline, TiO2, Hydrazine, Nanocomposite

Suggested Reading:

1. Yuzhen Li et. al., Applied Surface Science 273 (2013) 135-143.

2. E. Subramanian et. al., Indian Journal of Engineering & Material Sciences 19 (2012) 237-244.

3. M. Nagaraja et. al., Synthetic Metals 159 (2009) 718-722.

PHY 1

Abstract -Poster


Pag

e66

Fatty Acid Nanoparticle For Topical and Oral Delivery Applications

Misni Misran*, Teo Yin Yin, Woo Juin Onn, Vicit Rizal Eh Suk, Yew Han Choi

Colloid and Surface Laboratory,

Department of Chemistry,

University of Malaya,

50603 Kuala Lumpur

Contact: +603-79676776/4079

Abstract

Fatty acid nanoparticle is nano-sized colloidal system that has extensively been investigated

for controlled drug delivery, cosmetic and pharmaceutical application. Fatty acid

nanoparticles are prepared using fatty acids which possesses negligible toxicity,

biocompatible and avoids the use of organic solvents in the preparation makes them as

promising delivery system. In this work, a cost effective fatty acid nanoparticles with a wide

range of particle size (from 50 nm to 500 nm) were developed for topical and oral

applications.

Figure 1: TEM micrograph (left) and confocal laser scanning micrograph (right) of fatty acid

nanoparticles

The TEM micrograph of fatty acid nanoparticles showed that they were spherical shape and

laser confocal laser scanning micrograph revealed that lipophilic dye was successfully

incorporated into the solid matrix of nanoparticles. Fatty acid nanoparticles with high

encapsulation efficiency had successfully been developed by modified its composition with

liquid fatty acid. High actives loaded fatty acid nanoparticles was then incorporated into base

cream to evaluate its in vitro release using Franz Diffusion Cell. Fatty acid nanoparticles

enriched cream demonstrated a controlled release for the period of 24 hours. Our finding

PHY 2

Abstract -Poster


Pag

e67

suggests that the fatty acid nanoparticles prepared could be a promising delivery system for

the enhancement of the therapeutic efficacy in the topical and oral application.

Figure 2: Fatty acid nanoparticles prepared with different mean particle size

Keywords: Fatty acid, Nanoparticle, Topical delivery, Oral delivery

Patent Filled No.: PI2013002585

Abstract -Poster


Pag

e68

Y-shaped Carbohydrate Surfactants by ‘Click Chemistry’ for Oil-in-Water

Emulsions

T. H. Ali, R. S. D. Hussen* and T. Heidelberg

Chemistry Department, Faculty of Science, University of Malaya, 50603 Kuala Lumpur


Abstract

A series of Y-shaped, sugar-based surfactants varying in the linkage between two hydrophilic

glucose units and a hydrophobic hydrocarbon chain were prepared by copper(I) assisted

azide-alkyne cycloaddition (CuAAC). The compounds were obtained in moderate overall

yields of 23-39% based on 6-7-step processes involving a chromatographic purification. The

chemical structures were confirmed by proton nuclear magnetic resonance spectroscopy, and

the physical-chemical properties, i.e. self-assembly, Kraftt and cloud temperatures, air-water

interface behaviour as well as oil-in-water emulsions, were studied. While one compound

displayed a cubic phase, all others exclusively formed micellar solutions. All Krafft

temperatures were below 10 °C and no clouding was observed up to 80 °C. The air-water

interface investigations revealed an influence of the linkage on the critical micelle

concentration (CMC). Besides, the linkage also affected the emulsion behaviour.

Keywords: Non-ionic surfactants, Carbohydrate surfactants, Y-shaped surfactants, Wedges

shaped surfactants, Click chemistry synthesis

PHY 3

Abstract -Poster


Pag

e69

Preparation of microcapsules containing alkyd resin as core

Nurshafiza Shahabudin, Rosiyah Yahya and Seng Neon Gan

Chemistry Department, Science Faculty, University of Malaya, 50603 Kuala Lumpur,

Malaysia


Abstract

This work reports the preparation of poly(urea-melamine-formaldehyde) (PUMF)

microcapsules with a core of palm oil-based alkyd resin and the PUMF as the shell.

Poly(vinyl alcohol) (PVA) and ethylene maleic anhydride (EMA) were used as a viscosity

modifier. The effect of various parameters on the microencapsulation of the PUMF-alkyd

microcapsules was studied, these include dispersed phase to continuous phase ratio, agitation

rate and surfactants concentration. The microcapsules obtained were inspected using digital

microscopy, optical microscopy (OM) and also scanning electron microscopy (SEM). The

alkyd core content and the PUMF shell materials was verified using Fourier transform

infrared (FTIR) and differential scanning calorimetry (DSC). Thermal analysis by TGA has

shown that the core and shell materials have different thermal stabilities. The resultant

microcapsules appear white-yellowish and free-flowing, and have a rough, porous shell which

was formed by PUMF nanoparticles. Their diameters range from 500 to 150 microns. The

size of the microcapsules is controllable by the agitation rate and the ratio of the dispersed

phase to continuous phase.

Keywords: poly(urea-melamine-formaldehyde), alkyd, microcapsule, polymerization,

surfactant

Suggested Reading:

1. BROWN, E. N., KESSLER, M. R., SOTTOS, N. R. & WHITE, S. R. 2003. In situ poly(urea-formaldehyde)

microencapsulation of dicyclopentadiene. Journal of Microencapsulation, 20, 719-730.

2. SURYANARAYANA, C., RAOB, K. C. & KUMARA, D. 2008. Preparation and characterization of

microcapsules containing linseed oil and its use in self-healing coatings. Progress in Organic Coatings, 63,

72-78.

3. THEN, S., GAN S. N. & KASIM, N. H. A. 2011. Performance of Melamine Modified Urea–Formaldehyde

Microcapsules in a Dental Host Material. Journal of Applied Polymer Science, 122, 2557-2562.

PHY 4

Abstract -Poster


Pag

e70

Adsorption of Methylene blue onto Chitosan-Based Activated Carbon:

Isotherm and Kinetic Studies

M.S. Nusari and *A. Mainal

Department of Chemistry, Faculty of Science, University of Malaya, Lembah Pantai, 50603,

Kuala Lumpur, MALAYSIA


Abstract

Adsorption of Methylene blue from aqueous solution onto activated carbon prepared from

chitosan was studied in a batch system. Experiments were conducted as functions of initial

dye concentration, pH, contact time, adsorbent dose and temperature. Equilibrium

adsorption isotherms and kinetics were investigated. The Langmuir, Freundlich, and Temkin

isotherms models were used to analyze the experimental data. The experimental data matched

well with the Freundlich isotherm. Adsorption kinetics data were modeled using the pseudo-

first-order and pseudo-second-order equations. The results showed that the chitosan-based

activated carbon could be an alternative for the more expensive adsorbents used for the

elimination of Methylene blue from aqueous solution.

Keywords: chitosan; activated carbon; adsorption; isotherm; kinetics

PHY 5

Abstract -Poster


Pag

e71

Hot-Spot Motif Characterization of Interface between a Designed

Ankyrin-Repeat Protein and Its Target Kinase

Vannajan Sanghiran Lee1,2

Vertika Gautam 1

Wei Lim Chong1, Sharifuddin M. Zain

1,

Noorsaadah Abd. Rahman1

1Department of Chemistry, Faculty of Science, University of Malaya 50603 , Kuala Lumpur

Malaysia

2Computational Simulation and Modeling Laboratory (CSML), Center of Excellence in

Physics (ThEP), CHE, Ministry of Education, Bangkok 10400, Thailand

Abstract

DARPins (designed ankyrin repeat proteins) are a novel class of binding molecules with the

potential to overcome limitations of monoclonal antibodies, hence allowing novel therapeutic

approaches. As a small, single domain proteins which can be selected to bind any given target

protein with high affinity and specificity. These characteristics make them ideal agonistic,

antagonistic or inhibitory drug candidates. Altogether, DARPins are a prominent member of the

next generation of protein therapeutics with the potential to surpass existing antibody drugs. With

the knowledge of role of heterotrimeric complex between ILK, PINCH and Parvin in signaling

platform, ILK-AR (3F6Q) with high affinity for PINCH1 was used as a model system to explore a

structure-based computational protocol to probe and characterize binding affinity hot spots at

protein–protein interfaces. For the purpose, long time scale dynamics simulations with GPU

accelerated molecular dynamics (MD) simulations in AMBER12 have been performed to locate

the hot spots of protein-protein interaction by the analysis of the (MM-PBSA/GBSA) of the MD

trajectories. The dynamic conformational changes of the AR complex, 3F6Q, were observed by

RMSD of all the Cα atoms in which steady oscillations indicate that the equilibrium has been

obtained. The negative values of PB(TOT) of 3F6Q from both MM-PBSA/GBSA methods infer a

good binding interaction between ILK-AR and PINCH. Moreover, critical residues for binding

HIS32(-2.17), ARG42(-6.43), SER75(-3.3), HIS98(-1.43), PHE 108(-6.55), TRP109 (-4.59) were

identified by decomposition energy. The negative values corresponding to the residues identified

having critical role in favourable binding.

Keywords: Integrin-linked kinase (ILK), Designed Ankyrin repeat protein (DARPins),

Molecular dynamics (MD) simulations

Suggested Reading

1. Michael, T., Stumpp, H., Binz, K., & Amstutz, P. (2008). DARPins: A new generation of protein

therapeutics. Drug Discovery Today, 13(15/16), 695-701.

PHY 6

Abstract -Poster


Pag

e72

An in vitro biological evaluation of electrospun poly(3-hydroxybutyrate)

and bovine hydroxyapatite composite scaffold for bone tissue engineering

Pedram Azari1, Haris Akram

3, Gan Seng Neon

1, Rosiyah Yahya

1, Wong Chiow San

2,

Belinda-Pingguan3 Murphy

1Department of Chemistry, Faculty of science, University of Malaya, 50603 Kuala Lumpur,

Malaysia

2Plasma Research Laboratory, Physics Department, Faculty of science, University of Malaya,


3Department of Biomedical engineering, Faculty of Engineering, University of Malaya, 50603

Kuala Lumpur, Malaysia

Abstract

Design and fabrication of a suitable scaffold for bone tissue regeneration with

osteocunductive and osteoinductive properties have been a challenge for the last decade.

Various biopolymers and bioceramics have been studied for their potential to serve as

scaffolding materials. The success has been limited. However, lower risks of disease transfer

as well as its lower costs compared to bone grafts, keeps the scaffold as a more feasible option

for future studies. In this research, we have produced composite scaffolds of poly(3-

hydroxybutyrate) (PHB) containing bovine derived micro particles of hydroxyapatite (BHA)

through electrospinning. The morphology and structure of the scaffolds were studied by field

emission microscopy and infrared spectroscopy. For biological evaluation, rat derived bone

marrow stem cells were seeded on the scaffolds and cultured for a period of 14 days. Cell

proliferation assay was performed to quantify the number of cells adherent to the scaffold.

Alkaline phosphate assay was carried out to study any possible osteogenic stem cell

differentiation. The results show that electrospun scaffolds of PHB/BHA promote cell growth

as well as having osteocunductive properties.

Keywords: Nanofiber, Electrospinning, Poly(3-hydroxybutyrate), Hydroxyapatite,

Scaffolding

PHY 7

Abstract -Poster


Pag

e73

Synthesis, Characterization And Application Of Polyaniline (PAni)

Optical Sensor For pH Detection

Pameswari Subramani,Yeong Siang Chiam, Seng Neon Gan, Sook Wai Phang*

Dept. of Chemistry, Faculty of Science, University of Malaya, 50603 Kuala Lumpur,

Malaysia


Abstract

A simple glass fiber optical sensor coated with polyaniline (PAni) is demonstrated for pH

detection. PAni is a conducting polymer which was synthesized using chemical oxidation

method. In this study, dioctyl sodium sulfosuccinate (AOT) is used as dopant while

ammonium persulfate (APS) is used as oxidant during polymerization. PAni was synthesized

using different dopant ratio (Aniline/APS/AOT) of “5:5:3”, “5:5:5” and “5:5:7”. Fourier

Transform Infrared (FTIR) and Ultra Visible (UV) spectroscopy was carried out to confirm

the chemical structure of PAni. Furthermore, four point probe measurement was carried out to

detect the conductivity of the resulted PAni. It is followed by the coating of PAni film on the

optical sensor for pH detection. The response of this sensor was studied by the optical sensor

set up with supporting characterization of FTIR, UV and conductivity measurement.

Keywords: Polyaniline, conducting polymer, pH detection

Suggested Reading:

1) Wu, G. & Zhang, H. 2013. Synthesis and characterization of camphor sulfonic acid fully doped

polyaniline. Research and Application of Material, 1(1):5-8.

2) Kiran Kumari, Ali, V., Anand Kumar, Sushil Kumar & Zulfequar,M. 2011. D.C. conductivity and

spectroscopic studies of polyaniline doped with binary dopant ZrOCl2/AgI. Bulletin of Material

Science, 34(6): 1237–1243.

PHY 8


Abstract -Poster


Pag

e74

Hydrogen bonds formation in α/β-D-mannose and n-octyl-α/β-D-

mannopyranoside using AIM and NBO analyses

Zahrabatoul Mosapour Kotena*1,3

, Reza Behjatmanesh–Ardakani2, Rauzah Hashim

1

1Chemistry Department, Faculty of Science, University of Malaya, 50603 Kuala Lumpur,

Malaysia

2Department of Chemistry, Payame Noor University, PO Box 19395-3697 Tehran, Iran

3Kavli Institute of Theoretical Physics China, Chinese Academy of Sciences, Beijing 100190,

China


Abstract

Density functional theory calculations on α/β-D-mannose (α/β-D-Man) and the corresponding

glycosides of n-octyl-α/β-D-mannopyranoside (C8O-α/β-D-Man) were carried out for

geometrical optimization and stability predictions at the B3LYP/6-31G level of theory. These

compounds are related anomerically, since they differ by only the orientation of the hydroxyl

group at the C1 position. The aim of this study is to investigate the effect of the hydroxyl

group's orientations (axial vs. equatorial) at the C1 position on the intra-molecular interactions

and the conformational stability of these isomers. The structural parameters of X-H∙∙∙Y intra-

molecular hydrogen bonds were analyzed, while the nature of these bonds was considered

using the atoms-in-molecules (AIM) approach. Natural bond orbital analysis (NBO) was used

to determine bond orders and the effective non-bonding interactions. We have also reported

thermodynamic properties and the electronic properties, such as the highest occupied

molecular orbital, lowest unoccupied molecular orbital, ionization energy, electron affinity,

electronic chemical potential, chemical hardness, softness, and electrophilicity index in the

gas phase for all compounds. These results showed that while α-anomers possess only one

intra-molecular hydrogen bond, β-anomers possesses two intra-molecular hydrogen bonds,

which further confirms the anomalous stability of the latter in the self-assembly phenomena.

Keywords: Mannose, Hydrogen bonding, Density functional theory, Atoms in molecules

theory, Natural bond orbital analysis

PHY 9

Abstract -Poster


Pag

e75

Bio-Functionalization of Inorganic Nanoparticles

Abbas Abdulameer Salman and Thorsten Heidelberg*

Chemistry Department, University of Malaya, 50603 Kuala Lumpur, MY


Abstract

A group of surface modification reagents was developed and applied for the post-synthetic

and the in-situ modification of luminescent nanoparticles. The reagents comprise of an

ethylene oxide based core for good water solubility, a phosphonic acid anchor-group to

mediate covalent binding to the nanocrystal, and a functional group suitable for coupling of a

complementary functionalized receptor under mild ‘click’-chemistry conditions. Application

of the reagent did neither alter size nor morphology of the particles, but enabled a significant

surface loading of a model receptor. An average loading of about 20 molecules per particle

with a correlated particle surface area of ~6 nm2 was found for narrowly distributed nearly

spherical nanophosphors of ~6 nm diameter. These data indicate the bio-functionalization

approach as promising for potential medicinal applications, e.g. as analytical marker or for

in-vitro or in-vivo diagnosis, since the receptor loading is economic, while still providing a

significant clustering effect to ensure strong receptor interactions.

Keywords: Nanoparticle surface modification; ethylene oxide based phosphonates, click-

coupling, biological receptor, carbohydrate coated nanocrystals

PHY 10

Abstract -Poster


Pag

e76

Exploration on the Role of Metal Cofactors and Water on the Catalytic

Mechanism of Creatininase-Creatinine in Aqueous Solution from

Molecular Dynamics Simulation/Quantum Study

Vannajan Sanghiran Lee1,2

, Kanchanok Kodchakorn3, Jitrayut Jitonnom

2, Piyarat

Nimmanpipug2, Prachya Kongtawelert

3, Bhusana Premanode

4, Wei Lim Chong

2, Sharifuddin

M. Zain2, Noorsaadah Abd. Rahman

2

1Computational Simulation and Modeling Laboratory (CSML), Center of Excellence in

Physics (ThEP), CHE, Ministry of Education, Bangkok 10400, Thailand

2Department of Chemistry, Faculty of Science, University of Malaya, Kuala Lumpur

50603, Malaysia

3Thailand Excellence Center for Tissue Engineering and Stem Cells, Department of

Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand

4Institute of Biomedical Engineering, Imperial College, London, UK

Abstract

The catalytic reaction mechanism of creatine formation from the binding of creatinine to

creatininase was explored using ab initio quantum mechanical/molecular mechanical

combined approach. X-ray crystallography structure of creatininase-creatinine complex was

modified before MD simulations. Two X-ray water molecules were observed to be catalytic

from MD simulations as they remained in the binding sites. Molecular Mechanics Poisson-

Boltzmann Surface Area (MM-PBSA) protocol was employed to calculate the binding free

energy and it suggested that the binding activity were strong between creatinine and Zn2+

, Asp

45 and Glu 183. A two-step mechanism was proposed for water adding step and ring opening

step for Mn2+

/Zn2+

and Zn2+

/Zn2+

pathway in presence of two catalytic waters. The pathway of

the fragment in the binding region was successfully determined by synchronous transit

methods with local density approximations with PWC functional. A lower activation energy

occur during the water adding step and also a lower energy barrier for the ring opening step

clarifying Zn2+

/Zn2+

pathway was the preferable pathway.

Keywords: creatininase-creatinine, catalytic mechanism, molecular dynamics simulation,

quantum mechanics

PHY 11

Abstract -Poster


Pag

e77

Synthesis and characterization of of new sol–gel titanium(IV) butoxide–

cyanopropyltriethoxysilane in cooperated with imidazolium-based ionic

liquids

Shabnam Bakhshaei*, Sharifah Mohamad, Sharifuddin Md Zain

Department of Chemistry, Faculty of Science, University Malaya, Kuala Lumpur 50603,


Abstract

This work reports successful synthesis and characterization of titanium (IV) butoxide-

cyanopropyltriethoxysilane hybrids (Ti-CNPrTEOS ) in cooperated with two selected

imidazolium-based ionic liquids of 1-methyl-3-(trimethoxysilylpropyl)imidazolium

chloride (M[MItmsp]-Ti-CNPrTEOS) and 1-benzyl-3-

(trimethoxysilylpropyl)imidazolium chloride (Bz[MItmsp]-Ti-CNPrTEOS). The new

sorbents were prepared through sol-gel method in acidic catalyzed condition. In

synthesize of our sorbents, titanium(IV) butoxide was used as precursor,

cyanopropyltriethoxysilane and imidazolium-based ionic liquids played as co-precursor.

Relatively, the cation of ionic liquid was continuing attachment to the hydroxyl groups on

the surface of silica and titania through methoxysilyl head to form hybrid sorbent

Characterization studies were operated on Attenuated total reflectance Fourier transform

infrared spectroscopy (ATR-FTIR), thermogaravimetric analysis (TGA), X-ray

diffraction (XRD), field emission scanning electron microscopy (FE-SEM) and

Brunauer-Emmett-Teller (BET) to support the formation of sorbents structure. The results

of different characterization techniques clarified the formation of mesoporous structures

.This suggests new sorbents are capable of removing both polar and non-polar

compounds.

Keywords: Sol-gel method, titanium (IV) butoxide, Cyanopropyltriethoxysilane,

imidazolium-based ion liquid.

PHY 12

http://umexpert.um.edu.my/cv_papar.php?id=0856ec8b935501be41c84944e5acc26e


Abstract -Poster


Pag

e78

Effect of Water Concentration on the Structural and Diffusion Properties of

Guanidinium Trifluoromethanesulfonate Ionic Liquid− Mixture

Naimah Haron1*

, Nor Asrina Sairi1, Mohamed Kheireddine Aroua

2, Yatimah Alias

1

1Chemistry Department, University of Malaya, 50603 Kuala Lumpur, Malaysia

2Chemical Engineering Department, University of Malaya, 50603 Kuala Lumpur, Malaysia

Abstract

We have performed molecular dynamic simulations in order to investigate the properties of

guanidinium trifluoromethanesulfonate [Gdm][Tfo] ionic liquid (IL) − water system. We

observe the transition of those this mixture from pure IL to an aqueous solution by analyzing

the changes in density and microscopic properties (radial distribution function and hydrogen

bonding) as well as dynamical properties (diffusion coefficient) at 7 different concentration

samplings of each mixture ranging from 0 to 100 mol % water. Our simulations discovered

across all of the different structural, bonding and dynamical properties major structural

changes consistent with a transition from IL−water mixture to aqueous solution at water

concentration around 80 mol %. Among the structural changes observed was rapid increase in

the frequency of hydrogen bonds, both water - water and water - anion. Finally, the diffusion

coefficient of individual cation and anion show a rapid transition from rates consistent with

diffusion in IL to rates consistent with diffusion in water beginning at 80 mol % water.

Keywords: Molecular dynamics, Guanidinium ionic liquid, Water, Microscopic physical

properties

PHY 13

Abstract -Poster


Pag

e79

CO2 Capture in Ionic Liquid: A review on mixed solvent systems

Nor Asrina Sairi1, Mohd Azlan Kassim

1, Rozita Yusoff

2, Mohamed Kheireddine Taieb

Aroua2


Malaysia

2Chemical Engineering Department, Faculty of Engineering, University of Malaya, 50603


Abstract

The growing concern of climate change and global warming has given rise to a thriving

research field dedicated to finding solution. One area in particular has received considerable

attention in lowering of CO2 emission from a large-scale source such fossil fuel power plant.

Through numerous CO2 capture technologies have been proposed, absorption are currently

believed to be the most suitable ones for fossil fuel power plant. The operation of absorption

process is reviewed in this paper, together with the use of absorbent, such as physical

absorbents, chemical absorbents and their blended solutions. Major concern such as CO2

capture efficiency, absorption rates, energy requirement in regeneration and volume of

absorbents, are addressed.

Keywords: CO2 capture, Absorption, Mixed solvent system

PHY 14

Abstract -Poster


Pag

e80

Transesterification reaction: Facile reaction by ionic liquids as catalyst – A

review

Zati Ismah Ishak1, Nor Asrina Sairi

1, Yatimah Alias

1, Mohamed Kheireddine Taieb Aroua

2


Malaysia

2Chemical Engineering Department, Faculty of Engineering, University of Malaya, 50603


Abstract

The expanding production of biodiesel through transesterification reaction of vegetables oil

and methanol have generated glycerol in quantities exceeding the current demand. As a fall

of the glycerol price and the risk of seeing a large amount of glycerol being accumulated as

waste, there is a need of efford towards converting glycerol into various value-added

chemicals. The production of biodiesel and convertion of glycerol into glycerol carbonate as

one of the value-added product hold a common method which is transesterification reaction.

The reaction is catalyzed either by acid, base and enzyme catalyst. In this review paper, the

ionic liquids catalyzed transesterification reaction towards biodiesel production and

conversion of glycerol are throughly discussed. Ionic liquids has always been applied as

environmentally-friendly catalyst in moving towards sustainable process.

Keywords: Transesterification, Biodiesel, Glycerol, Ionic Liquids, Catalyst

PHY 15

Abstract -Poster


Pag

e81

The Role of Hydrogen Bonding by New Protic Ionic Liquids in Driving

Phase Separation or Phase Miscibility in

UCST Ternary Mixtures.

Wan Melissa Diyana Wan Normazlan1*

, Vijaya Ranganathan2, Usman Ali Rana

2, Nor Asrina Sairi

1,

Yatimah Alias1 and Douglas MacFarlane

2

1 Chemistry Department, Faculty of Science, University of Malaya, 50603 Kuala

Lumpur, Malaysia.

2 School of Chemistry, Monash University, Clayton 3800, Victoria, Australia.


Abstract

Extracting organic solvent from water are always become an interest in relevance industry. Liquid-

liquid equilibria is one common type of separation process that is widely used industrially. In this

study, two new protic ionic liquids i.e. bis-(2-ethylhexyl)ammonium tosylate and tris-(2-

ethylhexyl)ammonium tosylate were synthesized and characterized to be used as an extractor to

separate azeotropic mixture of water and isopropanol. The miscibility of protic ionic liquids with

water and isopropanol generally increases upon heating, and both systems undergo an upper critical

solution temperature (UCST) type phase transition. Minor changes on temperature were the parameter

to control the phase separation. In order to understand more on the chemical activities during phase

separation and phase miscibility, both ternary mixtures were analyzed using Proton Magnetic Nuclear

Resonance (1HNMR). The removal of hydrogen(s) attached to nitrogen of protic ionic liquid’s cation

was the driving force for phase separation. This has been observed on both ternary mixtures.

As an addition to this study, the compositions for protic ionic liquid, water and isopropanol in organic

and aqueous rich phase were determined at phase separation temperature 293 – 315 K. The reported

composition values indicated that bis-(2-ethylhexyl)ammonium tosylate were able to extract 60.97 %

of isopropanol from water and tris-(2-ethylhexyl)ammonium tosylate successfully extracted 47.92 %

of isopropanol. Hence, from these values, bis-(2-ethylhexyl)ammonium tosylate shows a better ability

as an extractant compared to tris-(2-ethylhexyl)ammonium tosylate.

Keywords: Ionic liquid, Protic ionic liquid, UCST, 2-propanol

Suggested Reading:

1. Y. Kohno and H. Ohno, Phys. Chem. Chem. Phys., 2012, 5063.

2. L. Zhang, J. Han, D. Dongshun and J. Jianbing, Fluid Phase Equilibria, 2007, 255, 179.

3. M.G. Freire, L.M.N.B.F. Santos, A.M. Fernandes, J.A.P. Cautinho and I.M. Marrucho, Fluid Phase Equilibria,

2007, 449.

PHY 16

Abstract -Poster


Pag

e82

A Fabrication of Surface-Enhanced Raman Scattering (SERS) Substrate

Using an Ionic Surfactant-Mediated Langmuir-Blodgett Method

Prompong Pienpinijtham,1 Xiao Xia Han,

2 Sanong Ekgasit,

1,* and Yukihiro Ozaki

2,*

1Sensor Research Unit, Department of Chemistry, Faculty of Science,

Chulalongkorn University, Bangkok 10330, Thailand.

2Department of Chemistry, School of Science and Technology,

Kwansei Gakuin University, Sanda, Hyogo 669-1337, Japan.

*Email: [email protected]; [email protected]

Abstract

Surface-enhanced Raman scattering (SERS) spectroscopy is a sensitive technique for

measuring the Raman spectrum of a small number of molecules adsorbed on a noble metal

surface or nanoaggregate. In this study, gold nanoparticles (AuNPs) were employed to

fabricate a gold nanoparticle film for using as SERS substrate by an ionic surfactant-mediated

Langmuir-Blodgett (LB) method. The gold film was formed by adding ethanol to a gold

colloid/hexane mixture in the presence of dodecyltrimethylammonium bromide (DTAB).

Consequently, gold nanoparticles (AuNPs) assembled at the water/hexane interface due to the

decrease in surface charge density of AuNPs. DTAB was easily replaced by target molecules

for SERS purposes because of the Coulombic interaction between DTAB and gold surface.

The SERS enhancement factor of the 80 nm gold nanoparticle film was approximately 1.2

106 using crystal violet (CV) as a Raman dye. The SERS signal from the proposed DTAB-

mediated film was approximately 10 times higher than that from the octanethiol-modified

gold film, while the reproducibility and stability of this film compared to an octanethiol-

modified film were similar. This method can also be applied to other metal nanostructures to

fabricate metal films for use as a sensitive SERS substrate with a higher enhancement factor.

Keywords: Surface-enhanced Raman scattering (SERS), Gold nanoparticles, Langmuir-

Blodgett (LB), Ionic surfactant

PHY 17

Abstract -Poster


Pag

e83

Electrospun Titanium Dioxide Fibers as Stationary Phase in

Thin Layer Chromatography

Supamas Kanjanakunthon1, Nipaka Sukpirom

2 and Puttaruksa Varanusupakul

2,*

1Program of Petrochemistry and Polymer Science, Faculty of Science, Chulalongkorn

University, Bangkok, 10330, Thailand

2Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok, 10330,

Thailand


Abstract

Electrospun fibers are interesting materials to use as stationary phase for thin layer

chromatography (TLC). Titanium dioxide electrospun fibers are nanostructures, uniform, and

good selectivity for basic compounds. The electrospinning factors including the electric

potential, the distance between a needle and a collector, and the flow rate of the solution

influenced the fiber morphology. In addition, the anatase structure of titanium dioxide was

transformed to rutile structure when temperature of calcination was increased. The obtained

electrospun fibrous titanium dioxide was then used as a stationary phase for thin layer

chromatography (TLC). Separation of dye compounds containing basic groups were

performed and compared with conventional silica-based TLC. The efficiency of the

separation using the electrospun fibrous titanium dioxide TLC was better than that of the

conventional silica-based TLC. In addition, the analysis time and the amount of consumables

required for the analysis were subsequently reduced.

Keywords: thin layer chromatography; titanium dioxide; electrospun fiber; stationary phase

PHY 18

Abstract -Poster


Pag

e84

Effects of Sintering Temperature on Conductivity and Oxygen Permeation

of La0.3Sr0.7Co0.9Fe0.1O3 Perovskite

Anucha Koedtruad,1 Koichiro Mitsuke

2 and Soamwadee Chaianansutcharit

1,*

1Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok, Thailand

2Department of Molecular Science, Institute for Molecular Science, Okazaki, Aichi, 4448585,

Japan


Abstract

Perovskite La0.3Sr0.7Co0.9Fe0.1O3 (LSCF3791) has been recognized as a potential cathode

material for Solid oxide fuel cell (SOFC) due to its mixed electronic and ionic conductivity

(MEIC). The electrical conductivity and oxygen permeation of materials varied depending

upon the sintering temperatures from 1100o to 1300

oC. LSCF sintered at 1100

oC exhibited

metallic-like behavior and dominated in p-type carrier. On the contrary, LSCFs sintered at

1200 and 1300oC showed semiconducting-like behavior with the decreasing of p-type carriers

and the increase in n-type carriers. Moreover, LSCF sintered at 1200oC also exhibited high

oxygen permeation rate as a result of high quantity of oxygen vacancy around Co3+

ion sites

and low surface -CO32-

, –OH species, respectively.

Keywords: LSCF, Perovskite, Solid oxide fuel cell, conductivity, oxygen permeation

PHY 19

Abstract -Poster


Pag

e85

Formation of Branched-Chain Glycolipids Nano-Emulsions for Topical

Drug Delivery Systems

Norazlinaliza Salim, Rauzah Hashim and Noraini Ahmad


Malaysia


Abstract

Nano-emulsion is a dispersion of two immiscible liquids, usually water and oil, which are generally

stabilized by a surfactant. It has droplet size in the nanometer range, typically less than 200 nm and

visually it appears transparent to translucent1. Low viscosity, high kinetic stability against creaming or

sedimentation, and large interfacial area make nano-emulsions of increasing use in different practical

applications2. It offers several significant advantages including powerful permeation ability, no skin

irritation, and high drug-loading capacity3. The most important factor in the study of nano-

emulsion system is the selection of an appropriate surfactant which will efficiently emulsify or

solubilized the chosen active ingredients4. Among the synthetic glycolipids, branched-chain

glycolipids provide a closer alternative to natural ones, which are difficult to extract from natural

resources5. In this point of view, we have synthesized a new class of branched-chain glycolipids for

surfactant functions6-7

. In this research, we focused on two glycosides namely, 2-hexyldecyl-β(/α)-D-

glucoside (2-HDG) and 2-hexyldecyl-β(/α)-D-maltoside (2-HDM). Both have identical number of

hydrocarbon chain length (C16) but differ in their head group size and polarity, hence differ in

hydrophilic-lipophilic balance (HLB). The self-assembly properties of the glycolipids have been

studied, observing rich phase behaviours under thermotropic and lyotropic conditions7. Due to their

amphiphilic characteristics and specifically non-irritant to the skin, these synthetic branched-chain

glycolipids, not only provided alternative nonionic surfactant, but also could be used as a new drug

carrier system especially for the treatment of the skin diseases topically.

Keywords: Surfactant; Branched-chain glycolipids; Nano-emulsion; Topical drug delivery.

References:

1. Solans, C., Izquierdo, P., Nolla, J., García-Celma, M. J. Curr. Opin. Colloid Interface Sci. 2005, 10, 102-

110.

2. Tadros, T., Izquierdo, P., Esquena, J., Solans, C. Adv. Colloid Interface Sci. 2004, 108-109, 303-318.

3. Mason, T. G., Wilking, J. N., Meleson, K., Chang, C. B. and Graves, S. M. J. Phys.: Condens. Matter 2006,

18(41), 635–666.

4. Kuneida, H., Shinoda, K. J. Colloid Interface Sci. 1985, 107(1), 107-121.

5. Hill, K., von Rybinski, W., Stoll, G. Alkyl Polyglycosides: Technology, Properties and Applications, VCH,

Weinheim, 1997.

6. Hashim, R., Hashim, H. H. A., Rodzi, N. Z. M, Hussen, R. S. D., Heidelberg, T. Thin Solid Films 2006, 509,

27-35.

7. Ahmad, N., Ramsch, R. Esquena, J., Solans, C., Tajuddin, H. A., Hashim, R. Langmuir 2012, 28(5), 2395-

2403.

PHY 20

Abstract -Poster


Pag

e86

Kinetic and isotherm adsorption of phenol from wastewater using activated

carbons prepared from jatropha seed husks by KOH activation

Faheem Ahmed Qaid*, Abdul Hamid bin Yahaya and Rosiyah binti Yahya

Department of Chemistry, Faculty of Science, University of Malaya, Kuala Lumpur, 50603

Malaysia


Abstract

Presence of phenol in the environment has been a serious concern especially with rapid

industrialization which has created new uses for phenol. The acute toxicity of phenol to

aquatic life and humans and the stringent effluent standard to be met by industries as specified

by regulatory organizations have necessitated the development of innovative, effective and

economical methods for treating wastewater bearing the phenol. In this study batch isotherm

and kinetic studies were carried out on a laboratory scale to evaluate the adsorption capacity

and contact time on phenol removal. The equilibrium time was 250 minutes. The kinetics of

adsorption of phenol ions on Jatropha seed husks could be adequately described by the

Langmuir model and pseudo-second order reaction rate model

.

Keywords: Adsorption, phenol, waste water, Jatropha seed husks

PHY 21

Abstract -Poster


Pag

e87

Synthesis and Mesomorphic Properties of Schiff’s Base Ester with

Terminal Methoxy Substituent

Yee Ting Chong1, Norazilawati Muhamad Sarih

1,* Sie Tiong Ha,

2 Rezaul Karim Sheikh

3

1Department of Chemistry, Faculty of Science, Universiti Malaya, Lembah Pantai, 50603


2Department of Chemical Science, Faculty of Science, Universiti Tunku Abdul Rahman, Jln

Universiti, Bandar Barat, Kampar, 31900 Perak, Malaysia.

3Department of Applied Chemistry & Chemical Engineering, University of Rajshahi,

Rajshahi-6205, Bangladesh.

* Email address: [email protected]

Abstract

Liquid crystal is fascinating material and often applied in organic electronic and energy

conversion applications. N-(4-Methoxybenzylidene)-4-butylaniline (MBBA) was the first

synthesized Schiff base liquid crystal that exhibit nematic phase at room temperature1

and

mesomorphic properties of aromatic Schiff’s base were arising from terminal substituents

either flexible chains or varying in the polarity of the terminal groups were previously

reported in previous studies.2-5

In previous studies, the results revealed that Schiff base and

ester are some of the common useful linking units for generating mesomorphism in two and

three aromatic rings compounds.2-5

The presence of different polarity of terminal substituents

has been well reported that will either promote or suppress the mesomorphic properties.

A homologues series (Figure 1) of two aromatic ring Schiff base ester containing

alkanoyloxy chain (n = 8, 10, 12, 14, 16 and 18) in one end and methoxy group in other end

were synthesized based on modification methods from literatures.6-7

The structures of the

compounds were determined by spectroscopic methods such as FTIR, 1H NMR,

13C NMR.

Phase transitions temperatures were determined through thermal analysis through using

differential scanning calorimeter (DSC). The liquid crystalline textures of the newly

synthesized compound were determined through polarized optical microscope (POM). All of

the synthesized compounds were showed the present of nematic phase. Nematic phase is

favourable due to the terminal intermolecular interaction was much stronger than that of the

lateral intermolecular interaction and hence disrupted the lamellar packing of the molecules.

PHY 22

Abstract -Poster


Pag

e88

Figure 1: Structure of 4-n-alkanoyloxybenzylidene-4’-methoxy-aniline

Keywords: Liquid Crystals; Schiff base; Nematic

References

1. H. Kelker, B. Scheurle, Angew. Chem. Int. Edn. 81 (1969) 903.

2. Z. Galewski, H. J. Coles, J. Mol. Liq. 79 (1999) 77.

3. J. Godzwon, M. J. Sienkowska, Z. Galewski. Acta Physica Polonica A. 113 (2008) 4.

4. S. Sakagami, T. Koga, A. Takase. Liq. Cryst. 29 (2002) 1087.

5. S.T. Ha, G. Y. Yeap, P. L. Boey. Australian Journal of Basic and Applied Sciences. 3 (2009) 3417.

6. G. Y. Yeap, W. S. Ooi, Y. Nakamura et al. Mol. Cryst. Liq. Cryst. 381 (2002) 169.

7. G. Y. Yeap, S. T. Ha, P. L. Lim et al. Mol. Cryst. Liq. Cryst. 423 (2004) 73.

Abstract -Poster


Pag

e89

Preparation and characterization of poly (3-hydroxybutyric

acid)/poly(vinyl acetate) thin films

1 Olla .H.Sharhan,

1Abdul Hamid Yahaya and

2Mohamed Mahmoud Nasef

1Chemistry Department, Faculty of Science, University of Malaya,


2Chemical Engineering Department, Faculty of Chemical and Natural Resources Engineering ,

University Teknologi Malaysia, Jalan Semarak,



Abstract

Poly(3-hydroxybutyric acid) (PHB) is an interesting biodegradable polymer having properties

similar to polypropylene (PP) that was not applied due to its poor mechanical properties and

biodegradability. So this study aims to blend PHB with poly (vinyl acetate) (PVAc) at various

ratios to improve its working properties and confer it a controlled biodegradability that can be

recovered by converting PVAc to polyvinyl alcohol upon disposal by treatment with NaOH

solution. In this study, films of the blends were characterized by Fourier transform infrared

(FTIR) spectroscopy. The morphology and thermal properties of (PHB) and (PVAc) blends

were investigated by scanning electron microscopy (SEM) and thermogravimetric analysis

(TGA). Results suggest that PVAc is compatible with PHB and molecular chain interaction

takes place as revealed by the decrease in intensity of C=O of PHB ester group with the

increase in PVAc ratio. Although the addition of polyvinyl acetate shifts the onset of PHB

decomposition to higher temperature, the PHB/PVAC blends are thermally more stable in

terms of the pure polymers.

PHY 23


Abstract -Poster


Pag

e90

Development of in vivo Inflammation Imaging Probes

Sung-Jin Park1, Nam-Young Kang

1, Anandhkumar Raju

1, Xiao Wei Emmiline Ang

1,

Animesh Samanta1, Seong-Wook Yun

1 and Young-Tae Chang*

,1,2

1Singapore Bioimaging Consortium

Agency for Science, Technology and Research

2 Department of Chemistry & Med Chem Program

Life Sciences Institute, National University of Singapore


Abstract

Inflammation is immune response of a body normally triggered by infection, tissue damage or

allergic substance. During immune reaction, macrophages are localized at the center, because

macrophages infiltrate into inflamed area, initiate immune response by antigen-presenting and

terminate immune reaction by scavenger functions (phagocytosis). Therefore, development of

technology for macrophage visualization in live animals has been of great interest for the

better understanding of inflammation and the development of therapeutics for immune

disorders. Here, we developed small molecule probes that can selectively detects

macrophages by diversity oriented fluorescent library approach (DOFLA), and can show in

vivo animal imaging in the inflamed region, which was induced by lipopolysaccharide,

bacteria and cancer cell line, respectively. Our developed probes were applied for optical in

vivo imaging by Fluorescence Stereomicroscopy, IVIS Spectrum, Fluorescence Molecular

Tomography and Multi-Spectral Optoacoustic Tomography. So, we suggest that the

developed probes can be utilized for optical in vivo imaging tools and can be the motif of non-

invasive imaging probes for PET. In addition, our probes can be applied for intra-organ

inflamed area like atherosclerosis and Alzheimer disease.

Keywords: inflammation, imaging probe, macrophage, in vivo animal imaging

PHY 24

Abstract -Poster


Pag

e91

Development of in vivo imaging probes for pancreatic islets by Diversity

Oriented Fluorescence Library Approach (DOFLA)

Nam-Young Kang1, Sung-Chan Lee

1, Sung-Jin Park

1, Seong-Wook Yun

1, and Young-Tae

Chang1,2,*

1Laboratory of Bioimaging Probe Development, Singapore Bioimaging Consortium, Agency

for Science, Technology and Research , Singapore 138667, Republic of Singapore.

2Department of Chemistry & NUS MedChem Program of Life Sciences Institute, National

University of Singapore, Singapore 117543, Republic of Singapore

* Correspondence should be addressed to: [email protected]

Abstract

Glucose homeostasis is mainly regulated by hormones released from the islets of Langerhans.

Disruption or dysregulation of hormone production and secretion in the islets lead to

hyperglycemia and diabetes. Visualization of insulin secreting pancreatic beta cell is a

critically important research component in diabetic study, but an in situ imaging probe for the

intact Langerhans islets is lacking at present. Considering the central role of islet cells in the

development of diabetes and as the targets for treatment, it is useful to develop a non-invasive

method to examine functional states of the islet cells. Therefore, we propose to develop novel

Bioimaging Probes for pancreatic islet via a unique approach “Diversity Oriented

Fluorescence Library Approach (DOFLA)” composed of more than 10,000 intrinsically

fluorescent small molecules by combinatorial chemistry. As an expansion of high throughput

DOFL screening, we discovered a live cell imaging glucagon probe that stains alpha cell

selectively. We aim to discover fluorescent compounds that stain pancreatic islet selectively.

Selected fluorescent compounds will be further optimized as bioimaging probes to allow a

unique and powerful tool for pancreatic islet imaging and facilitated isolation as well as in

vivo imaging of islets byoptical imaging, nuclear imaging (PET/SPECT) and MRI.

Keywords: Langerhans islets, Diabetes, Bioimaging Probes, DOFLA

PHY 25


Abstract -Poster


Pag

e92

Fluorescent chemical imaging probes for live stem cells

Young-Tae Chang1,2

and Seong-Wook Yun2

1Department of Chemistry & NUS MedChem Program of Life Sciences Institute, National

University of Singapore, Singapore.

2Laboratory of Bioimaging Probe Development, Singapore Bioimaging Consortium, Agency

for Science, Technology and Research, Singapore.


Abstract

There has been a remarkable advancement in the technology of using stem cells during last

decade. Now human embryonic stem cells can be expanded and differentiated into specific

types of cells in vitro. Somatic cells obtained from patients suffering from genetic diseases

can be reprogrammed into pluripotent stem cells to be used for disease mechanism study and

drug development. Neural stem cells transplanted into damaged lesion of the brain or spinal

cord help recover impaired function. For successful utilization and application of the stem

cells, however, strict control of their quality is required due to their tendency to differentiate

into heterogeneous cell types. Differentiation stages and types of stem cells have been

typically identified by detecting marker expressions using antibodies, which often requires

cells to be fixed and permeabilized. Therefore, development of more convenient tools that can

be applied to detect, isolate and characterize live stem cells is necessary. By image-based high

content screening of our Diversity Oriented Fluorescence Library (DOFL), we discovered

colorful fluorescent chemical probes CDy1, CDg4 and CDb8 that stain embryonic stem cells,

and CDr3 that stains neural stem cells selectively. Applications of the probes to assay

development and adult stem cell isolation will be further discussed.

Keywords: DOFL, Embryonic stem cell, Imaging Probe, Live cell imaging, Neural stem cell

PHY 26

Abstract -Poster


Pag

e93

Near-Infrared Raman Reporters for SERS-based in vivo Cancer detection

Animesh Samanta1,Kaustabh Kumar Maiti,

2U. S. Dinish

1andYoung-Tae Chang*

1Affiliation of first authorSingapore Bioimaging Consortium, Agency for Science Technology

and Research (A*STAR), Singapore

2CSIR-National Institute for Interdisciplinary Science & Technology (NIIST), Chemical

Science & Technology Division (CSTD), Organic chemistry section, Industrial Estate,

Thiruvananthapuram - 695019, Kerala, India


Abstract

We explored the application of tricarbocyanine dyes as Raman reporters for advanced

imaging techniques such as Surface Enhanced Raman Scattering (SERS). SERS probes are

based on the 109–10

15 fold scattering enhancement caused by the proximity of Raman active

signature molecules to the surface of metal nanoparticles (NPs) which can be modulated with

molecular recognition motifs to render diagnostic tools for optical imaging and therapeutic

studies. However, the preparation of ultrasensitive SERS probes is hampered by the limited

availability, sensitivity, and reproducibility of Raman-active compounds at near-infrared

(NIR) region. We designed a combinatorial approach to discover highly sensitive SERS

reporters and identified CyNAMLA-381 as the most sensitive NIR SERS reporter.

Furthermore, we conjugated target specific antibody such as scFv anti-HER2 and analyzed its

cell localization by mapping experiments. Finally, we validated the in vivo application of this

targeted nanotags after i.v. injection in nude mice bearing xenografts generated form SKBR3

breast cancer cells. Furthermore, this Reporter was applied along with two more partners

(Cy7LA and Cy7.5LA) for multiplex targeted in vivo cancer detection in mice bearing

xenograft generated from OSCC cells.

Keywords: tricarbocyanine, gold nanoparticles, tumor, surface-receptor, sensitive.

PHY 27

Abstract -Poster


Pag

e94

Effect Of Pure Cationic Micelle ([Ctabr]T On The Rate Of Alkaline

Hydrolysis Of N-(2-Aminophenyl)Phthalimide

Wan Hamdah Wan Ahmad

Department of Chemistry, Faculty of Science, University Malaya, 50603 Kuala Lumpur


Abstract

The hydrolysis of N-(2-aminophenyl)phthalimide (N2AmPhPT) (2.0 × 10-4

M) was studied

within the total concentration of [CATBr]T ranging from 4 × 10-4

M to 1.7 × 10-1

M at 2 × 10-

3M NaOH respectively and 35ºC. Pseudo first-order rate constants, kobs are shown graphically

in Fig.1. The observed data were treated in the frame of the pseudophase ion exchange (PIE)

theory proposed by Romsted1 (Eq.1). The nonlinear least-squares calculated values of mr

Mk

and CTA

SK are (38.8±2.7) s-1

and (49.2 ± 4.1)M-1

respectively, with 103kw = 71.6 s

-1 at 10

5 cmc

= 4.00M.

PHY 28

Abstract -Poster


Pag

e95

Quantitative Correlation Between Counterion (X) Affinity to Cationic

Micelles and X-Induced Micellar Growth for X = 2,6-Dichlorobenzoate Ions

Norazizah A. Razak*, Nor Saadah M. Yusof and M. Niyaz Khan


Malaysia


Abstract

A semi empirical kinetic (SEK) method has been used to determine the ratio of

cetyltrimethylammonium bromide (CTABr) micellar binding constants of counterion X- and

Br- (a reference counterion), i.e. KX/KBr (= RX

Br). The values of KX and KBr have been derived

from the kinetic parameters obtained in the presence spherical/non-spherical and spherical

micelles, respectively. This rather new method gives the respective mean values of RXBr

as

4.7 ± 0.6 for X = 2,6-Cl2C6H3CO2-. Literature report on the values of RX

Br for X = 2,6-

Cl2C6H3CO2- (2,6-Cl2Bz

-) for which the reported value is 5.0. The values of RX

Br offer

quantitative evidence of the perception that the strong micellar binding of certain counterions

is the cause of the micellar structural transition from spherical to cylindrical to wormlike

entangled micelles. Rheological properties, such as Newtonian behavior, reveal indirectly the

presence of spherical micelles (SM) in the CTABr micellar solutions containing MX for X =

2,6-Cl2Bz-. The micelles remain spherical within [2,6-Cl2Bz

-] range 0.01 – 0.34 M at 0.015 M

CTABr. It can be concluded that the magnitudes of the thermodynamic of ion-exchange

constant, RXBr

for ion exchange X-/Br

- on the cationic micellar surface in aqueous solution

could affect the physical properties such as the structure of micelles of ionic surfactant

solutions.

Keywords: Rheology, Kinetics, Spherical micelles, Counterion (X-) effects, Micellar growth,

Quantified X- - affinity to micelles

PHY 29


Abstract -Poster


Pag

e96

Multidonor Substituted Perylene Dyes through Unusual Bromination of

Perylene Monoimide

Ashok Keerthi, 1, 2

Yeru Liu,2, 3

Qing Wang,2, 3

Suresh Valiyaveettil1, 2

*

1 Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore

117543

2NUSNNI-Nanocore, National University of Singapore, Singapore 117574

3 Department ofMaterials Science and Engineering, Faculty of Engineering, National

University of Singapore, Singapore 117574

*Coresponding authour e-mail: [email protected]

Abstract

Recently, design and synthesis of advanced materials using perylene chromophore has been

an active area of research. Unique light-harvesting and redox properties on conjunction with

high thermal stabilities of perylene dyes offer potential applications in organic photovoltaics.

Perylene monoimide (PMI) was brominated to give tetra- and tribrominated molecules, which

undergoes Suzuki coupling reaction with 4-(diphenylamine) phenyl boronic acid and gave

PMI derivatives. The photophysical, electrochemical and theoretical calculations of the

synthesized compounds were investigated. Singles crystals of tetra substituted PMI were

grown and studied in detail. The structure property relationships were studied to see the effect

of position and number of substituents on perylene core unit. All molecules showed a broad

absorption up to 750 nm. Corresponding anhydrides of PMIs were used for fabrication of dye-

sensitized solar cells.

Acknowledgement: The authors acknowledge the support from Department of Chemistry,

National University of Singapore for funding and technical support. WC thanks the National

University for a graduate scholarship.

PHY 30


Abstract -Poster


Pag

e97

Morphology Studies of Doped Polyaniline Nanocomposites Containing TiO2

Nanoparticles and Graphene Nanoplatelets

Perakassh veloo, Yen Nee Koh, Sook Wai Phang,*

Department of Chemistry, Faculty of Science, University Malaya,



Abstract

Polyaniline (PAni) nanocomposite containing hexanoic acid (HA) as dopant, titanium

dioxide (TiO2) nanoparticles and graphene nanoplatelets was synthesized by using chemical

oxidation method. In this study, magnetic material (graphene nanoplatelets) and dielectric

material (TiO2) was added during polymerization. The nanocomposites were characterized

using Fourier Transform Infrared (FTIR) Spectroscopy, UV-Vis (UV) spectroscopy, X-Ray

Diffractometry (XRD) and Thermogravimetric analysis. Additional analysis on the

conductivity and morphology studies was investigated by using four-point probe and Field

Emission Scanning Electron Microscope (FESEM). The nanocomposites recorded

conductivity in the range of 3.559 X 10-1

– 2.557 S/cm.

Keywords: Polyaniline, Nanocomposite, Graphene nanoplatelets

Suggested reading:

1. Amantia, D., Gutierrez, D., Aubouy, L., & Mart, M. (2013). with exfoliated graphene nanoplatelets ( GNPs ),

10450–10457.

2. Li, Y., Peng, H., Li, G., & Chen, K. (2012). Synthesis and electrochemical performance of sandwich-like

polyaniline/graphene composite nanosheets. European Polymer Journal, 48(8), 1406–1412.

3. Xiang, J., & Drzal, L. T. (2012). Templated growth of polyaniline on exfoliated graphene nanoplatelets (GNP)

and its thermoelectric properties. Polymer, 53(19), 4202–4210.

PHY 31

Abstract -Poster


Pag

e98

Development of Photosensitive Ceramic Thin Films for Photovoltaic

Applications

Muhammad Adil Mansoor, Muhammad Mazhar and Zainudin Artfin.

Department of Chemistry, Faculty of Science, University of Malaya, Lembah

Pantai, 50603 Kuala Lumpur, Malaysia.

Abstract

Production of clean energy is a big challenge to humanity because the conventional fossil fuel or

nuclear energy are highly environment polluting. The alternate environment friendly sources of

energy are solar energy and hydrogen therefore efforts are being made to discover benign

materials for photovoltaic applications and production of H2 from abundantly available water

source. The energy difference between the oxygen evolution potential and the hydrogen evolution

potential is 1.229 eV at 25 oC.1 Therefore; ideally one would like to have a chemically and

optically stable semiconductor, in which the conduction and valence bands are positioned

favourably so that they straddle the hydrogen and oxygen evolution potentials. To overcome the

overpotential which is mainly associated with oxygen evolution, a semiconductor material with a

band gap of 1.8-2.0 eV is preferred. This poster presentation highlights synthetic strategy for the

synthesis of single source molecular precursors that are capable of delivering all the elements of

interest bonded in one structure so that desired metal oxide thin films can be deposited onto the

target substrate.2-6 Such molecular precursors provide opportunity to deposit thin films by Aerosol

Assisted Chemical Vapour Deposition (AACVD) with controlled composition and architecture.7,8

We therefore report the design, synthesis and characterization of a series of specifically tailored

new single source molecular precursors (i.e. [Mn2Zn2(TFA)8(THF)4] (1),

[Fe6(PhCOO)10(acac)2(O)2(OH)2] (2), [Fe2(acac)2(dmaeH)2]2+ [ZnCl3(THF)]- (3) and their use for

the deposition of nanostructured MnZnO3, α-Fe2O3, ZnFe2O4 thin films respectively on FTO glass

substrates using AACVD for their possible technological applications.

References:

1. A. Tahir and K. G. U. Wijayantha, Journal of Photochemistry and Photobiology A: Chemistry, 2010, 216,

119.

2. M. Hamid, A. A. Tahir, M. Mazhar, M. Zeller, K. C. Molloy, and A. D. Hunter, Inorg. Chem. 2006, 45,

10457.

3. M. Veith, Dalton Trans.2002,2405.

4. V. G. Kessler, Chem. Commun.2003,1213.

5. A. C. Jones, J. Mater. Chem. 2002,12,2576.

6. M. Veith, M. Haas and V. Huch, Chem. Mater. 2005, 17,95.

7. A. Brethon, L. G. Hubert-Pfalzgraf and J. C. Daran , Dalton Trans. 2006,250.

8. M. Afzaal, M. A. Malik and P. O'Brien J. Mater. Chem..2010,20,4031

PHY 32

Abstract -Poster


Pag

e99

Development of a Reusable Biosensor for Small Molecules

Adam Henry Sivapathama, Nadiya Taha Darwish

a, Mai Mai Khoo

a and Sook Mei Khor

a*

aDepartment of Chemistry, Faculty of Science University of Malaya, 50603 Kuala Lumpur,

MALAYSIA

*Corresponding author: Dr. Sook Mei Khor; E-mail: [email protected]; Tel: +603-

79677022/Ext: 2520; Fax: +603-79674195.

Abstract

Biosensors are chemical sensors that can transform chemical information into analytically

useful signals. They provide simple, rapid and cost-effective analyses in various industries.

They are reagent-free, non-toxic waste producing and have high selectivity and sensitivity,

among others. A reusable biosensor allows repeatable usage over time which is advantageous

in that it provides high throughput analysis with high accuracy, precision and better

reproducibility. Thus, this study aims to develop a new method for surface regeneration in

order to create a biosensor which can be used repeatedly for small molecules detection, in this

case, biotin. Indeed, small molecule detection is important in the development of novel

pharmaceuticals, in relation to drug design. Pulse voltammetry methods were explored to

regenerate the sensing interface.

AN-EV 1


Abstract -Poster


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Identification and Evaluation of Air Pollution Tolerance Index of Plant

Species under the Impacts of Marble Industry Pollutants of

Potwar Region of Pakistan

1,2,3Mehwish Jamil Noor,

2Muhammad Aqeel Ashraf,

3Mushtaq Ahmad,

1Amber latif,

1Sonia

Fatima

1Department of Environmental Sciences, Faculty of science and Technology, Fatima Jinnah

Women University, Rawalpindi. Pakistan

2Geology Department, University Malaya 50603 Kuala Lumpur

3Department of Plant Sciences, Quaid-i-Azam University, Islamabad, Pakistan

Abstract

Biological monitoring and assessment studies due to Marble industries pollutants were carried

out using Air Pollution Tolerance Index (APTI) of plants. Four parameters ascorbic acid, total

chlorophyll, relative water content and leaf extract pH of selected plant leaves were carried

out with a view to find out the air pollution tolerance as well as sensitivity of the plant species

and signifying the APTI of different plants life forms. Vitisvinifera, Lantana camara,

Ricinuscommunis, Calatropisprocera, Psidiumguajava, Eucalyptus globules, Cannabis

sativa, Broussonetiapapyrifera and Amaranthusviridiswere selected in pairs from

experimental and control site and were analyzed for their biochemical and physiological

parameters.APTI was higher for Lantana camara showed highest APTI and tolerance among

selected plant species.Ascorbic acid content was nearly equal in all species from both sites.

Higher Relative water content and pH values for leaf extract, Stomatal clogging, reduction in

average leaf area, chlorosis, wilting, brown patches, and necrosis was observed in vegetation

in experimental sight. Soil moisture was less in experimental site. It was concluded that

marble industries are having a considerable impact on the surrounding vegetation. It was

concluded that marble industries are having a considerable impact on the surrounding

vegetation.

Keywords: Marble, pollutants, plant species, biological monitoring, assessment

AN-EV 2

Abstract -Poster


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1

Biodegradation Studies of Dichlorvos under Different Sets of Conditions

1, 2Rizwana Naureen,

1Imran Hashmi,

3Mohd, Jamil Maah,

2Ismail Yusoff,

2Muhammad Aqeel

Ashraf

1Institute of Environmental Sciences and Engineering, National University of Science and

Technology, Islamabad, Pakistan

2Geology Department, University Malaya 50603 Kuala Lumpur

3Department of Chemistry, University Malaya 50603 Kuala Lumpur

Abstract

The objective of the research was to isolate dichlorvos (2, 2 – dichlorovinyl dimethyl

phosphate) degrading strain of Pseudomonas sp. The acclimatized bacterial culture was

identified through morphological, physical and biochemical characterization. Identification

was performed up-to species level using analytical profile index (API), where isolated strain

was identified as Pseudomonas aeruginosa. Degradation was studied at different pH,

temperature and at different dichlorvos concentrations of 100, 300 and 500 mg L-1

. The

decrease in organic matter was measured after every 24 h, indirectly by Chemical Oxygen

Demand (COD) while degradation metabolites of dichlorvos were analyzed by GC-MS. The

results showed that maximum degradation was achieved for 100 mg L-1

of dichlorvos after

120 h of incubation period at pH 7 and 30o C, whereas the COD removal was 80, 65 and 53%

at varying pH while at varying temperature it was 86,67 and 59% for 100, 300 and 500 mg/L,

respectively. Quantitative analysis through gas chromatography showed percent degradation

of 85, 64 and 60% at pH 7 for 100, 300 and 500 mg/L of dichlorvos, whereas at 30oC, the

maximum degradation observed was 91, 73 and 68%, respectively. The degradation

metabolites of dichlorvos extracted with n-hexane were studied using retention time and

fragmentation pattern by GC-MS analysis. Dimethylphosphate and dimethylmonochlorvos

were major degradation by-products with m/z value of 109 and 185 respectively, indicating a

90% degradation rate.

Keywords: Dichlorvos, isolation, pseudomonas sp., characterization, degradation

AN-EV 3

Abstract -Poster


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2

Prediction of cetirizine hydrochloride content in medication tablet using

ATR-FTIR and PLS

Shiau Yi Tan and Kah Hin Low*

Department of Chemistry, University Malaya, Kuala Lumpur, Malaysia


Abstract

An alternative approach for the determination of cetirizine hydrochloride in pharmaceutical

tablet was developed using attenuated total reflectance-Fourier transform infrared

spectrometry coupled with chemometric. Partial least square regression models were

constructed using unit vector normalized and first order derivatized spectra in the region of

1800-1100 cm-1

. The coefficient of determination found to be more than 0.9 with the root

mean square of errors of prediction ~0.2 % for both cases. The proposed approach is

relatively simple, rapid and compatible to the assay by high performance liquid

chromatography.

Keywords: cetirizine hydrochloride, chemometric, infrared, partial least square

Suggested Reading:

1. Beebe, KR., Pell, RJ. & Seasholtz, MB. (1998). Chemometrics A Practical Guide. New York: John

Wiley & Sons, Inc.

2. Low, K.H., Zain, S.Md., Abas, M.R., Misran, M. & Ali Mohd, M. (2009). J. Korean Chem. Soc.

53(6):717-716.

3. Müller, ALK., Flores, EMM., Müller, EI., Silva, FEB. & Ferrão MF. (2011). J. Braz. Chem. Soc.. 22

(10): 1903-1912.

AN-EV 4

Abstract -Poster


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3

Remediation of Heavy Metal Contaminated Soil Using Banana Stem as the

Organic Fixing Additive

Mehrnaz Ashrafi1*, Sharifah Mohamad

2, Ismail Yusoff

3, Fauziah Shahul Hamid

1

1 Institute of Biological Sciences, Faculty of Science, University of Malaya

2 Department of Chemistry, Faculty of Science, University of Malaya

3 Department of Geology, Faculty of Science, University of Malaya

* Email: [email protected]

Abstract

Heavy metal pollution of soil is an increasingly urgent problem all over the world mainly due

to anthropogenics activities. In this study banana stem amendment, as an inexpensive fixing

agent, was applied to an artificially metal-contaminated soil to fix Pb, Cd and Zn in the soil. A

metal leaching experiment was designed to simulate the rainfall conditions in order to obtain

information on the potential mobility of metals. The results from the metal leaching analysis

revealed that banana stem amendment generally reduced the Cd leaching. Specifically, the

cumulative amount of Cd in the leachates after 6 leaching events was reduced by 78% in the

amended soil. Moreover, a sequential extraction analysis was carried out at the end of the

experiment to find out the speciation of the heavy metals. The findings from the sequential

extraction analysis indicated that the addition of banana stem amendment notably reduced

exchangeable form of Cd and increased its residual form in the soil. Our study implies that

banana stem amendment can be used as a low-cost and environmentally safe additive for the

remediation of Cd-contaminated soil.

Keywords: Heavy metals, Remediation, Metal leaching, Sequential extraction

AN-EV 5


Abstract -Poster


Pag

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4

Development and Validation of Liquid Chromatography Tandem Mass

Spectrometer (LCMSMS) for the Simultaneous Determination of Common

Drugs of Abuse in Forensic Cases in Malaysia: Application to Dried Blood

Stain (DBS)

Fathiah Zubaidi1,2

, Guan Huat Tan1, Choo Yeun Mun

1

1Department of Chemistry, University of Malaya, Kuala Lumpur, Malaysia.

2Department of Chemistry Malaysia, Ministry of Science, Technology and Innovation,

Petaling Jaya, Malaysia.

Abstract

A novel liquid chromatography – tandem mass spectrometer (LC-MS-MS) with multiple

reactions monitoring procedure has been developed for the simultaneous determination of

multiple common drugs of abuse in postmortem blood specimens for medico legal purposes in

Malaysia. This concise method is capable to facilitate twenty multiple drugs of abuse and

their metabolites commonly found in medico-legal cases in a single run, which significantly

reduces analysis time compared to separated run. The results demonstrated high selectivity

with the use of Restek PFP Propyl (5 μm, 50 x 2.1 mm i.d.) column. Different buffer systems

were studied and 2 mM ammonium formate with 0.2% formic acid in water: 2 mM

ammonium formate with 0.2% formic acid in acetonitrile of gradient operating condition

proved the best for sample dissolution. The method was proven to be repeatable and

reproducible. The study ranges covering 80-120% of the tested concentrations of analytes

obtained r2

>0.9990. Limits of detection of up to 5ng/ml and recovery of 85-110% were also

obtained. The capability of the method was verified using ten real case samples and

proficiency testing samples received by Malaysian enforcement laboratory.

Keywords: LC-MS-MS, Drugs of Abuse (DOA), Dried Blood Stain (DBS).

AN-EV 6

Abstract -Poster


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5

Preliminary Result On Screening Of Pharmaceuticals In Hospital Sungai

Buloh Wastewater Treatment Plant

Ummi Noor Salhah Masseren*, Tay K.S, Abas M.R.B

Environment Research Grant, Department of Chemistry, Faculty of Science, University of

Malaya.

Abstract

Pharmaceuticals pollution in water environment has been a concern not only to human health,

but also aquatic organisms. Studies have recently shown that pharmaceutical products at trace

levels in water environment including wastewater, surface water, groundwater and more

recently drinking water yielded negative effects to environment and human when exposed. A

screening analysis was conducted for pharmaceuticals in wastewater treatment plant of

Hospital Sungai Buloh, Selangor. The objective was to investigate the potential for

pharmaceuticals contamination of treated hospitals wastewater. The samples were taken from

two stages of the conventional treatment; influent and effluent. This analytical procedure

involved solid-phase extraction (SPE) and gas chromatography-mass spectrometry (GC-MS).

After filtration using glass fibre filter, samples were extracted and subsequently separated into

different fractions of acids, bases and neutrals. The separation is important to reduce

complexity, which later results in lower matrix effects. This was achieved with separate

method, using C18 Bondelut and Oasis HLB SPE cartridge, depends on the type of compound.

The determination of pharmaceuticals in wastewater has employed GC separation techniques

coupled to MS. The identification of pharmaceuticals is made by spectral interpretation from

GC-MS analysis. Targeted pharmaceuticals are selected from the statistic of pharmaceuticals

utilization in Malaysia, 2008.From the structure of the compound, the mass is identified and

compared in mass spectra of GC-MS analysis results.The following 20 compounds were

detected in the wastewater: Acids; Naproxen, Tolfenamic acid, Clofibric acid, Aspirin,

Gemfibrozil, Ibuprofen, Ketoprofen, Salicylic acid, Mefanamic acid. Bases; Sotalol, Atenolol,

Ciprofloxacin, Ranitidine, Norfloxacin, Acebutolol, Metoprolol. Neutrals; Cotinine,

Acetaminophen, Caffeine, Carbamazepine.

Keywords: Mixed-mode solid-phase extraction, Pharmaceutical analysis, Influent, Effluent,

Hospital wastewater treatment

AN-EV 7

Abstract -Poster


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6

Detection of creatinine in urine samples by gold nanoparticles Jarinya Sittiwong, Fuangfa Unob

*

Department of Chemistry, Faculty of Science, Chulalongkorn University, Payathai Road,

Bangkok 10330, Thailand


Abstract

A method based on gold nanoparticles (AuNPs) reaction was proposed for detection of

creatinine in human urine samples after extraction on sulfonic acid functionalized silica gel.

The parameters affecting the extraction of creatinine by the adsorbent were studied. With the

proposed extraction method, the matrix and pH of urine samples showed no interfering effect

on creatinie detection. In the presence of creatinine, the aggregation of gold nanoparticles,

resulting in a change in the surface plasmon resonance and solution color, was observed and

quantitated by a spectrophotometer. The effect of AuNPs concentration and reaction time

between AuNPs and creatinine on the determination was investigated. The method provided a

determination of creatinine in a range of 15-40 mg L-1

with a detection limit of 13.7 mg L-1

. It

was successfully used in the detection of creatinine in human urine samples.

Keywords: gold nanoparticles, creatinine, urine samples, surface plasmon resonance

AN-EV 8

Abstract -Poster


Pag

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7

Chemometric Analysis of Spectroscopic Data on Shape Evolution of Silver

Nanoparticles Induced by Hydrogen Peroxide

Kanet Wongravee*1

, Tewalak Parnklang

1, Yukihiro Ozaki

2, Chuchaat Thammacharoen

1,

Sanong Ekgasit1

1Sensor Research Unit, Department of Chemistry, Faculty of Science, Chulalongkorn

University, Bangkok 10330, Thailand.

.2Department of Chemistry, School of Science and Technology, Kwansei Gakuin

University, Sanda, Hyogo.


Abstract

An alternative approach for synthesizing colloidal silver nanoprisms with controllable

localized surface plasmon resonance (LSPR) via a chemical shape transformation of silver

nanosphere induced by H2O2 is proposed. According to the growth mechanism of silver

nanoplates, the spectrophotometric method combined with chemometric analysis has potential

to reveal the structural evolution process as observed by surface plasmon resonance

phenomena. The extinction spectra of the evolving nanostructures were analyzed by factor

analysis and error indicator functions. Five major components attributed to the different

particle shapes and sizes were theoretically predicted. Furthermore, the concentration profiles

and pure spectra of these components were resolved using multivariate curve resolution–

alternative least squares (MCR–ALS) analysis. The predicted structural morphologies of each

component given by chemometric calculation were in excellent agreement with those

observed by transmission electron microscope (TEM) images. The procedure was powerful

and accurate which exhibits all hidden information without a requirement of extensive

laboratory measurements. Because of the simplicity, the low operating cost, and the rapid

spectrophotometric measurements, the purposed procedure opens up a new insight to the

study of metal nanoparticle evolution.

Keywords: Silver nanoprisms, Hydrogen peroxide, Chemometrics

AN-EV 9

Abstract -Poster


Pag

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8

The Influence of Triton-X on the Evaporation Rate of Methanol- An

analysis using Reversed-Flow Gas Chromatography (RF-GC)

Methodologies

H.H. Mohammad1,*

, Khalisanni Khalid1,2

, Kheng Soo Tay1, Sharifuddin Md. Zain

1,

Rashid Atta Khan1

1Department of Chemistry, Faculty of Science, University of Malaya,


2Food and Agricultural Analysis Laboratory Program, Technical Service Centre,

Malaysian Agricultural Research and Development Institute (MARDI),

43400 Serdang, Selangor, Malaysia

*Corresponding author: [email protected]

Abstract

Reversed-Flow Gas Chromatography (RF-GC) is a relatively new technique to determine the

physicochemical properties of solute. So far, RF-GC has been used to determine the diffusion

coefficient of various solvents. However, the used of RF-GC in other applications such as

environmental studies have not been reported. In this study, RF-GC which is a part of flow-

perturbation gas chromatography was used to investigate the rate of evaporation of methanol

in the presence surfactant (Triton X-100). Waste methanol is considered as an ignitable

hazardous waste by US Environmental Protection Agency (USEPA) when its concentrations

is equal to or greater than 24% in water. The aim of this study was to determine the effect of

Triton X-100 as non-ionic surfactant to suppress evaporation rate of methanol. The result of

this study indicated that the evaporation rate of methanol was found to be retarded by the

presence of Triton X-100. The percentage of retardation was found to increase with

increasing concentration of Triton X-100.

Keywords: evaporation rate, diffusion rate, Reversed-Flow Gas Chromatography (RF-GC)

AN-EV 10

Abstract -Poster


Pag

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9

Efficient removal of engineered nanoparticles from water using renewable

resources

Ramakrishna Mallampati, Ong Pin Jin, Suresh Valiyaveettil

Department of Chemistry, Faculty of Science,

National University of Singapore, Singapore, 117543.


Abstract

The increasing use of engineered nanoparticles (NP) in industrial and household applications

is expected to lead the contamination of environment. Results from ecotoxicological studies

showed that certain NPs induce significant toxicity to living organisms. Unlike, other

pollutants, nanomaterials are difficult to remove due to differences in size, shape,

composition, charges and stability in water. In this study, we employed biopeels to extract

ZnO, TiO2 and SiO2 nanoparticles from water. The structure of adsorbents was characterized

using FESEM, TEM, EDS and XRD. The adsorption capacity of biopeel towards different

NPs was investigated with varying contact time intervals. Results showed that biopeels can

adsorb nanoparticles efficiently. The adsorption mechanism was investigated based on the

surface charge of the pollutants and the functional groups present on the adsorbent. It is

expected that such a simple and efficient method can solve the nanotoxicity problem

significantly.

Acknowledgement: The authors thank the Environment and Water Industry Programme

Office (EWI) under the National Research Foundation of Singapore (PUBPP 21100/36/2,

NUS WBS no. R-706-002-013-290, R-143-000-458-750, R-143-000-458-731) for the

financial support of the work. The authors also thank Faculty of Science, Department of

Chemistry, NUS Environmental Research Institute (NERI) for funding and technical support.

AN-EV 11


Abstract -Poster


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Multi-residue Analysis of β-Agonists in Tissues by LC-MS/MS

Mak Oi Wei1, Maheswari D/O Paliyanny

2

1Department of Chemistry, University of Malaya

2Food Additive Laboratory, Department of Chemistry of Malaysia


Abstract

We have developed QuEChERS method to determine the presence of different β-agonists’

members in animal tissues by improving the extraction and cleanup, followed by UPLC-

MS/MS. β-agonists were originally used in the therapeutic treatment of asthma and

emphysema but also misused as a feed addictive to promote leanness of meat and reduce fat.

Intake of β-agonists may cause anxiety, hypertension, essential tremor. β-agonists have been

banned for use as growth promoters in livestock in Malaysia. So it is necessary to develop

highly sensitive QuEChERS method for this analysis.

Keywords: QuEChERS, β-agonists, extraction, UPLC-MS/MS

Suggested Reading:

1. Juan, C., Igualada, C., Moragues, F., León, N., & Mañes, J. (2010). Development and validation of a liquid

chromatography tandem mass spectrometry method for the analysis of β-agonists in animal feed and drinking

water. Journal of Chromatography A, 1217(39), 6061-6068.

2. Lee, M. S. (Ed.). (2012). Mass spectrometry handbook (Vol. 7). Wiley. com.

3. Lehotay, S. J., Collaborators, M. O., Hans, A. V. G. M. C., Gnter, M. V. H. T. A., Mette, L. R. F. K. M.,

Hammack, E. P. A. B. W., & Parker, A. W. A. (2007). Determination of pesticide residues in foods by

acetonitrile extraction and partitioning with magnesium sulfate:collaborative study. Journal of AOAC

International, 90(2), 485-520.

UP 1


Abstract -Poster


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1

Extraction Of Phytonutrients From Crude Palm Oil And Red Palm Oil

Using Ionic Liquid

Ong Pei Pei1and Dr. Ng Mei Han

2

1Department of chemistry, Faculty of Science, University of Malaya, 50603, Kuala Lumpur,

Malaysia.

2Malaysian Palm Oil Board, No.6, Persiaran Institusi, Bandar Baru Bangi, 43000, Kajang,

Selangor, Malaysia.


[email protected]

Abstract

Ionic liquid can replace organic solvent such as hexane in the extraction of phytonutrients.

There is a need to find a substitute for hexane as organic solvent is volatile and can evaporate

to atmosphere with detrimental effects on the environment and human health. Ionic liquids in

room temperature are highly thermal- and electrochemically stable. They possess negligible

vapour pressure, have relatively low viscosity and high density. Thus, it can be used as

environmentally friendly media for a range of industrially important chemical processes.

Throughout the whole project, the amount of Ionic Liquid used in extraction was varied to

obtain the optimum ratio of Ionic liquid needed for successful extraction of phytonutrients

from Crude Palm Oil (CPO) and Red Palm Oil (RPO). Vitamin E and Carotene content

analysed by using High performance Liquid Chromatography (HPLC) and UV-VIS

spectrophotometer.

Keywords: Ionic Liquid

Suggested Reading:

1. Dupont, J., Consorti, C. S., SUAREZ, P. A., & DE SOUZA, R. F. (2002). Preparation of 1-butyl-3-methyl

imidazolium-based room temperature ionic liquids. Organic syntheses, 79, 236-243.

2. Earle, M. J., & Seddon, K. R. (2000). Ionic liquids. Green solvents for the future. Pure and Applied

Chemistry, 72(7), 1391-1398.

3. Ng, M. H., Choo, Y. M., Ma, A. N., Chuah, C. H., & Hashim, M. A. (2004). Separation of vitamin E

(tocopherol, tocotrienol, and tocomonoenol) in palm oil. Lipids, 39(10), 1031-1035.

UP 2



Abstract -Poster


Pag

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2

Alkaloids from Alstonia sp.

Su-Han Ng and Toh-Seok Kam


Malaysia


Abstract

A study of the alkaloidal composition of the leaves of Alstonia penangiana was carried out. A

total of 8 alkaloids were obtained, consisting of four pure alkaloids and two unresolvable

alkaloid pairs. Structural determination of these alkaloids were based on spectroscopic

methods. The alkaloids isolated were vincorine (S1), norvincorine (S2), alstomaline (S3),

demethoxyalstonamide (S4), alstonerine (S5) and alstonerinal (S6), alstophylline (S7) and

alstophyllal (S8).

Keywords: Alstonia penangiana , alkaloids

Suggested Reading:

1. Alexander, M. K. An Introduction to the Chemistry of Alkaloids, Page Bros, London.

2. 1970. Hesse, M. Alkalolds: Natures curse or blessing?, Wiley-VCH, Weinheim, 2002.

UP 3

Abstract -Poster


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3

Analysis of Compound P, A By-Product of Palm-Based Ester

Using HPLC-MWD

Sim-Yee Cha1, Bonnie Yen-Ping Tay

2, and Pei-Meng Woi

1

1Department of Chemistry, Faculty of Science University Malaya, 50603 Kuala Lumpur

2Quality and Environmental Assessment Unit, Advanced Oleochemical Technology Division,

Malaysian Palm Oil Board


Abstract

The title of the project is the analysis of Compound P, a by-product of palm-based ester using

High Performance Liquid Chromatography-Multi-Wavelength Detector (HPLC-MWD). The

main objective of the project is method development. A best method to detect Compound P in

various cosmetic samples by using HPLC-MWD is needed to be found. We manipulated the

HPLC conditions, by changing the column used, solvent ratio, solvent used and flow rate. By

screening through different types of cosmetic samples, we analyzed the peak of Compound P

by calculating its recovery using external standard as calibration. The project was divided into

two parts, each part with different type of columns, to find out which column is better in

determining Compound P. For method 1, Chrom Reversed Phase Endcapped 100-4.6mm

column was used and for method 2, HG Reversed Phase 250x4mm column was used.

UP 4

Sponsors


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4

SPONSORS

DKSH Malaysia Sdn. Bhd.

Bumipadu Solution Sdn. Bhd.

5th um-nus-cu trilateral mini symposium and scientific meeting 2014

Science

yeong siang chiam

sofian azirun dean

lipozyme rm im

gwaram nura suleiman

jatropha seed husks

differential scanning calorimetry

kavirajaa pandian sambasevam

woo juin onn