2004-2005Pharmacology Review

of Everything(Principles, Cardiovascular and Respiratory drugs have been

updated)

April 21, 202303:09 PM

Spectinomycin

AntibioticBacteriostatic protein synthesis

inhibitor

30S ribosome

Spironolactone

Potassium sparing diureticAntiandrogen

Aldosterone receptor antagonistAndrogen receptor antagonist

Testosterone synthesis inhibitorAntihypertensive

Heart failure treatment

St. John’s Wort

Dietary supplement

Antidepressant

Streptokinase

Thrombolytic

Streptomycin

Aminoglycoside antibioticBactericidal protein synthesis

inhibitor

30S ribosomeFreezes initiation

Succinylcholine

Paralytic

Depolarizing blockerParalyzes skeletal muscles

Bronchoconstrictor

Sucralfate

Antiulcer

Sufentanil

OpioidGeneral anaesthetic

Intravenous anaesthetic

Sulfacetamide

Sulfonamide antibioticMicrobial nucleic acid

and protein synthesis inhibitor

Inhibits dihydropteroate synthetase

Topical

Sulfadoxine

Sulfonamide antibioticMicrobial nucleic acid

and protein synthesis inhibitor

Dihydropteroate synthetase inhibitor

Sulfamethoxazole

Sulfonamide antibioticMicrobial nucleic acid

and protein synthesis inhibitor

Inhibits dihydropteroate synthetase

Sulfasalazine

Disease modifyinganti-rheumatic drug (DMARD)

Metabolized to sulfonamide+ salicylate (NSAID)

Treatment of IBD

Sulfinpyrazone

Uricosuric

Anti-gout

Sulfisoxazole

Sulfonamide antibioticNucleic acid and

protein synthesis inhibitor

Inhibits dihydropteroate synthetase

Sulfonamides

AntibioticsNucleic acid and

protein synthesis inhibitors

Inhibit dihydropteroate synthetase

Sulindac

NSAIDAnalgesic, Anti-inflammatory,

Antipyretic

Cyclooxygenase inhibitor

Suramin

Tropical antiparasitic

Treatment of African Trypanosomiasis

Tacrolimus

ImmunosuppressiveAntineoplastic

Binds FKBP (FK506 binding protein)

Inhibits calcineurin

Tamoxifen

Antineoplastic Antiestrogen

Estrogen receptor anatagonist

Tegaserod

IBS treatment

5HT4 receptor agonist

Telmisartan

Antihypertensive

Angiotensin receptor blocker(ARB)

Temazepam

Sedative/Hypnotic

Benzodiazepine Acts on GABAA receptor

complex

Tenecteplase

Thrombolytic

Tissue plasminogen activator (tPA)

Terazosin

Sympatholytic1 adrenergic antagonist

AntihypertensiveTreatment for benign prostatic

hypertrophy

Terbinafine

Allylamine antifungal

Inhibits ergosterol synthesis by inhibiting squalene epoxidase

Terbutaline

Sympathomimetic2 adrenergic agonist

Short acting bronchodilator Tocolytic

Uterine relaxant

Testosterone

Androgen

Natural male gonadal steroid

Testosterone cypionate

Androgen

Synthetic depot

Testosterone enanthate

Androgen

Synthetic depot

Testosterone propionate

Androgen

Synthetic depot

Tetracaine

Local anaesthetic

Tetracycline

AntibioticBacteriostatic protein synthesis

inhibitor Antiulcer

30S ribosomePrevents aminoacyl tRNA attachment

Thalidomide

AntineoplasticLeprosy treatment

Anti-angiogenicAnti-TNF

Theophylline

Bronchodilator

MethylxanthinePhosphodiesterase inhibitor

Used in asthma

Thiabendazole

Antihelminthic

Treatment of intestinal roundworms

6-Thioguanine

Antineoplastic

Antimetabolite (“pseudofeedback inhibition” of

HGPRT and PRP – purine synthesis)

Thiopental

General Anaesthetic

Ultra-short-acting barbiturate

Thioridazine

Antipsychotic

Phenothiazine

Thiotepa

Antineoplastic

Alkylating agent

Thiothixene

Antipsychotic

Thrombopoietin

Cytokine

Platelet synthesis stimulator

Thromboxane A2 (TXA2)

Autacoid

Promotes platelet aggregation Cyclooxygenase product of arachidonate metabolism

Thyrotropin-releasing Hormone (TRH)

Hypothalamic hormone

Stimulates release of thyroid stimulating hormone (TSH) from

the anterior pituitary

ThyrotropinThyroid-stimulating Hormone

(TSH)

Anterior pituitary hormone

Stimulates production of thyroxine (T4), triiodothyronine

(T3) and thyroglobulin

Ticarcillin

Penicillin antibioticCell wall synthesis inhibitor

Anti-pseudomonal penicillinInhibits peptidoglycan cross-

linking

Ticlopidine

Antiplatelet

ADP receptor antagonist

Timolol

Sympatholytic adrenergic antagonist

AntihypertensiveGlaucoma treatment

Anti-anginalBronchoconstrictor

Tissue plasminogen activators

Thrombolytics

alteplase, reteplase, tenecteplase

Tobramycin

Aminoglycoside antibioticBactericidal protein synthesis

inhibitor

30S ribosomeFreezes initiation

Tocainide

Class I antiarrhythmic

Na+ channel blocker(activated channels)

Tolbutamide

Oral hypoglycemic

SulfonylureaInsulinotropic

Tolterodine

Anticholinergic

Muscarinic receptor antagonistPrevents urination

Toremifene

Estrogen antagonist

Selective estrogen receptor modulator (SERM)

Tosemide

Loop diuretic

Na-K-2Cl symporter inhibitor

Trandopril

Antihypertensive

Converting enzyme inhibitor

Tranylcypromine

Antidepressant

Monoamine oxidase inhibitor (MAO-I)

Trastuzumab

Antineoplastic

Anti-HER2 antibody

Triamcinolone

AdrenocorticosteroidGlucocorticoid

Anti-inflammatory steroidInhaled

Triamterene

Potassium sparing diuretic

Sodium channel inhibitorAntihypertensive

Triazolam

Sedative/Hypnotic

Benzodiazepine Acts on GABAA receptor

complex

Trifluoperazine

Antipsychotic

Phenothiazine

Trifluridine

Antiherpes

Pyrimidine analogPhosphorylated to inhibitor of

viral DNA polymerase

Trihexyphenidyl

Antiparkinson

Antimuscarinic

Trimethaphan

SympatholyticAnticholinergic

Nicotinic antagonistAntihypertensive

Trimethoprim

AntibioticProtein and nucleic acid

synthesis inhibitor

Inhibits bacterial dihydrofolate reductase

Tripelennamine

Classical antihistamine

H1 antagonist

Tubocurarine

Paralytic

Paralyzes skeletal muscles

Tumor necrosis factor

CytokineAntineoplastic

Tyramine

Indirect sympathomimetic

VasoconstrictorVasopressor

Ultralente insulin

HormoneInsulin analogue

Long acting

Urokinase

Thrombolytic

Valacyclovir

Antiherpes

Purine analogPhosphorylated to inhibitor of

viral DNA polymerase

Valsartan

Antihypertensive

Angiotensin receptor blocker(ARB)

Valganciclovir

Antiherpes

Purine analogPhosphorylated to inhibitor of

viral DNA polymerase

Valproic acid

Anticonvulsant

Valsartan

Antihypertensive

Angiotensin receptor blocker(ARB)

Vancomycin

AntibioticInhibits cell wall synthesis

Not a lactam

Arginine vasopressin(Antidiuretic hormone;

ADH)

Hypothalamic (posterior pituitary) hormone

AntidiureticVasoconstrictor

Vecuronium

Paralytic

Paralyze skeletal muscles

Verapamil

Class IV antiarrhythmicAntihypertensive

L-type Ca2+ channel blocker Antianginal

Vigabatrin

Anticonvulsant

Irreversible GABA aminotransferase inhibitor

Vinblastine

Antineoplastic

Vinca alkaloidNatural product

Vincristine

Antineoplastic

Vinca alkaloidNatural product

Voriconazole

Triazole antifungal

Inhibits synthesis of ergosterol by inhibiting lanosterol 14

demethylase

Warfarin

Anticoagulant

Vitamin K synthesis inhibitor

Zafirlukast

Leukotriene inhibitor

LTR1 and LTD4 antagonistAsthma treatment

Zalcitabine

Antiretroviral

Nucleoside reverse transcriptase inhibitor (NRTI)

Dideoxycytidine (ddC)

Zanamivir

Antiviral

Inhibits neuraminidaseand decreases viral release

Treatment of Influenza A & B

Zidovudine

Antiretroviral

Nucleoside reverse transcriptase inhibitor (NRTI)

Azidothymidine (AZT)

Zileuton

Leukotriene inhibitor

5-lipoxygenase inhibitorUsed in asthma

Zolpidem

Sedative/Hypnotic

Non-benzodiazepine