9a23601 computational molecular biology

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Code: 9A23601

B.Tech III Year II Semester (R09) Regular & Supplementary Examinations, April/May 2013

COMPUTATIONAL MOLECULAR BIOLOGY(Biotechnology)

Time: 3 hours Max Marks: 70Answer any FIVE questions

All questions carry equal marks

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1 (a) What is dynamic programming? Discuss in detail its principles with an example.

(b) Describe any two biological problems that can be solved by using dynamic programming.

2 (a) Discuss in detail the significance of DNA sequence.

(b) Explain homology based gene prediction.

3 What are microarrays? Discuss in detail the process of microarray technology with an

example.

4 Discuss the different methods available for structure determination of proteins.

5 (a) Write about protein homology modeling.

(b) Discuss the protein design emphasis on structural bioinformatics.

6 (a) Discuss the rooted phylogenetic tree.

(b) Discuss the weighted parsimony method for construction of phylogenetic trees.

7 What are dendrograms? Discuss the distance based methods for construction of phylogenetic

trees.

8 Discuss in detail how computational tools aid in drug discovery.

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1 Define transcription. How transcription is used for global expression analysis?

2 (a) Discuss in detail how computational molecular biology differs with basic molecular biology.

(b) Differentiate functional genomics and comparative genomics.

3 Discuss in detail the structural properties of proteins leading to stability.

4 What is microarray? Explain its procedure in detail with example.

5 What is single nucleotide polymorphism? How is it helpful in analyzing genetic disorders?

6 (a) structure predication of protein.

(b) Protein threading.

7 Discuss in detail the rational drug design.

8 (a) What is dendrograms? Write about its significance.

(b) Write about dendrograms and its interpretation.

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1 Discuss the various involved in the graphical representation of biochemical systems.

2 (a) Applications of SNP.

(b) EST approach.

3 Discuss in detail the steps involved in microarray analysis.

4 Discuss in detail the various tools to predict the secondary structure of proteins.



6 What are dendrograms? Discuss in detail the different types od dendrograms.

7 Discuss in detail the basic concepts in evolution to its molecular level.

8 Discuss in detail the different phases of drug discovery cycle to its formulation.

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1 Add notes on:

(a) S-system equations.

(b) Steady state analysis with an example.

2 (a) Discuss in detail the significance of DNA sequence.

(b) Explain homology based gene prediction.

3 Discuss in detail the steps involved in microarray analysis.



5 Discuss in detail the structural properties of proteins leading to stability.

6 (a) Discuss the rooted phylogenetic tree.

(b) Discuss the weighted parsimony method for construction of phylogenetic trees.

7 (a) What is dendrograms? Write about its significance.

(b) Write about dendrograms and its interpretation.

8 Discuss in detail the rational drug design.

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9a23601 computational molecular biology

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