9th international congress on biocatalysis · 2 programme overview sunday, 26 august building h...

CONGRESS PROGRAMME26–30 AUGUST 2018HAMBURG UNIVERSITY OF TECHNOLOGY l GERMANY

© Technische Universität Hamburg

9th INTERNATIONALCONGRESS ON BIOCATALYSIS

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Programme overview

Sunday, 26 AugustBuilding H Audimax I Room H0.01–H0.09 Audimax I Room H0.01–H0.09

08:30–10:30 08:30–10:30

p. 9 p. 14

11:00–13:10 11:00–12:40

p. 14

p. 9

14:00–15:00 14:00–15:30

14:30–15:30 14:30–16:30

p. 3515:30–17:00

15:50–16:50

p. 26

p. 8 16:50–18:1017:00–18:45

p. 12 p. 56

p. 8

19:00–22:00Welcome reception

p. 8

Lightning talk Session 2 Topic 1

17:00–22:30

Industrial implementations Afternoon session 2 Topic 1

Congress dinner on the boat Louisiana Star

Coffee break and industrial exhibition

Poster session 2 Topic 1

Lunch at Mensa

Monday, 27 August

Tuesday, 28 August

Industrial implementations Morning session 2 Topic 5

Invited speaker session 2Topic 3

Coffee break and industrial exhibition Coffee break and industrial exhibition

Registration

Opening ceremony

Invited speaker session 1 Topic 2

Morning session 1 Topics 2+1

Poster session 1 Topic 3

Afternoon session 1 Topic 4

Lightning talk session 1 Topic 3


Lunch at Mensa

p. 17

p. 10

p. 15

326–30 August 2018 Hamburg university of technology l germany

Programme overview

Thursday, 30 August

Audimax I Room H0.01–H0.09 Ditze Lecture Hall Audimax I08:30–10:30

09:00–11:00

p. 24

p. 1811:00–13:00

11:30–13:20 11:30–13:20

p. 24p. 18 p. 19 13:00–13:30

Closing remarksp. 25

14:40–15:50 14:40–16:40

p. 19

p. 43

17:00–18:00 17:00–18:00

p. 22 p. 22

Opening/Closing/Social programme



Poster session


Lunch at Mensa

Lightning talk session 3 Topics 2+4+5

Poster session 3 Topics 2+4+5

Lightning talk session

Registration

Session

Invited speaker session 4 Topic 3+4

Industrial implementations Morning session 5 Topic 3


Wednesday, 29 August



Invited speaker session 3 Topic 1


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tAble of contents

Organisation and imprint ...................................................................................................... 5

Committees ............................................................................................................................ 6

Welcome note ....................................................................................................................... 7

Scientific programme Sunday, 26 August ....................................................................................................... 8 Monday, 27 August ..................................................................................................... 9 Tuesday, 28 August ...................................................................................................... 14 Wednesday, 29 August ................................................................................................ 18 Thursday, 30 August .................................................................................................... 24

Poster presentations Monday, 27 August ..................................................................................................... 26 Tuesday, 28 August ...................................................................................................... 35 Wednesday, 29 August ................................................................................................ 43

Sponsors, exhibitors and media cooperations ..................................................................... 54

Floor plan ............................................................................................................................... 55

Social programme ................................................................................................................. 56

General information .............................................................................................................. 57

General tips for authors and presenters .............................................................................. 59

Index of authors and chairs ................................................................................................... 60


orgAnisAtion And imprint

VenueHamburg University of Technology (TUHH) Audimax IAm Schwarzenberg-Campus 521073 Hamburg, Germany

Date26–30 August 2018

Congress website www.biocat-conference.de

Congress organisation and industrial exhibitionConventus Congressmanagement & Marketing GmbH Dana NostitzCarl-Pulfrich-Straße 1 07745 Jena, GermanyPhone +49 3641 31 [email protected]

Design/layoutLayout krea.tif-studio UG (haftungsbeschränkt) Print siblog – Gesellschaft für Dialogmarketing, Fulfillment & Lettershop mbHCirculation 400Editorial deadline 6 August 2018

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committees

Congress chairProf. Dr. Dr. h.c. Garabed AntranikianHamburg University of Technology (TUHH)Technical Microbiology V-7Kasernenstraße 12 (F)21073 Hamburg, Germany

Local organizing committeeAnna Krüger Hamburg University of Technology, GermanyPetra Esselun Hamburg University of Technology, GermanyAndreas Liese Hamburg University of Technology, GermanyChristian Schäfers Hamburg University of Technology, GermanyCarola Schröder Hamburg University of Technology, GermanyRalf Grote Hamburg University of Technology, Germany

Scientific advisory boardCarolina Andrade SENAI, BrazilYasuhisa Asano Toyama Prefectural University, JapanHaruyuki Atomi Kyoto University, JapanChristoph Bolten Nestlé Research Center, SwitzerlandUwe T. Bornscheuer University of Greifswald, GermanyThomas Brück Technical University of Munich, GermanyArnold Driessen University of Groningen, NetherlandsKurt Faber University of Graz, AustriaLaurence Hecquet University Clermont Auvergne, FranceStefan Heinrich Hamburg University of Technology, GermanyGjalt Huisman Codexis, USARomas Kazlauskas University of Minnesota, USAMartin Keller National Renewable Energy Laboratory, USAByung-Gee Kim Seoul National University, KoreaAndreas Kohl Clariant, GermanyVladimír Křen Czech Academy of Sciences, Czech RepublicWolfgang Kroutil University of Graz, AustriaKarl-Heinz Maurer AB Enzymes, GermanyPierre Monsan National Institute of Applied Science, FranceMarco Moracci University of Naples ‘Federico II’, ItalyMosè Rossi National Council of Research of Italy, ItalyNicholas Turner The University of Manchester, United KingdomAlex Zaks Akermin, USAAn-Ping Zeng Hamburg University of Technology, Germany


Welcome note

Dear colleagues,

Developing a bio-based economy is a worldwide strategy to address the global challenges of dwindling fossil energy reserves, environmental pollution and climate change in the light of a growing world population. Biocatalysis is one of the key technologies to address this complex task helping to produce sustainable raw materials and energy supply from biomass, while at the same time taking responsibility for the world’s food supply. Biotechnological products already find application in food, feed, chemical, pharmaceutical and cosmetics industry and the developing bioeconomy is expected to create new processes and products and new job opportunities.

To face the current enormous and diverse challenges bridging the gap between research and markets of the future is particularly important. The successful concept of biocat is due to an interdisciplinary approach integrating the know-how of highly acknowledged biologists, biochemists, chemists and engineers from academia and industry. Biocat offers a platform to form strategic alliances for future projects and innovations.

It is my great pleasure and honor to invite scientists from all over the world to the 9th Inter-national Congress on Biocatalysis 2018 (biocat2018) to be held from

August 26–30, 2018 at the Hamburg University of Technology (TUHH), Germany.

Since 2002 we have been organizing the biennial biocat congress series, which is focused on the rapidly evolving fields of biocatalysis and industrial biotechnology. The preceding International Congresses on Biocatalysis attracted more than 2,900 participants from over 40 countries.

The major topics to be addressed are:

Topic 1 – Enzyme discovery, production and applicationTopic 2 – Structure-function analysis and enzyme designTopic 3 – Enzymatic and whole cell biotransformationsTopic 4 – Bioprocess engineering and downstream processingTopic 5 – Sustainable industrial processes, biorefinery and bioeconomy

It is our aim to create a stimulating and open scientific atmosphere to foster the development of new collaborations. We are looking forward to welcoming you in Hamburg, an exciting and cosmopolitan city, and to share a successful and enjoyable meeting with you.

Garabed Antranikian

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Programme l sundAy, 26 August

15:30–17:00 REGISTRATIONBuilding H

17:00–18:45 OPENING CEREMONYAudimax I Garabed Antranikian (Hamburg/DE)

Music SwingING. Bigband

© www.gero-weiland.de/de/105706-SwingING-Big-Band

17:45 Directed evolution of stereoselective enzymes – a prolific source of OL1 catalysts for asymmetric reactions Manfred T. Reetz (Mülheim an der Ruhr/DE)

18:15 Synthetic biochemistry at GSKOL2 Joe Adams (Stevenage/GB)

19:00–22:00 WELCOME RECEPTIONBuilding I, Mensa

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Programme l mondAy, 27 August

08:30–10:30 INVITED SPEAKER SESSION 1 – TOPIC 2Audimax I Structure-function analysis and enzyme designChair Byung-Gee Kim (Seoul/KR)

08:30 Engineering oxidative flavoenzymes for industrial processesIL2-1 Marco W. Fraaije (Groningen/NL)

09:00 Dissecting prokaryotic polyunsaturated fatty acid synthasesIL2-2 Tohru Dairi (Hokkaido/JP)

09:30 Recent advances in the discovery, engineering and application ofIL2-3 monooxygenases Uwe T. Bornscheuer (Greifswald/DE)

10:00 Imine reductases in the stereoselective synthesis of IL2-4 N-heterocyclic amines Bettina Nestl (Stuttgart/DE)

10:30–11:00 Coffee break and industrial exhibition

11:00–13:10 MORNING SESSION 1 – TOPICS 2+1Audimax I Structure-function analysis and enzyme design + Enzyme discovery, production and applicationChair Uwe T. Bornscheuer (Greifswald/DE)

11:00 Archaeal metabolism and its applicationIL1-4 Haruyuki Atomi, Takaaki Sato, Tamotsu Kanai (Kyoto/JP)

11:30 Biocatalytic production of quercetin with rutinosidase – novel conceptL1-1 of “solid state biocatalysis” Vladimír Křen, Jana Kapesova, Michal Kotik Lucie Petraskova (Prague/CZ), Martin Rebros Kristina Markosova (Bratislava/SK)

11:50 A prolyl endopeptidase from Flammulina velutipes for the improved L1-2 processing of celiac disease provoking cereal proteins Kathrin Schulz, Lucienne Giesler, Diana Linke Ralf Günter Berger (Hannover/DE)

12:10 Actinobacterial genomes – a treasure trove of oxidative enzymesL1-3 Marilize Le Roes-Hill (Bellville/ZA) Kim Durrell (Bellville, Stellenbosch/ZA), Alaric Prins (Bellville/ZA) Amos Musengi (Harare/ZW), Tukayi Kudanga (Durban/ZA)

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12:30 Biocatalytic degradation of synthetic polymers with thermophilic L1-4 bacterial polyester hydrolases Ren Wei, Wolfgang Zimmermann (Leipzig/DE)

12:50 Purification and characterization of a viral RNA polymerase isolated from L1-5 an antarctic environmental sample Jenny Blamey, Giannina Espina (Santiago/CL), Michael Goodson Nancy Kelley-Loghnane, Svetlana Harbaugh Irina Drachuk (Wright Patterson Air Force Base, OH/US), Javiera Aviles Belen Rickmers (Santiago/CL)

13:10–14:30 Lunch at Mensa

14:30–16:30 POSTER SESSION 1 – TOPIC 3 (see page 26) Enzymatic and whole cell biotransformations – P3-1–P3-78

14:30–15:30 LIGHTNING TALK SESSION 1 – TOPIC 3Audimax I Enzymatic and whole cell biotransformationsChair Andreas Liese (Hamburg/DE)

P3-1 Finally – diterminal oxidation of medium chain alkanes Youri van Nuland, Gerrit Eggink, Ruud Weusthuis (Wageningen/NL)

P3-2 Aldol additions of pyruvate analogs to formaldehyde — synthesis of optically active β-hydroxycarboxylic esters Pere Clapes, Karel Hernández, Jordi Bujons, Jesús Joglar Roser Marín (Barcelona/ES)

P3-3 Biosynthesis of N-heterocycles from diamine at the expense of molecular oxygen and molecular hydrogen Ammar Al-Shameri (Berlin/DE), Niels Borlinghaus Bettina Nestl (Stuttgart/DE), Lars Lauterbach (Berlin/DE)

P3-4 Compartmentalized aqueous-organic emulsions for efficient biocatalysis Changzhu Wu (Odense M/DK)

P3-5 Accessing enantiopure epoxides and sulfoxides via group E monooxygenases Thomas Heine, Anika Scholtissek, Lucas Siegel, Sarah Hofmann Xiaoqi Gao, Philipp Rathsack (Freiberg/DE) Dirk Tischler (Freiberg, Bochum/DE)

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P3-6 Selective aerobic oxidation of C-H bonds by combining photochemistry and biocatalysis Wuyuan Zhang, Elena Fernández-Fueyo, Yan Ni, Morten van Schie Jenö Gacs, Bastien O. Burek, Jonathan Z. Bloh, Rokus Renirie Ron Wever, Francesco G. Mutti, Dörte Rother, Miguel Alcalde Frank Hollmann (Delft/NL)

P3-7 Whole cell biocatalyst expressing a surface-displayed P450 allows for efficient hydroxylation reactions Marcus Probst, Cindy Kunze (Frankfurt am Main/DE), Eva Kranen Ruth Maas (Düsseldorf/DE), Dirk Holtmann (Frankfurt am Main/DE)

P3-8 Ionization basis for activation of enzymes in zwitterionic liquids Guangnan Ou, Biyan He (Xiamen/CN)

P3-9 Model optimization of DERA-catalyzed double aldol addition Ana Vrsalović Presečki, Anera Švarc, Đurđa Vasić-Rački (Zagreb/HR) Karel Hernandez, Pere Clapés (Barcelona/ES) Zvjezdana Findrik Blažević (Zagreb/HR)

P3-10 Enzyme catalysed synthesis of esters in water Ulf Hanefeld (Delft/NL)

P3-11 New bioactive prodigiosin derivatives – a bridge between chemistry and biology Hannah U. C. Braß, Andreas S. Klein, Thomas Classen, Anita Loeschcke Thomas Drepper (Jülich/DE), Sonja Sievers (Dortmund/DE) Karl-Erich Jaeger, Jörg Pietruszka (Jülich/DE)

P3-12 Enrichment of mono-unsaturated long chain fatty acids from camelina and crambe seed oils by engineered lipase variants Isabel Oroz-Guinea, Katja Zorn, Henrike Brundiek Uwe T. Bornscheuer (Greifswald/DE)

P3-13 Catalytic properties of the fluoroketone reductase from Pichia farinosa NBRC0462 Sayaka Kamai, Sayaka Shichida (Imizu, Toyama/JP) Shinsuke Miki (Kawagoe/JP), Kimiyasu Isobe, Makoto Hibi Yasuhisa Asano (Imizu, Toyama/JP)

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P3-14 Microbial electrosynthesis of chiral alcohols using resting recombinant Escherichia coli cells Jeannine Mayr (Braunschweig/DE), Luis F. M. Rosa (Leipzig/DE) Jan-Hendrik Grosch (Braunschweig/DE), Falk Harnisch (Leipzig/DE) Antje C. Spiess (Braunschweig/DE)

P3-15 Stereoselective one-pot enzyme cascade towards γ‑butyrolactone fragrances Ceyda Kumru, Thomas Classen, Jörg Pietruszka (Jülich/DE)

P3-16 Synthesis of syringaresinol from 2,6-dimethoxy-4-allylphenol using an oxidase/peroxidase enzyme system Mohamed Habib (Groningen/NL; Cairo/EG), Milos Trajkovic Marco W. Fraaije (Groningen/NL)

P3-17 Biocatalysis alternatives dedicated to flavors and fragrances production Madalina Tudorache, Sabina Ion, Cristina Sora, Simona Reznicencu Vasile Parvulescu (Bucharest/RO)

P3-18 Aromatic hydroxylases as part of enzymatic cascading reactions Martin Dippe, Susann Hermann, Benjamin Weigel Ludger Wessjohann (Halle an der Saale/DE)


16:50–18:10 AFTERNOON SESSION 1 – TOPIC 4Audimax I Bioprocess engineering and downstream processingChair Marco Moracci (Naples/IT)

16:50 Application of periodic counter-current chromatography for the L4-1 continuous purification of industrial relevant proteins Chantal Brämer, Thomas Scheper, Sascha Beutel (Hannover/DE)

17:10 Process considerations for overcoming major hurdles in amine L4-2 transaminase catalysed synthesis of chiral amines – strategies for resolving issues with stability, inhibition and thermodynamic limitations Carl Grey (Lund/SE)

17:30 Combination of enantioselective chromatography and enzymatic L4-3 racemization – initial characterization and experimental demonstration Katarzyna Wrzosek, Isabel Harriehausen Andreas Seidel-Morgenstern (Magdeburg/DE)

17:50 Stepwise cascade reaction for cofactor supply of enzymatic oxidationsL4-4 Florian Busch (Geleen/NL; Bochum/DE), Martin Schürmann (Geleen/NL) Robert Kourist (Graz/AT)

c-LEcta GmbHPerlickstr. 504103 LeipzigGermany

Phone +49 (0)341 355 214-0Fax +49 (0)341 355 214-33Email [email protected]

c-LEcta is a leading industrial biotechnology company, using best-in-class technologies to efficiently provide customized enzymes and microbial strains for industrial applications in regulated markets like pharma and food. Scientific excellence is combined with in-depth commercial and regulatory know-how to bring innovative and competitive bioprocessed products into scale. Besides its in-house project and product pipeline, c-LEcta has a strong focus on strategic cooperation with industrial partners. Moreover, c-LEcta is an established enzyme supplier, manufacturing unique, quality-controlled enzyme products in large industrial scale.

BIODIVERSITY ENZYME ENGINEERING STRAIN ENGINEERING BIOPROCESS DEVELOPMENT

Your ideal partner for the development and production of high-quality biotechnological products

Outstanding enzyme development platform

Enzyme discovery and engineering to enable

disruptive process technologies.

Outstanding production platform Pilot-scale production facility

Highly efficient, compliant with demanding regulatory requirements.

3 hosts with GRAS status.

In-depth regulatory experience

Approval of food enzymes andfood ingredients.

Certificates: ISO9001 to full cGMP, HACCP, kosher and halal.

Proven track record in commercialization of products

Established supplier of enzymesin highly regulated markets.

Routine production in 20 to 40 m3 scale.

c-LEcta GmbHPerlickstr. 504103 LeipzigGermany

Phone +49 (0)341 355 214-0Fax +49 (0)341 355 214-33Email [email protected]

c-LEcta is a leading industrial biotechnology company, using best-in-class technologies to efficiently provide customized enzymes and microbial strains for industrial applications in regulated markets like pharma and food. Scientific excellence is combined with in-depth commercial and regulatory know-how to bring innovative and competitive bioprocessed products into scale. Besides its in-house project and product pipeline, c-LEcta has a strong focus on strategic cooperation with industrial partners. Moreover, c-LEcta is an established enzyme supplier, manufacturing unique, quality-controlled enzyme products in large industrial scale.

BIODIVERSITY ENZYME ENGINEERING STRAIN ENGINEERING BIOPROCESS DEVELOPMENT

Your ideal partner for the development and production of high-quality biotechnological products

Outstanding enzyme development platform

Enzyme discovery and engineering to enable

disruptive process technologies.

Outstanding production platform Pilot-scale production facility

Highly efficient, compliant with demanding regulatory requirements.

3 hosts with GRAS status.

In-depth regulatory experience

Approval of food enzymes andfood ingredients.

Certificates: ISO9001 to full cGMP, HACCP, kosher and halal.

Proven track record in commercialization of products

Established supplier of enzymesin highly regulated markets.

Routine production in 20 to 40 m3 scale.

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Programme l tuesdAy, 28 August

08:30–10:30 INVITED SPEAKER SESSION 2 – TOPIC 3Audimax I Enzymatic and whole cell biotransformationsChair Haruyuki Atomi (Kyoto/JP)

08:30 Production of omega-hydroxy fatty acids using biocatalysisIL3-1 Hee-Wang Yoo, Bum-Gi Park, Sung-Youn Joo, Hyungdon Yoon Byung-Gee Kim (Seoul/KR)

09:00 Enzymatic and microbial conversion of waste plasticsIL3-2 Harry P. Austin, Mark D. Allen (Portsmouth/GB), Bryon S. Donohoe Mary Ann Franden, Lahiru Jayakody Christopher W. Johnson (Golden, CO/US), Fiona Kearns (Tampa, FL/US) Nicholas A. Rorrer (Golden, CO/US), H. Lee Woodcock (Tampa, FL/US) John E. McGeehan, Gregg Beckham (Golden, CO/US)

09:30 Discovery and development of novel glucanotransferases for healthier IL3-3 foods Tim Börner (Lausanne/CH), Joana Gangoit (Groningen/NL), Lisa Lamothe Stéphane Duboux (Lausanne/CH), S. van Leeuwen Lubbert Dijkhuizen (Groningen/NL), Christina Vafeiadi (Lausanne/CH)

10:00 Exploring and engineering the application potential of GH13IL3-4 glycosyltransferases Tom Desmet (Gent/BE)


11:00–12:40 INDUSTRIAL IMPLEMENTATIONS – MORNING SESSION 2 – TOPIC 5Audimax I Sustainable industrial processes, biorefinery and bioeconomyChair Andreas Kohl (Planegg/DE)

11:00 Self-sufficient co-immobilized PLP-dependent ω-transaminases and L5-1 cofactor for flow-biocatalysis Martina Letizia Contente (Nottingham/GB), Francesca Paradisi Fernando López-Gallego (Nottingham/GB; Zaragoza/ES) Ana I. Benítez-Mateos (San Sebastián/ES)

11:20 Flexible bio-production based on Cupriavidus necator – heterotrophic, L5-2 autotrophic and eletrotrophic production of terpenoids Dirk Holtmann (Frankfurt am Main/DE)

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11:40 From hit to process – examples of chiral amine synthesis from small to L5-3 large scale Serena Bisagni, Ahir Pushpanath, Annette Alcasabas, Amin Bornadel Iustina Slabu, David Woodlock, Chloe Fisher Beatriz Dominguez (Cambridge/GB)

12:00 OrganoCat – biogenic lignocellulose fractionation for biorefineriesL5-4 Pablo Dominguez de Maria (Las Palmas de Gran Canaria/ES) Philipp Grande (Jülich/DE), Holger Klose (Jülich, Aachen/DE) Walter Leitner (Mülheim an der Ruhr, Aachen/DE) Ulrich Schurr (Jülich/DE), Björn Usadel (Jülich, Aachen/DE)

12:20 Industrial application of RedAms for biocatalytic reductive aminationL5-5 Markus Schober (Stevenage/GB)


14:00–15:30 POSTER SESSION 2 – TOPIC 1 (see page 35) Enzyme discovery, production and application – P1-1–P1-63

14:00–15:00 LIGHTNING TALK SESSION 2 – TOPIC 1Audimax I Enzyme discovery, production and applicationChair Selin Kara (Hamburg/DE)

P1-1 RosB is an 8-amino-8-demethyl-riboflavin-5’-phosphate synthase and the first member of a novel class of enzymes which are oxidoreductases, decarboxylases and aminotransferases in one Matthias Mack (Mannheim/DE)

P1-2 Acceleration of enzymatic degradation of poly(ethylene terephthalate) by coating its surface with anionic surfactants Makoto Furukawa, Norifumi Kawakami, Kenji Miyamoto (Yokohama/JP)

P1-3 New laccases from Fusarium oxysporum Natalia Kwiatos, Marzena Jędrzejczak-Krzepkowska Stanisław Bielecki (Łódź/PL)

P1-4 Continuous protein hydrolysis for the production of bioactive peptides Tim Sewczyk (Hannover/DE), Marieke Hoog Antink Michael Maas (Bremen/DE), Sascha Beutel (Hannover/DE)

P1-5 Rational identification of aggregation hotspots based on secondary structure and amino acid hydrophobicity Daisuke Matsui, Shogo Nakano, Yasuhisa Asano (Imizu/JP)

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P1-6 Biocatalytic potential of the epoxide hydrolase (YlEH) from a tropical marine yeast Yarrowia lipolytica NCIM 3589 Vijaya Godase (Pune, Kolhapur/IN), Ameeta Ravikumar (Pune/IN)

P1-7 Exploration of biocatalysts diversity by integrating bioinformatics with biochemical testing Pavel Vanacek, Eva Sebestova, Petra Babkova, Sarka Bidmanova Lukas Daniel, Pavel Dvorak, Veronika Stepankova, Radka Chaloupkova Jan Brezovsky, Jiri Damborsky, Zbynek Prokop (Brno/CZ)

P1-8 New strategy for the discovery of carbohydrate-active enzymes through integrated omics Philip Busch, Marcel Suleiman, Christian Schäfers Garabed Antranikian (Hamburg/DE)

P1-9 Influence of recalcitrant substrates on microbial diversity of samples from Azorean hot springs Marcel Suleiman, Barbara Klippel, Philip Busch, Christian Schäfers Garabed Antranikian (Hamburg/DE)

P1-10 News from vanillyl alcohol oxidase Gudrun Gygli (Stuttgart/DE; Wageningen/NL), Tom A. Ewing Willem J. H. van Berkel (Wageningen/NL)

P1-11 The monolignol oxidoreductase AtBBE-like protein 15 – characterization, rational engineering and biocatalytic applications Bastian Daniel, Sabine Pils, Peter Macheroux, Jörg H. Schrittwieser Wolfgang Kroutil (Graz/AT)

P1-12 Stereoselective conversion of α-angelica lactone to (R)-γ-valerolactone in a one-pot two-step enzymatic cascade Marina Simona Robescu, Laura Cendron (Padova/IT) Riccardo Motterle (Montecchio Maggiore/IT) Elisabetta Bergantino (Padova/IT), Mélanie Hall (Graz/AT)

P1-13 Aggregating flavoprotein as a catalyst for 1-dehydro-3-ketosteroids production Agnieszka M. Wojtkiewicz, Patrycja Wójcik, Monika Sroczyk Maria Oszajca, Kamila Sofińska, Jakub Barbasz, Olga Zastawny Maciej Guzik (Krakow/PL), Elvira Romero Marco W. Fraaije (Groningen/NL), Maciej Szaleniec (Krakow/PL)

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P1-14 Costa Rican lipases from native coffee plantation fungi as a green alternative for the management of agroindustrial coffee by-products Jorge Campos Rodríguez, Nicole Hernández Herrera Daniela Pereira Arce, Elias Quesada Carrillo, Randall Syedd León Frank Solano Campos, Luis Roberto Villegas-Peñaranda Manuel Sandoval Barrantes (Heredia/CR)

P1-15 Laccase production from hazelnut husk via submerged cultivation of white-rot fungi Zeynep Yilmaz Sercinoglu, Nihat Alpagu Sayar (Istanbul/TR)

P1-16 A novel biocatalyst for the biotransformation of Taxanes/Taxol® Eugen Schell, Marion Ansorge-Schumacher (Dresden/DE)


15:50–16:50 INDUSTRIAL IMPLEMENTATIONS – AFTERNOON SESSION 2 – TOPIC 1Audimax I Enzyme discovery, production and applicationChair Gregg Beckham (Golden, CO/US)

15:50 MetaFluidics – ultra-high throughput metagenomic enzyme discoveryL1-6 Michael Roggenbuck, Keith McCall, Martin S. Borchert (Bagsvaerd/DK)

16:10 Mining and engineering of novel redox enzymes from genomic and L1-7 metagenomic libraries for the biocatalytic conversion of lignin and lignocellulosic biomass Giang-Son Nguyen (Trondheim/NO), Noelia Villarroel Rodriguez Narcis Fernandez-Fuentes, Joe Gallagher (Aberystwyth/GB) Anna S. Lewin, Geir Klinkenberg, Håvard Sletta Trond E. Ellingsen (Trondheim/NO), Eva Kranen Ruth Maas (Düsseldorf/DE), Vincent G. H. Eijsink (Ås/NO) Alexander Wentzel (Trondheim/NO)

16:30 EziGTM-immobilised biocatalysts – applications in organic solvents and L1-8 continuous flow Matthew Thompson (Stockholm/SE)

17:00–22:30 congress dinner on tHe boAt louisiAnA stAr biocat award ceremony (see page 56)

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Programme l WednesdAy, 29 August

09:00–11:00 INVITED SPEAKER SESSION 3 – TOPIC 1Audimax I Enzyme discovery, production and applicationChair Tom Desmet (Gent/BE)

09:00 Substrate specificity of tRNA-dependent amide bond-forming enzymeIL1-1 Yoshimitsu Hamano (Fukui/JP)

09:30 New tools facilitating discovery, expression, engineering and application IL1-2 of enzymes from eukaryotes Anton Glieder (Graz/AT)

10:00 Engineering a GH89 α-N-acetylglucosaminidase in an α-thioglycoligaseIL1-3 for the chemoenzymatic synthesis of α-N-glycoconjugates A. Strazzulli (Naples/IT), N.O. Tshililo (Matieland/ZA) B. Cobucci-Ponzano, R. Iacono, L. Maurelli, E. Bedini M.M. Corsaro (Naples/IT), E. Strauss (Matieland/ZA) Marco Moracci (Naples/IT)

10:30 Use of L-amino acid deaminase in one-step or multi-step biocatalysisIL2-5 Loredano Pollegioni, Roberta Melis, Elena Rosini, Valentina Pirillo Antonio Savinelli, Paolo Motta, Gianluca Molla (Varese/IT)


11:30–13:20 MORNING SESSION 3 – TOPICS 5+2 (PARALLEL SESSION)Audimax I Sustainable industrial processes, biorefinery and bioeconomy + Structure-function analysis and enzyme designChair Marco W. Fraaije (Groningen/NL)

11:30 Greek bioeconomy – current status, initiatives and perspectives IL5-1 Constantinos E. Vorgias (Athens/GR)

12:00 Thermotolerant biotechnology – biocatalysts for added manufacturingL2-1 Kersten Rabe (Eggenstein-Leopoldshafen/DE)

12:20 Data-integrated simulation of enzymesL2-2 Jürgen Pleiss (Stuttgart/DE)

12:40 A novel (R)-selective amine transaminase with extraordinary substrate L2-3 scope Aline Telzerow (Graz/AT), Maria Håkansson (Lund/SE) Juraj Paris (Bielefeld/DE), Martin Schuermann (Geleen/NL) Javier Sabin (Oviedo/ES), Helmut Schwab, Kerstin Steiner (Graz/AT)

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13:00 Computational design of enzyme catalyst on new scaffolds for the L2-4 synthesis of cephalosporin antibiotics Yushan Zhu (Beijing/CN)

11:30–13:20 MORNING SESSION 4 – TOPICS 2+3 (PARALLEL SESSION)Ditze Lecture Hall Structure-function analysis and enzyme design + Enzymatic and whole cell biotransformationsChair Bettina Nestl (Stuttgart/DE)

11:30 Simple standardisation of MD and QM protocols to derive highly active L2-8 lipases at low pH optima and enantiospecific keto reductases Rithvik Vinekar, Akshai Shreenivasan, Naveen Krishna, Kiran Takur Shivakumar Venkataraju, Naveen Kulkarni R. Pravin Kumar (Bangalore/IN)

12:00 Amano’s biotransformarion enzymes for chiral synthesisL2-9 Yukihide Sato (Oxfordshire/GB)

12:20 H2-driven cofactor regeneration in a recombinant Pseudomonas putida L3-1 strain for production of 1-octanol Lars Lauterbach, Tom Lonsdale (Berlin/DE), Sumire Honda Malca Bettina Nestl, Bernhard Hauer (Stuttgart/DE), Oliver Lenz (Berlin/DE)

12:40 Enantioselective synthesis of the key intermediate of suvorexant via L3-2 enzymatic intramolecular asymmetric reductive amination Zefei Xu, Peiyuan Yao, Shanshan Yu, Qiaqing Wu, Dunming Zhu Xuerong Xing (Tianjin/CN)

13:00 Light-driven enzymatic decarboxylation of free fatty acidsL3-3 Mieke Huijbers, Wuyuan Zhang, Frank Hollmann (Delft/NL)


14:40–16:40 POSTER SESSION 3 – TOPICS 2+4+5 (see page 43) Structure-function analysis and enzyme design – P2-1–P2-43 Bioprocess engineering and downstream processing – P4-1–P4-24 Sustainable industrial processes, biorefinery and bioeconomy – P5-1–P5-17

14:40–15:50 LIGHTNING TALK SESSION 3 – TOPICS 2+4+5Audimax I Structure-function analysis and enzyme designChair Andreas Liese (Hamburg/DE)

P2-1 Understanding enzyme interactions under process conditions Valerio Ferrario, Jürgen Pleiss (Stuttgart/DE)

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P2-2 In vitro activity of piromyces xylose isomerase and its in vivo performance in yeast Misun Lee, Henriëtte Rozeboom (Groningen/NL), Maarten Verhoeven Paul de Waal, Jack Pronk (Delft/NL), Dick B. Janssen (Groningen/NL)

P2-3 Structure-based engineering of steroidogenic CYP260A1 for stereo- and regioselective hydroxylation of progesterone Yogan Khatri (Saarbrücken/DE; Ann Arbor, MI/US) Ilona Jóźwik (Groningen/NL), Michael Ringle, Irina Ionescu Martin Litzenburger, Michael Hutter (Saarbrücken/DE) Andy Thunnissen (Groningen/NL), Rita Bernhardt (Saarbrücken/DE)

P2-4 Novel insights into β-etherase catalysis Jana Husarcikova, Hauke Voß, Anett Schallmey (Braunschweig/DE)

P2-5 Combinatorial engineering of proteolytically resistant APPI variants that selectively inhibit human mesotrypsin for cancer therapy Niv Papo (Beer Sheva/IL)

P2-6 Dynamics of sub-unit assembly within multi enzyme complex and its mutants Sibel Ilhan, Uwe Jandt, Cornelius Müller (Hamburg/DE)

P2-7 Design and evaluation of metal-binding sites in a new engineered protein scaffold for achieving artificial metalloenzymes Dominik Renn, Johannes Fischer (Thuwal/SA; Garching/DE) Felix Quitterer (Garching/DE), Anand Radhakrishnan, Meina Liu Magnus A. Rueping, Stefan T. Arold (Thuwal/SA) Michael Groll (Garching/DE), Jörg Eppinger (Thuwal/SA)

P2-8 Engineering enzymes for the fabrication of robust and highly active heterogeneous biocatalyst Andoni Rodriguez-Abetxuko, Ana Beloqui (Donostia-San Sebastián/ES)

P2-9 Engineering of phosphoserine aminotransferase for a novel biosynthetic pathway of 1,3-propanediol from glucose via homoserine Yujun Zhang, Chengwei Ma (Hamburg/DE) Wanda Dischert (Clermont-Ferrand/FR), An-Ping Zeng (Hamburg/DE)

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Bioprocess engineering and downstream processing

P4-1 Development of an in situ-product crystallization (ISPC)-concept to shift the reaction equilibria of selected transaminase-catalyzed reactions Dennis Hülsewede (Rostock/DE), Philipp Süss Ulf Menyes (Greifswald/DE), Jan von Langermann (Rostock/DE)

P4-2 Rational strategy for nuclease immobilisation on synthetic resins Simona Serban, Alessandra Basso (Llantrisant/GB), Valerio Ferrario Juergen Pleiss (Stuttgart/DE), Benjamin Summers (Llantrisant/GB)

P4-3 Impact of yeast extract on amino acid de novo synthesis and glycosylation of recombinant proteins Jan Förster, Lars Blank (Aachen/DE), Katelijne Bekers (Hamburg/DE)

P4-4 Chiral amines synthesis and in situ product recovery for process intensification for application in organic fine chemicals and pharmaceuticals Claudia Matassa (Mol/BE; Greifswald/DE), Matthias Höhne (Greifswald/DE) Dominic Ormerod, Yamini Satyawali (Mol/BE)

P4-5 Improvement of bioreactor performance using immobilized lipase in supercritical carbon dioxide for development of lipid modification process Masakazu Naya, Atsushi Shono (Tokyo/JP) Masanao Imai (Kanagawa-pref./JP)

P4-6 Development and scale-up of efficient biocatalytic oxidations using oxygen Jan Brummund, Catharina Kleist, Harrie Straatman, Martin Schürmann Monika Müller (Geleen/NL)

P4-7 In situ monitoring of the biocatalyzed (S)-naproxen synthesis with process raman spectroscopy Anne Stöbener, Tim Ramelow, Miriam Assmann Selin Kara (Hamburg/DE), Hanns Simon Eckhardt (Oberursel/DE) Andreas Liese (Hamburg/DE)

Sustainable industrial processes, biorefinery and bioeconomy

P5-1 Development of a chemo-enzymatic route for the synthesis of chiral vicinal amino alcohols-application for the synthesis of ethambutol, an anti-tuberculosis drug Yudhisthir Mandal, K.K Balasubramanian, Anju Chadha (Tamil Nadu/IN)

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P5-2 Bioelectrochemical NADPH regeneration using biocatalysis in redox hydrogel matrices Leonardo Castañeda Losada, Carolina Laverde Perdomo Michael Richter, Nicolas Plumeré (Straubing/DE)

P5-3 Lurgi process-based fatty alcohol synthesis via a chemoenzymatic reaction sequence Kim Schlipköter, Andreas Liese, Joscha Kleber Anne Stöbener (Hamburg/DE), Harald Gröger Tobias Betke (Bielefeld/DE)

P5-4 Biorefinery of australian rock lobster shells (Jasus edwardsii) by microwave intensified enzymatic deproteinization and demineralization for production of multiple functional food ingredients Wei Zhang, Trung Nguyen (Adelaide/AU)

P5-5 Micropollutant degradation in enzymatic membrane bioreactor (EMBR) Faisal Hai, Muhammad Bilal Asif (Wollongong/AU)


17:00–18:00 AFTERNOON SESSION 3 – TOPIC 3 (PARALLEL SESSION)Audimax I Enzymatic and whole cell biotransformationsChair An-Ping Zeng (Hamburg/DE)

17:00 Chemo-enzymatic cascade synthesis of optically pure alkanoic acids L3-4 using engineered arylmalonate decarboxylase variants Junichi Enoki, Carolin Mügge (Bochum/DE) Kenji Miyamoto (Yokohama/JP), Robert Kourist (Bochum/DE; Graz/AT)

17:20 Development of a modular whole cell glycosylation platform for smallL3-5 molecules Constantin Ruprecht, Friedericke Bönisch, Wolfgang R. Streit Ulrich Rabausch (Hamburg/DE)

17:40 Biocatalytic asymmetric synthesis of N-functionalized L-aspartic acidsL3-6 Jielin Zhang, Haigen Fu, Pieter G. Tepper Gerrit J. Poelarends (Groningen/NL)

17:00–18:00 AFTERNOON SESSION 4 – TOPIC 2 (PARALLEL SESSION)Ditze Lecture Hall Structure-function analysis and enzyme designChair Mosè Rossi (Napoli/IT)

17:00 Loop swapping as protein engineering approach to optimise L2-5 NADH-binding of ene reductases Christoph Mähler, Dirk Weuster-Botz (Garching/DE) Kathrin Castiglione (Erlangen/DE)

17:20 Enhancement of lipase selectivity by semi-rational designL2-6 Katja Zorn, Isabel Oroz-Guinea, Henrike Brundiek Uwe T. Bornscheuer (Greifswald/DE)

17:40 The many roads to Rome – How to overcome limitations for the L2-7 production of chiral β-amino acids via ω-transaminases (ω-TAs) Jens Rudat, Oliver Buß (Karlsruhe/DE)

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Programme l tHursdAy, 30 August

08:30–10:30 INVITED SPEAKER SESSION 4 – TOPIC 3+4Audimax I Enzymatic and whole cell biotransformations + Bioprocess engineering and downstream processingChair Joe Adams (Stevenage/GB)

08:30 Enzyme design in synthetic biology – a key role from proof-of-concept IL3-5 towards precision function Yan Feng (Shanghai/CN)

09:00 Complex N-acetylhexosamines prepared by engineered enzymes for IL3-6 targeting lectins Pavla Bojarová (Praha/CZ), Dominic Laaf (Aachen/DE), Petr Chytil Tomáš Etrych (Praha/CZ), Lothar Elling (Aachen/DE) Vladimír Křen (Praha/CZ)

09:30 Computer-aided engineering of enzymes for in vitro and in vivoIL4-1 production of novel precursors Isabelle André (Toulouse/FR)

10:00 The Nestlé culture collection – from gene to activityIL4-2 Christoph Bolten (Lausanne/CH)


11:00–13:00 INDUSTRIAL IMPLEMENTATIONS – MORNING SESSION 5 – TOPIC 3Audimax I Enzymatic and whole cell biotransformationsChair Andreas Liese (Hamburg/DE)

11:00 Glycosynthases – a biocatalytic approach to the synthesis of glycosidesL3-7 Marc Hayes (Düsseldorf/DE), Jörg Pietruszka (Düsseldorf, Jülich/DE)

11:20 Selective ring-opening of di-substituted epoxides by halohydrin L3-8 dehalogenases Anett Schallmey, Elia Calderini, Julia Koopmeiners (Braunschweig/DE)

11:40 H2-driven heterogeneous biocatalysis for the atom-efficient synthesis ofL3-9 α‑chiral amines Jack Rowbotham, Lisa Thompson, Barnabas Poznansky, Xu Zhao Jake Nicholson, Holly Reeve, Kylie Vincent (Oxford/GB)

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Programme l tHursdAy, 30 August

12:00 Smart engineering of aldolases for asymmetric synthesis of L3-10 β-hydroxyl-α-amino acids on industrial scale Marco Bocola, Haibin Chen (Ningbo/CN) Thomas Daußmann (Ningbo/CN; Düsseldorf/DE) Yong Koy Bong (Ningbo/CN)

12:20 Suppression of by-product hydroxyproline generation in the growth L3-11 coupled production of hydroxypipecolic acid by recombinant microorganisms Ryoma Miyake, Takanobu Iura, Kenji Oki, Yuriko Iwano Haruka Sasano (Yokohama/JP), Hiroshi Kawabata (Yokohama, Tokyo/JP)

12:40 Industrial synthesis of functional ingredients by enzyme cascade L3-12 reactions Andreas Vogel (Leipzig/DE)

13:00–13:30 CLOSING REMARKSAudimax I Poster awards (see page 59)

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poster l mondAy, 27 August

14:30–16:30 POSTER SESSION 1 – TOPIC 3Room H0.01–H0.09 Enzymatic and whole cell biotransformations

P3-1 Finally – diterminal oxidation of medium chain alkanes Youri van Nuland, Gerrit Eggink, Ruud Weusthuis (Wageningen/NL)

P3-2 Aldol additions of pyruvate analogs to formaldehyde – synthesis of optically active β-hydroxycarboxylic esters Pere Clapes, Karel Hernández, Jordi Bujons, Jesús Joglar Roser Marín (Barcelona/ES)

P3-3 Biosynthesis of N-heterocycles from diamine at the expense of molecular oxygen and molecular hydrogen Ammar Al-Shameri (Berlin/DE), Niels Borlinghaus Bettina Nestl (Stuttgart/DE), Lars Lauterbach (Berlin/DE)

P3-4 Compartmentalized aqueous-organic emulsions for efficient biocatalysis Changzhu Wu (Odense M/DK)

P3-5 Accessing enantiopure epoxides and sulfoxides via group E monooxygenases Thomas Heine, Anika Scholtissek, Lucas Siegel, Sarah Hofmann Xiaoqi Gao, Philipp Rathsack (Freiberg/DE) Dirk Tischler (Freiberg, Bochum/DE)

P3-6 Selective aerobic oxidation of C-H bonds by combining photochemistry and biocatalysis Wuyuan Zhang, Elena Fernández-Fueyo, Yan Ni, Morten van Schie Jenö Gacs, Bastien O. Burek, Jonathan Z. Bloh, Rokus Renirie Ron Wever, Francesco G. Mutti, Dörte Rother, Miguel Alcalde Frank Hollmann (Delft/NL)

P3-7 Whole cell biocatalyst expressing a surface-displayed P450 allows for efficient hydroxylation reactions Marcus Probst, Cindy Kunze (Frankfurt am Main/DE), Eva Kranen Ruth Maas (Düsseldorf/DE), Dirk Holtmann (Frankfurt am Main/DE)

P3-8 Ionization basis for activation of enzymes in zwitterionic liquids Guangnan Ou, Biyan He (Xiamen/CN)

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P3-9 Model optimization of DERA-catalyzed double aldol addition Ana Vrsalović Presečki, Anera Švarc, Đurđa Vasić-Rački (Zagreb/HR) Karel Hernandez, Pere Clapés (Barcelona/ES) Zvjezdana Findrik Blažević (Zagreb/HR)

P3-10 Enzyme catalysed synthesis of esters in water Ulf Hanefeld (Delft/NL)

P3-11 New bioactive prodigiosin derivatives – a bridge between chemistry and biology Hannah U. C. Braß, Andreas S. Klein, Thomas Classen, Anita Loeschcke Thomas Drepper (Jülich/DE), Sonja Sievers (Dortmund/DE) Karl-Erich Jaeger, Jörg Pietruszka (Jülich/DE)

P3-12 Enrichment of mono-unsaturated long chain fatty acids from camelina and crambe seed oils by engineered lipase variants Isabel Oroz-Guinea, Katja Zorn, Henrike Brundiek Uwe T. Bornscheuer (Greifswald/DE)

P3-13 Catalytic properties of the fluoroketone reductase from Pichia farinosa NBRC0462 Sayaka Kamai, Sayaka Shichida (Imizu, Toyama/JP) Shinsuke Miki (Kawagoe/JP), Kimiyasu Isobe, Makoto Hibi Yasuhisa Asano (Imizu, Toyama/JP)

P3-14 Microbial electrosynthesis of chiral alcohols using resting recombinant Escherichia coli cells Jeannine Mayr (Braunschweig/DE), Luis F. M. Rosa (Leipzig/DE) Jan-Hendrik Grosch (Braunschweig/DE), Falk Harnisch (Leipzig/DE) Antje C. Spiess (Braunschweig/DE)

P3-15 Stereoselective one-pot enzyme cascade towards γ‑Butyrolactone fragrances Ceyda Kumru, Thomas Classen, Jörg Pietruszka (Jülich/DE)

P3-16 Synthesis of syringaresinol from 2,6-dimethoxy-4-allylphenol using an oxidase/peroxidase enzyme system Mohamed Habib (Groningen/NL, Cairo/EG), Milos Trajkovic Marco W. Fraaije (Groningen/NL)

P3-17 Biocatalysis alternatives dedicated to flavors and fragrances production Madalina Tudorache, Sabina Ion, Cristina Sora, Simona Reznicencu Vasile Parvulescu (Bucharest/RO)

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P3-18 Aromatic hydroxylases as part of enzymatic cascading reactions Martin Dippe, Susann Hermann, Benjamin Weigel Ludger Wessjohann (Halle an der Saale/DE)

P3-19 Biotransformation of unnatural substrates by sesquiterpene cyclases Vanessa Harms, Clara Oberhauser, Katja Seidel Andreas Kirschning (Hannover/DE)

P3-20 A light-driven enzyme cascade reaction for the synthesis of lactones Hanna Christiane Büchsenschütz (Graz/AT) Fabian Schultes (Bochum/DE), Sandy Schmidt, Robert Kourist (Graz/AT)

P3-21 Reaction mechanisms, product selectivity and characterization of the recombinant SUMO (+)-zizaene synthase from Vetiveria zizanioides Francisco Aguilar, Stephan Hartwig, Thomas Scheper Sascha Beutel (Hannover/DE)

P3-22 Sialylated human milk oligosaccharides produced in optimized enzymatic one-pot reactions Sabine Schelch, Barbara Petschacher, Stefanie Gross Belduma Manuel Eibinger (Graz/AT), Uma Reddy, Jürgen Kuballa (Hamburg/DE) Bernd Nidetzky (Graz/AT)

P3-23 Growth of Gulf of Mexico Rhodococcus erythropolis PC20 strain under the influence of pressure and dispersant Steffen Hackbusch, Juan Viamonte, Nuttapol Noirungsee (Hamburg/DE) Xiaoxu Sun (Atlanta, GA/US), Paul Bubenheim (Hamburg/DE) Joel Kostka (Atlanta, GA/US), Andreas Liese (Hamburg/DE)

P3-24 Multienzymatic cascade reactions in a 2-phase system Jens Johannsen, Claudia Engelmann, Andreas Liese, Georg Fieg Paul Bubenheim, Thomas Waluga (Hamburg/DE)

P3-25 Enzymatic synthesis of glycerol ethers derivatives as new green solvents Susana Velasco-Lozano, Alejandro Leal-Duaso, Elisabeth Pires José Ignacio García, José Antonio Mayoral Fernando López-Gallego (Zaragoza/ES)

P3-26 Peroxygenases – dream catalysts for selective oxyfunctionalization reactions? Florian Tieves (Delft/NL), Patricia Gómez de Santos Elena Fernández-Fueyo, Miguel Alcalde (Madrid/ES) Frank Hollmann (Delft/NL)

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P3-27 Photobiocatalytic routes towards chiral amines Christoph K. Winkler, Silvan Poschenrieder, Valentina Jurkaš Sandy Schmidt, Hanna C. Büchsenschütz, Viktorija Vidimce Robert Kourist, Wolfgang Kroutil (Graz/AT)

P3-28 One-pot multi-enzyme synthesis of UDP-Man Reza Mahour (Magdeburg/DE) Cláudia Filipa Duarte Bento (Magdeburg/DE; Caparica/PT) Thomas F. T. Rexer, Udo Reichl (Magdeburg/DE)

P3-29 Evolving transaminases towards sugar substrates Ryan Cairns (Nottingham/GB), Moritz Voss Uwe T. Bornscheuer (Greifswald/DE), Elaine O’Reilly (Nottingham/GB)

P3-30 Development of E. coli based whole cell biocatalysts for plant P450 monooxygenases Stefan Wohlgemuth, Esther Ricklefs, Sarah Kranz-Finger Vlada B. Urlacher (Düsseldorf/DE)

P3-31 Mathematical modeling of DERA-catalyzed statin side-chain intermediate production Anera Švarc, Đurđa Vasić-Rački, Zvjezdana Findrik Blažević (Zagreb/HR) Karel Hernandez, Pere Clapés (Barcelona/ES) Ana Vrsalović Presečki (Zagreb/HR)

P3-32 Hetero-and autotrophically driven biotransformations in C. necator Leen Assil Companioni, Sandy Schmidt, Petra Heidinger, Helmut Schwab Robert Kourist (Graz/AT)

P3-33 Selective biocatalytic synthesis of nordihydroguaiaretic acid (NDGA) glucosides and analysis of their chemical, physical and pharmacological properties Johannes Nolte, Lara-Alina Pöttgen, Alexander Kempa, Julia Sperlich Ulrich Schörken (Leverkusen/DE)

P3-34 Avoiding cross-reactivities in multi-step biocatalysis by light‑induced enzyme deactivation Tim Gerlach, Fabienne Hilgers, Nora Bitzenhofer, Thomas Drepper Dörte Rother (Jülich/DE)

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P3-35 High-yield production of cortisone by establishment of an efficient whole-cell system in Bacillus megaterium Lisa König, Philip Hartz, Rita Bernhardt Frank Hannemann (Saarbrücken/DE)

P3-36 Site-specific covalent immobilization of a recombinant fungal L-amino acid oxidase for efficient production of alpha-keto acids Tobias Beuel, Svenja Bloess, Karthikeyan Radhakrishnan Gabriele Fischer von Mollard, Thomas Dierks (Bielefeld/DE)

P3-37 Enzymatic tandem approach to Knoevenagel condensation of enol acetates with aldehydes in organic media Dominik Koszelewski, Ryszard Ostaszewski (Warsaw/PL)

P3-38 Chemoenzymatic tandem reaction promoted by sugar esters for the synthesis of α-acyloxy carboxamides containing coumarin scaffold Daniel Paprocki, Ryszard Ostaszewski (Warsaw/PL)

P3-39 Fusion enzyme of FMO-E and HLADH for a convergent cascade reaction in non-conventional media Lei Huang (Hamburg/DE), Friso S. Aalbers (Groningen/NL) Wei Tang (Hamburg/DE), Marco W. Fraaije (Groningen/NL) Selin Kara (Hamburg/DE)

P3-40 Asymmetric enzymatic synthesis of the metallo-β-lactamase inhibitor aspergillomarasmine A and related aminocarboxylic acids Haigen Fu, Jielin Zhang, Mohammad Saifuddin, Gea Cruiming Pieter Tepper, Gerrit Poelarends (Groningen/NL)

P3-41 Lipase from porcine pancreas – efficient biocatalyst for the synthesis of ortho-aminocarbonitriles Kiran Dalal, Dipak Dalal, Bhushan Chaudhari (Jalgaon/IN)

P3-42 Characterisation of Baeyer-Villiger monooxygenases and optimisation of the convergent cascade for synthesis of Epsilon-Caprolactone Jennifer Engel (Hamburg/DE), Katlego Mthethwa Dirk Opperman (Bloemfontein/ZA), Selin Kara (Hamburg/DE)

P3-43 Potential of carbon dioxide fine bubbles in biocatalysis Daniel Ohde, Benjamin Thomas, Simon Matthes Paul Bubenheim (Hamburg/DE), Koichi Terasaka (Tokio/DE) Michael Schlüter, Andreas Liese (Hamburg/DE)

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P3-44 Enzymatic kinetic resolution of enol lactones as a new approach towards chiral peptidomimetics Anna Brodzka, Ryszard Ostaszewski (Warsaw/PL)

P3-45 Structural and physicochemical characterization of sophorolipids from Starmerella bombicola and Candida kuoi Christian Zerhusen, Yifei Zhan, Timo Bollmann, Sonja Müller Birgit Glüsen, Ulrich Schörken (Leverkusen/DE)

P3-46 Probing enzyme active sites in promiscious ugi reaction by isocyanates Monika Wilk, Damian Trzepizur, Ryszard Ostaszewski (Warsaw/PL)

P3-47 Independent cell transamination Stylianos Grigoriou, Frederik Walter, Evelina Kulcinskaja, John King Phil Hill, Elaine O’Reilly (Nottingham/GB)

P3-48 A novel assay for the detection of carboxylic acid reductase (CAR) activity in whole cells Daniel Schwendenwein (Graz/AT), Anna Ressmann Florian Rudroff (Vienna/AT), Margit Winkler (Graz/AT)

P3-49 (R,R)-Butane-2,3-diol dehydrogenase from Bacillus clausii DSM 8716T – a versatile biocatalyst for synthesis of α-hydroxy ketones/diols and biosensor development Lukas Muschallik, Denise Molinnus, Melanie Jablonski, Carina Kipp Johannes Bongaerts, Torsten Wagner, Martina Pohl, Thorsten Selmer Michael J. Schöning, Petra Siegert (Jülich/DE)

P3-50 Fine bubbles for biochemical transformation Benjamin Thomas, Daniel Ohde, Simon Matthes Paul Bubenheim (Hamburg/DE), Koichi Terasaka (Tokyo/JP) Michael Schlüter, Andreas Liese (Hamburg/DE)

P3-51 Screening for hydrolases catalyzing the esterification of cyclic (di-) carboxylic acids Robert Hiessl, Yvonne Schade (Hamburg/DE) Carmen Plass (Bielefeld/DE), Joscha Kleber (Hamburg/DE) Rainer Otter (Ludwigshafen/DE), Harald Gröger (Bielefeld/DE) Andreas Liese (Hamburg/DE)

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P3-52 One-step process for production of N-methylated amino acids Melanie Mindt (Bielefeld/DE), Hendrik Gruß (Biefeled/DE) Joe Max Risse (Bielefeld/DE), Marcel Freese Norbert Sewald (Biefeled/DE), Bernhard Eikmanns (Ulm/DE) Volker Wendisch (Bielefeld/DE)

P3-53 Small laccase from Streptomyces coelicolor A3(2) – secretory expression and application for the synthesis of antioxidants Tukayi Kudanga, Deepti Yadav, Blessing Nemadziva Nokuthula Mchunu (Durban/ZA), Marilize Le Roes-Hill (Cape Town/ZA)

P3-54 Large-scale production of oligocaprolactone in aqueous media Vishnu S. T. Srinivasamurthy, Dominique Böttcher Uwe T. Bornscheuer (Greifswald/DE)

P3-55 Production of milk oligosaccharide constituent sialic acid in Saccharomyces cerevisiae Uma Katha, Jürgen Kuballa (Hamburg/DE)

P3-56 Biocatalytic terpene platform Antonino Biundo (Solna/SE), Arne Stamm (Stockholm/SE) Maryam Mousa, Ylva Grevenfors (Solna/SE), Linda Fogelström Eva Malmström (Stockholm/SE), Per-Olof Syrén (Solna/SE)

P3-57 Application of enzymatic dynamic kinetic resolution of homoallylic alcohols to the synthesis of chiral δ-lactones Filip Borys, Dominik Koszelewski, Ryszard Ostaszewski (Warsaw/PL)

P3-58 Stereospecific reductions of substituted β-keto-esters using microbial whole-cell conversions and isolated microbial enzymes Chris Drewniok, Katerina Barková, Akadil Belgara, Janine Heinrich Philipp Röbisch, Corinna Schuster, Christian Trapp, Dieter Greif Annett Fuchs, Marek Jan Pecyna, Thomas Wiegert (Zittau/DE)

P3-59 In vitro studies on cyclases from polyketide biosynthetic pathways for the synthesis of heterocycles Lisa Wagner, Tim Hollmann (Bayreuth/DE) Gesche Berkhan (Hannover/DE), Frank Hahn (Bayreuth/DE)

P3-60 Characterization of fungal linoleate diol synthases with diverse regio-specificities and biotransformation to hydroxy fatty acids using recombinant cells expressing these enzymes Min-Ju Seo, Kyung-Chul Shin, Deok-Kun Oh (Seoul/KR)

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P3-61 Biocatalytic oxidative cascade for the conversion of fatty acids to α-Ketoacids via internal H2O2 recycling Somayyeh Gandomkar, Alexander Dennig, Lucas Hammerer Anđela Đordić, Mathias Pickl, Mélanie Hall, Wolfgang Kroutil Kurt Faber (Graz/AT)

P3-62 Effect of elevated pressure on bacterial communities Nuttapol Noirungsee, Steffen Hackbusch, Juan Viamonte Paul Bubenheim, Rudolf Müller, Andreas Liese (Hamburg/DE)

P3-63 Synthesis of hops prenylflavonoids sulphates by Desulfitobacterium hafniense aryl-sulfate sulfotransferase Jarosław Popłoński, Sandra Sordon, Tomasz Tronina (Wrocław/PL) Aloysius Hartog, Ron Wever (Amsterdam/NL) Ewa Huszcza (Wrocław/PL)

P3-64 Cross-linked enzyme-adhered nanoparticles (CLEANs) and their applications Flóra Nagy, András Szilágyi, György T. Balogh, Diána Balogh-Weiser László Poppe (Budapest/HU)

P3-65 Transformation of lactose to value-added products with immobilized β-galactosidase Helena Hronská, Silvia Michalíková, Michal Rosenberg (Bratislava/SK)

P3-66 Catalytic and substrate promiscuity of L-threonine aldolase Kateryna Lypetska (Fesko) (Graz/AT)

P3-67 F420H2 dependent ene-reductases – revealing a new class of enantioselective and regioselective biocatalysts Milos Trajkovic, Sam Mathew, Hemant Kumar (Groningen/NL) Quoc-Thai Nguyen (Ho Chi Minh City/VN) Marco W. Fraaije (Groningen/NL)

P3-68 Kinetic resolution of amino acids by using covalently immobilized lipase enzymes Bianka Szokol, József Nagy (Budapest/HU) László Poppe (Budapest/HU; Cluj-Napoca/RO)

P3-69 Biosynthesis of the Nylon 12 monomer, ω-aminododecanoic acid with novel cytochrom P450, alcohol dehydrogenase, and omega-transaminase enzymes Hyunwoo Jeon, hyungdon Yun (Seoul/KR)

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P3-70 The kinetic resolution of racemic amines using a whole-cell biocatalyst co-expressing amine dehydrogenase and NADH oxidase Sanghan Yoon, Hyunwoo Jeon, Hyungdon Yun (Seoul/KR)

P3-71 A highly effective and enantioselective Kurthia gibsonii SC0312 for the asymmetric oxidation of racemic 1-phenyl-1,2-ethanediol Wenyong Lou (Guangzhou/CN)

P3-72 Production of flavonoids with catechol moiety by rhodotorula genus Sandra Sordon, Jarosław Popłoński, Magdalena Milczarek Martyna Stachowicz, Tomasz Tronina, Joanna Wietrzyk Ewa Huszcza (Wrocław/PL)

P3-73 Chemoenzymatic dynamic kinetic resolution of benzylic amines in fully continuous-flow mode Emese Farkas, Márk Oláh, Attila Földi (Budapest/HU) Csaba Paizs (Cluj-Napoca/RO), Gábor Hornyánszky (Budapest/HU) László Poppe (Budapest/HU; Cluj-Napoca/RO; Budapest/HU)

P3-74 Mutability-landscape guided enzyme engineering for improved performance in aqueous-ethanol solvents Chao Guo (Groningen/NL)

P3-75 Mimicking metabolism in the brain – analysis of cytochrome P450 mediated drug metabolism in iPS-derived cortical organoids Nina Beyer, Matthias Vogel, Denna Tabari, Karim Barakat Catharina Scholl, Julia Stingl (Bonn/DE)

P3-76 Orange peel-application/usage by an artificial enzymatic cascade expressed in Pichia pastoris Erna Zukic (Vienna/AT), Anton Glieder, Martina Geier (Graz/AT) Nikolin Oberleitner, Anna Ressmann, K. Bica, P. Gärtner (Vienna/AT) Marco W. Fraaije (Groningen/NL), Uwe T. Bornscheuer (Greifswald/DE) Marko Mihovilovic, Florian Rudroff (Vienna/AT)

P3-77 Cell-free bio-conversion of n-octane to n-octanol via a bio-catalytic approach Shanna Swart, Athanasios Kotsiopoulos, Susan Harrison (Cape Town/ZA)

P3-78 Production of selenium nanoparticles in Pseudomonas putida KT2440 and identification of genes involved Roberto Avendaño, Nefertiti Chaves, Paola Fuentes, Rafael Montenegro Sofía Vieto, Ethel Sánchez (San José/CR), Jose I. Jiménez (Guildford/GB) Max Chavarría (San José/CR)

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poster l tuesdAy, 28 August

14:00–15:30 POSTER SESSION 2 – TOPIC 1Room H0.01–H0.09 Enzyme discovery, production and application

P1-1 RosB is an 8-amino-8-demethyl-riboflavin-5’-phosphate synthase and the first member of a novel class of enzymes which are oxidoreductases, decarboxylases and aminotransferases in one Matthias Mack (Mannheim/DE)

P1-2 Acceleration of enzymatic degradation of poly(ethylene terephthalate) by coating its surface with anionic surfactants Makoto Furukawa, Norifumi Kawakami, Kenji Miyamoto (Yokohama/JP)

P1-3 New laccases from Fusarium oxysporum Natalia Kwiatos, Marzena Jędrzejczak-Krzepkowska Stanisław Bielecki (Łódź/PL)

P1-4 Continuous protein hydrolysis for the production of bioactive peptides Tim Sewczyk (Hannover/DE), Marieke Hoog Antink Michael Maas (Bremen/DE), Sascha Beutel (Hannover/DE)

P1-5 Rational identification of aggregation hotspots based on secondary structure and amino acid hydrophobicity Daisuke Matsui, Shogo Nakano, Yasuhisa Asano (Imizu/JP)

P1-6 Biocatalytic potential of the epoxide hydrolase (YlEH) from a tropical marine yeast Yarrowia lipolytica NCIM 3589 Vijaya Godase (Pune, Kolhapur/IN), Ameeta Ravikumar (Pune/IN)

P1-7 Exploration of biocatalysts diversity by integrating bioinformatics with biochemical testing Pavel Vanacek, Eva Sebestova, Petra Babkova, Sarka Bidmanova Lukas Daniel, Pavel Dvorak, Veronika Stepankova, Radka Chaloupkova Jan Brezovsky, Jiri Damborsky, Zbynek Prokop (Brno/CZ)

P1-8 New strategy for the discovery of carbohydrate-active enzymes through integrated ‚omics Philip Busch, Marcel Suleiman, Christian Schäfers Garabed Antranikian (Hamburg/DE)

P1-9 Influence of recalcitrant substrates on microbial diversity of samples from Azorean hot springs Marcel Suleiman, Barbara Klippel, Philip Busch, Christian Schäfers Garabed Antranikian (Hamburg/DE)

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P1-10 News from vanillyl alcohol oxidase Gudrun Gygli (Stuttgart/DE; Wageningen/NL), Tom A. Ewing Willem J.H. van Berkel (Wageningen/NL)

P1-11 The monolignol oxidoreductase AtBBE-like protein 15 – characterization, rational engineering and biocatalytic applications Bastian Daniel, Sabine Pils, Peter Macheroux, Jörg H. Schrittwieser Wolfgang Kroutil (Graz/AT)

P1-12 Stereoselective conversion of α-angelica lactone to (R)-γ-valerolactone in a one-pot two-step enzymatic cascade Marina Simona Robescu, Laura Cendron (Padova/IT) Riccardo Motterle (Montecchio Maggiore/IT) Elisabetta Bergantino (Padova/IT), Mélanie Hall (Graz/AT)

P1-13 Aggregating flavoprotein as a catalyst for 1-dehydro-3-ketosteroids production Agnieszka M. Wojtkiewicz, Patrycja Wójcik, Monika Sroczyk Maria Oszajca, Kamila Sofińska, Jakub Barbasz, Olga Zastawny Maciej Guzik (Krakow/PL), Elvira Romero Marco W. Fraaije (Groningen/NL), Maciej Szaleniec (Krakow/PL)

P1-14 Costa Rican lipases from native coffee plantation fungi as a green alternative for the management of agroindustrial coffee by-products Jorge Campos Rodríguez, Nicole Hernández Herrera Daniela Pereira Arce, Elias Quesada Carrillo, Randall Syedd León Frank Solano Campos, Luis Roberto Villegas-Peñaranda Manuel Sandoval Barrantes (Heredia/CR)

P1-15 Laccase production from hazelnut husk via submerged cultivation of white-rot fungi Zeynep Yilmaz Sercinoglu, Nihat Alpagu Sayar (Istanbul/TR)

P1-16 A novel biocatalyst for the biotransformation of Taxanes/Taxol® Eugen Schell, Marion Ansorge-Schumacher (Dresden/DE)

P1-17 Discovering the elusive ethyl acetate producing alcohol acetyltransferase from yeast Ruud Weusthuis (Wageningen/NL)

P1-18 Production of novel terpenoid structures via bioconversion of unnatural and synthetic substrates with a recombinant patchoulol synthase Kimia Ekramzadeh, Thomas Scheper, Sascha Beutel (Hannover/DE)

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P1-19 Investigation of an algal polysaccharide degradation pathway using sulfatases from a marine microorganism Marcus Bäumgen (Greifswald/DE), Aurélie Prechoux (Roscoff/FR) Lukas Reisky (Greifswald/DE), Craig Robb (Bremen/DE) Marie-Katherin Zühlke (Greifswald/DE), Gurvan Michel (Roscoff/FR) Thomas Schweder (Greifswald/DE), Jan-Hendrik Hehemann (Bremen/DE) Uwe T. Bornscheuer (Greifswald/DE)

P1-20 Screening, characterization and biotechnological use of decarbamoylating enzymes for production of chiral β-Amino acids Carolin Lohmann (Karlsruhe/DE)

P1-21 Catabolism of 2-hydroxypyridine by Burkholderia sp. MAK1 – a five-gene cluster encoded 2-hydroxypyridine 5-monooxygenase HpdABCDE catalyses the first step of biodegradation Vytautas Petkevičius, Justas Vaitekūnas, Jonita Stankevičiūtė Renata Gasparavičiūtė, Rolandas Meškys (Vilnius/LT)

P1-22 In vitro CO2 fixation by pyruvate – Ferredoxin oxidoreductase from Desulfovibrio africanus and Sulfolobus acidocaldarius Hartmut Grammel (Biberach/DE)

P1-23 Methyl transfer with cobalamin as a cofactor Christopher Grimm, Judith Farnberger, Wolfgang Kroutil (Graz/AT)

P1-24 From genes towards industry – discovery of a panel of new thermostable self-sufficient cytochrome P450s and application for the whole-cell 5-hydroxylation of diclofenac Michele Tavanti, Joanne Porter, Colin Levy Selina Sabatini (Manchester/GB), Rowan Lindeque Mafalda Dias Gomes (Copenhagen/DK) José Rubén Gómez Castellanos (Mexico City/MX) John Woodley (Copenhagen/DK), Nicholas Turner Sabine Flitsch (Manchester/GB)

P1-25 Acetaldehyde-dependent aldolases – understanding and optimization towards an efficient biocatalyst Julia Bramski, Markus Dick, Carolin Bisterfeld, Thomas Classen Jörg Pietruszka (Jülich/DE)

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P1-26 Structural insights into substrate selectivity and activity of bacterial polyphosphate kinases Boguslaw Nocek (Argonne, IL/US), Anna Khusnutdinova (Toronto/CA) Milosz Ruszkowski (Argonne/US), Robert Flick (Toronto/CA) Malgorzata Burda (Wroclaw/PL), Khorcheska Batyrova Greg Brown (Toronto/CA), Artur Mucha (Wroclaw/PL) Andrzej Joachimiak (Argonne/US), Lukasz Berlicki (Wroclaw/PL) Alexander Yakunin (Toronto/CA)

P1-27 Characterization of novel β-etherases identified by peptide pattern recognition Hauke Voß, Carina Amata Heck, Anett Schallmey (Braunschweig/DE)

P1-28 The use of the auxotrophic host and synthetic nucleosides for a rapid selection of hydrolases from metagenomic libraries Nina Urbelienė, Simonas Kutanovas, Rita Meškienė Renata Gasparavičiūtė, Daiva Tauraitė, Rolandas Meškys (Vilnius/LT)

P1-29 Discovery of nucleoside – nucleotide – phosphotransferases, tumor marker, in Chromatin, Cytoplasm and bloodplasma of Morris Hepatoma 9121 Karin Lenger (Offenbach/DE)

P1-30 Rational evolution of cytochrome P450 reductase to enhance activity with NADH yields variants with increased activity towards specific P450s Silja J. Strohmaier (Brisbane/AU), Weiliang Huang (Baltimore, MD/US) Jong-Min Baek, Dominic J. B. Hunter Elizabeth M. J. Gillam (Brisbane/AU)

P1-31 Reaction of immobilized enzyme novozym 435 in reactor of fixed bed series Américo Cruz Jr., Luimar Marques Porto, Benevides Pessela C. João José Manuel Guisán Seijas (Florianópolis/BR)

P1-32 Biocatalytic asymmetric reductive amination using reductive aminases (RedAms) James R. Marshall, Sarah L. Montgomery (Manchester/GB) James D. Finnigan (Halthwhistle, Northumberland/GB) Juan Mangas-Sanchez (Manchester/GB), Darren J. Cook Simon J. Charnock (Halthwhistle, Northumberland/GB) Nicholas J. Turner (Manchester/GB)

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P1-33 Recombinant expression, purification and characterization of a fungal L-amino acid oxidase Svenja Bloess, Marc Christian Heß, Joe Max Risse, Karl Friehs Gabriele Fischer von Mollard (Bielefeld/DE)

P1-34 Application of promiscuous cytochrome P450s from actinomycetes for the production of drug metabolites Davide Decembrino, Thomas Hilberath, Priska Le-Huu Vlada B. Urlacher (Düsseldorf/DE)

P1-35 Cultivation of fungus Rhizomucor miehei ATCC 26282 in airlift bioreactor Américo Cruz Jr., Luismar Marques Porto, José Manuel Guisán Seijas Benevides Pessela C. João (Florianópolis/BR)

P1-36 Characterization of dihydropyrimdinases for biocatalytic production of chiral beta amino acids within an enzyme cascade process Ulrike Engel, Carolin Lohmann (Karlsruhe/DE)

P1-37 Cloning and characterization of serine racemase from the green alga Chlamydomonas reinhardtii Miya Koike, Yu Yasuda, Minoru Tanigawa Katushi Nishimura (Tokyo, Tiyoda, Kanda/JP)

P1-38 High level expression of secretory phytases in Pichia pastoris Zhen Ming XIE, Hei Tsing Cheryl Yeung, Wing Ping Fong Wai Kei Paul Tsang (Hong Kong/CN)

P1-39 Kinetic characterization of an engineered tyrosinase Amal Alghamdi, Kevin O’Connor, Reeta Davis (Dublin/IE)

P1-40 Discovery of a novel NAD-dependent formate dehydrogenase from Rhodococcus jostii suitable for cofactor regeneration and CO2 fixation Alexander Boldt, Marion Ansorge-Schumacher (Dresden/DE)

P1-41 Biochemical characterisation of a novel imine reductase from Pseudomonas putida Justyna Kuska, James Ryan, Elaine O’Reilly (Nottingham/GB)

P1-42 Exploring marine Pseudomonas species for polyester hydrolases Alexander Bollinger, Stephan Thies, Maha Raauf Alina Kuklinski (Jülich/DE), Cristina Coscolín, Manuel Ferrer (Madrid/ES) Karl-Erich Jaeger (Jülich/DE)

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P1-43 Novel enzymes from metagenomes for the biodegradation of polyethylene terephthalate Dominik Danso, Jennifer Chow, Christel Vollstedt Wolfgang Streit (Hamburg/DE)

P1-44 Effects of pressure on activity and stability of alanine racemase from the psychrophilic and piezophilic bacterium Shewanella violacea DSS12 Keisuke Itabashi (Kanda Chiyoda-ku, Tokyo/JP), Justin Miyake Miya Koike, Mayumi Tokuhisa, Minoru Tanigawa, Chiaki Kato (Tokyo/JP) Katsushi Nishimura (Tokyo, Chiba/JP)

P1-45 A combined in vitro transcription and translation system for cell-free screening and characterization of genes and proteins from non-cultivated organisms and hyperthermophilic archaea Pablo Pérez-García, Mareike Janus, Birhanu M. Kinfu (Hamburg/DE), Ulrich Schwaneberg (Aachen/DE), Jennifer Chow Wolfgang R. Streit (Hamburg/DE)

P1-46 Heterologous production and application of unspecific peroxygenases Sebastian Bormann, Angelika E. W. Horst Dirk Holtmann (Frankfurt am Main/DE)

P1-47 Discovery of bacterial peroxidases from environmental samples Abdulkadir Yayci, Cindy Juric, Nathalie Gibas, Martin Kemler Dominik Begerow, Julia Bandow (Bochum/DE)

P1-48 Analytical approach to understand the interferences of compounds to lignocellulolytic enzyme activity assays Zeynep Yilmaz Sercinoglu, Nihat Alpagu Sayar (Istanbul/TR)

P1-49 Novel thermostable and acidophilic β-glucosidases from a thermophilic fungus Thermomyces lanuginosus with broad substrate activity on glucans Nokuthula Mchunu (Durban/ZA)

P1-50 Exploring the metabolic pathways of Rhodotorula glutinis for the valorization of olive mill wastewater Panagiotis Kelefiotis-Stratidakis (Heraklion/GR), Agris Pentjuss Egils Stalidzans (Riga/LV), Friedrich W. Herberg (Kassel/DE) Ioannis V. Pavlidis (Heraklion/GR; Kassel/DE)

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P1-51 Chitosan-CLEAs of Aspergillus niger type A feruloyl esterase – using a sustainable co-feeder to obtain a thermostable biocatalyst Daniel Alberto Grajales Hernández, Ana Daniela Vega Rodríguez Mariana Antonieta Armendáriz Ruiz (Zapopan/MX) Susana Velasco Lozano, Fernando López Gallego (Zaragoza/ES) Rosa María Camacho Ruíz, Jorge Alberto Rodríguez González Juan Carlos Mateos Díaz (Zapopan/MX)

P1-52 Vanadium chloroperoxidase-catalyzed halolactonization of γ,δ–unsaturated carboxylic acids Sabry Younes, Florian Tieves, Frank Hollmann (Delft/NL)

P1-53 A colorimetric high-throughput screening method for synthetic activity and diastereoselectivity of threonine aldolases Xi Chen, Qijia Chen, Jinhui Feng, Qiaqing Wu, Dunming Zhu Xuerong Xing (Tianjin/CN)

P1-54 Novel endo-β-glucanase (glycoside hydrolase family 9) with unusual substrate specificity from a biogas reactor metagenome Carola Schröder, Christin Burkhardt, Philip Busch Garabed Antranikian (Hamburg/DE)

P1-55 Identification of novel ᴅ-carbamoylases for the production of optically pure amino acids Neele Meyer-Heydecke, Anna Krüger, Christian Schäfers, Anke Peters Garabed Antranikian (Hamburg/DE)

P1-56 Acyl-peptide hydrolase (APEH) as new target involved in human diseases associated with defect in proteostasis Gianna Palmieri, Ennio Cocca, Marta Gogliettino, Marco Balestrieri Bruna Agrillo, Carmela Fusco, Sara Mirino, Mosè Rossi (Napoli/IT)

P1-57 Sequence-based functional metagenome approach for novel β-glucosidase search extracted from gut larvae, gut adult, or galleries of Costa Rican Passalidae beetles Luis Alonso Porras-Reyes (Pavas, San José/CR) Ibrahim Zúñiga-Chaves (San Pedro de Montes de Oca/CR) Jose Anibal Mora-Villalobos (Pavas, San José/CR) Giselle Tamayo-Castillo Adrián Pinto-Tomás (San Pedro de Montes de Oca/CR)

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P1-58 Cholest-4-en-3-one Δ1-dehydrogenase – a biocatalyst for regioselective dehydrogenation of steroids Patrycja Wójcik, Michał Glanowski, Agnieszka Winiarska Agnieszka Wojtkiewicz, Maciej Szaleniec (Krakow/PL)

P1-59 Actinobacteria associated with rooibos (Aspalathus linearis) and their multicopper oxidases Alaric Prins, Bronwyn Kirby-McCullough Marilize Le Roes-Hill (Cape Town/ZA)

P1-60 Transferring academic knowledge to industrial application Katrin Hecht, Rebecca Buller (Wädenswil/CH)

P1-61 Characterization of a novel 2-deoxy-d-ribose-5-phosphate aldolase Eman Abdelraheem, Meera Haridas, Lemin Chen, Carolin Bisterfeld Rosario Medici, Ulf Hanefeld (Delft/NL)

P1-62 Bioinformatic identification of novel flavin-dependent halogenases Pia Neubauer, Daniel Wibberg, Marcel Frese, Jörn Kalinowski Norbert Sewald (Bielefeld/DE)

P1-63 Alcohol dehydrogenases as fusion enzymes for biocatalysis Friso Aalbers, Marco W. Fraaije (Groningen/NL)

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poster l WednesdAy, 29 August

14:40–16:40 POSTER SESSION 3 – TOPICS 2+4+5Room H0.01–H0.09 Structure-function analysis and enzyme design

P2-1 Understanding enzyme interactions under process conditions Valerio Ferrario, Jürgen Pleiss (Stuttgart/DE)

P2-2 In vitro activity of Piromyces xylose isomerase and its in vivo performance in yeast Misun Lee, Henriëtte Rozeboom (Groningen/NL), Maarten Verhoeven Paul de Waal, Jack Pronk (Delft/NL), Dick B. Janssen (Groningen/NL)

P2-3 Structure-based engineering of steroidogenic CYP260A1 for stereo- and regioselective hydroxylation of progesterone Yogan Khatri (Saarbrücken/DE; Ann Arbor, MI/US) Ilona Jóźwik (Groningen/NL), Michael Ringle, Irina Ionescu Martin Litzenburger, Michael Hutter (Saarbrücken/DE) Andy Thunnissen (Groningen/NL), Rita Bernhardt (Saarbrücken/DE)

P2-4 Novel insights into β-etherase catalysis Jana Husarcikova, Hauke Voß, Anett Schallmey (Braunschweig/DE)

P2-5 Combinatorial engineering of proteolytically resistant APPI variants that selectively inhibit Hhuman Mesotrypsin for cancer therapy Niv Papo (Beer Sheva/IL)

P2-6 Dynamics of sub-unit assembly within multi enzyme complex and its mutants Sibel Ilhan, Uwe Jandt, Cornelius Müller (Hamburg/DE)

P2-7 Design and evaluation of metal-binding sites in a new engineered protein scaffold for achieving artificial metalloenzymes Dominik Renn, Johannes Fischer (Thuwal/SA; Garching/DE) Felix Quitterer (Garching/DE), Anand Radhakrishnan, Meina Liu Magnus A. Rueping, Stefan T. Arold (Thuwal/SA) Michael Groll (Garching/DE), Jörg Eppinger (Thuwal/SA)

P2-8 Engineering enzymes for the fabrication of robust and highly active heterogeneous biocatalyst Andoni Rodriguez-Abetxuko, Ana Beloqui (Donostia-San Sebastián/ES)

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P2-9 Engineering of phosphoserine aminotransferase for a novel biosynthetic pathway of 1,3-propanediol from glucose via homoserine Yujun Zhang (Hamburg/DE)

P2-10 Influence of viscosity and temperature on coupled bioluminescent enzyme systems Oleg Sutormin, Irina Sukovataya, Valentina Kratasyuk (Krasnoyarsk/RU)

P2-11 Identification and analysis of binding residues in the CBM68 of pullulanase PulA from Anoxybacillus sp. LM18-11 Hui Song, Hongchen Zheng (Tianjin/CN)

P2-12 Fatty acid hydroxylation by cytochrome P450s Lucas Hammerer, Christoph K. Winkler, Wolfgang Kroutil (Graz/AT)

P2-13 Thermal stabilization of Pseudomonas fluorescens esterase I and characterization of improved variants Diana M. Mate, Noé R. Rivera, José Berenguer Aurelio Hidalgo (Madrid/ES)

P2-14 Engineering rieske non-heme iron oxygenases for light-driven dihydroxylations Peter Wied, Birgit Ungerböck, Ingo Klimant, Robert Kourist Sandy Schmidt (Graz/AT)

P2-15 Investigation on CYP4B1 isoforms – ligand characterization and bioactivation of pro-toxins Marco Girhard, Constanze Wiek, Katharina Roellecke (Düsseldorf/DE) Allan E. Rettie (Seattle, WA/US), Helmut Hanenberg (Düsseldorf/DE)

P2-16 C-C bond formation by designed proteins harboring artificial cofactors Horst Lechner, Birte Höcker (Bayreuth/DE)

P2-17 S-adenosyl-L-homocysteine hydrolase inhibition by a synthetic nicotinamide cofactor biomimetic Lyn Lisette Kailing, Daniela Bertinetti (Kassel/DE) Caroline Emilie Paul (Wageningen/NL), Tomasz Manszewski Mariusz Jaskolski (Poznan/PL), Friedrich W. Herberg (Kassel/DE) Ioannis V. Pavlidis (Kassel/DE, Heraklion/GR)

P2-18 Design and characterization of thermostable HheG mutants Jennifer Solarczek, Patrick Schrepfer Anett Schallmey (Braunschweig/DE)

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P2-19 A semi-rational approach towards protein engineering of Streptococcus pyogenes sortase A Magdalena Wojcik (Groningen/NL), Fabio Parmeggiani (Bristol/GB) Ykelien Boersma (Groningen/NL)

P2-20 Molecular basis of substrate preference of an O-methyltransferase Qingyun Tang, Uwe T. Bornscheuer (Greifswald/DE) Ioannis V. Pavlidis (Heraklion/GR)

P2-21 Anti-Markovnikov alkene oxidation by metal-oxo-mediated enzyme catalysis Stephan Hammer (Stuttgart/DE), Grzegorz Kubik, Ella Watkins Shan Huang (Pasadena, CA/US), Hannah Minges (Bielefeld/DE) Frances Arnold (Pasadena, CA/US)

P2-22 Thermostabilization of the pyruvate aldolase YfaU using an enhanced folding reporter Sandra Bosch, Esther Sánchez, María Luisa del Pozo (Madrid/ES) Karel Hernández (Barcelona/ES), José Berenguer (Madrid/ES) Pere Clapés (Barcelona/ES), Aurelio Hidalgo (Madrid/ES)

P2-23 Screening of novel antibiotics in microorganisms isolated from natural sources Yuki Miyauchi, Miya Koike, Minoru Tanigawa, Motohiko Ukiya Katsushi Nishimura (Chiyoda; Tokyo/JP)

P2-24 Alternative binding mode impairs enantioselectivity of arylmalonate decarboxylase Anna Schweiger (Graz/AT), Junichi Enoki, Carolin Mügge (Bochum/DE) Robert Kourist (Graz/AT)

P2-25 A quantum mechanics based engineering approach to improve transaminases for the conversion of bulky substrates Moritz Voss, Maika Genz, Hubert Kasprowski Jakub Kustosz (Greifswald/DE), Pravin Kumar, Naveen Kulkarni Devashish Das, Anurag Kumar (Bangalore/IN), Uwe T. Bornscheuer Matthias Höhne (Greifswald/DE)

P2-26 Characterization of H216A mutant enzyme of D-threonine aldolase from the green alga Chlamydomonas reinhardtii Katsushi Nishimura (Tokyo, Funabashi/JP), Yuji Kanno (Tokyo/JP) Yuki Hirato (Funabashi/JP), Masaru Goto (Narashino/JP), Miya Koike Mayumi Tokuhisa, Minoru Tanigawa (Tokyo/JP)

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P2-27 Rapid enzyme stabilization by computationally designed libraries of HMF oxidase Caterina Martin, Amaury Ovalle Maqueo, Hein J. Wijma Marco W. Fraaije (Groningen/NL)

P2-28 Thermostabilization of a new halohydrin dehalogenase by protein engineering Julia Koopmeiners (Braunschweig/DE), Sandra Bosch (Madrid/ES) Giovanna Petrillo (Barcelona/ES), Willem P. Dijkman (Braunschweig/DE) Isabel Uson (Barcelona/ES), Aurelio Hidalgo (Madrid/ES) Anett Schallmey (Braunschweig/DE)

P2-29 Structure-function analysis and engineering of tafazzins from various organisms Henrik Müller, Uwe T. Bornscheuer, Kathleen Balke (Greifswald/DE)

P2-30 Investigation of the regioselectivity of P45017α towards progesterone Lisa Morlock, Sascha Grobe, Uwe T. Bornscheuer (Greifswald/DE)

P2-31 Probing the general mechanistic and structural features of substrate selectivity in lipases and acyl transferases Henrique F. Carvalho, Jürgen Pleiss (Stuttgart/DE)

P2-32 Computational engineering of enzyme stability and activity Hein J. Wijma, Siewert-Jan Marrink, Dick B. Janssen (Groningen/NL)

P2-33 From experimental data to kinetic and molecular modelling – a workflow assisting enzyme application Gudrun Gygli, Valerio Ferrario, Patrick C. F. Buchholz Jürgen Pleiss (Stuttgart/DE)

P2-34 iSAR – a new approach for protein engineering and screening Frédéric Cadet, Nicolas Fontaine, Matthieu Ng Fuk Chong Rudy Pandjaitan (Paris/FR)

P2-35 Characterization and engineering of novel flavin dependent halogenases Mohamed Ismail, Christiane Widmann, Marcel Frese Thomas Patschkowski, Hartmut Niemann, Karsten Niehaus Norbert Sewald (Bielefeld/DE)

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P2-36 Dihydroxy-acid dehydratase – a crucial enzyme in biofuel production Sonya Tadrowski (Brisbane/AU), Jörg Carsten Volker Sieber (Straubing/DE), Gerhard Schenk Luke Guddat (Brisbane/AU)

P2-37 Unrevealing enzymatic mechanisms using X-ray crystallography at EMBL Hamburg Isabel Bento, Gleb Bourenkov, Johanna Hakanpää, Guillaume Pompidor Saravanan Panneerselvam, David von Stetten, Maria G. Alai Thomas R. Schneider (Hamburg/DE)

P2-38 Structural studies on the substrate and cofactor binding mode of FAD-dependent monooxygenases J. Kratky, R. H. Weiße (Leipzig/DE), T. Heine, D. Tischler (Freiberg/DE) N. Sträter (Leipzig/DE)

P2-39 The catalytic machinery of BBE-like proteins – a catalytic base and an oxyanion hole prime the substrate for hydride transfer to the flavin cofactor Julia Messenlehner, Marina Toplak, Sabine Pils, Silvia Wallner Bastian Daniel, Peter Macheroux (Graz/AT)

P2-40 Förster resonance energy transfer, a tool to investigate the interaction between structure and activity in enzymes Kim Ingenbosch, Kerstin Hoffmann-Jacobsen (Krefeld/DE)

P2-41 Profiling the substrate diversity of S-adenosyl methionine (SAM) synthesis by SalL for biocatalytic C-alkylation Iain McKean (Glasgow/GB), Joanna C. Sadler, Luke D. Humphreys Markus Schober (Stevenage/GB), Paul A. Hoskisson Glenn A. Burley (Glasgow/GB)

P2-42 Synthesis of secondary and tertiary chiral alcohols using artificial carboligases Xavier Garrabou, Duncan S. Macdonald, Donald Hilvert (Zürich/CH)

P2-43 Synthetic metabolic pathways for the assimilation of formate Simon Burgener, Luca Schulz (Marburg/DE) Arren Bar-Even (Potsdam-Golm/DE), Tobias J. Erb (Marburg/DE)

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Bioprocess engineering and downstream processing

P4-1 Development of an in situ-product crystallization (ISPC)-concept to shift the reaction equilibria of selected transaminase-catalyzed reactions Dennis Hülsewede (Rostock/DE), Philipp Süss Ulf Menyes (Greifswald/DE), Jan von Langermann (Rostock/DE)

P4-2 Rational strategy for nuclease immobilisation on synthetic resins Simona Serban, Alessandra Basso (Llantrisant/GB), Valerio Ferrario Juergen Pleiss (Stuttgart/DE), Benjamin Summers (Llantrisant/GB)

P4-3 Impact of yeast extract on amino acid de novo synthesis and glycosylation of recombinant proteins Jan Förster, Lars Blank (Aachen/DE), Katelijne Bekers (Hamburg/DE)

P4-4 Chiral amines synthesis and in-situ product recovery for process intensification for application in organic fine chemicals and pharmaceuticals Claudia Matassa (Mol/BE; Greifswald/DE) Matthias Höhne (Greifswald/DE), Dominic Ormerod Yamini Satyawali (Mol/BE)

P4-5 Improvement of bioreactor performance using immobilized lipase in supercritaical corbon dioxide for development of lipid modification process Masakazu Naya, Atsushi Shono (Tokyo/JP) Masanao Imai (Kanagawa-pref./JP)

P4-6 Development and scale-up of efficient biocatalytic oxidations using oxygen Jan Brummund, Catharina Kleist, Harrie Straatman, Martin Schürmann Monika Müller (Geleen/NL)

P4-7 In situ monitoring of the biocatalyzed (S)-naproxen synthesis with process raman spectroscopy Anne Stöbener, Tim Ramelow, Miriam Assmann Selin Kara (Hamburg/DE), Hanns Simon Eckhardt (Oberursel/DE) Andreas Liese (Hamburg/DE)

P4-8 Coupled two reactor-concept for an in situ-product crystallization in transaminase-catalyzed reactions Dennis Hülsewede, Jan-Niklas Dohm, Jan von Langermann (Rostock/DE)

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P4-9 Adsorbent-based downstream-processing of a decarboxylase-based synthesis of 2,6-dihydroxy-4-methylbenzoic acid Lars-Erik Meyer (Rostock/DE), Katharina Plasch, Silvia M. Glueck Kurt Faber (Graz/AT), Udo Kragl, Jan von Langermann (Rostock/DE)

P4-10 Reactor technology with additively manufactured packings Niclas Büscher (Hamburg/DE), Felix Jakob, Kristin Rübsam (Aachen/DE) Marcel Fassbender, Philipp Hergoss, Claas Spille, Gerrit A. Luinstra Claus Emmelmann (Hamburg/DE), Ulrich Schwaneberg (Aachen/DE) Michael Schlüter, Selin Kara, Andreas Liese (Hamburg/DE)

P4-11 Application of an immobilized biocatalyst to increase the performance of crystallization-based enantioseparation Thiane Carneiro, Katarzyna Wrzosek Andreas Seidel-Morgenstern (Magdeburg/DE)

P4-12 Construction of metal nanoparticles using phage display system and their application as catalysts and optical devises Mizuki Kuga, Miya Koike, Minoru Tanigawa, Tetsuo Umegaki Kosuke Sugawa (Tokyo/JP), Katsushi Nishimura (Chiba/JP)

P4-13 Development of multienzyme nanobiocatalysts for cascade reactions Arxontoula Giannakopoulou, Michaela Patila, Elena Gkantzou Alexandra V. Chatzikonstantinou, Angeliki Polydera (Ioannina/GR) Ioannis V. Pavlidis (Heraklion, Ioannina/GR) Haralambos Stamatis (Ioannina/GR)

P4-14 Scale-up of a novel aldolase approach to produce statin side chain API intermediate Melinda Fekete, Philipp Süss, Rainer Wardenga (Greifswald/DE)

P4-15 Design of enzymatic micro tubular reactor for enantio synthesis of (S)-ibuprofen Masakazu Naya, Yuri Ikazaki, Katsuto Otake, Atsushi Shono (Tokyo/JP)

P4-16 Oxidation of short chain alkanes by whole cell biocatalyst Frederic Perz, Gerrit Sluyter (Hamburg/DE), Susanne Leuchs Simone Sieberz, Bastian Grund (Marl/DE) Paul Bubenheim (Hamburg/DE), Oliver Thum (Marl/DE) Andreas Liese (Hamburg/DE)

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generAl informAtion

50


P4-17 Enzyme cascades for flavor synthesis Claudia Engelmann, Jens Johannsen, Georg Fieg, Andreas Liese Thomas Waluga, Paul Bubenheim (Hamburg/DE)

P4-18 Influence of dispersant Corexit EC9500A on crude oil biodegradation under high pressure conditions Juan Viamonte, Steffen Hackbusch, Nuttapol Noirungsee Paul Bubenheim, Rudolf Müller, Andreas Liese (Hamburg/DE)

P4-19 Space-resolved inline analytics for determination of enzyme deactivation in reactive distillation Marc-Andreas Christlieb, Steffen Kühn, Björn Wind, Joscha Kleber Anne Stöbener, Irina Smirnova, Andreas Liese (Hamburg/DE)

P4-20 Combination of enantioselective chromatography and racemization – model based process optimisation Isabel Harriehausen, Katarzyna Wrzosek Andreas Seidel-Morgenstern (Magdeburg/DE)

P4-21 Model-based process design for the synthesis of pharmaceutical ingredients with thiamin diphosphate-dependent enzymes Dominik Hertweck, Victor N. Emenike, René Schenkendorf Ulrike Krewer, Antje Spieß (Braunschweig/DE)

P4-22 Computational fluid dynamics as a tool for process development and optimization Fabian Freiberger, Johannes Möller, Ralf Pörtner (Hamburg/DE)

P4-23 Fed-Batch processes of Corynebacterium glutamicum controlled and optimized via the OLFO algorithm Philipp Levermann, Fabian Freiberger, Johannes Möller, Ralf Pörtner Jürgen Kuballa, Michael Schoop (Hamburg/DE) Volker Hass (Villingen-Schwenningen/DE)

P4-24 Comparison of fungal spore or mycelium inoculum for enzymes production by solid state fermentation Aurore Thorigné, Sophie Lefevre, Nancy Newton Sébastien Givry (Nogent sur Seine/FR)

51

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Sustainable industrial processes, biorefinery and bioeconomy

P5-1 Development of a chemo-enzymatic route for the synthesis of chiral vicinal amino alcohols-application for the synthesis of Ethambutol, an anti-tuberculosis drug Yudhisthir Mandal, K.K Balasubramanian, Anju Chadha (Tamil Nadu/IN)

P5-2 Bioelectrochemical NADPH regeneration using biocatalysis in redox hydrogel matrices Leonardo Castañeda Losada, Carolina Laverde Perdomo Michael Richter, Nicolas Plumeré (Straubing/DE)

P5-3 Lurgi process-based fatty alcohol synthesis via a chemoenzymatic reaction sequence Kim Schlipköter, Andreas Liese, Joscha Kleber Anne Stöbener (Hamburg/DE), Harald Gröger Tobias Betke (Bielefeld/DE)

P5-4 Biorefinery of Australian rock lobster shells (Jasus edwardsii) by microwave intensified enzymatic deproteinization and demineralization for production of multiple functional food ingredients Wei Zhang, Trung Nguyen (Adelaide/AU)

P5-5 Micropollutant degradation in enzymatic membrane bioreactor (EMBR) Faisal Hai, Muhammad Bilal Asif (Wollongong/AU)

P5-6 Biomimetic oxidation of organic compounds in the presence of manganese porphyrins bonded to the novel modified SBA-15 Sseed Rayati, Parinaz Nafarieh (Tehran/IR)

P5-7 Cultivation of enzyme secreting higher fungi on side streams of the food processing industries Miriam Große, Nina-Katharina Krahe, Eric Rottmann Ralf Günter Berger (Hannover/DE)

P5-8 A novel concept for a sustainable production of high value fatty aldehydes Jens Johannsen, Georg Fieg, Thomas Waluga (Hamburg/DE)

P5-9 Cultivation of Cutaneotrichosporon oleaginosus on marine microalgae hydrolysates for sustainable production of lipids Pariya Shaigani, Tobias Fuchs, Thomas Brück (München/DE)

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52


P5-10 Enhanced biocatalytic conversion strategies of renewables to tailor made glycolipid biosurfactants in deep eutectic solvents Jens Grüninger, Christoph Syldatk (Karlsruhe/DE)

P5-11 Synthetic Escherichia coli-Corynebacterium glutamicum consortia for L-lysine production from starch and sucrose Elvira Sgobba (Bielefeld/DE), Anna K. Stumpf (Bielefeld, Münster/DE) Marina Vortmann, Nina Jagmann, Martin Krehenbrink (Münster/DE) Mareike Dirks-Hofmeister (Ascheberg/DE), Bruno Moerschbacher Bodo Philipp (Münster/DE), Volker F. Wendisch (Bielefeld/DE)

P5-12 Integration of next generation biosurfactant production into biorefinery processes Stephan Thies, Karl-Erich Jaeger (Juelich/DE), Jochen Büchs (Aachen/DE) Georg Wandrey (Aachen, Juelich/DE)

P5-13 Engineered pichia pastoris for lactic acid production Jorge Lepikson-Neto, Nadiele T. M. Mello (Três Lagoas/BR) Kelly C. L. Mulder, André Morais Nicola, Lucas S. Carvalho Gisele S. Menino, Eduardo Mulinari (Brasília/BR) Carolina M. M. Andrade (Três Lagoas/BR), Nádia S. Parachin (Brasília/BR)

P5-14 Efficient genetically engineering Kluyveromyces lactis yeast to produce hyaluronic acid Nadiele Melo, Kelly C. L. Mulder (Brasília/BR) Giselle Carvalho (Três Lagoas/BR), André Nicola, Lucas Carvalho Gisele S. Menino, Eduardo Mulinari (Brasília/BR) Carolina Machado C. Andrade (Três Lagoas/BR) Nádia S. Parachin (Brasília/BR)

P5-15 Genetic modifications in Clostridium acetobutylicum for improvement of the production of alcohols Myrna Barbosa Gomes, Fernando A. G. Torres (Brasília/BR) Luiz André F. S. Schlittler (Rio de Janeiro/BR), Luiza P. C. Lopes Giselle Carvalho, Carolina Machado C. Andrade (Três Lagoas/BR)

P5-16 Textiles as modern substrates for lipase immobilization and its applications Dennis Wunschik, Kim Ingenbosch, Katharina Courth, Klaus Opwis Jochen Gutmann, Kerstin Hoffmann-Jacobsen (Krefeld/DE)

P5-17 Biotransformation of rice and sunflower side-streams by monosporic strains of Pleurotus sapidusin a biorefinery approach Pablo Postemsky, Maximiliano Bidegain (Bahia Blanca/AR) Marcelo Fernandez-Lahore, Alejandra Omarini (Bremen/DE)

Nestlé Research is based in Lausanne, Switzerland and employs approximately 800 people. It consists of three major research institutes: Health Sciences, Material Sciences and Food Safety & Analytical Sciences. Nestlé Research combines fundamental science at the highest level, high-end analytical platforms leveraged by all research teams, and strong prototyping capabilities to accelerate the translation of science into innovation. Nestlé Research published around 1,000 scientifi c publications in peer review journals over the last fi ve years, and fi les about 80 patents every year. Nestlé Research collaborates with approximately 100 universities or research institutes around the world. Learn more about Nestlé Research at www.nestle.com/randd

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generAl informAtion



Nestlé Research is based in Lausanne, Switzerland and employs approximately 800 people. It consists of three major research institutes: Health Sciences, Material Sciences and Food Safety & Analytical Sciences. Nestlé Research combines fundamental science at the highest level, high-end analytical platforms leveraged by all research teams, and strong prototyping capabilities to accelerate the translation of science into innovation. Nestlé Research published around 1,000 scientifi c publications in peer review journals over the last fi ve years, and fi les about 80 patents every year. Nestlé Research collaborates with approximately 100 universities or research institutes around the world. Learn more about Nestlé Research at www.nestle.com/randd

54

sponsors, exHibitors And mediA cooperAtions

Silver sponsorsPurolite GmbH (Wales/GB)

Quantumzyme LLP (Bengaluru/IN)

Bronze sponsorsAmano Enzyme Inc. (Oxfordshire/GB)

c-LEcta GmbH (Leipzig/DE)

Nestlé Research (Vevey/CH)

Further sponsorsDeutsche Forschungsgemeinschaft e. V. (Bonn/DE)

MAXIMATOR GmbH (Nordhausen/DE)

Megazyme (Wicklow/IR)

Merelex Corporation DBA American Elements (Los Angeles, CA/US)

Exhibitors Booth numberAmano Enzyme Inc. (Oxfordshire/GB) 4

Bio-Prodict BV (Nijmegen/NL) 3

Purolite GmbH (Wales/GB) 1

Quantumzyme LLP (Bengaluru/IN) 2

SpinChem AB (Umea/SE) 5

Media cooperationsWiley-VCH Verlag GmbH & Co. KGaA (Weinheim/DE)“Biotechnology Journal”

BIOCOM AG (Berlin/DE)“European Biotechnologie Magazine”

State at printing


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sociAl progrAmme

Get togetherBe our guest and enjoy the evening with food and drinks. Meet your colleagues, friends and industrial partners in a relaxed atmosphere.

Date Sunday, 26 AugustTime 19:00Location TUHH l Building l l Cafeteria/Mensa © Rawpixel.com/Fotolia

Congress dinnerShip ahoi!

Through Hamburg harbour according to your wishes and updated every day. For example, from the Finkenwerder along the St. Pauli piers down the Elbe towards Oevelgönne (museum port) Teufelsbrück, along the picturesque banks of the Elbe to Blankenese, straight on to the Kohlbrandbrücke in the container port back up the Elbe to the Blohm & Voss docks past the music tent, past the City sport boat harbour (fire ship – now a restaurant) with a

view of the Michel and the city silhouette, to our Elbphilhar-monie and the new Hafencity past the Überseebrücke (Cap San Diego museum ship).

Date Tuesday, 28 AugustDeparture 17:00 (from the venue)Time 17:00–22:30Location the boat Louisiana StarTransfer A shuttle will pick you up from the congress venue and take you directly to the departure point. After the evening you have the opportunity to go back by © Elbreederei GmbH & Co. KG bus.

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Biocat award ceremonySince 2004 the biocat Award is given to outstanding individuals to acknowledge their achievements in the field of biocatalysis in the course of the International Congress on Biocatalysis. This prize, which is awarded in the categories “Science”, “Life-time achievement” and “Industry” is among the most prestigious awards in the field of biotechnology.The award ceremony will take place on Tuesday, 28 August on the boat Louisiana Star during the congress dinner.

Catering Catering will be served during the official coffee and lunch breaks and is covered by the registration fee.

Lunch will take place in the cafeteria. You will get vouchers for lunch at the check-in. These vouchers have a value of 7.50 EUR. Usually, this value is enough for a full meal. However, if you still get over the value, then you have to pay the difference cash.

Certificate of attendance Certificates of attendance will be available on the last day of the congress at the check-in desk.

CloakroomThe coat and luggage room at the congress is free and unsecure.

GTC

General terms and conditionsPlease find our general terms and conditions at www.biocat-conference.de.

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generAl informAtion

Name badgePlease wear your name badge during all congress events, including the networking activities.Admission to scientific sessions and to the industrial exhibition is restricted to par-ticipants wearing their badge. Participants will receive their name badge when collecting their congress documents at the check-in desk.

Opening hours check-in and industrial exhibitionSunday Monday Tuesday Wednesday Thursday15:00–19:00 08:00–18:30 08:30–17:00 09:00–18:00 08:30–14:00

Publication of abstractsAll abstracts will be published on a USB flash drive which can be collected at the check-in.

WIFI accessWIFI is available for free throughout the whole congress area.

SSID BC2018Password N3wBYVyN


generAl tips for AutHors And presenters

Presentation uploadThe Media check-in for uploading your presentation is located in lecture hall. For submission, please use a USB flash drive, CD or DVD disc that is not protected by any software. Profes-sional staff and equipment will be available for you to arrange and preview your presentation.

Submitting your presentation/technical informationThe presentation should be prepared as PDF, MS Office PowerPoint for Windows or key for Macintosh DVD in format 16:9. A presentation notebook with a PDF reader and MS Office PowerPoint 2016 will be provided. The use of personal notebooks is possible upon agreement. However, it may interrupt the flow of the programme in the lecture hall. Please provide an adapter for VGA if necessary. To guarantee a smooth running programme please upload your presentation on time – at least 2 hours before your presentation starts.

Time allotmentPlease prepare your presentation for the allotted amount of time. Chairs may interrupt, should you overrun your time limit.

Poster sessionYou can find your permanent programme ID in the programme part of this book. Every poster wall is marked with a permanent programme ID, so that authors can find their place within the poster exhibition. All poster authors are asked to hang up their posters on Sunday, 26 August from 16:00 and remove them on Wednesday, 29 August until 17:30. Mounting materials will be provided on each poster board. Please do not use any other type of pins than those provided.

Poster session 1 – Topic 3 l 27 August, 14:30–16:30Enzymatic and whole cell biotransformations

Poster session 2 – Topic 1 l 28 August, 14:00–15:30Enzyme discovery, production and application

Poster session 3 – Topic 2+4+5 l 29 August, 14:40–16:40Structure-function analysis and enzyme designBioprocess engineering and downstream processingSustainable industrial processes, biorefinery and bioeconomy

Lightning talkPlease note that additional to your poster you have the possibility for a talk (only 3 minutes). Please prepare 3 slides for it.

Poster awardsThe best 10 oral poster presentations will be awarded a prize money of 100 EUR. The award ceremony will be held on Thursday, 30 August during the closing remarks.

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index of AutHors And cHAirs

aAalbers, F. S. 30Abdelraheem, E. 42Adams, J. 8, 24Agrillo, B. 41Aguilar, F. 28Alai, M. G. 47Alcalde, M. 11, 26, 28Alcasabas, A. 14Alghamdi, A. 39Allen, M. D. 14Al-Shameri, A. 10, 26Andrade, C. M. M. 52André, I. 24Ansorge-Schumacher, M. 17 36, 39Antranikian, G. 8, 16, 35, 41Armendáriz Ruiz, M. A. 41Arnold, F. 45Arold, S. T. 20, 43Asano, Y. 11, 15, 27, 35Asif, M. B. 22, 51Assil Companioni, L. 29Assmann, M. 21, 48Atomi, H. 9, 14Austin, H. P. 14Avendaño, R. 34Aviles, J. 10

bBabkova, P. 16, 35Baek, J.-M. 38Balasubramanian, K. 21, 51Balestrieri, M. 41Balke, K. 46Balogh, G. T. 33Balogh-Weiser, D. 33Bandow, J. 40Barakat, K. 34Barbasz, J. 16, 36Barbosa Gomes, M. 52Bar-Even, A. 47Barková, K. 32Basso, A. 21, 48Batyrova, K. 38Bäumgen, M. 37Beckham, G. 14, 17Bedini, E. 18Begerow, D. 40Bekers, K. 21, 48Belgara, A. 32Beloqui, A. 20, 43

Benítez-Mateos, A. I. 14Bento, C. F. D. 29Bento, I. 47Berenguer, J. 44, 45Bergantino, E. 16, 36Berger, R. G. 9, 51Berkhan, G. 32Berlicki, L. 38Bernhardt, R. 20, 30, 43Bertinetti, D. 44Betke, T. 22, 51Beuel, T. 30Beutel, S. 12, 15, 28, 35, 36Beyer, N. 34Bica, K. 34Bidegain, M. 52Bidmanova, S. 16, 35Bielecki, S. 15, 35Bisagni, S. 14Bisterfeld, C. 37, 42Bitzenhofer, N. 29Biundo, A. 32Blamey, J. 10Blank, L. 21, 48Bloess, S. 30, 39Bloh, J. Z. 11, 26Bocola, M. 24Boersma, Y. 45Bojarová, P. 24Boldt, A. 39Bollinger, A. 39Bollmann, T. 31Bolten, C. 24Bong, Y. K. 24Bongaerts, J. 31Bönisch, F. 22Borchert, M. S. 17Borlinghaus, N. 10, 26Bormann, S. 40Bornadel, A. 14Börner, T. 14Bornscheuer, U. T. 9, 11, 23 27, 29, 32, 34, 37, 45, 46Borys, F. 32Bosch, S. 45, 46Böttcher, D. 32Bourenkov, G. 47Brämer, C. 12Bramski, J. 37Braß, H. U. C. 11, 27Brezovsky, J. 16, 35

Brodzka, A. 31Brown, G. 38Brück, T. 51Brummund, J. 21, 48Brundiek, H. 11, 23, 27Bubenheim, P. 28, 30, 31 33, 49, 50Buchholz, P. C. F. 46Büchs, J. 52Büchsenschütz, H. C. 28Bujons, J. 10, 26Buller, R. 42Burda, M. 38Burek, B. O. 11, 26Burgener, S. 47Burkhardt, C. 41Burley, G. A. 47Busch, F. 12Busch, P. 16, 35, 41Büscher, N. 49Buß, O. 23Byung-Gee, K. 9, 14

cCadet, F. 46Cairns, R. 29Calderini, E. 24Camacho Ruíz, R. M. 41Campos Rodríguez, J. 16, 36Carneiro, T. 49Carsten, J. 47Carvalho, G. 52Carvalho, H. F. 46Carvalho, L. 52Carvalho, L. S. 52Castañeda Losada, L. 21, 51Castellanos, J. R. G. 37Castiglione, K. 22Cendron, L. 16, 36Chadha, A. 21, 51Chaloupkova, R. 16, 35Charnock, S. J. 38Chatzikonstantinou, A. V. 49Chaudhari, B. 30Chavarría, M. 34Chaves, N. 34Chen, H. 24Chen, L. 42Chen, Q. 41Chen, X. 41Chow, J. 40



Christlieb, M.-A. 50Chytil, P. 24Clapés, P. 11, 27, 29, 45Classen, T. 11, 12, 27, 37Cobucci-Ponzano, B. 18Cocca, E. 41Contente, M. L. 14Cook, D. J. 38Corsaro. M. M. 18Coscolín, C. 39Courth, K. 52Cruiming, G. 30Cruz Jr., A. 38, 39

dDairi, T. 9Dalal, D. 30Dalal, K. 30Damborsky, J. 16, 35Daniel, B. 16, 36, 47Daniel, L. 16, 35Danso, D. 40Das, D. 45Daußmann, T. 24Davis, R. 39Decembrino, D. 39del Pozo, M. L. 45Dennig, A. 33Desmet, T. 14, 18Dias Gomes, M. 37Dick, M. 37Dierks, T. 30Dijkhuizen, L. 14Dijkman, W. P. 46Dippe, M. 12, 28Dirks-Hofmeister, M. 52Dischert, W. 20Dohm, J.-N. 48Dominguez de Maria, P. 15Dominguez, B. 14Donohoe, B. S. 14Đordić, A. 33Drachuk, I. 10Drepper, T. 11, 27, 29Drewniok, C. 32Duboux, S. 14Durrell, K. 9Dvorak, P. 16, 35

eEckhardt, H. S. 21, 48

Eggink, G. 10, 26Eibinger, M. 28Eijsink, V. G. H. 17Eikmanns, B. 32Ekramzadeh, K. 36Elling, L. 24Ellingsen, T. E. 17Emenike, V. N. 50Emmelmann, C. 49Engel, J. 30Engel, U. 39Engelmann, C. 28, 50Enoki, J. 22, 45Eppinger, J. 20, 43Erb, T. J. 47Espina, G. 10Etrych, T. 24Ewing, T. A. 16, 36

fFaber, K. 33, 49Farkas, E. 34Farnberger, J. 37Fassbender, M. 49Fekete, M. 49Feng, J. 41Fernandez-Fuentes, N. 17Fernández-Fueyo, E. 11, 26, 28Fernandez-Lahore, M. 52Ferrario, V. 19, 21, 43, 46, 48Ferrer, M. 39Fieg, G. 28, 50, 51Findrik Blažević, Z. 11, 27, 29Finnigan, J. D. 38Fischer von Mollard, G. 30, 39Fischer, J. 20, 43Fisher, C. 14Flick, R. 38Flitsch, S. 37Fogelström, L. 32Földi, A. 34Fong, W. P. 39Fontaine, N. 46Förster, J. 21, 48Fraaije, M. W. 9, 12, 16, 18, 27 30, 33, 34, 36, 42, 46Franden, M. A. 14Freese, M. 32Freiberger, F. 50Frese, M. 42, 46Friehs, K. 39

Fu, H. 22, 30Fuchs, A. 32Fuchs, T. 51Fuentes, P. 34Furukawa, M. 15, 35Fusco, C. 41

gGacs, J. 11, 26Gallagher, J. 17Gandomkar, S. 33Gangoit, J. 14Gao, X. 10, 26García, J. I. 28Garrabou, X. 47Gärtner, P. 34Gasparavičiūtė, R. 37, 38Geier, M. 34Genz, M. 45Gerlach, T. 29Giannakopoulou, A. 49Gibas, N. 40Giesler, L. 9Gillam, E. M. J. 38Girhard, M. 44Givry, S. 50Gkantzou, E. 49Glanowski, M. 42Glieder, A. 18, 34Glueck, S. M. 49Glüsen, B. 31Godase, V. 15, 35Gogliettino, M. 41Gómez de Santos, P. 28Goodson, M. 10Goto, M. 45Grajales Hernández, D. A. 41Grammel, H. 37Grande, P. 15Greif, D. 32Grevenfors, Y. 32Grey, C. 12Grigoriou, S. 31Grimm, C. 37Grobe, S. 46Gröger, H. 22, 31, 51Groll, M. 20, 43Grosch, J.-H. 12, 27Gross Belduma, S. 28Große, M. 51Grund, B. 49

62

Grüninger, J. 52Gruß, H. 32Guddat, L. 47Guo, C. 34Gutmann, J. 52Guzik, M. 16, 36Gygli, G. 16, 36, 46

HHabib, M. 12, 27Hackbusch, S. 28, 33, 50Hahn, F. 32Hai, F. 22, 51Hakanpää, J. 47Håkansson, M. 18Hall, M. 16, 33, 36Hamano, Y. 18Hammer, S. 45Hammerer, L. 33, 44Hanefeld, U. 11, 27, 42Hanenberg, H. 44Hannemann, F. 30Harbaugh, S. 10Haridas, M. 42Harms, V. 28Harnisch, F. 12, 27Harriehausen, I. 12, 50Harrison, S. 34Hartog, A. 33Hartwig, S. 28Hartz, P. 30Hass, V. 50Hauer, B. 19Hayes, M. 24He, B. 11, 26Hecht, K. 42Heck, C. A. 38Hehemann, J.-H. 37Heidinger, P. 29Heine, T. 10, 26Heinrich, J. 32Herberg, F. W. 40, 44Hergoss, P. 49Hermann, S. 12, 28Hernández Herrera, N. 16, 36Hernández, K. 10, 26, 45Hertweck, D. 50Heß, M. C. 39Hibi, M. 11, 27Hidalgo, A. 44, 45, 46Hiessl, R. 31

Hilberath, T. 39Hilgers, F. 29Hill, P. 31Hilvert, D. 47Hirato, Y. 45Höcker, B. 44Hoffmann-Jacobsen, K. 47, 52Hofmann, S. 10, 26Höhne, M. 21, 45, 48Hollmann, F. 11, 19, 26, 28, 41Hollmann, T. 32Holtmann, D. 11, 14, 26, 40Honda Malca, S. 19Hoog Antink, M. 15, 35Hornyánszky, G. 34Horst, A. E. W. 40Hoskisson, P. A. 47Hronská, H. 33Huang, L. 30Huang, S. 45Huang, W. 38Huijbers, M. 19Hülsewede, D. 20, 48Humphreys, L. D. 47Hunter, D. J. B. 38Husarcikova, J. 20, 43Huszcza, E. 33, 34Hutter, M. 20, 43

iIkazaki, Y. 49Ilhan, S. 20, 43Imai, M. 21, 48Ingenbosch, K. 47, 52Ion, S. 12, 27Ionescu, I. 20, 43Ismail, M. 46Isobe, K. 11, 27Itabashi, K. 40Iura, T. 25Iwano, Y. 25

JJablonski, M. 31Jaeger, K.-E. 11, 27, 39, 52Jagmann, N. 52Jakob, F. 49Jandt, U. 20, 43Janssen, D. B. 20, 43, 46Janus, M. 40Jaskolski, M. 44

Jayakody, L. 14Jędrzejczak-Krzepkowska, M. 15, 35Jeon, H. 33, 34Jiménez, J. I. 34Joachimiak, A. 38Joglar, J. 10, 26Johannsen, J. 28, 50, 51Johnson, C. W. 14Joo, S.-Y. 14Jóźwik, I. 20, 43Juric, C. 40Jurkaš, V. 29

KKailing, L. L. 44Kalinowski, J. 42Kamai, S. 11, 27Kanai, T. 9Kanno, Y. 45Kapesova, J. 9Kara, S. 15, 21, 30, 48, 49Kasprowski, H. 45Katha, u. 32Kato, C. 40Kawabata, H. 25Kawakami, N. 15, 35Kearns, F. 14Kelefiotis-Stratidakis, P. 40Kelley-Loghnane, N. 10Kemler, M. 40Kempa, A. 29Khatri, Y. 20, 43Khusnutdinova, A. 38Kim, B.-G. 14Kinfu, B. M. 40King, J. 31Kipp, C. 31Kirby-McCullough, B. 42Kirschning, A. 28Kleber, J. 22, 31, 50, 51Klein, A. S. 11, 27Kleist, C. 21, 48Klimant, I. 44Klinkenberg, G. 17Klippel, B. 16, 35Klose, H. 15Kohl, A. 14Koike, M. 39, 40, 45, 49König, L. 30Koopmeiners, J. 24, 46




Kostka, J. 28Koszelewski, D. 30, 32Kotik, M. 9Kotsiopoulos, A. 34Kourist, R. 12, 22, 28 29, 44, 45Kragl, U. 49Krahe, N.-K. 51Kranen, E. 11, 17, 26Kranz-Finger, S. 29Kratasyuk, V. 44Kratky, J. 47Krehenbrink, M. 52Křen, V. 9, 24Krewer, U. 50Krishna, N. 19Kroutil, W. 16, 29, 33 36, 37, 44Krüger, A. 41Kuballa, J. 28, 32, 50Kubik, G. 45Kudanga, T. 9, 32Kuga, M. 49Kühn, S. 50Kuklinski, A. 39Kulcinskaja, E. 31Kulkarni, N. 19, 45Kumar, A. 45Kumar, H. 33Kumar, R. P. 19Kumru, C. 12, 27Kunze, C. 11, 26Kuska, J. 39Kustosz, J. 45Kutanovas, S. 38Kwiatos, N. 15, 35

lLaaf, D. 24Lacono, R. 18Lamothe, L. 14Lauterbach, L. 10, 19, 26Laverde Perdomo, C. 21, 51Le Roes-Hill, M. 9, 32, 42Leal-Duaso, A. 28Lechner, H. 44Lee, M. 20, 43Lefevre, S. 50Le-Huu, P. 39Leitner, W. 15Lenger, K. 38

Lenz, O. 19Lepikson-Neto, J. 52Leuchs, S. 49Levermann, P. 50Levy, C. 37Lewin, A. S. 17Liese, A. 10, 19, 21, 22, 24, 28 30, 31, 33, 48, 49, 50, 51Lindeque, R. 37Linke, D. 9Litzenburger, M. 20, 43Liu, M. 20, 43Loeschcke, A. 11, 27Lohmann, C. 37, 39Lonsdale, T. 19Lopes, L. P. 52López-Gallego, F. 14, 28Lou, W. 34Luinstra, G. A. 49Lypetska (Fesko), K. 33

mMa, C. 20Maas, M. 15, 35Maas, R. 11, 17, 26Macdonald, D. S. 47Machado C. Andrade, C. 52Macheroux, P. 16, 36, 47Mack, M. 15, 35Mähler, C. 22Mahour, R. 29Malmström, E. 32Mandal, Y. 21, 51Mangas-Sanchez, J. 38Manszewski, T. 44Manuel Guisán Seijas, J. 38, 39Marín, R. 10, 26Markosova, K. 9Marques Porto, L. 39Marrink, S.-J. 46Marshall, J. R. 38Martin, C. 46Matassa, C. 21, 48Mate, D. M. 44Mateos Díaz, J. C. 41Mathew, S. 33Matsui, D. 15, 35Matthes, S. 30, 31Maurelli, L. 18Mayoral, J. A. 28Mayr, J. 12, 27

McCall, K. 17McGeehan, J. E. 14Mchunu, N. 32, 40McKean, I. 47Medici, R. 42Melis, R. 18Mello, N. T. M. 52Melo, N. 52Menino, G. S. 52Menyes, U. 20, 48Meškienė, R. 38Meškys, R. 37, 38Messenlehner, J. 47Meyer, L.-E. 49Meyer-Heydecke, N. 41Michalíková, S. 33Michel, G. 37Mihovilovic, M. 34Miki, S. 11, 27Milczarek, M. 34Mindt, M. 32Minges, H. 45Mirino, S. 41Miyake, J. 40Miyake, R. 25Miyamoto, K. 15, 22, 35Miyauchi, Y. 45Moerschbacher, B. 52Molinnus, D. 31Molla, G. 18Möller, J. 50Montenegro, R. 34Montgomery, S. L. 38Moracci, M. 12, 18Morais Nicola, A. 52Mora-Villalobos, J. A. 41Morlock, L. 46Motta, P. 18Motterle, R. 16, 36Mousa, M. 32Mthethwa, K. 30Mucha, A. 38Mügge, C. 45Mulder, K. C. L. 52Mulinari, E. 52Müller, C. 20, 43Müller, H. 46Müller, M. 21, 48Müller, R. 33, 50Müller, S. 31Muschallik, L. 31

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Musengi, A. 9Mutti, F. G. 11, 26

nNafarieh, P. 51Nagy, F. 33Nagy, J. 33Nakano, S. 15, 35Naya, M. 21, 48, 49Nemadziva, B. 32Nestl, B. 9, 10, 19, 26Neubauer, P. 42Newton, N. 50Ng Fuk Chong, M. 46Nguyen, G.-S. 17Nguyen, Q.-T. 33Nguyen, T. 22, 51Ni, Y. 11, 26Nicholson, J. 24Nicola, A. 52Nidetzky, B. 28Niehaus, K. 46Niemann, H. 46Nishimura, K. 40, 45, 49Nocek, B. 38Noirungsee, N. 28, 33, 50Nolte, J. 29

oOberhauser, C. 28Oberleitner, N. 34O‘Connor, K. 39Oh, D.-K. 32Ohde, D. 30, 31Oki, K. 25Oláh, M. 34Omarini, A. 52Opperman, D. 30Opwis, K. 52O‘Reilly, E. 29, 31, 39Ormerod, D. 21, 48Oroz-Guinea, I. 11, 23, 27Ostaszewski, R. 30, 31, 32Oszajca, M. 16, 36Otake, K. 49Otter, R. 31Ou, G. 11, 26Ovalle Maqueo, A. 46

PPaizs, C. 34

Palmieri, G. 41Pandjaitan, R. 46Panneerselvam, S. 47Papo, N. 20, 43Paprocki, D. 30Parachin, N. S. 52Paradisi, F. 14Paris, J. 18Park, B.-G. 14Parmeggiani, F. 45Parvulescu, V. 12, 27Patila, M. 49Patschkowski, T. 46Paul de Waal, P. 43Paul, C. E. 44Pavlidis, I. V. 40, 44, 45, 49Pecyna, M. J. 32Pentjuss, A. 40Pereira Arce, D. 16, 36Pérez-García, P. 40Perz, F. 49Pessela C. João, B. 38, 39Peters, A. 41Petkevičius, V. 37Petraskova, L. 9Petrillo, G. 46Petschacher, B. 28Philipp, B. 52Pickl, M. 33Pietruszka, J. 11, 12, 24, 27, 37Pils, S. 16, 36, 47Pinto-Tomás, A. 41Pires, E. 28Pirillo, V. 18Plasch, K. 49Plass, C. 31Pleiss, J. 18, 19, 43, 46Plumeré, N. 21, 51Poelarends, G. J. 22Pohl, M. 31Pollegioni, L. 18Polydera, A. 49Pompidor, G. 47Popłoński, J. 33, 34Poppe, L. 33, 34Porras-Reyes, L. A. 41Porter, J. 37Pörtner, R. 50Poschenrieder, S. 29Postemsky, P. 52Pöttgen, L.-A. 29

Poznansky, B. 24Prechoux, A. 37Prins, A. 9, 42Probst, M. 11, 26Prokop, Z. 16, 35Pronk, J. 20, 43Pushpanath, A. 14

QQuesada Carrillo, E. 16, 36Quitterer, F. 20, 43

rRaauf, M. 39Rabausch, U. 22Rabe, K. 18Radhakrishnan, A. 20, 43Radhakrishnan, K. 30Ramelow, T. 21, 48Rathsack, P. 10, 26Ravikumar, A. 15, 35Rayati, S. 51Rebros, M. 9Reddy, U. 28Reetz, M. T. 8Reeve, H. 24Reichl, U. 29Reisky, L. 37Renirie, R. 11, 26Renn, D. 20, 43Ressmann, A. 31, 34Rettie, A. E. 44Rexer, T. F. T. 29Reznicencu, S. 12, 27Richter, M. 21, 51Ricklefs, E. 29Rickmers, B. 10Ringle, M. 20, 43Risse, J. M. 32, 39Rivera, N. R. 44Robb, C. 37Robescu, M. S. 16, 36Röbisch, P. 32Rodríguez González, J. A. 41Rodriguez, N. V. 17Rodriguez-Abetxuko, A. 20, 43Roellecke, K. 44Roggenbuck, M. 17Romero, E. 16, 36Rorrer, N. A. 14Rosa, L. F. 12, 27



Rosenberg, M. 33Rosini, E. 18Rossi, M. 22, 41Rother, D. 11, 26, 29Rottmann, E. 51Rowbotham, J. 24Rozeboom, H. 20, 43Rübsam, K. 49Rudat, J. 23Rudroff, F. 31, 34Rueping, M. A. 20, 43Ruprecht, C. 22Ruszkowski, M. 38Ryan, J. 39

sSabatini, S. 37Sabin, J. 18Sadler, J. C. 47Saifuddin, M. 30Sánchez, Es. 45Sánchez, Et. 34Sandoval Barrantes, M. 16, 36Sasano, H. 25Sato, T. 9Sato, Y. 19Satyawali, Y. 21, 48Savinelli, A. 18Sayar, N. A. 17, 36, 40Schade, Y. 31Schäfers, C. 16, 35, 41Schallmey, A. 20, 24, 38 43, 44, 46Schelch, S. 28Schell, E. 17, 36Schenk, G. 47Schenkendorf, R. 50Scheper, T. 12, 28, 36Schlipköter, K. 22, 51Schlittler, L. A. 52Schlüter, M. 30, 31, 49Schmidt, S. 28, 29, 44Schneider, T. R. 47Schober, M. 15, 47Scholl, C. 34Scholtissek, A. 10, 26Schöning, M. J. 31Schoop, M. 50Schörken, U. 29, 31Schrepfer, P. 44Schrittwieser, J. H. 16, 36

Schröder, C. 41Schultes, F. 28Schulz, K. 9Schulz, L. 47Schürmann, M. 12, 21, 48Schurr, U. 15Schuster, C. 32Schwab, H. 18, 29Schwaneberg, U. 40, 49Schweder, T. 37Schweiger, A. 45Schwendenwein, D. 31Sebestova, E. 16, 35Seidel, K. 28Seidel-Morgenstern, A. 12 49, 50Selmer, T. 31Seo, M.-J. 32Serban, S. 21, 48Sewald, N. 32, 42, 46Sewczyk, T. 15, 35Sgobba, E. 52Shaigani, P. 51Shichida, S. 11, 27Shin, K.-C. 32Shono, A. 21, 48, 49Shreenivasan, A. 19Sieber, V. 47Sieberz, S. 49Siegel, L. 10, 26Siegert, P. 31Sievers, S. 11, 27Slabu, I. 14Sletta, H. 17Sluyter, G. 49Smirnova, I. 50Sofińska, K. 16, 36Solano Campos, F. 16, 36Solarczek, J. 44Song, H. 44Sora, C. 12, 27Sordon, S. 33, 34Sperlich, J. 29Spiess, A. C. 12, 27Spille, C. 49Srinivasamurthy, V. S. T. 32Sroczyk, M. 16, 36Stachowicz, M. 34Stalidzans, E. 40Stamatis, H. 49Stamm, A. 32

Stankevičiūtė, J. 37Steiner, K. 18Stepankova, V. 16, 35Stingl, J. 34Stöbener, A. 21, 22, 48, 50, 51Straatman, H. 21, 48Sträter, N. 47Strauss, E. 18Strazzulli, A. 18Streit, W. R. 22, 40Strohmaier, S. J. 38Stumpf, A. K. 52Sugawa, K. 49Sukovataya, I. 44Suleiman, M. 16, 35Summers, B. 21, 48Sun, X. 28Süss, P. 20, 48, 49Sutormin, O. 44Švarc, A. 11, 27, 29Swart, S. 34Syedd León, R. 16, 36Syldatk, C. 52Syrén, P.-O. 32Szaleniec, M. 16, 36, 42Szilágyi, A. 33Szokol, B. 33

tTabari, D. 34Tadrowski, S. 47Takur, K. 19Tamayo-Castillo, G. 41Tang, Q. 45Tang, W. 30Tanigawa, M. 39, 40, 45, 49Tauraitė, D. 38Tavanti, M. 37Telzerow, A. 18Tepper, P. G. 22Terasaka, K. 30, 31Thies, S. 39, 52Thomas, B. 30, 31Thompson, L. 24Thompson, M. 17Thorigné, A. 50Thum, O. 49Thunnissen, A. 20, 43Tieves, F. 28, 41Tischler, D. 10, 26Tokuhisa, M. 40, 45

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Toplak, M. 47Torres, F. A. G. 52Trajkovic, M. 12, 27, 33Trapp, C. 32Tronina, T. 33, 34Trzepizur, D. 31Tsang, W. K. P. 39Tshililo, N. O. 18Tudorache, M. 12, 27Turner, N. J. 38

uUkiya, M. 45Umegaki, T. 49Ungerböck, B. 44Urbelienė, N. 38Urlacher, V. B. 29, 39Usadel, B. 15Uson, I. 46

vVafeiadi, C. 14Vaitekūnas, J. 37van Berkel, W. J. 36van Leeuwen, S. 14van Nuland, Y. 10, 26van Schie, M. 11, 26Vanacek, P. 16, 35Vasić-Rački, Đ. 11, 27, 29Vega Rodríguez, A. D. 41Velasco-Lozano, S. 28Venkataraju, S. 19Verhoeven, M. 20, 43Viamonte, J. 28, 33, 50Vidimce, V. 29Vieto, S. 34Villegas-Peñaranda, L. R. 16 36Vincent, K. 24Vinekar, R. 19Vogel, A. 25Vogel, M. 34Vollstedt, C. 40von Langermann, J. 20, 48, 49von Stetten, D. 47

Vorgias, C. E. 18Vortmann, M. 52Voß, H. 20, 38, 43Voss, M. 29, 45Vrsalović Presečki, A. 11, 27 29

wWagner, L. 32Wagner, T. 31Wallner, S. 47Walter, F. 31Waluga, T. 28, 50, 51Wandrey, G. 52Wardenga, R. 49Watkins, E. 45Wei, R. 10Weigel, B. 12, 28Weiße, R. H. 47Wendisch, V. F. 52Wentzel, A. 17Wessjohann, L. 12, 28Weuster-Botz, D. 22Weusthuis, R. 10, 26, 36Wever, R. 11, 26, 33Wibberg, D. 42Widmann, C. 46Wied, P. 44Wiegert, T. 32Wiek, C. 44Wietrzyk, J. 34Wijma, H. J. 46Wilk, M. 31Wind, B. 50Winiarska, A. 42Winkler, C. K. 29, 44Winkler, M. 31Wohlgemuth, S. 29Wojcik, M. 45Wójcik, P. 16, 36, 42Wojtkiewicz, A. M. 16, 36Woodcock, H. L. 14Woodley, J. 37Woodlock, D. 14Wrzosek, K. 12, 49, 50

Wu, C. 10, 26Wu, Q. 19, 41Wunschik, D. 52

xXie, Z. M. 39Xing, X. 19, 41Xu, Z. 19

yYadav, D. 32Yakunin, A. 38Yao, P. 19Yasuda, Y. 39Yayci, A. 40Yeung, H. T. C. 39Yilmaz Sercinoglu, Z. 17, 36, 40Yoo, H.-W. 14Yoon, H. 14Yoon, S. 34Younes, S. 41Yu, S. 19Yun, H. 33, 34

ZZastawny, O. 16, 36Zeng, A.-P. 20, 22Zerhusen, C. 31Zhan, Y. 31Zhang, J. 22, 30Zhang, We. 22, 51Zhang, Wu. 11, 19, 26Zhang, Y. 20, 44Zhao, X. 24Zheng, H. 44Zhu, D. 19, 41Zhu, Y. 18Zimmermann, W. 10Zorn, K. 11, 23, 27Zühlke, M.-K. 37Zukic, E. 34Zúñiga-Chaves, I. 41

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