a little nasal knowledge: tyler s. lorig, ph.d. washington and lee university the science of scent
TRANSCRIPT
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A Little Nasal Knowledge:
Tyler S. Lorig, Ph.D.
WASHINGTON AND LEE UNIVERSITY
The Scienceof Scent
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What smells?
A molecule of vanillin - grey spheres are carbon, red - oxygen, white - hydrogen
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Richard Axel Linda Buck2006
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Rhinencephalon or Limbic System
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The Rhinencephalon Defines the Brain of
Mammals•Territoriality
•Hunt/forage/food intake
•Maternal Behavior
•Infant Attachment
•Sexual Selection
•Hormone Regulation
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“From a clinical point of view, the importance of the olfactory system is slight, just as the sense of smell is of relatively minor importance in the normal life of civilized man.”
A. Brodal, Neurological Anatomy,
3rd
What about Humans?
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So...olfaction is vestigial in humans
•We almost never notice odors
•When we notice, we can’t identify
•Noses are funny
•Much of odor perception is a nuisance
•98% of undergrads would loose smellif given a choice
Not so fast…
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Your Brain and Jelly Beans
or SKITTLEs
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Smells, Tastes and Flavors
Sweet salty, bitter, sour, Umami…EVERYTHING ELSE is an odor
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You
Mate
Offspring
Love it!
Hates it!
????????
it
1000 Receptor Types ….only 330 expressed in humans
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U.S. Consumer Market 2001 : Source Kline & Co.
From Gilbert and Firestein, Nature Neuroscience 2003
Fine Fragrances for Men and Women 4.4 billion
Toiletries (soap, deodorant, bath) 6.6 billion
Hair care products 6.1 billion
Laundry products 6.1 billion
Home fragrances 2.3 billion
Functional Fragrances
Total Market 25.5 billion
Currently more than 40 billion (Kline)
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$1,691 per ounce
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1 oz $13,860.00
“Kyara”
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National Geographic (1986)
The New Speed Dating?
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(Associated Press, 2012)
Yes: Pheromone Parties
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If odors are so important, why don’t we know it?
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Odor Effects Without Detection
1983 & 1985 Kirk-Smith et al. Warwick Behavior & self-report1988 & 1990 Lorig & Schwartz Yale EEG1991 & 1993 Lorig et al. W&L ERP & Behavior1998 & 2000 Kline & Schwartz Arizona EEG & self-report1999 Sobel, et al. Berkeley fMRI2001 McClintock et al. Chicago PET2002 Walla et al. Vienna MEG2004 Jacquot, et al. Franche-Comte Skin conductance2005 Lundstrom & Olsson Uppsala Self-report2005 Holland et al. Radboud Behavior2009 Zucco et al. Padua, IT Behavior2010 Li et. al. Northwestern fMRI & self-report2010 Sela & Sobel Wiseman fMRI & self-reportand others
Lorig, 2012 Chemosensory Perception
Year Investigators University Dependent Var.
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Odor and HealthIs olfaction related to health?Sure! Just what you’d expect…
AgingAllergiesSinusitisNasal polypsSmokingVOC exposureHead Trauma
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Odor and Health
And many you wouldn’t…
Parkinson’s DiseaseMultiple SclerosisAnorexia nervosaDiabetesDown syndromeHIVEpilepsy (temporal lobe)Schizophrenia (including 1st degree relatives)AutismAlzheimer’s Disease (Serby, 1985)
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Olfaction and Alzheimer’s
Olfactory loss precedes cognitive impairmentbut variability and loss due to aging makes prediction hard
“Olfactory (bulb) tau pathology showed highly significant correlation with neuritic Braak staging in the brain, while both scores showed significant but low correlation with age.” Attems & Jellinger 2006
Perceptual and effects are related to ApoE4 and appear to be sensory rather than cognitive pathology
Course of AD
Olfactory Tau
Detectable olfactory loss
ApoE 4?
Cognitive Impairment
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