1

A nine letter word for hope

2

American Foundation for the Blind Headlines

3

MacuScopeTM

Accurately measures a patient’s Macular Protective Pigment Density (MPPD)

Low MPPD is a major risk factor for Macular Degeneration and is modifiable

Pigment deficiency can NOW be identified and monitored decades before clinical signs and/or symptoms appear

4

The Science

5

The FactsOverwhelming body of evidence that:

Yellow MPP blocks high energy blue light – has strong antioxidative properties

– resides anterior to the RPE layer and photoreceptors

6

Concentration of Macular Pigments

Consists solely of 3 carotenoids:

Lutein (L), Meso-zeaxanthin (MZ) & Zeaxanthin (Z) MZ is the dominant carotenoid at the fovea and is the most

potent antioxidant in the macula

7

Link to AMD

AMD Patients have low MPPD - a major risk factor

Reasons for low MPPD include:– Genetics– Smoking– Dietary insufficiency– Obesity– Inability to absorb– Lack of ability to convert L to MZ

8

(r = -0.286, p < 0.01)

Published in Exp Eye Res. December 2006

Age and Macular Pigment

9Published in Exp Eye Res. December 2006

Cigarette Smoking and Macular Pigment

10Published in Exp Eye Res. December 2006

Family History of AMD and Macular Pigment

11

Nutraceutical Supplementation Repigmentation of the macula reduces the risk of

developing AMD– Objective: prevent future permanent and cumulative

damage

Appropriate nutraceutical supplementation can rebuild Macular Pigment– a formulary containing all 3 carotenoids as found in

LMZ3: 10mg Lutein: 10 mg Meso-zeaxanthin: 2 mg Zeaxanthin

Measurable repigmentation can occur in as little as 6 months and usually plateaus in 2 years

12

AREDS Report 22

Archives of Ophthalmology, Sept. ’07

Evaluated dietary intake of carotenoids, vitamins A, C and E and their relationship to the progression of AMD

Conclusion: Only dietary intake of carotenoids correlated with a decreased rate of progression for any of the four stages of AMD

13

Leading Expert John Nolan BSc, PhD

– Fulbright Scholar @ University of Georgia– Deputy Director & Post Doctoral Research Fellow, Waterford

Institute of Technology

PhD thesis "Determinants of Macular Pigment in Healthy Subjects" was the largest cross-sectional study of its type in the world

Significant findings from his thesis:– Healthy middle-aged offspring of patients with age-related macular

degeneration (AMD) have a significant lack of macular pigment– This finding suggests that the observed lack of pigment may predispose

the sons and daughters of AMD sufferers to this disease– Appropriate dietary modification may delay, or even prevent the onset

of disease

           

  

14

Leading Expert Richard A. Bone PhD, Professor, Dept. of Physics, Florida

International University Research Interests: Experimental Biophysics - Physics of

the eye and visual system: MP and its possible relationship with AMD; non-invasive measurement of the MP; Cumulative light distribution on the human retina.

Recent Publications:– Bone, Landrum, Guerra, and Ruiz. (2003) Lutein and zeaxanthin dietary supplements raise macular pigment… J. Nutr.

133, 992-998.

– Krinsky, Landrum, Bone. (2003) Biologic mechanisms of the protective role of lutein… Annu. Rev. Nutr. 23, 171-201.

– Bone, Landrum (2004) Heterochromatic flicker photometery. Arch. Biochem. Biophys. 430, 137-142.

– Bone, Landrum, Gibert. (2004) Macular pigment and the edge hypothesis of flicker photometry. Vision Res. 44, 3045-3051.

– Rosenthal, Kim, de Monastario, Thompson, Bone et al (2006) Dose-ranging study of lutein…Invest. Ophthalmol. Vis. Sci. 47, 5227-5233.

–Bone, Landrum, Cao, Howard, Alvarez-Calderon. (2006) Macular pigment response…Nutr. Metab. 4:12.

– Bone, Brener, Gibert (2007) Macular pigment, photopigments, and melanin…Vision Res. 47, 3259-3268.

Bone and Draper (2007) Optical anisotropy of the human cornea…Applied Optics 46, 8351-8357.

15

“It’s a great tool for identifying patients at risk for AMD.  There is great relief on their faces when they get the results and find out they are not at risk.  The thing patients fear most is going blind.   For those who are at risk, they’re thrilled that there is something that can be done about it through supplementation and re-testing six months later.” 

“We are seen as the technological leader in the community because no one else has this.  We’re getting patients from across the state wanting to take the test.”                                                                                                                                                                                         

 Elaine Happ OD, Monticello, MN

Testimonials on Technology

16

“The MacuScope uses technology that needs to be available in every practice. It allows doctors to provide preventative eye care which may be vital to keeping quality vision for our patients. Our MacuScope raises the standard of care we provide and has been a welcome addition to our practice.”

Wes Kemp, O.D., Bolivar, MO

Testimonials on Technology

17

“Trying to prevent blindness is a big part of what we do. You feel good about being an O.D. when a patient returns for their six month re-check, their macular protective pigment has increased, and you get a great big thank you! It’s wonderful to give patients hope”

Harriet Pelton, O.D., Bloomfield Twp, MI

Testimonials on Technology

18

Help your patients Help your patients at risk for AMDat risk for AMD

The MacuScopeThe MacuScopeTMTM Helping to Preserve the Helping to Preserve the

World’s VisionWorld’s VisionAmsler Grid with Advanced AMD