a presentation on beryllium exposure and cancer risks
DESCRIPTION
A presentation made at the BeST meeting in Berlin during June 2013. The work describes the SHEcan study results for beryllium (Be) on occupational cancer.TRANSCRIPT
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INSTITUTE OF OCCUPATIONAL MEDICINE . Edinburgh . UK www.iom-world.org
Health and economic impacts associated with introducing
an OEL for beryllium
John Cherrie for the SHEcan Research Team
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Summary…
• The SHEcan project• Evaluation of 25 candidate substances for
changes to the Carcinogens & Mutagens Directive
• Beryllium• Estimated baseline health and socioeconomic
impacts• The effect of setting an exposure limit
• The results for Be in the context of the other substances evaluated• Our recommendations to the EC
BeST meeting, Berlin
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SHEcan
• A project for the EC DG Employment to undertake a Socioeconomic, Health and Environmental impact assessment
• Basis for developing plans to update the Carcinogens Directive• Prime focus was the impact of introducing new
Occupational Exposure Limits
• Collaboration involved IOM, Imperial College, AMEC, with assistance from other scientists
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Methodology…
• Exposure levels reliant on stakeholder data or when unavailable published sources
• Risk assessment reliant on epidemiological studies or analogy
• Health impact carried out using the methodology developed for the British cancer burden study
• Socioeconomic assessment based on EC guidance
EPICOH SHEcan Mini-Symposium
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Summary of results…
In Annex III
OELs Suggested by EC
Process generated
Typical OELs
EPICOH SHEcan Mini-Symposium
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Beryllium…
• We selected 2 μg/m3 as a typical European OEL
• For risk estimates used Ward et al (1992) • High exposed groups used the smoking-
adjusted SMR for the entire cohort = 1.12• Medium = 1.03, based excluding high-risk
plants• Low (background) exposed groups risk = 1
• Exposure information provided by industry
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Cardiff AWE personal sampling…
We assumed that exposure decreased 4% per year
Johnson et al. (2001). Beryllium Exposure Control Program at the Cardiff Atomic Weapons Establishment in the United Kingdom. Applied Occupational and Environmental Hyg; 16(5): 619-630.
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Baseline health assessment…
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Baseline assessment
99% compliance with OEL
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Introducing an OEL of 2 µg/m3 would…• Require further investment for 6% and 12%
of companies involved in handling beryllium or beryllium alloys. • Assumed that only 10% can achieve compliance
using best practice measures • Others will need improved local ventilation
• The total cost of implementing changes was judged to be €5-34bn, calculated over the period up to 2069
• Total benefits estimated as €11m - €30m
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Recommendations…• Respirable crystalline silica• Chrome VI• Hardwood dust• Diesel engine exhaust• Rubber fume• Benzo[a]pyrene• Trichloroethylene• Hydrazine• Epichlorohydrin• O-Toluidine• Mineral oils as used engine oil• MDA
Strong case
A case
A limited case
Uncertainty
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Conclusions…• Little evidence for any important health
impact from current and relatively recent past exposure to beryllium
• Less than about 10 cases of lung cancer per year across the whole EU
• Very high cost of complying with a limit of 0.002 mg/m3
• No case for further intervention for beryllium
Our summary report is available at… http://ec.europa.eu/social/main.jsp?catId=716&langId=en
BeST meeting, Berlin