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A REVIEW ON CHRONOTHERAPEUTIC DRUG

DELIVERY SYSTEMS

Dissertation submitted to the University of Kerala,

Thiruvananthapuram in partial fulfilment of the requirement for

the award of the degree in Bachelor of Pharmacy

Submitted by

NISHAMOL.U

MARCH2012

UNDER THE GUIDANCE OF

Mrs.TINTU JOY KUNDUKULAM, M.Pharm

Department of Pharmaceutics

St.Josephs College of Pharmacy

Dharmagiri College Campus, Cherthala-688524

Kerala, India

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St.Josephs College of Pharmacy,Dharmagiri College Campus,

Cherthala, Alappuzha

Kerala688 524

CERTIFICATE

This is to certify that the project work entitled; A REVIEW ON

CHRONOTHERAPEUTIC DRUG DELIVERY SYSTEMSsubmitted to The

University of Kerala, Thiruvananthapuram, in partial fulfilment of the

requirement for the award of the Degree in Bachelor of Pharmacy, was carried

out by Miss.NISHAMOL .U Final year B.Pharm is abonafide work, and was

conducted in the Department of Pharmaceutics, St. Josephs College of

Pharmacy, Cherthala ,Kerala under the guidance and supervision of

Mrs.TINTU JOY KUNDUKULAM, M.Pharm, Asst. professor. in

Pharmaceutics..

Date: Dr. Sr. BETTY CARLA, M.Pharm., Ph.D.,Principal,

St. Josephs College of Pharmacy,

Cherthala, Kerala,

India.

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St.Josephs College of Pharmacy,Dharmagiri College Campus,

Cherthala, AlappuzhaKerala-688 524

CERTIFICATE

This is to certify that the project work entitled; A REVIEW ON

CHRONOTHERAPEUTICDRUG DELIVERY SYSTEMSsubmitted to The

University of Kerala, Thiruvananthapuram, in partial fulfilment of the

requirement for the award of the Degree in Bachelor of Pharmacy, was carried

out by Miss.NISHAMOL.U Final year B.Pharm is abonafide work, and was

conducted in the Department of Pharmaceutics, St. Josephs college of

pharmacy, cherthala, Kerala under my guidance and supervision.

Date: Mrs. TINTU JOY KUNDUKULAM, M.PHARM

Asst. Professor,Dept. of Pharmaceutics,

St. Josephs College ofPharmacy,Cherthala, Kerala,

India.

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DECLARATION

I hereby declare that the project work entitled; A REVIEW ON

CHRONOTHERAPEUTICDRUG DELIVERY SYSTEMSwas carried out by

me under the guidance and supervision of Mrs.TINTU JOY

KUNDUKULAM, M.Pharmat the Department of Pharmaceutics, St.Josephs

College of Pharmacy, Cherthala.

NISHAMOL .U

Final Year B.Pharm

St. Josephs College of Pharmacy

Date: Cherthala, Alappuzha Dist.

Kerala-688 524

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ACKNOWLEDGEMENT

I praise the Lord-the Creator and invisible power who showers mercy upon

me every time.

I express my boundless sense of gratitude to each and every person who

directly and indirectly helped me in completing this dissertation.

I hereby dedicate this little piece of work to the Almighty.

I prevail my sense of gratitude and indebtness to our Principal Dr.Sr.Betty

Carla, M.Pharm PhD, St. Josephs College of Pharmacy, Cherthala for permitting me to

utilize necessary facilities to carry out this work.

It was a great privilege to work under the guidance of Mrs .TINTU

J OY KUNDUKULAM, M.Pharm, Department of Pharmaceutics, St.Josephs College of

Pharmacy, Cherthala. It gives me great pleasure to thank her for her meticulous guidance,

inestimable encouragement, dedicated involvement and valuable suggestions rendered for the

successful completion of my project work.

I am thankful to all the Teaching and Non teaching staff of St.Josephs College

of Pharmacy for their extended help during the work. With immense pleasure I extend my

whole hearted thanks to all my friends and classmates for their constructive suggestions in

the work.

I bow for the prayers and appreciation of my family members.

NISHAMOL .U

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INDEX

SLNO. PARTCULARS CONTENTS

1 Introduction 1

2 Objectives of work 4

3 Ideal characteristics of chronotheapeutic drug

delivery system

4

4 Advantages& Disadvantages of

Chronotherapeutic drug Delivery system

5

5 Approaches for Chronotheapeutic drug

Delivery system

6

6 Chronotherapeutical Technologies 12

7 Marketed products 25

8 Evaluation Techniques 26

9 Applications of Chronotherapeutic Drug

Delivery system

29

10 Literature Review 34

11 Future Prospects 36

12 Summary and Conclusions 38

13 Reference 40

14 Errata 44