abandoned drug infographic

Resurrection and reincarnation: giving abandoned drugs new life Receptor 1 Receptor 2 Abandoned drug: a drug that is no longer supported by the pharmaceutical company; a company can stop drug development at any stage How can an abandoned drug be given a new life? Receptor 1 Receptor 2 Compare downstream pathways Strategic partnerships Drug re-purposing Effectiveness of drug and injection site Effectiveness (%) 0 20 40 60 80 Timepoint (day) 0 1 2 3 4 5 Injection 1 Injection 2 Adjust study protocol Off-target or non-specific: all drugs have effects they are not supposed to, but the secret is balancing desired vs. undesired Failed clinical trials: 95% of drugs fail to be effective in humans (Source: Nature journal) Cost is insurmountable: development of one new drug can cost $350 million to $5 billion; if no chance to recoup, then it becomes a black hole expenditure Assess whether the off-target effects actually have a benefit Optimize the clinical trials or look at other clinical end points Escape the black hole Placebo Treatment Cholesterol X X Infection X Other endpoints Protein Gene Receptor 1 X ✓ Receptor 2 ✓ ✓ ©2014, Created by Firhan Malik (fi[email protected]) Why are drugs abandoned?

Upload: firhan-malik

Post on 16-Jul-2015

40 views

Category:

Documents

1 download

Report

Download

Tags:

Embed Size (px):

TRANSCRIPT

Resurrection and reincarnation: giving abandoned drugs new life

Receptor 1 Receptor 2

Abandoned drug: a drug that is no longer supported by the pharmaceutical company; a company can stop drug development at any stage

How can an abandoned drug be given a new life?

Receptor 1 Receptor 2

Compare downstream pathways

Strategic partnerships

Drug re-

purposing

Effectiveness of drug and injection site

Effe

ctive

ness

(%)

Timepoint (day)0 1 2 3 4 5

Injection 1Injection 2

Adjust study protocol

Off-target or non-specific: all drugs have effects they are not supposed to, but the secret is balancing desired vs. undesired

Failed clinical trials: 95% of drugs fail to be effective in humans (Source: Nature journal)

Cost is insurmountable: development of one new drug can cost $350 million to $5 billion; if no chance to recoup, then it becomes a black hole expenditure

Assess whether the off-target effects actually have a benefit

Optimize the clinical trials or look at other clinical end points Escape the black hole

Placebo Treatment

Cholesterol X XInfection X

Other endpointsProtein Gene

Receptor 1 X ✓Receptor 2 ✓ ✓

Why are drugs abandoned?

mailto:[email protected]