TRANSLATION OF ANIMAL DOSE INTO HUMAN DOSE AND INTERSTING FACT ABOUT SD RAT

Presented by:Jayant kumar MS (Pharm.)

Department of Pharmacology and ToxicologyNational Institute of Pharmaceutical Education and Research, SAS

Nagar(Punjab)

Translation Of Human Dose Into Animal Dose

HED Animal dose Human Km

Animal Km

HED = HUMAN EQUIVELENT DOSE

Human km A=37Ch=25Rat=6Mouse=3Rabit=12G.p.=8

BEHAVIORAL STUDY ON RAT

Exhausted = animal will see very tired

Sluggish = slow moving or inactive animal

Somnolent = animal will see sleepy drowsy

Rear = raise itself upright on it hind leg

Grooming = brush or clean the coat

Coprophagy = eating of faeces or dung

Normal behavior of animal 1. Leaping 2. Chasing3. Hudding4. Climbing5. Walking6. Standing7. Burrowing8. Nesting9. Gnowing10. Foraging11. retreating

BEHAVIORAL STUDY ON RAT

THE SPRAGUE DAWLEY RAT

Good general model for underlining study :-I. Human toxicologyII. Reproduction pharmacologyIII. Behavioral researchIV. Diabetes

It is widely used due to its calmness and ability to be handled easily.

Life span = up to 3.5

Body wt. female = 250-300g

male = 450-520g

Birth wt = 5-6 g

HR = 330-480 bpm

Respiratory rate = 85 breaths per minutes

Body temp. = 35.9-37.5 c

Blood volume = 50-70ml/kg

Urine volume = 3.3 ml/100g bwt/day

FACTS ABOUT SD RAT

Sexually mature at about 65 days old.

Gestation period of the sprague dawley is only 22 days.

Litters can consist of up to 12 pups.

Pups can be weaned at around 3 weeks and females can begin cycling again

only 2-4 days after weaning.

The pup’s eyes begin to open around 2 weeks.

They begin to eat an adult rat’s diet at around 3 weeks of age.  By 4 weeks

they are completely independent.

Conted….

These rats are unable to vomit due to the placement of the esophagus as it enters the

stomach. 

These rats have no gall bladder.

Peculiar lung arrangement: the left lung has one lobe, while the right lung has four.

Most interestingly, sprague dawley rats produce secretions from their eyes when stressed

that contain a pigment which, when dry, has the appearance of dried blood.

SOME INTERESTING FACTS ABOUT SD RAT